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Protein

Hexokinase

Gene

CNH01400

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:CNH01400Imported
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)Imported
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000002149 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiFungiDB:CNH01400.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi214684.CNH01400.

Structurei

3D structure databases

ProteinModelPortaliQ5KCL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000162670.
InParanoidiQ5KCL1.
KOiK00844.
OMAiVTYHAED.
OrthoDBiEOG79SF68.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5KCL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETPDQLAT RVQNLSTAPT TTQRTGSGSA VLENGTNIGS AAGRKASIPA
60 70 80 90 100
QVDPERIIST SGSGRTSRRG SGLVMTPGGV QTVYHTRTNE DIEFPHAGKK
110 120 130 140 150
TMADLLRKYE SLFTLTPQRM RMIVHAIEET LDNGLQKNGQ VVPMIPTYVF
160 170 180 190 200
GWPTGNEVGD FLALDLGGTN LRVCLVTLLG SGKFEVTQTK YRLTEEQKQG
210 220 230 240 250
EGQALLDFCA ECLNSFIRDT LGRTEKDGIL PLGFTFSYPC SQDRIDHGVL
260 270 280 290 300
IRWTKGFGAP NIEGYDVAAM FKDSLKRMDV PAELTALIND TTGTLIASNY
310 320 330 340 350
VDPHTKIAVI FGTGCNAAYM ETAGSIPKID YVGLPEEQGM AINCEWGAFD
360 370 380 390 400
SFDHQHLPRT KYDIIIDESS NKPGEQSFEK MIAGLYLGEI FRLVLCELID
410 420 430 440 450
SGDLFLGQNT YKLEKAYAFD TAFLSLMEAD VTEELLTIIG VFAHFFGLET
460 470 480 490 500
TLEERQFFKK LAVLVGTRSA RLSACGIAAI VSKKGYLEEG CAVGADGSLY
510 520 530 540 550
NKYPNFADRV HEALTDIFGE SGKKIVTHHA EDGSGVGSAI IAAMTKARKD

SGFFVEY
Length:557
Mass (Da):60,724
Last modified:February 15, 2005 - v1
Checksum:iE888A8C802A84E0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017348 Genomic DNA. Translation: AAW45021.1.
AE017348 Genomic DNA. Translation: AAW45022.1.
RefSeqiXP_572328.1. XM_572328.1.
XP_572329.1. XM_572329.1.
UniGeneiFne.7113.

Genome annotation databases

EnsemblFungiiAAW45021; AAW45021; CNH01400.
AAW45022; AAW45022; CNH01400.
GeneIDi3259022.
KEGGicne:CNH01400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017348 Genomic DNA. Translation: AAW45021.1.
AE017348 Genomic DNA. Translation: AAW45022.1.
RefSeqiXP_572328.1. XM_572328.1.
XP_572329.1. XM_572329.1.
UniGeneiFne.7113.

3D structure databases

ProteinModelPortaliQ5KCL1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214684.CNH01400.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAW45021; AAW45021; CNH01400.
AAW45022; AAW45022; CNH01400.
GeneIDi3259022.
KEGGicne:CNH01400.

Organism-specific databases

EuPathDBiFungiDB:CNH01400.

Phylogenomic databases

HOGENOMiHOG000162670.
InParanoidiQ5KCL1.
KOiK00844.
OMAiVTYHAED.
OrthoDBiEOG79SF68.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Loftus B., Amedeo P., Roncaglia P., Vamathevan J., Utterback T., Van Aken S., Fraser C.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: JEC21.
  2. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JEC21Imported and JEC21 / ATCC MYA-565Imported.

Entry informationi

Entry nameiQ5KCL1_CRYNJ
AccessioniPrimary (citable) accession number: Q5KCL1
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: May 27, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.