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Q5KQT7 (CP1A1_FELCA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 1A1

EC=1.14.14.1
Alternative name(s):
CYPIA1
Gene names
Name:CYP1A1
OrganismFelis catus (Cat) (Felis silvestris catus) [Reference proteome]
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Protein attributes

Sequence length517 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics By similarity.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Microsome membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 517517Cytochrome P450 1A1
PRO_0000226726

Sites

Metal binding4621Iron (heme axial ligand) By similarity
Binding site2291Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5KQT7 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 9CB7E5E3419362D1

FASTA51758,707
        10         20         30         40         50         60 
MMLSVFGLSV PISATELLLA SFVFCLVFWV VRAWQPRVPK GLKSPPGPWG WPLLGHVLTL 

        70         80         90        100        110        120 
GKNPHLVLAR LSQHYGDVLQ IRIGSTPVLV LSGLDTIRQA LVRQGDDFKG RPNLYSFTLI 

       130        140        150        160        170        180 
SEGQSMSFSP DSGPVWAARR RLAQNALKSF SIASDPASSS SCYLEDHVSK EAEYLIGKFQ 

       190        200        210        220        230        240 
ELMAKVGHFD PYRYVVVSVA NVICAMCFGR RYDHDDQELL SIVNLSNEFG DGTASGNPVD 

       250        260        270        280        290        300 
FFPILRYLPN PALDFFKDVN EKFSIFIHKM VKEHYKTFEK GHIRDITDSL IEHCQDKRLD 

       310        320        330        340        350        360 
ENANIQLSDE KIVNVVSDLF GAGFDTVTTA ISWCLMYLVT SPNVQEKIQK ELDTVIGRER 

       370        380        390        400        410        420 
QPRLSDRLQL PYMEAFILEM FRHTSFVPFT IPHSTTKDTS LSGFYIPKER CVFVNQWQIN 

       430        440        450        460        470        480 
HDQKLWGDPS EFRPERFLTP DGTINKALSE KVILFGLGKR KCIGETIARL EVFLFLAILL 

       490        500        510 
QQVEFSVPQG TKVDMTPIYG LTMKHARCEH FQVRMRT 

« Hide

References

[1]"Feline cytochrome P450 1A1."
Tanaka N., Yokota H.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB199730 mRNA. Translation: BAD86852.1.
RefSeqNP_001020030.1. NM_001024859.1.

3D structure databases

ProteinModelPortalQ5KQT7.
SMRQ5KQT7. Positions 37-514.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9685.ENSFCAP00000001863.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSFCAT00000002015; ENSFCAP00000001863; ENSFCAG00000002016.
GeneID554347.
KEGGfca:554347.

Organism-specific databases

CTD1543.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00750000117317.
HOGENOMHOG000036991.
HOVERGENHBG106944.
KOK07408.
OMANPALDFF.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP1A1_FELCA
AccessionPrimary (citable) accession number: Q5KQT7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: February 15, 2005
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families