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Protein

Flavin-containing monooxygenase

Gene

CNG00460

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Cofactori

FADUniRule annotation

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. N,N-dimethylaniline monooxygenase activity Source: InterPro
  3. NADP binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotationSAAS annotation, Oxidoreductase

Keywords - Ligandi

FADUniRule annotationSAAS annotation, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Flavin-containing monooxygenaseUniRule annotation (EC:1.-.-.-UniRule annotation)
Gene namesi
Ordered Locus Names:CNG00460Imported
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)Imported
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000002149: Chromosome 7

Structurei

3D structure databases

ProteinModelPortaliQ5KEH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000213862.
InParanoidiQ5KEH9.
OMAiTARIKYG.
OrthoDBiEOG7PK98B.

Family and domain databases

InterProiIPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
[Graphical view]
PfamiPF00743. FMO-like. 2 hits.
[Graphical view]
PRINTSiPR00370. FMOXYGENASE.

Sequencei

Sequence statusi: Complete.

Q5KEH9-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSFPRQISTL VVGGGPAGIV SLKYTVEYGE AWSEGEEPLL IDMESEIGGT
60 70 80 90 100
FRWRGYQNAE LVSSKQLTCF SDFRYPLDSP DHPSLPNFVD YLNCYIDHFD
110 120 130 140 150
LRHMIRTSTK LVSLEYASSD SKDLYKHRAT IQPLNDNGLP QGDPLIVLAK
160 170 180 190 200
RVIITTGLHV TPNIPLIPGL NSTPCIPEPP KWIHSSAYKS RNQLKDKKVL
210 220 230 240 250
VLGCGETGMD IGYEAIMAPA KKVWLGVRTG FLSFPKLFET AYVHPWVAAS
260 270 280 290 300
HIRWFISDLV IKRLLWVLTG TMAGCNQWAG ELPPERQGRA YVFLNKSAKA
310 320 330 340 350
MQFINRPFYS LSPIHRWIAH YIDPPPPPGD PKIDIVPFPQ GFDSEGRAVF
360 370 380 390 400
PAPPEHRRKE TAWKDECKPD LVVLCTGYRQ DWSWLGEGYP RGPEDCEIRG
410 420 430 440 450
ITSTKDLSIA FIGFVRPGVG AIPPIAEMQA QLFILLTEKR VPIPVSPETY
460 470 480 490 500
HLLHSPTSRI QYGVDYSTYM STLAKDIGSA PGLLRLWWDY GLFVLFVYCF
510 520 530 540 550
GAAFPTFYRL TGPFKITKAR EIVETELWDT IRRRGVIGNI FMGVIPMVFY
560 570 580 590
AYLNIGAYIL EFVWRVVTPI FDLPASPLEL FQEKSTTVKS I
Length:591
Mass (Da):66,732
Last modified:February 15, 2005 - v1
Checksum:i19BD1224C5C839D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017347 Genomic DNA. Translation: AAW44441.1.
RefSeqiXP_571748.1. XM_571748.1.
UniGeneiFne.5428.

Genome annotation databases

EnsemblFungiiAAW44441; AAW44441; CNG00460.
GeneIDi3258902.
KEGGicne:CNG00460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017347 Genomic DNA. Translation: AAW44441.1.
RefSeqiXP_571748.1. XM_571748.1.
UniGeneiFne.5428.

3D structure databases

ProteinModelPortaliQ5KEH9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAW44441; AAW44441; CNG00460.
GeneIDi3258902.
KEGGicne:CNG00460.

Phylogenomic databases

HOGENOMiHOG000213862.
InParanoidiQ5KEH9.
OMAiTARIKYG.
OrthoDBiEOG7PK98B.

Family and domain databases

InterProiIPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
[Graphical view]
PfamiPF00743. FMO-like. 2 hits.
[Graphical view]
PRINTSiPR00370. FMOXYGENASE.
ProtoNetiSearch...

Publicationsi

  1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JEC21 / ATCC MYA-565Imported.

Entry informationi

Entry nameiQ5KEH9_CRYNJ
AccessioniPrimary (citable) accession number: Q5KEH9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: January 7, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.