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Q5KQT7

- CP1A1_FELCA

UniProt

Q5KQT7 - CP1A1_FELCA

Protein

Cytochrome P450 1A1

Gene

CYP1A1

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics By similarity.By similarity

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei229 – 2291SubstrateBy similarity
    Metal bindingi462 – 4621Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. vitamin D 24-hydroxylase activity Source: Ensembl

    GO - Biological processi

    1. amine metabolic process Source: Ensembl
    2. drug metabolic process Source: Ensembl
    3. heterocycle metabolic process Source: Ensembl
    4. hydrogen peroxide biosynthetic process Source: Ensembl
    5. response to toxic substance Source: Ensembl
    6. toxin metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Gene namesi
    Name:CYP1A1
    OrganismiFelis catus (Cat) (Felis silvestris catus)
    Taxonomic identifieri9685 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
    ProteomesiUP000011712: Chromosome B3

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 517517Cytochrome P450 1A1PRO_0000226726Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi72 – 721O-linked (GlcNAc)By similarity

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi9685.ENSFCAP00000001863.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5KQT7.
    SMRiQ5KQT7. Positions 37-514.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00750000117317.
    HOGENOMiHOG000036991.
    HOVERGENiHBG106944.
    KOiK07408.
    OMAiNPALDFF.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5KQT7-1 [UniParc]FASTAAdd to Basket

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    MMLSVFGLSV PISATELLLA SFVFCLVFWV VRAWQPRVPK GLKSPPGPWG    50
    WPLLGHVLTL GKNPHLVLAR LSQHYGDVLQ IRIGSTPVLV LSGLDTIRQA 100
    LVRQGDDFKG RPNLYSFTLI SEGQSMSFSP DSGPVWAARR RLAQNALKSF 150
    SIASDPASSS SCYLEDHVSK EAEYLIGKFQ ELMAKVGHFD PYRYVVVSVA 200
    NVICAMCFGR RYDHDDQELL SIVNLSNEFG DGTASGNPVD FFPILRYLPN 250
    PALDFFKDVN EKFSIFIHKM VKEHYKTFEK GHIRDITDSL IEHCQDKRLD 300
    ENANIQLSDE KIVNVVSDLF GAGFDTVTTA ISWCLMYLVT SPNVQEKIQK 350
    ELDTVIGRER QPRLSDRLQL PYMEAFILEM FRHTSFVPFT IPHSTTKDTS 400
    LSGFYIPKER CVFVNQWQIN HDQKLWGDPS EFRPERFLTP DGTINKALSE 450
    KVILFGLGKR KCIGETIARL EVFLFLAILL QQVEFSVPQG TKVDMTPIYG 500
    LTMKHARCEH FQVRMRT 517
    Length:517
    Mass (Da):58,707
    Last modified:February 15, 2005 - v1
    Checksum:i9CB7E5E3419362D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB199730 mRNA. Translation: BAD86852.1.
    RefSeqiNP_001020030.1. NM_001024859.1.

    Genome annotation databases

    EnsembliENSFCAT00000002015; ENSFCAP00000001863; ENSFCAG00000002016.
    GeneIDi554347.
    KEGGifca:554347.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB199730 mRNA. Translation: BAD86852.1 .
    RefSeqi NP_001020030.1. NM_001024859.1.

    3D structure databases

    ProteinModelPortali Q5KQT7.
    SMRi Q5KQT7. Positions 37-514.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9685.ENSFCAP00000001863.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSFCAT00000002015 ; ENSFCAP00000001863 ; ENSFCAG00000002016 .
    GeneIDi 554347.
    KEGGi fca:554347.

    Organism-specific databases

    CTDi 1543.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00750000117317.
    HOGENOMi HOG000036991.
    HOVERGENi HBG106944.
    KOi K07408.
    OMAi NPALDFF.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Feline cytochrome P450 1A1."
      Tanaka N., Yokota H.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A1_FELCA
    AccessioniPrimary (citable) accession number: Q5KQT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3