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Q5KQT6

- CP1A2_FELCA

UniProt

Q5KQT6 - CP1A2_FELCA

Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation By similarity.By similarity

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei222 – 2221SubstrateBy similarity
    Metal bindingi454 – 4541Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: UniProtKB
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A2 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA2
    Gene namesi
    Name:CYP1A2
    OrganismiFelis catus (Cat) (Felis silvestris catus)
    Taxonomic identifieri9685 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
    ProteomesiUP000011712: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 512511Cytochrome P450 1A2PRO_0000226727Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi65 – 651O-linked (GlcNAc)By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ5KQT6.

    Interactioni

    Protein-protein interaction databases

    STRINGi9685.ENSFCAP00000000315.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5KQT6.
    SMRiQ5KQT6. Positions 30-510.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiNOG266486.
    HOGENOMiHOG000036991.
    HOVERGENiHBG106944.
    KOiK07409.
    OrthoDBiEOG7RBZ85.
    TreeFamiTF105095.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5KQT6-1 [UniParc]FASTAAdd to Basket

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    MAISPTATEL LLASFAFCLV FWVVRAWQPR VPKGLKSPPG PWGWPLLGHV    50
    LTLGKNPHLV LARLSQRYGD VLQIRIGSTP VLVLSGLDTI RQALVQQGDD 100
    FKGRPNLYSF SLVTDGHSMS FSPDSGPVWA ARRRLAQSAL NTFSIASDPA 150
    SSSSCYLEDH VSKEAEALLS RLQEQMAEVG SFDPHSQVVL SVANVIGAMC 200
    FGQHFPQDSE EKLSLIHSSN IFVENAYSGN PVDFFPILQY IPTPGLQRFK 250
    AFNQKLVQFL QKIIQEHYQD FDENNIQDIT GALLKHCKKG SRANGGRIPH 300
    EKIVSLINDI FGAGFDTVTT AISWSLMYLV TNPEKQRKIQ EELDTVVGRA 350
    RRPRLSDRLQ LPYLEASILE IFRHSSFIPF TVPHSTTRDT TLNGFYIPEK 400
    HLVFINQWQV NHDQKVWGDP FEFRPERFLT ADGTAINKIL SEKVMIFGLG 450
    KRRCIGEVLA KWEVFLFLAI LLQQLEFSVP AGVKVDLTPI YGLTMRHVRC 500
    EHVQARPRFS IK 512
    Length:512
    Mass (Da):57,662
    Last modified:February 15, 2005 - v1
    Checksum:i03C59CEC7676D7DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB199731 mRNA. Translation: BAD86853.1.
    RefSeqiNP_001041478.1. NM_001048013.1.

    Genome annotation databases

    GeneIDi554345.
    KEGGifca:554345.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB199731 mRNA. Translation: BAD86853.1 .
    RefSeqi NP_001041478.1. NM_001048013.1.

    3D structure databases

    ProteinModelPortali Q5KQT6.
    SMRi Q5KQT6. Positions 30-510.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9685.ENSFCAP00000000315.

    Proteomic databases

    PRIDEi Q5KQT6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 554345.
    KEGGi fca:554345.

    Organism-specific databases

    CTDi 1544.

    Phylogenomic databases

    eggNOGi NOG266486.
    HOGENOMi HOG000036991.
    HOVERGENi HBG106944.
    KOi K07409.
    OrthoDBi EOG7RBZ85.
    TreeFami TF105095.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Feline cytochrome P450 1A2."
      Tanaka N., Yokota H.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A2_FELCA
    AccessioniPrimary (citable) accession number: Q5KQT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3