Reviewed, UniProtKB/Swiss-Prot Q5KDT9 (HAT2_CRYNE)

Names and origin

Protein names

Recommended name:
    Histone acetyltransferase type B subunit 2
    EC=2.3.1.48

Gene names

Name:	HAT2
Ordered Locus Names:	CNG02800

Organism

Cryptococcus neoformans (Filobasidiella neoformans) [Complete proteome]

Taxonomic identifier

5207 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Tremellaceae › Filobasidiella › Filobasidiella/Cryptococcus neoformans species complex

Protein attributes

Sequence length	435 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Component of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing By similarity.
Catalytic activity	Acetyl-CoA + histone = CoA + acetylhistone.
Subunit structure	Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. Contains 6 WD repeats.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm Nucleus
Domain	Repeat WD repeat
Molecular function	Acyltransferase Chromatin regulator Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 435	435	Histone acetyltransferase type B subunit 2		PRO_0000227737
Regions
	Repeat	135 – 175	41	WD 1
	Repeat	188 – 228	41	WD 2
	Repeat	238 – 278	41	WD 3
	Repeat	284 – 324	41	WD 4
	Repeat	328 – 368	41	WD 5
	Repeat	385 – 425	41	WD 6

Sequences

	Sequence		Length	Mass (Da)
	Q5KDT9-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: A47BC4BAD7F12AB9	FASTA	435	48,478
	10 20 30 40 50 60 MAHNEPITID DAGDDFDAVE DNQAINEQYK VWKKNTPFLY DTVITHALTW PSLTCQWLPD 70 80 90 100 110 120 ITDVPDTDYT SQRLIIGTHT SGQANDHLII AEVLLPKKGA GISDKALADL YDEEKQEIGS 130 140 150 160 170 180 YTASPARIRA IQTINHAGEV NRARYMPQNP ELIATKTVTG EVYVFDRTKH ESKAPANGEC 190 200 210 220 230 240 KPDIRLKGQT KEGYGLSWNA LKEGHILSAS EDTTIGHWDI QGYSKQDPSL QPLRLYTGHS 250 260 270 280 290 300 AYVADVEWHP KNENMFGSVS DDGQIMIWDT RSDNTAKASS QVQGHNAEIN CISFAPSSEY 310 320 330 340 350 360 LFLTGSSDNT IALWDLRKLS TKHHSFEAHT NDVLQLSWSP TSPVHFASAS ADRRVHIWDL 370 380 390 400 410 420 DAIGAEQTPD DAEDGPPELL FVHGGHTSKV CDISWSPSSP WTIASASEDN ILQVWEPSRH 430 LRTPYEAEFD EKDLE

References

[1]

"The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans." Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S. , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W. Science 307:1321-1324(2005) [PubMed: 15653466] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: B-3501A and JEC21.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017347 Genomic DNA. Translation: AAW44637.1. AAEY01000038 Genomic DNA. Translation: EAL19568.1.
RefSeq	XP_571944.1. XP_774215.1.
UniGene	Fne.3538
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5KDT9.
Genome annotation databases
GeneID	3258762. 4937231.
GenomeReviews	Gene locus CNG02800 in contig AE017347_GR. Gene locus HAT2 in contig CM000046_GR.
KEGG	cnb:CNBG1970. cne:CNG02800.
Phylogenomic databases
HOGENOM	Q5KDT9.
OMA	VTHALEW.
Enzyme and pathway databases
BRENDA	2.3.1.48. 2772.
Family and domain databases
InterPro	IPR020472. G-protein_beta_WD-40_rep_reg. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019782. WD40_repeat_2. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. IPR019781. WD40_repeat_sg. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 5 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
ProDom	PD000018. WD40. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00320. WD40. 6 hits. [Graphical view]
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. 4 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HAT2_CRYNE

Accession

Primary (citable) accession number: Q5KDT9
Secondary accession number(s): Q55PL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	February 15, 2005
Last modified:	November 3, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)