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Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation (By similarity).By similarity

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei222 – 2221SubstrateBy similarity
Metal bindingi454 – 4541Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A2 (EC:1.14.14.1)
Alternative name(s):
CYPIA2
Gene namesi
Name:CYP1A2
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 512511Cytochrome P450 1A2PRO_0000226727Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651O-linked (GlcNAc)By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5KQT6.

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000000315.

Structurei

3D structure databases

ProteinModelPortaliQ5KQT6.
SMRiQ5KQT6. Positions 30-510.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiNOG266486.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiQ5KQT6.
KOiK07409.
OrthoDBiEOG7RBZ85.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5KQT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAISPTATEL LLASFAFCLV FWVVRAWQPR VPKGLKSPPG PWGWPLLGHV
60 70 80 90 100
LTLGKNPHLV LARLSQRYGD VLQIRIGSTP VLVLSGLDTI RQALVQQGDD
110 120 130 140 150
FKGRPNLYSF SLVTDGHSMS FSPDSGPVWA ARRRLAQSAL NTFSIASDPA
160 170 180 190 200
SSSSCYLEDH VSKEAEALLS RLQEQMAEVG SFDPHSQVVL SVANVIGAMC
210 220 230 240 250
FGQHFPQDSE EKLSLIHSSN IFVENAYSGN PVDFFPILQY IPTPGLQRFK
260 270 280 290 300
AFNQKLVQFL QKIIQEHYQD FDENNIQDIT GALLKHCKKG SRANGGRIPH
310 320 330 340 350
EKIVSLINDI FGAGFDTVTT AISWSLMYLV TNPEKQRKIQ EELDTVVGRA
360 370 380 390 400
RRPRLSDRLQ LPYLEASILE IFRHSSFIPF TVPHSTTRDT TLNGFYIPEK
410 420 430 440 450
HLVFINQWQV NHDQKVWGDP FEFRPERFLT ADGTAINKIL SEKVMIFGLG
460 470 480 490 500
KRRCIGEVLA KWEVFLFLAI LLQQLEFSVP AGVKVDLTPI YGLTMRHVRC
510
EHVQARPRFS IK
Length:512
Mass (Da):57,662
Last modified:February 14, 2005 - v1
Checksum:i03C59CEC7676D7DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB199731 mRNA. Translation: BAD86853.1.
RefSeqiNP_001041478.1. NM_001048013.1.

Genome annotation databases

GeneIDi554345.
KEGGifca:554345.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB199731 mRNA. Translation: BAD86853.1.
RefSeqiNP_001041478.1. NM_001048013.1.

3D structure databases

ProteinModelPortaliQ5KQT6.
SMRiQ5KQT6. Positions 30-510.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000000315.

Proteomic databases

PRIDEiQ5KQT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi554345.
KEGGifca:554345.

Organism-specific databases

CTDi1544.

Phylogenomic databases

eggNOGiNOG266486.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiQ5KQT6.
KOiK07409.
OrthoDBiEOG7RBZ85.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Feline cytochrome P450 1A2."
    Tanaka N., Yokota H.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP1A2_FELCA
AccessioniPrimary (citable) accession number: Q5KQT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2006
Last sequence update: February 14, 2005
Last modified: March 3, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.