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Q5KQT6

- CP1A2_FELCA

UniProt

Q5KQT6 - CP1A2_FELCA

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Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation By similarity.By similarity

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei222 – 2221SubstrateBy similarity
Metal bindingi454 – 4541Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A2 (EC:1.14.14.1)
Alternative name(s):
CYPIA2
Gene namesi
Name:CYP1A2
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 512511Cytochrome P450 1A2PRO_0000226727Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651O-linked (GlcNAc)By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5KQT6.

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000000315.

Structurei

3D structure databases

ProteinModelPortaliQ5KQT6.
SMRiQ5KQT6. Positions 30-510.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiNOG266486.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiQ5KQT6.
KOiK07409.
OrthoDBiEOG7RBZ85.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5KQT6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAISPTATEL LLASFAFCLV FWVVRAWQPR VPKGLKSPPG PWGWPLLGHV
60 70 80 90 100
LTLGKNPHLV LARLSQRYGD VLQIRIGSTP VLVLSGLDTI RQALVQQGDD
110 120 130 140 150
FKGRPNLYSF SLVTDGHSMS FSPDSGPVWA ARRRLAQSAL NTFSIASDPA
160 170 180 190 200
SSSSCYLEDH VSKEAEALLS RLQEQMAEVG SFDPHSQVVL SVANVIGAMC
210 220 230 240 250
FGQHFPQDSE EKLSLIHSSN IFVENAYSGN PVDFFPILQY IPTPGLQRFK
260 270 280 290 300
AFNQKLVQFL QKIIQEHYQD FDENNIQDIT GALLKHCKKG SRANGGRIPH
310 320 330 340 350
EKIVSLINDI FGAGFDTVTT AISWSLMYLV TNPEKQRKIQ EELDTVVGRA
360 370 380 390 400
RRPRLSDRLQ LPYLEASILE IFRHSSFIPF TVPHSTTRDT TLNGFYIPEK
410 420 430 440 450
HLVFINQWQV NHDQKVWGDP FEFRPERFLT ADGTAINKIL SEKVMIFGLG
460 470 480 490 500
KRRCIGEVLA KWEVFLFLAI LLQQLEFSVP AGVKVDLTPI YGLTMRHVRC
510
EHVQARPRFS IK
Length:512
Mass (Da):57,662
Last modified:February 15, 2005 - v1
Checksum:i03C59CEC7676D7DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB199731 mRNA. Translation: BAD86853.1.
RefSeqiNP_001041478.1. NM_001048013.1.

Genome annotation databases

GeneIDi554345.
KEGGifca:554345.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB199731 mRNA. Translation: BAD86853.1 .
RefSeqi NP_001041478.1. NM_001048013.1.

3D structure databases

ProteinModelPortali Q5KQT6.
SMRi Q5KQT6. Positions 30-510.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9685.ENSFCAP00000000315.

Proteomic databases

PRIDEi Q5KQT6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 554345.
KEGGi fca:554345.

Organism-specific databases

CTDi 1544.

Phylogenomic databases

eggNOGi NOG266486.
HOGENOMi HOG000036991.
HOVERGENi HBG106944.
InParanoidi Q5KQT6.
KOi K07409.
OrthoDBi EOG7RBZ85.
TreeFami TF105095.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Feline cytochrome P450 1A2."
    Tanaka N., Yokota H.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP1A2_FELCA
AccessioniPrimary (citable) accession number: Q5KQT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3