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Q5KQT7

- CP1A1_FELCA

UniProt

Q5KQT7 - CP1A1_FELCA

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Protein

Cytochrome P450 1A1

Gene

CYP1A1

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (By similarity).By similarity

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei229 – 2291SubstrateBy similarity
Metal bindingi462 – 4621Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. vitamin D 24-hydroxylase activity Source: Ensembl

GO - Biological processi

  1. amine metabolic process Source: Ensembl
  2. cellular response to organic cyclic compound Source: Ensembl
  3. drug metabolic process Source: Ensembl
  4. heterocycle metabolic process Source: Ensembl
  5. hydrogen peroxide biosynthetic process Source: Ensembl
  6. response to toxic substance Source: Ensembl
  7. toxin metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Gene namesi
Name:CYP1A1
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Chromosome B3

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Cytochrome P450 1A1PRO_0000226726Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721O-linked (GlcNAc)By similarity

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000001863.

Structurei

3D structure databases

ProteinModelPortaliQ5KQT7.
SMRiQ5KQT7. Positions 37-514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiQ5KQT7.
KOiK07408.
OMAiNPALDFF.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5KQT7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMLSVFGLSV PISATELLLA SFVFCLVFWV VRAWQPRVPK GLKSPPGPWG
60 70 80 90 100
WPLLGHVLTL GKNPHLVLAR LSQHYGDVLQ IRIGSTPVLV LSGLDTIRQA
110 120 130 140 150
LVRQGDDFKG RPNLYSFTLI SEGQSMSFSP DSGPVWAARR RLAQNALKSF
160 170 180 190 200
SIASDPASSS SCYLEDHVSK EAEYLIGKFQ ELMAKVGHFD PYRYVVVSVA
210 220 230 240 250
NVICAMCFGR RYDHDDQELL SIVNLSNEFG DGTASGNPVD FFPILRYLPN
260 270 280 290 300
PALDFFKDVN EKFSIFIHKM VKEHYKTFEK GHIRDITDSL IEHCQDKRLD
310 320 330 340 350
ENANIQLSDE KIVNVVSDLF GAGFDTVTTA ISWCLMYLVT SPNVQEKIQK
360 370 380 390 400
ELDTVIGRER QPRLSDRLQL PYMEAFILEM FRHTSFVPFT IPHSTTKDTS
410 420 430 440 450
LSGFYIPKER CVFVNQWQIN HDQKLWGDPS EFRPERFLTP DGTINKALSE
460 470 480 490 500
KVILFGLGKR KCIGETIARL EVFLFLAILL QQVEFSVPQG TKVDMTPIYG
510
LTMKHARCEH FQVRMRT
Length:517
Mass (Da):58,707
Last modified:February 15, 2005 - v1
Checksum:i9CB7E5E3419362D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB199730 mRNA. Translation: BAD86852.1.
RefSeqiNP_001020030.1. NM_001024859.1.

Genome annotation databases

EnsembliENSFCAT00000002015; ENSFCAP00000001863; ENSFCAG00000002016.
GeneIDi554347.
KEGGifca:554347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB199730 mRNA. Translation: BAD86852.1 .
RefSeqi NP_001020030.1. NM_001024859.1.

3D structure databases

ProteinModelPortali Q5KQT7.
SMRi Q5KQT7. Positions 37-514.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9685.ENSFCAP00000001863.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSFCAT00000002015 ; ENSFCAP00000001863 ; ENSFCAG00000002016 .
GeneIDi 554347.
KEGGi fca:554347.

Organism-specific databases

CTDi 1543.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118992.
HOGENOMi HOG000036991.
HOVERGENi HBG106944.
InParanoidi Q5KQT7.
KOi K07408.
OMAi NPALDFF.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Feline cytochrome P450 1A1."
    Tanaka N., Yokota H.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP1A1_FELCA
AccessioniPrimary (citable) accession number: Q5KQT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3