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Q5KQT6 (CP1A2_FELCA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 1A2

EC=1.14.14.1
Alternative name(s):
CYPIA2
Gene names
Name:CYP1A2
OrganismFelis catus (Cat) (Felis silvestris catus) [Reference proteome]
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation By similarity.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Microsome membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 512511Cytochrome P450 1A2
PRO_0000226727

Sites

Metal binding4541Iron (heme axial ligand) By similarity
Binding site2221Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5KQT6 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 03C59CEC7676D7DF

FASTA51257,662
        10         20         30         40         50         60 
MAISPTATEL LLASFAFCLV FWVVRAWQPR VPKGLKSPPG PWGWPLLGHV LTLGKNPHLV 

        70         80         90        100        110        120 
LARLSQRYGD VLQIRIGSTP VLVLSGLDTI RQALVQQGDD FKGRPNLYSF SLVTDGHSMS 

       130        140        150        160        170        180 
FSPDSGPVWA ARRRLAQSAL NTFSIASDPA SSSSCYLEDH VSKEAEALLS RLQEQMAEVG 

       190        200        210        220        230        240 
SFDPHSQVVL SVANVIGAMC FGQHFPQDSE EKLSLIHSSN IFVENAYSGN PVDFFPILQY 

       250        260        270        280        290        300 
IPTPGLQRFK AFNQKLVQFL QKIIQEHYQD FDENNIQDIT GALLKHCKKG SRANGGRIPH 

       310        320        330        340        350        360 
EKIVSLINDI FGAGFDTVTT AISWSLMYLV TNPEKQRKIQ EELDTVVGRA RRPRLSDRLQ 

       370        380        390        400        410        420 
LPYLEASILE IFRHSSFIPF TVPHSTTRDT TLNGFYIPEK HLVFINQWQV NHDQKVWGDP 

       430        440        450        460        470        480 
FEFRPERFLT ADGTAINKIL SEKVMIFGLG KRRCIGEVLA KWEVFLFLAI LLQQLEFSVP 

       490        500        510 
AGVKVDLTPI YGLTMRHVRC EHVQARPRFS IK 

« Hide

References

[1]"Feline cytochrome P450 1A2."
Tanaka N., Yokota H.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB199731 mRNA. Translation: BAD86853.1.
RefSeqNP_001041478.1. NM_001048013.1.

3D structure databases

ProteinModelPortalQ5KQT6.
SMRQ5KQT6. Positions 30-510.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9685.ENSFCAP00000000315.

Proteomic databases

PRIDEQ5KQT6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID554345.
KEGGfca:554345.

Organism-specific databases

CTD1544.

Phylogenomic databases

eggNOGNOG266486.
HOGENOMHOG000036991.
HOVERGENHBG106944.
KOK07409.
OrthoDBEOG7RBZ85.
TreeFamTF105095.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP1A2_FELCA
AccessionPrimary (citable) accession number: Q5KQT6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: February 15, 2005
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families