Q5KDL9 (Q5KDL9_CRYNJ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Malate dehydrogenase RuleBase RU003405
EC=1.1.1.37 RuleBase RU003405

Gene names

Ordered Locus Names:

CNG03490

Organism

Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) [Reference proteome] EMBL AAW44731.1

Taxonomic identifier

214684 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Tremellaceae › Filobasidiella › Filobasidiella/Cryptococcus neoformans species complex › Cryptococcus neoformans › Cryptococcus neoformans var. neoformans

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate + NAD+ = oxaloacetate + NADH. RuleBase RU003405
Sequence similarities	Belongs to the LDH/MDH superfamily. MDH type 1 family. RuleBase RU004065

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle RuleBase RU003405
Ligand	NAD RuleBase RU003405
Molecular function	Oxidoreductase RuleBase RU003405
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro malate metabolic process Inferred from electronic annotation. Source: InterPro tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	L-malate dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5KDL9 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 6D826ACDC47FFBB1	FASTA	338	35,659
	10 20 30 40 50 60 MFARQVAKNS SSLARGFASS ARSNRKVAVL GAAGGIGQPM SLLLKQNPGV TGLSLYDIRG 70 80 90 100 110 120 APGVAADISH VNTHSTVKGF EKDDIKEALT GAEIVIIPAG VPRKPGMTRD DLFNTNASIV 130 140 150 160 170 180 RDLAEACAEY CPKAFIGIIS NPVNSTVPIF AEVLKKKGVF DEKRVFGITT LDVVRASRFL 190 200 210 220 230 240 GEIKGKDPKD IKVTVVGGHS GVTIVPLLSQ TPEGKDVSGE AYKALVNRIQ FGGDEVVKAK 250 260 270 280 290 300 AGTGSATLSM GYAGARFTDS LIRALNGETG IVEPTFVKSP LYESEGVEYF ASNVELGPEG 310 320 330 VKKINPVGQL SAEEQELLKA CLPDLVKNIK KGVDFVKA

References

[1]

"The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans." Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S. , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W. Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JEC21 / ATCC MYA-565.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017347 Genomic DNA. Translation: AAW44731.1.
RefSeq	XP_572038.1. XM_572038.1.
UniGene	Fne.6681.
3D structure databases
ProteinModelPortal	Q5KDL9.
SMR	Q5KDL9. Positions 26-337.
ModBase	Search...
Protein-protein interaction databases
STRING	214684.CNG03490.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3258550.
KEGG	cne:CNG03490.
Phylogenomic databases
HOGENOM	HOG000213792.
KO	K00026.
OrthoDB	EOG4CRQ7W.
Family and domain databases
Gene3D	3.40.50.720. 1 hit. 3.90.110.10. 1 hit.
InterPro	IPR001557. L-lactate/malate_DH. IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR001252. Malate_DH_AS. IPR010097. Malate_DH_type1. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR11540. PTHR11540. 1 hit. PTHR11540:SF1. PTHR11540:SF1. 1 hit.
Pfam	PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view]
PIRSF	PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAM	SSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMs	TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITE	PS00068. MDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q5KDL9_CRYNJ

Accession

Primary (citable) accession number: Q5KDL9
Secondary accession number(s): Q55PT6

Entry history

Integrated into UniProtKB/TrEMBL:	February 15, 2005
Last sequence update:	February 15, 2005
Last modified:	May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)