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Q5KU03

- Q5KU03_MOUSE

UniProt

Q5KU03 - Q5KU03_MOUSE

Protein
Submitted name:

Glycogen synthase kinase 3 beta

Gene

Gsk3b

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. beta-catenin binding Source: MGI
    3. protein binding Source: MGI
    4. protein kinase activity Source: MGI
    5. protein serine/threonine kinase activity Source: MGI
    6. tau-protein kinase activity Source: MGI

    GO - Biological processi

    1. axonogenesis Source: MGI
    2. canonical Wnt signaling pathway Source: MGI
    3. cell migration Source: MGI
    4. cell proliferation Source: MGI
    5. cellular response to mechanical stimulus Source: Ensembl
    6. epithelial to mesenchymal transition Source: Ensembl
    7. ER overload response Source: MGI
    8. establishment of cell polarity Source: Ensembl
    9. fat cell differentiation Source: MGI
    10. glycogen metabolic process Source: Ensembl
    11. hippocampus development Source: Ensembl
    12. intracellular signal transduction Source: MGI
    13. myoblast fusion Source: MGI
    14. myotube differentiation Source: MGI
    15. negative regulation of apoptotic process Source: MGI
    16. negative regulation of cardiac muscle hypertrophy Source: MGI
    17. negative regulation of dendrite morphogenesis Source: Ensembl
    18. negative regulation of MAP kinase activity Source: Ensembl
    19. negative regulation of neuron maturation Source: MGI
    20. negative regulation of neuron projection development Source: MGI
    21. negative regulation of NFAT protein import into nucleus Source: Ensembl
    22. negative regulation of protein binding Source: Ensembl
    23. negative regulation of protein complex assembly Source: Ensembl
    24. organ morphogenesis Source: MGI
    25. peptidyl-serine phosphorylation Source: MGI
    26. positive regulation of apoptotic process Source: Ensembl
    27. positive regulation of cell-matrix adhesion Source: Ensembl
    28. positive regulation of peptidyl-serine phosphorylation Source: MGI
    29. positive regulation of peptidyl-threonine phosphorylation Source: MGI
    30. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
    31. positive regulation of protein binding Source: MGI
    32. positive regulation of protein complex assembly Source: Ensembl
    33. positive regulation of protein export from nucleus Source: Ensembl
    34. positive regulation of Rac GTPase activity Source: Ensembl
    35. positive regulation of stem cell differentiation Source: MGI
    36. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    37. protein export from nucleus Source: MGI
    38. protein localization to microtubule Source: MGI
    39. protein phosphorylation Source: MGI
    40. re-entry into mitotic cell cycle Source: MGI
    41. regulation of microtubule-based process Source: Ensembl
    42. regulation of neuronal synaptic plasticity Source: Ensembl
    43. response to drug Source: Ensembl
    44. response to lithium ion Source: Ensembl
    45. superior temporal gyrus development Source: Ensembl
    46. Wnt signaling pathway Source: MGI

    Keywords - Molecular functioni

    KinaseImported, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Glycogen synthase kinase 3 betaImported
    Submitted name:
    Glycogen synthase kinase 3 beta/tau protein kinase IImported
    Gene namesi
    Name:Gsk3bImported
    ORF Names:mCG_129094Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1861437. Gsk3b.

    Subcellular locationi

    GO - Cellular componenti

    1. beta-catenin destruction complex Source: MGI
    2. cell body Source: MGI
    3. centrosome Source: Ensembl
    4. cytosol Source: MGI
    5. dendritic shaft Source: MGI
    6. dendritic spine Source: Ensembl
    7. growth cone Source: MGI
    8. membrane-bounded organelle Source: MGI
    9. membrane raft Source: Ensembl
    10. neuronal cell body Source: MGI
    11. nucleus Source: MGI
    12. plasma membrane Source: Ensembl
    13. ribonucleoprotein complex Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ5KU03.

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG014652.
    KOiK03083.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5KU03-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR    50
    PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI 100
    MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK 150
    QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD 200
    FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL 250
    LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 300
    WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL 350
    PNGRDTPALF NFTTQELSSN PPLATILIPP HARIQAAASP PANATAASDT 400
    NAGDRGQTNN AASASASNST 420
    Length:420
    Mass (Da):46,710
    Last modified:May 10, 2005 - v1
    Checksum:i200C3FD1B38B4883
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB066114 mRNA. Translation: BAD86827.1.
    AK154293 mRNA. Translation: BAE32494.1.
    AK170965 mRNA. Translation: BAE42146.1.
    CH466521 Genomic DNA. Translation: EDK97969.1.
    RefSeqiNP_062801.1. NM_019827.6.
    UniGeneiMm.394930.

    Genome annotation databases

    GeneIDi56637.
    KEGGimmu:56637.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB066114 mRNA. Translation: BAD86827.1 .
    AK154293 mRNA. Translation: BAE32494.1 .
    AK170965 mRNA. Translation: BAE42146.1 .
    CH466521 Genomic DNA. Translation: EDK97969.1 .
    RefSeqi NP_062801.1. NM_019827.6.
    UniGenei Mm.394930.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 56637.
    KEGGi mmu:56637.

    Organism-specific databases

    CTDi 2932.
    MGIi MGI:1861437. Gsk3b.

    Phylogenomic databases

    HOVERGENi HBG014652.
    KOi K03083.

    Miscellaneous databases

    ChiTaRSi GSK3B. mouse.
    NextBioi 313081.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q5KU03.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    5. "Glycogen synthase kinase 3b gene: complete genomic and cDNA structures."
      Sano Y., Nakano A., Hirai K., Ohta S., Yanagisawa M., Sato S., Imahori K.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    10. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    11. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.

    Entry informationi

    Entry nameiQ5KU03_MOUSE
    AccessioniPrimary (citable) accession number: Q5KU03
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)