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Q5KP44

- IMDH_CRYNJ

UniProt

Q5KP44 - IMDH_CRYNJ

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Protein

Inosine-5'-monophosphate dehydrogenase

Gene

CNA04240

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

K(+)UniRule annotation

Enzyme regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi340 – 3401Potassium; via carbonyl oxygenUniRule annotation
Metal bindingi342 – 3421Potassium; via carbonyl oxygenUniRule annotation
Binding sitei343 – 3431IMPUniRule annotation
Active sitei345 – 3451Thioimidate intermediateUniRule annotation
Metal bindingi345 – 3451Potassium; via carbonyl oxygenUniRule annotation
Binding sitei470 – 4701IMPUniRule annotation
Metal bindingi529 – 5291Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation
Metal bindingi530 – 5301Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation
Metal bindingi531 – 5311Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi288 – 2903NADUniRule annotation
Nucleotide bindingi338 – 3403NADUniRule annotation

GO - Molecular functioni

  1. adenyl nucleotide binding Source: InterPro
  2. IMP dehydrogenase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenaseUniRule annotation (EC:1.1.1.205UniRule annotation)
Short name:
IMP dehydrogenaseUniRule annotation
Short name:
IMPDUniRule annotation
Short name:
IMPDHUniRule annotation
Gene namesi
Ordered Locus Names:CNA04240
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000002149: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 544544Inosine-5'-monophosphate dehydrogenasePRO_0000415685Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi214684.CNA04240.

Structurei

3D structure databases

ProteinModelPortaliQ5KP44.
SMRiQ5KP44. Positions 28-129, 242-543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini132 – 19261CBS 1UniRule annotationAdd
BLAST
Domaini194 – 25057CBS 2UniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni378 – 3803IMP bindingUniRule annotation
Regioni401 – 4022IMP bindingUniRule annotation
Regioni425 – 4295IMP bindingUniRule annotation

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.UniRule annotation
Contains 2 CBS domains.UniRule annotation

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

HOGENOMiHOG000165752.
InParanoidiQ5KP44.
KOiK00088.
OrthoDBiEOG793BHK.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01964. IMPDH.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PANTHERiPTHR11911:SF6. PTHR11911:SF6. 1 hit.
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5KP44-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADTNPNAPP RSDSLLNPAD ALKYLEEYPR GDGLSLQELM DSRKNGGLTY
60 70 80 90 100
NDFLVLPGHI SFPASDVSLQ SRATKNIVLN TPFLSSPMDT VTEDRMAIAL
110 120 130 140 150
ALHGGLGIIH HNCSAEEQAA MVRRVKKYEN GFITDPLCLG PDATVGDVLE
160 170 180 190 200
IKAKFGFCGV PITETGAPNS KLLGIVTGRD VQFQDAETPI KSVMTTEVVT
210 220 230 240 250
GSSPITLEKA NSLLRETKKG KLPIVDSNGH LVSLVARSDL LKNQNYPYAS
260 270 280 290 300
KVPESKQLYC GAAIGTRPGD KDRLKLLAEA GLDVVVLDSS QGDSVYQIEF
310 320 330 340 350
IKWIKQTYPK IEIIAGNVVT REQAAQLIAA GADGLRIGMG SGSICITQEV
360 370 380 390 400
MAVGRPQGTA VYAVAEFASR FGIPCIADGG IGNIGHIAKA LALGASAVMM
410 420 430 440 450
GGLLAGTTES PGEYFYHEGK RVKVYRGMGS IEAMEHTQRG SASGKRSILN
460 470 480 490 500
LDNAATARYF SEADAVKVAQ GVSGDVADKG SINKFVPYLF TGLQHSFQDA
510 520 530 540
GVKSVSELHS CARSGSLRFE LRTASAQLEG GVHGLNSYTK RLFA
Length:544
Mass (Da):57,899
Last modified:February 15, 2005 - v1
Checksum:iE5AB349D78F302AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017341 Genomic DNA. Translation: AAW40949.1.
RefSeqiXP_566768.1. XM_566768.1.
UniGeneiFne.7688.

Genome annotation databases

EnsemblFungiiAAW40949; AAW40949; CNA04240.
GeneIDi3253376.
KEGGicne:CNA04240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017341 Genomic DNA. Translation: AAW40949.1 .
RefSeqi XP_566768.1. XM_566768.1.
UniGenei Fne.7688.

3D structure databases

ProteinModelPortali Q5KP44.
SMRi Q5KP44. Positions 28-129, 242-543.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 214684.CNA04240.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAW40949 ; AAW40949 ; CNA04240 .
GeneIDi 3253376.
KEGGi cne:CNA04240.

Phylogenomic databases

HOGENOMi HOG000165752.
InParanoidi Q5KP44.
KOi K00088.
OrthoDBi EOG793BHK.

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01964. IMPDH.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
PANTHERi PTHR11911:SF6. PTHR11911:SF6. 1 hit.
Pfami PF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000130. IMPDH. 1 hit.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JEC21 / ATCC MYA-565.

Entry informationi

Entry nameiIMDH_CRYNJ
AccessioniPrimary (citable) accession number: Q5KP44
Secondary accession number(s): Q55ZT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: February 15, 2005
Last modified: November 26, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3