ID   Q5KEH9_CRYNJ            Unreviewed;       615 AA.
AC   Q5KEH9;
DT   15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 2.
DT   27-MAR-2024, entry version 114.
DE   RecName: Full=Dimethylaniline monooxygenase {ECO:0008006|Google:ProtNLM};
GN   OrderedLocusNames=CNG00460 {ECO:0000313|EMBL:AAW44441.2};
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW44441.2, ECO:0000313|Proteomes:UP000002149};
RN   [1] {ECO:0000313|EMBL:AAW44441.2, ECO:0000313|Proteomes:UP000002149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- SIMILARITY: Belongs to the FMO family. {ECO:0000256|ARBA:ARBA00009183}.
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DR   EMBL; AE017347; AAW44441.2; -; Genomic_DNA.
DR   RefSeq; XP_571748.1; XM_571748.1.
DR   AlphaFoldDB; Q5KEH9; -.
DR   PaxDb; 214684-Q5KEH9; -.
DR   EnsemblFungi; AAW44441; AAW44441; CNG00460.
DR   VEuPathDB; FungiDB:CNG00460; -.
DR   eggNOG; KOG1399; Eukaryota.
DR   HOGENOM; CLU_006909_7_5_1; -.
DR   InParanoid; Q5KEH9; -.
DR   OrthoDB; 445965at2759; -.
DR   Proteomes; UP000002149; Chromosome 7.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR000960; Flavin_mOase.
DR   InterPro; IPR020946; Flavin_mOase-like.
DR   PANTHER; PTHR23023; DIMETHYLANILINE MONOOXYGENASE; 1.
DR   PANTHER; PTHR23023:SF304; DIMETHYLANILINE MONOOXYGENASE; 1.
DR   Pfam; PF00743; FMO-like; 2.
DR   PIRSF; PIRSF000332; FMO; 2.
DR   PRINTS; PR00370; FMOXYGENASE.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        511..532
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        564..584
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   615 AA;  69332 MW;  C8FBBB9CD55410F3 CRC64;
     MSFPRQISTL VVGGGPAGIV SLKYTVEYGE AWSEGEEPLL IDMESEIGGT FRWRGYQNAE
     LVSSKQLTCF SDFRYPLDSP DHPSLPNFVD YLNCYIDHFD LRHMIRTSTK LVSLEYASSD
     SKDLYKHRAT IQPLNDNGLP QGDPLIVLAK RVIITTGLHV TPNIPLIPGL NSTPCIPEPP
     KWIHSSAYKS RNQLKDKKVL VLGCGETGMD IGYEAIMAPA KKVWLGVRTG FLSFPKVLNN
     FRVLGTTFDG KLPIDGLITN LFETAYVHPW VAASHIRWFI SDLVIKRLLW VLTGTMAGCN
     QWAGELPPER QGRAYVFLNK SAKAMQFINR PFYSLSPIHR WIAHYIDPPP PPGDPKIDIV
     PFPQGFDSEG RAVFPAPPEH RRKETAWKDE CKPDLVVLCT GYRQDWSWLG EGYPRGPEDC
     EIRGITSTKD LSIAFIGFVR PGVGAIPPIA EMQAQLFILL TEKRVPIPVS PETYHLLHSP
     TSRIQYGVDY STYMSTLAKD IGSAPGLLRL WWDYGLFVLF VYCFGAAFPT FYRLTGPFKI
     TKAREIVETE LWDTIRRRGV IGNIFMGVIP MVFYAYLNIG AYILEFVWRV VTPIFDLPAS
     PLELFQEKST TVKSI
//