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Q5KDL9

- Q5KDL9_CRYNJ

UniProt

Q5KDL9 - Q5KDL9_CRYNJ

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Protein
Malate dehydrogenase
Gene
CNG03490
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Ordered Locus Names:CNG03490Imported
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)Imported
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000002149: Chromosome 7

PTM / Processingi

Proteomic databases

PRIDEiQ5KDL9.

Interactioni

Protein-protein interaction databases

STRINGi214684.CNG03490.

Structurei

3D structure databases

ProteinModelPortaliQ5KDL9.
SMRiQ5KDL9. Positions 26-337.

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000213792.
KOiK00026.
OrthoDBiEOG7GJ6Q7.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5KDL9-1 [UniParc]FASTAAdd to Basket

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MFARQVAKNS SSLARGFASS ARSNRKVAVL GAAGGIGQPM SLLLKQNPGV    50
TGLSLYDIRG APGVAADISH VNTHSTVKGF EKDDIKEALT GAEIVIIPAG 100
VPRKPGMTRD DLFNTNASIV RDLAEACAEY CPKAFIGIIS NPVNSTVPIF 150
AEVLKKKGVF DEKRVFGITT LDVVRASRFL GEIKGKDPKD IKVTVVGGHS 200
GVTIVPLLSQ TPEGKDVSGE AYKALVNRIQ FGGDEVVKAK AGTGSATLSM 250
GYAGARFTDS LIRALNGETG IVEPTFVKSP LYESEGVEYF ASNVELGPEG 300
VKKINPVGQL SAEEQELLKA CLPDLVKNIK KGVDFVKA 338
Length:338
Mass (Da):35,659
Last modified:February 15, 2005 - v1
Checksum:i6D826ACDC47FFBB1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017347 Genomic DNA. Translation: AAW44731.1.
RefSeqiXP_572038.1. XM_572038.1.
UniGeneiFne.6681.

Genome annotation databases

EnsemblFungiiAAW44731; AAW44731; CNG03490.
GeneIDi3258550.
KEGGicne:CNG03490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017347 Genomic DNA. Translation: AAW44731.1 .
RefSeqi XP_572038.1. XM_572038.1.
UniGenei Fne.6681.

3D structure databases

ProteinModelPortali Q5KDL9.
SMRi Q5KDL9. Positions 26-337.
ModBasei Search...

Protein-protein interaction databases

STRINGi 214684.CNG03490.

Proteomic databases

PRIDEi Q5KDL9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAW44731 ; AAW44731 ; CNG03490 .
GeneIDi 3258550.
KEGGi cne:CNG03490.

Phylogenomic databases

HOGENOMi HOG000213792.
KOi K00026.
OrthoDBi EOG7GJ6Q7.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JEC21 / ATCC MYA-565.

Entry informationi

Entry nameiQ5KDL9_CRYNJ
AccessioniPrimary (citable) accession number: Q5KDL9
Secondary accession number(s): Q55PT6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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