Reviewed, UniProtKB/Swiss-Prot Q5KUL0 (MURA1_GEOKA)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
    EC=2.5.1.7
Alternative name(s):
    Enoylpyruvate transferase 1
    UDP-N-acetylglucosamine enolpyruvyl transferase 1
      Short name=EPT 1

Gene names

Name:	murA1
Ordered Locus Names:	GK3341

Organism

Geobacillus kaustophilus [Complete proteome] [HAMAP]

Taxonomic identifier

1462 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity.
Catalytic activity	Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. HAMAP MF_00111
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00111
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family. MurA subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	UDP-N-acetylgalactosamine biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 HAMAP MF_00111		PRO_0000231206
Sites
	Active site	117	1	Proton donor By similarity
	Binding site	117	1	Phosphoenolpyruvate (covalent) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5KUL0-1 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 05BB0B5418E38874	FASTA	434	46,366
	10 20 30 40 50 60 MEKIIVRGGN RLSGTVKVEG AKNAVLPVIA ATLLATKGTS TIHDVPALSD VYTISEVLRY 70 80 90 100 110 120 LGADVHIADE TVTVDATGPL TVEAPFEYVR KMRASVLVMG PLLARNGRAR VALPGGCAIG 130 140 150 160 170 180 SRPIDQHLKG FEAMGASVKV GNGFIDAEVN GRLRGAKIYL DFPSVGATEN IMMAAVLAEG 190 200 210 220 230 240 TTVIENCAKE PEIVDLANFL NAMGAKVRGA GTGTIRIEGV DELVGTTHTV IPDRIEAGTF 250 260 270 280 290 300 MVAAAITGGN VLVQGAVPEH LGSLIAKLEE MGVTVIEEES GLRVIGPEKL KAVDIKTMPY 310 320 330 340 350 360 PGFPTDMQSQ MMALLLKAEG TSMITETVFE NRFMHVEEFR RMNADIKIEG RSVIINGPCQ 370 380 390 400 410 420 LQGAEVAATD LRAAAALILA GLAADGYTRV TELRHLDRGY VRFHEKLAAL GADIERVHEE 430 TEQFDQIQTI QWNG

References

[1]

"Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus." Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I. Nucleic Acids Res. 32:6292-6303(2004) [PubMed: 15576355] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HTA426.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000043 Genomic DNA. Translation: BAD77626.1.
RefSeq	YP_149194.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3186009.
GenomeReviews	Gene locus GK3341 in contig BA000043_GR.
KEGG	gka:GK3341.
NMPDR	fig|235909.3.peg.3383.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5KUL0.
OMA	VSRVYHL.
Enzyme and pathway databases
BioCyc	GKAU235909:GK3341-MON.
BRENDA	2.5.1.7. 281547.
Family and domain databases
HAMAP	MF_00111. [Tree]
InterPro	IPR001986. EPSP_synthase_core. IPR005750. UDP_GlcNAc_COvinyl_MurA. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
PANTHER	PTHR21090:SF4. AcGlu_Tran_MurA. 1 hit.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
ProDom	PD001867. EPSP_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01072. murA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURA1_GEOKA

Accession

Primary (citable) accession number: Q5KUL0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	February 1, 2005
Last modified:	November 3, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)