Reviewed, UniProtKB/Swiss-Prot Q5KGE6 (CCPR2_CRYNE)

Names and origin

Protein names

Recommended name:
    Putative heme-binding peroxidase
    EC=1.11.1.-

Gene names

Ordered Locus Names:

CNE03890, CNBE3880

Organism

Cryptococcus neoformans (Filobasidiella neoformans) [Complete proteome]

Taxonomic identifier

5207 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Tremellaceae › Filobasidiella › Filobasidiella/Cryptococcus neoformans species complex

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per subunit By similarity.
Sequence similarities	Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.

Ontologies

Keywords
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Putative heme-binding peroxidase		PRO_0000055585
Sites
	Active site	40	1	Proton acceptor By similarity
	Active site	185	1	Tryptophan radical intermediate By similarity
	Metal binding	169	1	Iron (heme axial ligand) By similarity
	Site	36	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5KGE6-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: F8595CF5A63A2F68	FASTA	315	33,825
	10 20 30 40 50 60 MASVKEGDYQ ALKEEIKKIM KQPGYDDGSA GPVLVRLAWH ASGNFSLVEH NGGSNGAGMR 70 80 90 100 110 120 FPPESVDPAN AGLHYAISFL LPLQSANSWI SHADLWTLAG VTAIEAMGGP QIPWEPGRLD 130 140 150 160 170 180 YESEQAAVEH RGDVSNRLPD GALGAAHIRD VFGRMGFSDQ EIVALSGAHN LGRCHADRSG 190 200 210 220 230 240 FDGPWVVNPT RFSNQYFKLL LPGTRLMMLP TDMALIEDPS FRPWVEKYAA DQNLFFKDFA 250 260 270 280 290 300 NAFGKLIELG VDRDDTGFAR LAKKAAEEGK PLDKTAPPAG DETCPVSGAV GGGVQRAAGG 310 GGCPFMAMQN REAKL

References

[1]

"The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans." Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S. , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W. Science 307:1321-1324(2005) [PubMed: 15653466] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: B-3501A and JEC21.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017345 Genomic DNA. Translation: AAW43705.1. AAEY01000028 Genomic DNA. Translation: EAL20467.1. Sequence problems.
RefSeq	XP_571012.1. XP_775114.1.
UniGene	Fne.5152
3D structure databases
ModBase	Search...
Protein family/group databases
PeroxiBase	2329. CnCcP02_JEC21.
Genome annotation databases
GeneID	3257737. 4936399.
GenomeReviews	Gene locus CNE03890 in contig AE017345_GR.
KEGG	cnb:CNBE3880. cne:CNE03890.
Phylogenomic databases
HOGENOM	Q5KGE6.
OMA	Q5KGE6. PTRFSNQ.
Family and domain databases
InterPro	IPR002207. Asc_perxdse. IPR002016. Haem_peroxidase_pln/fun/bac. IPR019794. Peroxidases_AS. IPR019793. Peroxidases_heam-ligand_BS. [Graphical view]
Pfam	PF00141. peroxidase. 1 hit. [Graphical view]
PRINTS	PR00459. ASPEROXIDASE. PR00458. PEROXIDASE.
PROSITE	PS00435. PEROXIDASE_1. False negative. PS00436. PEROXIDASE_2. 1 hit. PS50873. PEROXIDASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCPR2_CRYNE

Accession

Primary (citable) accession number: Q5KGE6
Secondary accession number(s): Q55RZ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	February 15, 2005
Last modified:	June 16, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)