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Protein

NADH-quinone oxidoreductase subunit D

Gene

nuoD

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. NADH dehydrogenase (quinone) activity Source: UniProtKB-HAMAP
  3. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciGKAU235909:GJO7-3466-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit DUniRule annotation (EC:1.6.99.5UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit DUniRule annotation
NDH-1 subunit DUniRule annotation
Gene namesi
Name:nuoDUniRule annotation
Ordered Locus Names:GK3353
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000001172 Componenti: Chromosome

Subcellular locationi

  1. Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367NADH-quinone oxidoreductase subunit DPRO_0000357819Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi235909.GK3353.

Structurei

3D structure databases

ProteinModelPortaliQ5KUJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0649.
HOGENOMiHOG000228264.
KOiK00333.
OMAiEYRTWTQ.
OrthoDBiEOG62G5MP.

Family and domain databases

Gene3Di1.10.645.10. 1 hit.
HAMAPiMF_01358. NDH1_NuoD.
InterProiIPR001135. NADH_Q_OxRdtase_suD.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00346. Complex1_49kDa. 2 hits.
[Graphical view]
SUPFAMiSSF56762. SSF56762. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5KUJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLRTEEMIL NVGPQHPSTH GVFRLILKID GEIIQEATPV IGYLHRGTEK
60 70 80 90 100
IAEGLQYTQI IPYTDRMDYL SAMTNNYVLC HAVETMMGIE VPERAEYLRV
110 120 130 140 150
LAMELGRIAS HLVWWGTYLL DLGATSPFLY AFREREMIIN LLNELSGARL
160 170 180 190 200
TFNYMRIGGV KWDAPDGWID KVKQFVPYMR EKLHGYHELV TGNEIFRQRV
210 220 230 240 250
TGVGRYTKEE AISYSLSGVN LRSTGVKWDL RKDEPYSIYD RFDFDVPVRE
260 270 280 290 300
GGDCLARYEC RMAEIEQSLR IIEQACEQFP PEGPIMGKVP RIIKAPPGET
310 320 330 340 350
FVRIEAPRGE IGCYIASDGK KEPYRLKFRR PSFYNLQILP KLLKGENLAN
360
VIAILGSIDI VLGEVDG
Length:367
Mass (Da):41,948
Last modified:February 1, 2005 - v1
Checksum:i7C2ACC9DF3AC0357
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD77638.1.
RefSeqiYP_149206.1. NC_006510.1.

Genome annotation databases

EnsemblBacteriaiBAD77638; BAD77638; GK3353.
KEGGigka:GK3353.
PATRICi21968291. VBIGeoKau81518_3575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD77638.1.
RefSeqiYP_149206.1. NC_006510.1.

3D structure databases

ProteinModelPortaliQ5KUJ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi235909.GK3353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD77638; BAD77638; GK3353.
KEGGigka:GK3353.
PATRICi21968291. VBIGeoKau81518_3575.

Phylogenomic databases

eggNOGiCOG0649.
HOGENOMiHOG000228264.
KOiK00333.
OMAiEYRTWTQ.
OrthoDBiEOG62G5MP.

Enzyme and pathway databases

BioCyciGKAU235909:GJO7-3466-MONOMER.

Family and domain databases

Gene3Di1.10.645.10. 1 hit.
HAMAPiMF_01358. NDH1_NuoD.
InterProiIPR001135. NADH_Q_OxRdtase_suD.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00346. Complex1_49kDa. 2 hits.
[Graphical view]
SUPFAMiSSF56762. SSF56762. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
    Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
    Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTA426.

Entry informationi

Entry nameiNUOD_GEOKA
AccessioniPrimary (citable) accession number: Q5KUJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: February 1, 2005
Last modified: April 29, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.