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Protein

NADH-quinone oxidoreductase subunit D

Gene

nuoD

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processTransport
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit DUniRule annotation (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit DUniRule annotation
NDH-1 subunit DUniRule annotation
Gene namesi
Name:nuoDUniRule annotation
Ordered Locus Names:GK3353
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillusGeobacillus thermoleovorans group
Proteomesi
  • UP000001172 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003578191 – 367NADH-quinone oxidoreductase subunit DAdd BLAST367

Keywords - PTMi

Quinone

Proteomic databases

PRIDEiQ5KUJ8

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi235909.GK3353

Structurei

3D structure databases

ProteinModelPortaliQ5KUJ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CQV Bacteria
COG0649 LUCA
HOGENOMiHOG000228264
KOiK00333
OMAiKKIAWPA
OrthoDBiPOG091H08K1

Family and domain databases

Gene3Di1.10.645.20, 1 hit
HAMAPiMF_01358 NDH1_NuoD, 1 hit
InterProiView protein in InterPro
IPR001135 NADH_Q_OxRdtase_suD
IPR038290 NADH_Q_OxRdtase_suD_sf
IPR022885 NDH1_su_D/H
IPR029014 NiFe-Hase_large
PfamiView protein in Pfam
PF00346 Complex1_49kDa, 2 hits
SUPFAMiSSF56762 SSF56762, 1 hit

Sequencei

Sequence statusi: Complete.

Q5KUJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLRTEEMIL NVGPQHPSTH GVFRLILKID GEIIQEATPV IGYLHRGTEK
60 70 80 90 100
IAEGLQYTQI IPYTDRMDYL SAMTNNYVLC HAVETMMGIE VPERAEYLRV
110 120 130 140 150
LAMELGRIAS HLVWWGTYLL DLGATSPFLY AFREREMIIN LLNELSGARL
160 170 180 190 200
TFNYMRIGGV KWDAPDGWID KVKQFVPYMR EKLHGYHELV TGNEIFRQRV
210 220 230 240 250
TGVGRYTKEE AISYSLSGVN LRSTGVKWDL RKDEPYSIYD RFDFDVPVRE
260 270 280 290 300
GGDCLARYEC RMAEIEQSLR IIEQACEQFP PEGPIMGKVP RIIKAPPGET
310 320 330 340 350
FVRIEAPRGE IGCYIASDGK KEPYRLKFRR PSFYNLQILP KLLKGENLAN
360
VIAILGSIDI VLGEVDG
Length:367
Mass (Da):41,948
Last modified:February 1, 2005 - v1
Checksum:i7C2ACC9DF3AC0357
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA Translation: BAD77638.1

Genome annotation databases

EnsemblBacteriaiBAD77638; BAD77638; GK3353
KEGGigka:GK3353

Similar proteinsi

Entry informationi

Entry nameiNUOD_GEOKA
AccessioniPrimary (citable) accession number: Q5KUJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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