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Protein

Elongation factor Tu

Gene

CNG03130

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-KW
  3. translation elongation factor activity Source: UniProtKB-KW

GO - Biological processi

  1. mitochondrial translational elongation Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Elongation factorUniRule annotationImported

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Gene namesi
Ordered Locus Names:CNG03130Imported
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)Imported
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000002149 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiFungiDB:CNG03130.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: EnsemblFungi
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi214684.CNG03130.

Structurei

3D structure databases

ProteinModelPortaliQ5KDQ7.
SMRiQ5KDQ7. Positions 73-461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229290.
InParanoidiQ5KDQ7.
KOiK02358.
OMAiHYRPQLF.
OrthoDBiEOG7GXPMZ.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5KDQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNALQSRL SSTLRTAELR AARPVAGPSV LAARTFVSKP LPSPRFRAAV
60 70 80 90 100
LTPRRLPTRS YAAEAGGKFT RSKPHFNIGT IGHVDHGKTT LTAAITKHLA
110 120 130 140 150
EQGGGKFMDY SQIDKAPEEK ARGITISTAH VEYETPNRHY AHIDCPGHAD
160 170 180 190 200
YIKNMITGAA QLDGAIIVVS ATDGQMPQTR EHLLLARQVG IKKLVVFINK
210 220 230 240 250
VDQVDDPEML ELVEMEMREL LGQYGFDGEE TPIVMGSALA ALEGRDPERG
260 270 280 290 300
AQKIQELMEK ADEWLDVPSR DLDKPFLMYV EDVFSISGRG TVVTGKVERG
310 320 330 340 350
TITKGSEVEI VGLGAPVKTI LTGIEMFHKE LERGEAGDNM GALLRGIKRE
360 370 380 390 400
QVRRGQVLVQ PGSIKSVKKF KAQIYILTKE EGGRYTPFMA NYRPQLFIRT
410 420 430 440 450
TDVTCALTFP EGTEGAHEKL VMPGDNVEMI GDLVHDIALE PGSRFTLREG
460
GKTIGTGIVS EIYE
Length:464
Mass (Da):50,930
Last modified:February 15, 2005 - v1
Checksum:i498AA1F7AB036528
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017347 Genomic DNA. Translation: AAW44713.1.
RefSeqiXP_572020.1. XM_572020.1.
UniGeneiFne.7634.

Genome annotation databases

EnsemblFungiiAAW44713; AAW44713; CNG03130.
GeneIDi3258600.
KEGGicne:CNG03130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017347 Genomic DNA. Translation: AAW44713.1.
RefSeqiXP_572020.1. XM_572020.1.
UniGeneiFne.7634.

3D structure databases

ProteinModelPortaliQ5KDQ7.
SMRiQ5KDQ7. Positions 73-461.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214684.CNG03130.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAW44713; AAW44713; CNG03130.
GeneIDi3258600.
KEGGicne:CNG03130.

Organism-specific databases

EuPathDBiFungiDB:CNG03130.

Phylogenomic databases

HOGENOMiHOG000229290.
InParanoidiQ5KDQ7.
KOiK02358.
OMAiHYRPQLF.
OrthoDBiEOG7GXPMZ.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JEC21 / ATCC MYA-565Imported.

Entry informationi

Entry nameiQ5KDQ7_CRYNJ
AccessioniPrimary (citable) accession number: Q5KDQ7
Secondary accession number(s): Q55PQ1
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: April 29, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.