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Q5KUJ8

- NUOD_GEOKA

UniProt

Q5KUJ8 - NUOD_GEOKA

Protein

NADH-quinone oxidoreductase subunit D

Gene

nuoD

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NAD binding Source: InterPro
    2. NADH dehydrogenase (quinone) activity Source: UniProtKB-HAMAP
    3. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciGKAU235909:GJO7-3466-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit DUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit DUniRule annotation
    NDH-1 subunit DUniRule annotation
    Gene namesi
    Name:nuoDUniRule annotation
    Ordered Locus Names:GK3353
    OrganismiGeobacillus kaustophilus (strain HTA426)
    Taxonomic identifieri235909 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
    ProteomesiUP000001172: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367NADH-quinone oxidoreductase subunit DPRO_0000357819Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi235909.GK3353.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5KUJ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 49 kDa subunit family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0649.
    HOGENOMiHOG000228264.
    KOiK00333.
    OMAiRIIEQAC.
    OrthoDBiEOG62G5MP.

    Family and domain databases

    Gene3Di1.10.645.10. 1 hit.
    HAMAPiMF_01358. NDH1_NuoD.
    InterProiIPR001135. NADH_Q_OxRdtase_suD.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view]
    PfamiPF00346. Complex1_49kDa. 2 hits.
    [Graphical view]
    SUPFAMiSSF56762. SSF56762. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5KUJ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMLRTEEMIL NVGPQHPSTH GVFRLILKID GEIIQEATPV IGYLHRGTEK    50
    IAEGLQYTQI IPYTDRMDYL SAMTNNYVLC HAVETMMGIE VPERAEYLRV 100
    LAMELGRIAS HLVWWGTYLL DLGATSPFLY AFREREMIIN LLNELSGARL 150
    TFNYMRIGGV KWDAPDGWID KVKQFVPYMR EKLHGYHELV TGNEIFRQRV 200
    TGVGRYTKEE AISYSLSGVN LRSTGVKWDL RKDEPYSIYD RFDFDVPVRE 250
    GGDCLARYEC RMAEIEQSLR IIEQACEQFP PEGPIMGKVP RIIKAPPGET 300
    FVRIEAPRGE IGCYIASDGK KEPYRLKFRR PSFYNLQILP KLLKGENLAN 350
    VIAILGSIDI VLGEVDG 367
    Length:367
    Mass (Da):41,948
    Last modified:February 1, 2005 - v1
    Checksum:i7C2ACC9DF3AC0357
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000043 Genomic DNA. Translation: BAD77638.1.
    RefSeqiYP_149206.1. NC_006510.1.

    Genome annotation databases

    EnsemblBacteriaiBAD77638; BAD77638; GK3353.
    GeneIDi3184186.
    KEGGigka:GK3353.
    PATRICi21968291. VBIGeoKau81518_3575.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000043 Genomic DNA. Translation: BAD77638.1 .
    RefSeqi YP_149206.1. NC_006510.1.

    3D structure databases

    ProteinModelPortali Q5KUJ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 235909.GK3353.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD77638 ; BAD77638 ; GK3353 .
    GeneIDi 3184186.
    KEGGi gka:GK3353.
    PATRICi 21968291. VBIGeoKau81518_3575.

    Phylogenomic databases

    eggNOGi COG0649.
    HOGENOMi HOG000228264.
    KOi K00333.
    OMAi RIIEQAC.
    OrthoDBi EOG62G5MP.

    Enzyme and pathway databases

    BioCyci GKAU235909:GJO7-3466-MONOMER.

    Family and domain databases

    Gene3Di 1.10.645.10. 1 hit.
    HAMAPi MF_01358. NDH1_NuoD.
    InterProi IPR001135. NADH_Q_OxRdtase_suD.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view ]
    Pfami PF00346. Complex1_49kDa. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56762. SSF56762. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
      Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
      Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HTA426.

    Entry informationi

    Entry nameiNUOD_GEOKA
    AccessioniPrimary (citable) accession number: Q5KUJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3