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Protein

Malate dehydrogenase

Gene

CNG03490

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei199 – 1991Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Ordered Locus Names:CNG03490Imported
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)Imported
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
Proteomesi
  • UP000002149 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiFungiDB:CNG03490.

PTM / Processingi

Proteomic databases

PaxDbiQ5KDL9.
PRIDEiQ5KDL9.

Interactioni

Protein-protein interaction databases

STRINGi214684.XP_572038.1.

Structurei

3D structure databases

ProteinModelPortaliQ5KDL9.
SMRiQ5KDL9. Positions 26-337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 167142Ldh_1_NInterPro annotationAdd
BLAST
Domaini169 – 336168Ldh_1_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1494. Eukaryota.
COG0039. LUCA.
HOGENOMiHOG000213792.
InParanoidiQ5KDL9.
KOiK00026.
OMAiSHVNTHS.
OrthoDBiEOG092C34N7.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5KDL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFARQVAKNS SSLARGFASS ARSNRKVAVL GAAGGIGQPM SLLLKQNPGV
60 70 80 90 100
TGLSLYDIRG APGVAADISH VNTHSTVKGF EKDDIKEALT GAEIVIIPAG
110 120 130 140 150
VPRKPGMTRD DLFNTNASIV RDLAEACAEY CPKAFIGIIS NPVNSTVPIF
160 170 180 190 200
AEVLKKKGVF DEKRVFGITT LDVVRASRFL GEIKGKDPKD IKVTVVGGHS
210 220 230 240 250
GVTIVPLLSQ TPEGKDVSGE AYKALVNRIQ FGGDEVVKAK AGTGSATLSM
260 270 280 290 300
GYAGARFTDS LIRALNGETG IVEPTFVKSP LYESEGVEYF ASNVELGPEG
310 320 330
VKKINPVGQL SAEEQELLKA CLPDLVKNIK KGVDFVKA
Length:338
Mass (Da):35,659
Last modified:February 15, 2005 - v1
Checksum:i6D826ACDC47FFBB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017347 Genomic DNA. Translation: AAW44731.1.
RefSeqiXP_572038.1. XM_572038.1.
UniGeneiFne.6681.

Genome annotation databases

EnsemblFungiiAAW44731; AAW44731; CNG03490.
GeneIDi3258550.
KEGGicne:CNG03490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017347 Genomic DNA. Translation: AAW44731.1.
RefSeqiXP_572038.1. XM_572038.1.
UniGeneiFne.6681.

3D structure databases

ProteinModelPortaliQ5KDL9.
SMRiQ5KDL9. Positions 26-337.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214684.XP_572038.1.

Proteomic databases

PaxDbiQ5KDL9.
PRIDEiQ5KDL9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAW44731; AAW44731; CNG03490.
GeneIDi3258550.
KEGGicne:CNG03490.

Organism-specific databases

EuPathDBiFungiDB:CNG03490.

Phylogenomic databases

eggNOGiKOG1494. Eukaryota.
COG0039. LUCA.
HOGENOMiHOG000213792.
InParanoidiQ5KDL9.
KOiK00026.
OMAiSHVNTHS.
OrthoDBiEOG092C34N7.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5KDL9_CRYNJ
AccessioniPrimary (citable) accession number: Q5KDL9
Secondary accession number(s): Q55PT6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.