Reviewed, UniProtKB/Swiss-Prot Q5KQT7 (CP1A1_FELCA)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 1A1
    EC=1.14.14.1
Alternative name(s):
    CYPIA1

Gene names

Name:

CYP1A1

Organism

Felis catus (Cat) (Felis silvestris catus)

Taxonomic identifier

9685 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

Protein attributes

Sequence length	517 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics By similarity.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Microsome membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 517	517	Cytochrome P450 1A1		PRO_0000226726
Sites
	Metal binding	462	1	Iron (heme axial ligand) By similarity
Amino acid modifications
	Modified residue	365	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5KQT7-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 9CB7E5E3419362D1	FASTA	517	58,707
	10 20 30 40 50 60 MMLSVFGLSV PISATELLLA SFVFCLVFWV VRAWQPRVPK GLKSPPGPWG WPLLGHVLTL 70 80 90 100 110 120 GKNPHLVLAR LSQHYGDVLQ IRIGSTPVLV LSGLDTIRQA LVRQGDDFKG RPNLYSFTLI 130 140 150 160 170 180 SEGQSMSFSP DSGPVWAARR RLAQNALKSF SIASDPASSS SCYLEDHVSK EAEYLIGKFQ 190 200 210 220 230 240 ELMAKVGHFD PYRYVVVSVA NVICAMCFGR RYDHDDQELL SIVNLSNEFG DGTASGNPVD 250 260 270 280 290 300 FFPILRYLPN PALDFFKDVN EKFSIFIHKM VKEHYKTFEK GHIRDITDSL IEHCQDKRLD 310 320 330 340 350 360 ENANIQLSDE KIVNVVSDLF GAGFDTVTTA ISWCLMYLVT SPNVQEKIQK ELDTVIGRER 370 380 390 400 410 420 QPRLSDRLQL PYMEAFILEM FRHTSFVPFT IPHSTTKDTS LSGFYIPKER CVFVNQWQIN 430 440 450 460 470 480 HDQKLWGDPS EFRPERFLTP DGTINKALSE KVILFGLGKR KCIGETIARL EVFLFLAILL 490 500 510 QQVEFSVPQG TKVDMTPIYG LTMKHARCEH FQVRMRT

References

[1]	"Feline cytochrome P450 1A1." Tanaka N., Yokota H. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB199730 mRNA. Translation: BAD86852.1.
RefSeq	NP_001020030.1.
3D structure databases
SMR	Q5KQT7. Positions 37-514.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5KQT7.
Genome annotation databases
Ensembl	ENSFCAT00000002015; ENSFCAP00000001863; ENSFCAG00000002016; Felis catus. [Genome view]
GeneID	554347.
Organism-specific databases
CTD	554347.
Phylogenomic databases
eggNOG	maNOG05805.
HOVERGEN	Q5KQT7.
Enzyme and pathway databases
BRENDA	1.14.14.1. 273949.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008066. Cyt_P450_E_grp-I_CYP1. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit. PTHR19383:SF63. Cyt_P450_E_grp-I_CYP1. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01683. EP450ICYP1A. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP1A1_FELCA

Accession

Primary (citable) accession number: Q5KQT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	February 15, 2005
Last modified:	January 19, 2010
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)