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Protein

GPI mannosyltransferase 2

Gene

Pigv

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).By similarity

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiR-RNO-162710. Synthesis of glycosylphosphatidylinositol (GPI).
UniPathwayiUPA00196.

Protein family/group databases

CAZyiGT76. Glycosyltransferase Family 76.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI mannosyltransferase 2 (EC:2.4.1.-)
Alternative name(s):
GPI mannosyltransferase II
Short name:
GPI-MT-II
Phosphatidylinositol-glycan biosynthesis class V protein
Short name:
PIG-V
Gene namesi
Name:Pigv
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1309526. Pigv.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313CytoplasmicSequence analysisAdd
BLAST
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST
Topological domaini35 – 7743LumenalSequence analysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence analysisAdd
BLAST
Topological domaini99 – 11315CytoplasmicSequence analysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence analysisAdd
BLAST
Topological domaini135 – 1362LumenalSequence analysis
Transmembranei137 – 15721HelicalSequence analysisAdd
BLAST
Topological domaini158 – 1614CytoplasmicSequence analysis
Transmembranei162 – 18221HelicalSequence analysisAdd
BLAST
Topological domaini183 – 19210LumenalSequence analysis
Transmembranei193 – 21321HelicalSequence analysisAdd
BLAST
Topological domaini214 – 23421CytoplasmicSequence analysisAdd
BLAST
Transmembranei235 – 25521HelicalSequence analysisAdd
BLAST
Topological domaini256 – 32772LumenalSequence analysisAdd
BLAST
Transmembranei328 – 34821HelicalSequence analysisAdd
BLAST
Topological domaini349 – 37830CytoplasmicSequence analysisAdd
BLAST
Transmembranei379 – 39921HelicalSequence analysisAdd
BLAST
Topological domaini400 – 46869LumenalSequence analysisAdd
BLAST
Transmembranei469 – 48921HelicalSequence analysisAdd
BLAST
Topological domaini490 – 4923CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492GPI mannosyltransferase 2PRO_0000246236Add
BLAST

Post-translational modificationi

Not N-glycosylated.By similarity

Proteomic databases

PaxDbiQ5KR61.

Expressioni

Gene expression databases

GenevisibleiQ5KR61. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000133.

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGV family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2647. Eukaryota.
COG5542. LUCA.
GeneTreeiENSGT00390000013174.
HOGENOMiHOG000232162.
HOVERGENiHBG080592.
InParanoidiQ5KR61.
KOiK07542.
OMAiALFVWCT.
OrthoDBiEOG7VDXPB.
PhylomeDBiQ5KR61.
TreeFamiTF314515.

Family and domain databases

InterProiIPR007315. PIG-V/Gpi18.
[Graphical view]
PANTHERiPTHR12468. PTHR12468. 1 hit.
PfamiPF04188. Mannosyl_trans2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5KR61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLDPSQKE VLKFAVSCRI LTLVLQALFN IIIPDHHADA FSPPRLAPSG
60 70 80 90 100
SVDQLVEALL GGLSRWDAEH FLFIAEHGYL YEHNFAFFPG FPLALLMGTE
110 120 130 140 150
LLRPLQGLLS ERSCLLVSVA LLNSLFSVLA AVALHDLGCL VLHCPRQAFC
160 170 180 190 200
AALLFCLSPA NVFLAAGYSE ALFAFLTFSA MGQLERGRGW ASGLLFALAA
210 220 230 240 250
GVRSNGLVSV GFLLHSQCRG FCSSLVVLDP LKGLVKLMAS LCLSVLTVSL
260 270 280 290 300
PFALFQYYAY TQFCFPGSAH AIPEPLLRLA SDRGYRLAGD YEPPWCSRAP
310 320 330 340 350
PLIYSYIQDV YWNVGLLRYY ELRQVPNFLL ATPVTVLVVW ATWTYVTAHP
360 370 380 390 400
WLCLTLGLQR TKDRESLEKP HPGFLSAKVF VYLVHAAALL AFGGLCMHVQ
410 420 430 440 450
VLTRLLGSST PITYWFPAYL LQDREPLLRC VDTAPQKLLE NSPPGQKAPR
460 470 480 490
NCVMKLLYNW KTCSPVTKCI LVYFLTYWLL GLIMHCNFLP WT
Length:492
Mass (Da):54,701
Last modified:February 15, 2005 - v1
Checksum:i3C865F63B5280620
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196341 mRNA. Translation: BAD88519.1.
RefSeqiNP_001010966.1. NM_001010966.1.
XP_006239117.1. XM_006239055.2.
XP_008762381.1. XM_008764159.1.
UniGeneiRn.211496.

Genome annotation databases

EnsembliENSRNOT00000000133; ENSRNOP00000000133; ENSRNOG00000000121.
ENSRNOT00000081841; ENSRNOP00000073811; ENSRNOG00000000121.
GeneIDi366478.
KEGGirno:366478.
UCSCiRGD:1309526. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196341 mRNA. Translation: BAD88519.1.
RefSeqiNP_001010966.1. NM_001010966.1.
XP_006239117.1. XM_006239055.2.
XP_008762381.1. XM_008764159.1.
UniGeneiRn.211496.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000133.

Protein family/group databases

CAZyiGT76. Glycosyltransferase Family 76.

Proteomic databases

PaxDbiQ5KR61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000133; ENSRNOP00000000133; ENSRNOG00000000121.
ENSRNOT00000081841; ENSRNOP00000073811; ENSRNOG00000000121.
GeneIDi366478.
KEGGirno:366478.
UCSCiRGD:1309526. rat.

Organism-specific databases

CTDi55650.
RGDi1309526. Pigv.

Phylogenomic databases

eggNOGiKOG2647. Eukaryota.
COG5542. LUCA.
GeneTreeiENSGT00390000013174.
HOGENOMiHOG000232162.
HOVERGENiHBG080592.
InParanoidiQ5KR61.
KOiK07542.
OMAiALFVWCT.
OrthoDBiEOG7VDXPB.
PhylomeDBiQ5KR61.
TreeFamiTF314515.

Enzyme and pathway databases

UniPathwayiUPA00196.
ReactomeiR-RNO-162710. Synthesis of glycosylphosphatidylinositol (GPI).

Miscellaneous databases

NextBioi689494.
PROiQ5KR61.

Gene expression databases

GenevisibleiQ5KR61. RN.

Family and domain databases

InterProiIPR007315. PIG-V/Gpi18.
[Graphical view]
PANTHERiPTHR12468. PTHR12468. 1 hit.
PfamiPF04188. Mannosyl_trans2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol."
    Kang J.Y., Hong Y., Ashida H., Shishioh N., Murakami Y., Morita Y.S., Maeda Y., Kinoshita T.
    J. Biol. Chem. 280:9489-9497(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPIGV_RAT
AccessioniPrimary (citable) accession number: Q5KR61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 15, 2005
Last modified: May 11, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.