Phosphoribosylaminoimidazole carboxylase

Contribute

Send feedback

Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q5KGS6 (PUR6_CRYNE)

Last modified November 3, 2009. Version 40. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole carboxylase
    EC=4.1.1.21
Alternative name(s):
    AIR carboxylase
      Short name=AIRC

Gene names

Name:	ADE2
Ordered Locus Names:	CNE02500, CNBE2520

Organism

Cryptococcus neoformans (Filobasidiella neoformans) [Complete proteome]

Taxonomic identifier

5207 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Tremellaceae › Filobasidiella › Filobasidiella/Cryptococcus neoformans species complex

Hide | Top

Protein attributes

Sequence length	582 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

Hide | Top

General annotation (Comments)

Catalytic activity

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO₂.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.

Sequence similarities

In the C-terminal section; belongs to the AIR carboxylase family.

Contains 1 ATP-grasp domain.

Hide | Top

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazole carboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 582

582

Phosphoribosylaminoimidazole carboxylase

PRO_0000075023

Regions

Domain

114 – 305

192

ATP-grasp

Nucleotide binding

143 – 200

ATP By similarity

Natural variations

Natural variant

102

Q → K in strain: B-3501 and B-3501A.

Natural variant

173

G → E in strain: B-3501 and B-3501A.

Natural variant

212

R → Q in strain: B-3501 and B-3501A.

Natural variant

231

A → T in strain: B-3501 and B-3501A.

Natural variant

565

A → V in strain: B-3501 and B-3501A.

Hide | Top

Sequences

Sequence

Length

Mass (Da)

Tools

Q5KGS6-1 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: A2136CC3DAAEB142
Show »

FASTA

582

62,345

        10         20         30         40         50         60 
MAPRKTVGIL GGGQLGRMLT HPAALLGIPL LILDSGSYTP AKQTLLPPPP HSHPDGPFTS 

        70         80         90        100        110        120 
ETHIRKLASA CDILTVEIEH VNADVLEAVE KEGLCEVQPS PQTIRLIQNK YDQKKYLAER 

       130        140        150        160        170        180 
GVAVAPFEEL PANPTEEDFK AIAGRLGLPL MLKAKTLAYD GRGNSPLKSA SSGDIQASLK 

       190        200        210        220        230        240 
FLGDRPLYAE GWAPFVKEVA VMVVRNKEGE VRSYDAVETI HRESILRVCL APLRGEKGVN 

       250        260        270        280        290        300 
QRARELAEKA VGHLEGAGIF GVEMFLMPDG ELLLNEIAPR PHNSGHHTIE ACLTSQFENH 

       310        320        330        340        350        360 
LRAILSLPLG STALRVPSAA MVNILGASST MDAIDKMADN ALTVPGAAVH LYGKAESRKA 

       370        380        390        400        410        420 
RKMGHITVTA ESDAELNERL RALLFAQPDA HADWIDLIAP PSPAPAHSHA KPLVGIIMGS 

       430        440        450        460        470        480 
DSDLPVMHPA TKILEKFGVP YELTITSAHR TPERMVKYAK TAADRGLRAI IAGAGGAAHL 

       490        500        510        520        530        540 
PGMVASETSL PVIGVPVKAS VLDGVDSLYS IVQMPRGIPC ATVGINNSTN AALLAVRILG 

       550        560        570        580 
TSVPALNKAT EEYSKALEEE VLAKADILEE EGWDKYIERL KK

« Hide

Hide | Top

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular analysis of the Cryptococcus neoformans ADE2 gene, a selectable marker for transformation and gene disruption." Sudarshan S., Davidson R.C., Heitman J., Alspaugh J.A. Fungal Genet. Biol. 27:36-48(1999) [PubMed: 10413613] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: B-3501.
[2]	"The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans." Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S. Hyman R.W. Science 307:1321-1324(2005) [PubMed: 15653466] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: B-3501A and JEC21.

Hide | Top

Cross-references

Sequence databases
	AF112302 Genomic DNA. Translation: AAC98316.1. AE017345 Genomic DNA. Translation: AAW43646.1. AAEY01000024 Genomic DNA. Translation: EAL20891.1.
RefSeq	XP_570953.1. XP_775538.1.
UniGene	Fne.3750 Fne.5943
3D structure databases
HSSP	HSSP built from PDB template 1O4V based on UniProtKB Q9WYS7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5KGS6.
Genome annotation databases
GeneID	3257629. 4936262.
GenomeReviews	Gene locus CNE02500 in contig AE017345_GR. Gene locus CNBE2520 in contig CM000044_GR.
KEGG	cnb:CNBE2520. cne:CNE02500.
Phylogenomic databases
HOGENOM	Q5KGS6.
OMA	TSETHIR.
Enzyme and pathway databases
BRENDA	4.1.1.21. 2772.
Family and domain databases
InterPro	IPR016301. AIR_COase. IPR005875. AIR_COase_ATPase-su. IPR000031. AIR_COase_core. IPR011761. ATP-grasp. IPR003135. ATP-grasp_carboxylate-amine. IPR013816. ATP_grasp_subdomain_2. IPR013817. Pre-ATP_grasp. [Graphical view]
Gene3D	G3DSA:3.40.50.7700. AIR_carboxyl. 1 hit. G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit.
PANTHER	PTHR23047:SF1. PurK_ATP. 1 hit.
Pfam	PF00731. AIRC. 1 hit. PF02222. ATP-grasp. 1 hit. [Graphical view]
PIRSF	PIRSF001340. AIR_carboxylase. 1 hit.
ProDom	PD002193. AIR_carboxyl. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01162. purE. 1 hit. TIGR01161. purK. 1 hit.
PROSITE	PS50975. ATP_GRASP. 1 hit. [Graphical view]
ProtoNet	Search...

Hide | Top

Entry information

Entry name

PUR6_CRYNE

Accession

Primary (citable) accession number: Q5KGS6
Secondary accession number(s): O93936, Q55SD0, Q92233

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	February 15, 2005
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)

Hide | Top

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents