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Q5KGI6

- Q5KGI6_CRYNJ

UniProt

Q5KGI6 - Q5KGI6_CRYNJ

Protein
Submitted name:

Alpha-amylase, putative

Gene

CNE03480

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi141 – 1411Calcium 1UniRule annotation
    Metal bindingi182 – 1821Calcium 1; via carbonyl oxygenUniRule annotation
    Metal bindingi195 – 1951Calcium 1UniRule annotation
    Active sitei226 – 2261NucleophileUniRule annotation
    Metal bindingi226 – 2261Calcium 2UniRule annotation
    Metal bindingi230 – 2301Calcium 1; via carbonyl oxygenUniRule annotation
    Active sitei250 – 2501Proton donorUniRule annotation
    Metal bindingi250 – 2501Calcium 2UniRule annotation
    Sitei318 – 3181Transition state stabilizerUniRule annotation

    GO - Molecular functioni

    1. alpha-amylase activity Source: UniProtKB-EC
    2. calcium ion binding Source: InterPro

    GO - Biological processi

    1. carbohydrate catabolic process Source: InterPro

    Keywords - Molecular functioni

    GlycosidaseImported, Hydrolase

    Keywords - Ligandi

    CalciumUniRule annotation, Metal-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Alpha-amylase, putativeImported (EC:3.2.1.1Imported)
    Gene namesi
    Ordered Locus Names:CNE03480Imported
    OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)Imported
    Taxonomic identifieri214684 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
    ProteomesiUP000002149: Chromosome 5

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 58UniRule annotation
    Disulfide bondi170 ↔ 184UniRule annotation

    Keywords - PTMi

    Disulfide bondUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi214684.CNE03480.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5KGI6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000165530.
    KOiK01176.
    OrthoDBiEOG7RBZJ4.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR013777. A-amylase_fun.
    IPR015340. A_amylase_DUF1966_C.
    IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10357. PTHR10357. 1 hit.
    PfamiPF00128. Alpha-amylase. 1 hit.
    PF09260. DUF1966. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001024. Alph-amyl_fung. 1 hit.
    SMARTiSM00642. Aamy. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5KGI6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTYQAALAL IPFISFLPAY ALDADAMRSR SVYQVVTDRF ARNSSSTGDC    50
    NVADRTYCGG TWSALADKLD YIQGMGFDTV WISPVVENIG GTTGEGEAYH 100
    GYWTLDPESL NSNFGSADDL KTLSSSLHAR GMYLQVDVVV NHVAATSSST 150
    FQPSESYGPF STSEDYHPFC WITDYNNQTN VEQCWLGDDS VALADLNTES 200
    DTVVSYWNQW ITDLVSNYTF DAIRIDTVKH VRQSFWPDFV NAAGVFNQGE 250
    VLLADVPYVA GYQKNASINP FNYPVYYPLV RAFNGTGQSF SELINMVSYV 300
    NSNFTDPTLL GTFLDNHDNA RFESFVTDPS LIKNAQAYPL VTDGIPYVYY 350
    GSEAGFNGGN DPENREPMWT SNYDTSSDMY KFFTSLNAAR SAAGNASSTF 400
    YTDKMTLSQP SESTLLVAKK PLMSVFSNSG SSASNTSVSV DSSSSGWAAS 450
    TNVIDALTCE SFTTDDSGNL AVTIYQGEPR VLIEDSQKGS LCGGSSSNSS 500
    STSNDSGAGM TTKVSGWVAL AGVFVAGLQV LL 532
    Length:532
    Mass (Da):57,639
    Last modified:February 15, 2005 - v1
    Checksum:i05971682AD484190
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017345 Genomic DNA. Translation: AAW43607.1.
    RefSeqiXP_570914.1. XM_570914.1.
    UniGeneiFne.7153.

    Genome annotation databases

    EnsemblFungiiAAW43607; AAW43607; CNE03480.
    GeneIDi3257780.
    KEGGicne:CNE03480.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017345 Genomic DNA. Translation: AAW43607.1 .
    RefSeqi XP_570914.1. XM_570914.1.
    UniGenei Fne.7153.

    3D structure databases

    ProteinModelPortali Q5KGI6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 214684.CNE03480.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii AAW43607 ; AAW43607 ; CNE03480 .
    GeneIDi 3257780.
    KEGGi cne:CNE03480.

    Phylogenomic databases

    HOGENOMi HOG000165530.
    KOi K01176.
    OrthoDBi EOG7RBZJ4.

    Family and domain databases

    Gene3Di 2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR013777. A-amylase_fun.
    IPR015340. A_amylase_DUF1966_C.
    IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10357. PTHR10357. 1 hit.
    Pfami PF00128. Alpha-amylase. 1 hit.
    PF09260. DUF1966. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001024. Alph-amyl_fung. 1 hit.
    SMARTi SM00642. Aamy. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
      Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
      , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
      Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JEC21 / ATCC MYA-565Imported.

    Entry informationi

    Entry nameiQ5KGI6_CRYNJ
    AccessioniPrimary (citable) accession number: Q5KGI6
    Secondary accession number(s): Q55S33
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 15, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3