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Q5KU03

- Q5KU03_MOUSE

UniProt

Q5KU03 - Q5KU03_MOUSE

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Protein
Submitted name:

Glycogen synthase kinase 3 beta

Gene

Gsk3b

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. beta-catenin binding Source: MGI
  3. protein kinase activity Source: MGI
  4. protein serine/threonine kinase activity Source: MGI
  5. tau-protein kinase activity Source: MGI

GO - Biological processi

  1. axonogenesis Source: MGI
  2. canonical Wnt signaling pathway Source: MGI
  3. cell migration Source: MGI
  4. cell proliferation Source: MGI
  5. cellular response to mechanical stimulus Source: Ensembl
  6. epithelial to mesenchymal transition Source: Ensembl
  7. ER overload response Source: MGI
  8. establishment of cell polarity Source: Ensembl
  9. fat cell differentiation Source: MGI
  10. glycogen metabolic process Source: Ensembl
  11. hippocampus development Source: Ensembl
  12. intracellular signal transduction Source: MGI
  13. myoblast fusion Source: MGI
  14. myotube differentiation Source: MGI
  15. negative regulation of apoptotic process Source: MGI
  16. negative regulation of cardiac muscle hypertrophy Source: MGI
  17. negative regulation of dendrite morphogenesis Source: Ensembl
  18. negative regulation of MAP kinase activity Source: Ensembl
  19. negative regulation of neuron maturation Source: MGI
  20. negative regulation of neuron projection development Source: MGI
  21. negative regulation of NFAT protein import into nucleus Source: Ensembl
  22. negative regulation of protein binding Source: Ensembl
  23. negative regulation of protein complex assembly Source: Ensembl
  24. organ morphogenesis Source: MGI
  25. peptidyl-serine phosphorylation Source: MGI
  26. positive regulation of apoptotic process Source: Ensembl
  27. positive regulation of axon extension Source: MGI
  28. positive regulation of cell-matrix adhesion Source: Ensembl
  29. positive regulation of peptidyl-serine phosphorylation Source: MGI
  30. positive regulation of peptidyl-threonine phosphorylation Source: MGI
  31. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
  32. positive regulation of protein binding Source: MGI
  33. positive regulation of protein complex assembly Source: Ensembl
  34. positive regulation of protein export from nucleus Source: Ensembl
  35. positive regulation of Rac GTPase activity Source: Ensembl
  36. positive regulation of stem cell differentiation Source: MGI
  37. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  38. protein export from nucleus Source: MGI
  39. protein localization to microtubule Source: MGI
  40. protein phosphorylation Source: MGI
  41. re-entry into mitotic cell cycle Source: MGI
  42. regulation of microtubule-based process Source: Ensembl
  43. regulation of neuronal synaptic plasticity Source: Ensembl
  44. regulation of neuron projection development Source: MGI
  45. response to drug Source: Ensembl
  46. response to lithium ion Source: Ensembl
  47. superior temporal gyrus development Source: Ensembl
  48. Wnt signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Glycogen synthase kinase 3 betaImported
Submitted name:
Glycogen synthase kinase 3 beta/tau protein kinase IImported
Gene namesi
Name:Gsk3bImported
ORF Names:mCG_129094Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1861437. Gsk3b.

Subcellular locationi

GO - Cellular componenti

  1. beta-catenin destruction complex Source: MGI
  2. cell body Source: MGI
  3. centrosome Source: Ensembl
  4. cytosol Source: MGI
  5. dendritic shaft Source: MGI
  6. dendritic spine Source: Ensembl
  7. growth cone Source: MGI
  8. membrane-bounded organelle Source: MGI
  9. membrane raft Source: Ensembl
  10. neuronal cell body Source: MGI
  11. nucleus Source: MGI
  12. plasma membrane Source: Ensembl
  13. ribonucleoprotein complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ5KU03.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG014652.
KOiK03083.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5KU03-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR
60 70 80 90 100
PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI
110 120 130 140 150
MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK
160 170 180 190 200
QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD
210 220 230 240 250
FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL
260 270 280 290 300
LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP
310 320 330 340 350
WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL
360 370 380 390 400
PNGRDTPALF NFTTQELSSN PPLATILIPP HARIQAAASP PANATAASDT
410 420
NAGDRGQTNN AASASASNST
Length:420
Mass (Da):46,710
Last modified:May 10, 2005 - v1
Checksum:i200C3FD1B38B4883
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB066114 mRNA. Translation: BAD86827.1.
AK154293 mRNA. Translation: BAE32494.1.
AK170965 mRNA. Translation: BAE42146.1.
CH466521 Genomic DNA. Translation: EDK97969.1.
RefSeqiNP_062801.1. NM_019827.6.
UniGeneiMm.394930.

Genome annotation databases

GeneIDi56637.
KEGGimmu:56637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB066114 mRNA. Translation: BAD86827.1 .
AK154293 mRNA. Translation: BAE32494.1 .
AK170965 mRNA. Translation: BAE42146.1 .
CH466521 Genomic DNA. Translation: EDK97969.1 .
RefSeqi NP_062801.1. NM_019827.6.
UniGenei Mm.394930.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 56637.
KEGGi mmu:56637.

Organism-specific databases

CTDi 2932.
MGIi MGI:1861437. Gsk3b.

Phylogenomic databases

HOVERGENi HBG014652.
KOi K03083.

Miscellaneous databases

ChiTaRSi Gsk3b. mouse.
NextBioi 313081.
SOURCEi Search...

Gene expression databases

Genevestigatori Q5KU03.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  5. "Glycogen synthase kinase 3b gene: complete genomic and cDNA structures."
    Sano Y., Nakano A., Hirai K., Ohta S., Yanagisawa M., Sato S., Imahori K.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  10. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ5KU03_MOUSE
AccessioniPrimary (citable) accession number: Q5KU03
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)