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Protein

Malate dehydrogenase

Gene

CNG03490

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109SubstrateUniRule annotation1
Binding sitei141SubstrateUniRule annotation1
Binding sitei175SubstrateUniRule annotation1
Active sitei199Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Ordered Locus Names:CNG03490Imported
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)Imported
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000002149 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiFungiDB:CNG03490

PTM / Processingi

Proteomic databases

PaxDbiQ5KDL9
PRIDEiQ5KDL9

Interactioni

Protein-protein interaction databases

STRINGi214684.XP_572038.1

Structurei

3D structure databases

ProteinModelPortaliQ5KDL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 167Ldh_1_NInterPro annotationAdd BLAST142
Domaini169 – 336Ldh_1_CInterPro annotationAdd BLAST168

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1494 Eukaryota
COG0039 LUCA
HOGENOMiHOG000213792
InParanoidiQ5KDL9
KOiK00026
OMAiQCTPKVE
OrthoDBiEOG092C34N7

Family and domain databases

Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010097 Malate_DH_type1
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01772 MDH_euk_gproteo, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q5KDL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFARQVAKNS SSLARGFASS ARSNRKVAVL GAAGGIGQPM SLLLKQNPGV
60 70 80 90 100
TGLSLYDIRG APGVAADISH VNTHSTVKGF EKDDIKEALT GAEIVIIPAG
110 120 130 140 150
VPRKPGMTRD DLFNTNASIV RDLAEACAEY CPKAFIGIIS NPVNSTVPIF
160 170 180 190 200
AEVLKKKGVF DEKRVFGITT LDVVRASRFL GEIKGKDPKD IKVTVVGGHS
210 220 230 240 250
GVTIVPLLSQ TPEGKDVSGE AYKALVNRIQ FGGDEVVKAK AGTGSATLSM
260 270 280 290 300
GYAGARFTDS LIRALNGETG IVEPTFVKSP LYESEGVEYF ASNVELGPEG
310 320 330
VKKINPVGQL SAEEQELLKA CLPDLVKNIK KGVDFVKA
Length:338
Mass (Da):35,659
Last modified:February 15, 2005 - v1
Checksum:i6D826ACDC47FFBB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017347 Genomic DNA Translation: AAW44731.1
RefSeqiXP_572038.1, XM_572038.1
UniGeneiFne.6681

Genome annotation databases

EnsemblFungiiAAW44731; AAW44731; CNG03490
GeneIDi3258550
KEGGicne:CNG03490

Similar proteinsi

Entry informationi

Entry nameiQ5KDL9_CRYNJ
AccessioniPrimary (citable) accession number: Q5KDL9
Secondary accession number(s): Q55PT6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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