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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

CND02450

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:CND02450Imported
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)Imported
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000002149 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiFungiDB:CND02450

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiQ5KIM3

Interactioni

Protein-protein interaction databases

STRINGi214684.XP_570444.1

Structurei

3D structure databases

ProteinModelPortaliQ5KIM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 111Lipoyl-bindingInterPro annotationAdd BLAST77
Domaini193 – 230Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Phylogenomic databases

eggNOGiKOG0557 Eukaryota
COG0508 LUCA
HOGENOMiHOG000281566
InParanoidiQ5KIM3
KOiK00627
OMAiTMEFESF
OrthoDBiEOG092C32CQ

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR006257 LAT1
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 1 hit
TIGRFAMsiTIGR01349 PDHac_trf_mito, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00189 LIPOYL, 1 hit
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

Q5KIM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSFAQVAKR SAAVSFRRQA VASRTLRTSA PSNVLSKFAM PAMSPTMTEG
60 70 80 90 100
GVAQWKKKEG ESFSAGDVLI EIETDKATID VEAQDDGIMA KIIAQDGTKN
110 120 130 140 150
IAVGTPIAII GEEGDDLSQA DALAAESQSE SAPSQKEAAP KEEKTAPKEE
160 170 180 190 200
KSESSTTPAV GVPGEQKSGA GDAQTSPAKA PEHPSKGDRP KFFASPLARK
210 220 230 240 250
IALENGIPLA EIKGTGPNGR IVEADVKNYK PSAAAASTPA AGKSAAVPAD
260 270 280 290 300
YEDIPTSNMR RTIGKRLTES KQQLPHYYVT VEVNMDRVLK LREVFNKAGE
310 320 330 340 350
SKTKLSVNDF IVKAASLALA DVPEANSAWL GETIRTYKKA DICVAVATPN
360 370 380 390 400
GLITPIIKDV GAKGLATISA ETKALASRAR DGKLKPEEYQ GGSFTISNLG
410 420 430 440 450
MFGVDEFTAI INPPQSCILA VGKTTTKLEL APEDPKGFKA VQVMKVTLSA
460 470
DHRTVDGAVG ARWLKAFREY MEQPLTFML
Length:479
Mass (Da):50,790
Last modified:February 15, 2005 - v1
Checksum:i89D4D6870C6568AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017344 Genomic DNA Translation: AAW43137.1
RefSeqiXP_570444.1, XM_570444.1
UniGeneiFne.6690

Genome annotation databases

EnsemblFungiiAAW43137; AAW43137; CND02450
GeneIDi3257075
KEGGicne:CND02450

Entry informationi

Entry nameiQ5KIM3_CRYNJ
AccessioniPrimary (citable) accession number: Q5KIM3
Secondary accession number(s): Q55TR2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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