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Q5KUJ8 (NUOD_GEOKA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit D

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit D
NDH-1 subunit D
Gene names
Name:nuoD
Ordered Locus Names:GK3353
OrganismGeobacillus kaustophilus (strain HTA426) [Complete proteome] [HAMAP]
Taxonomic identifier235909 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP-Rule MF_01358

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP-Rule MF_01358

Subunit structure

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity HAMAP-Rule MF_01358.

Sequence similarities

Belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   LigandNAD
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

NADH dehydrogenase (quinone) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367NADH-quinone oxidoreductase subunit D HAMAP-Rule MF_01358
PRO_0000357819

Sequences

Sequence LengthMass (Da)Tools
Q5KUJ8 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 7C2ACC9DF3AC0357

FASTA36741,948
        10         20         30         40         50         60 
MMLRTEEMIL NVGPQHPSTH GVFRLILKID GEIIQEATPV IGYLHRGTEK IAEGLQYTQI 

        70         80         90        100        110        120 
IPYTDRMDYL SAMTNNYVLC HAVETMMGIE VPERAEYLRV LAMELGRIAS HLVWWGTYLL 

       130        140        150        160        170        180 
DLGATSPFLY AFREREMIIN LLNELSGARL TFNYMRIGGV KWDAPDGWID KVKQFVPYMR 

       190        200        210        220        230        240 
EKLHGYHELV TGNEIFRQRV TGVGRYTKEE AISYSLSGVN LRSTGVKWDL RKDEPYSIYD 

       250        260        270        280        290        300 
RFDFDVPVRE GGDCLARYEC RMAEIEQSLR IIEQACEQFP PEGPIMGKVP RIIKAPPGET 

       310        320        330        340        350        360 
FVRIEAPRGE IGCYIASDGK KEPYRLKFRR PSFYNLQILP KLLKGENLAN VIAILGSIDI 


VLGEVDG 

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References

[1]"Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HTA426.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000043 Genomic DNA. Translation: BAD77638.1.
RefSeqYP_149206.1. NC_006510.1.

3D structure databases

ProteinModelPortalQ5KUJ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING235909.GK3353.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD77638; BAD77638; GK3353.
GeneID3184186.
KEGGgka:GK3353.
PATRIC21968291. VBIGeoKau81518_3575.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0649.
HOGENOMHOG000228264.
KOK00333.
OMARIIEQAC.
OrthoDBEOG62G5MP.

Enzyme and pathway databases

BioCycGKAU235909:GJO7-3466-MONOMER.

Family and domain databases

Gene3D1.10.645.10. 1 hit.
HAMAPMF_01358. NDH1_NuoD.
InterProIPR001135. NADH_Q_OxRdtase_suD.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamPF00346. Complex1_49kDa. 2 hits.
[Graphical view]
SUPFAMSSF56762. SSF56762. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNUOD_GEOKA
AccessionPrimary (citable) accession number: Q5KUJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: February 1, 2005
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families