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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

CND02450

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:CND02450Imported
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)Imported
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000002149 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiFungiDB:CND02450.

Subcellular locationi

  • Mitochondrion matrix UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi214684.XP_570444.1.

Structurei

3D structure databases

ProteinModelPortaliQ5KIM3.
SMRiQ5KIM3. Positions 249-479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Phylogenomic databases

HOGENOMiHOG000281566.
InParanoidiQ5KIM3.
KOiK00627.
OMAiVESCIIT.
OrthoDBiEOG7TTQJ2.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5KIM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSFAQVAKR SAAVSFRRQA VASRTLRTSA PSNVLSKFAM PAMSPTMTEG
60 70 80 90 100
GVAQWKKKEG ESFSAGDVLI EIETDKATID VEAQDDGIMA KIIAQDGTKN
110 120 130 140 150
IAVGTPIAII GEEGDDLSQA DALAAESQSE SAPSQKEAAP KEEKTAPKEE
160 170 180 190 200
KSESSTTPAV GVPGEQKSGA GDAQTSPAKA PEHPSKGDRP KFFASPLARK
210 220 230 240 250
IALENGIPLA EIKGTGPNGR IVEADVKNYK PSAAAASTPA AGKSAAVPAD
260 270 280 290 300
YEDIPTSNMR RTIGKRLTES KQQLPHYYVT VEVNMDRVLK LREVFNKAGE
310 320 330 340 350
SKTKLSVNDF IVKAASLALA DVPEANSAWL GETIRTYKKA DICVAVATPN
360 370 380 390 400
GLITPIIKDV GAKGLATISA ETKALASRAR DGKLKPEEYQ GGSFTISNLG
410 420 430 440 450
MFGVDEFTAI INPPQSCILA VGKTTTKLEL APEDPKGFKA VQVMKVTLSA
460 470
DHRTVDGAVG ARWLKAFREY MEQPLTFML
Length:479
Mass (Da):50,790
Last modified:February 15, 2005 - v1
Checksum:i89D4D6870C6568AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017344 Genomic DNA. Translation: AAW43137.1.
RefSeqiXP_570444.1. XM_570444.1.
UniGeneiFne.6690.

Genome annotation databases

EnsemblFungiiAAW43137; AAW43137; CND02450.
GeneIDi3257075.
KEGGicne:CND02450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017344 Genomic DNA. Translation: AAW43137.1.
RefSeqiXP_570444.1. XM_570444.1.
UniGeneiFne.6690.

3D structure databases

ProteinModelPortaliQ5KIM3.
SMRiQ5KIM3. Positions 249-479.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214684.XP_570444.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAW43137; AAW43137; CND02450.
GeneIDi3257075.
KEGGicne:CND02450.

Organism-specific databases

EuPathDBiFungiDB:CND02450.

Phylogenomic databases

HOGENOMiHOG000281566.
InParanoidiQ5KIM3.
KOiK00627.
OMAiVESCIIT.
OrthoDBiEOG7TTQJ2.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JEC21 / ATCC MYA-565Imported.

Entry informationi

Entry nameiQ5KIM3_CRYNJ
AccessioniPrimary (citable) accession number: Q5KIM3
Secondary accession number(s): Q55TR2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: June 24, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.