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Protein

DNA ligase

Gene

CNI04170

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. base-excision repair Source: EnsemblFungi
  2. DNA biosynthetic process Source: InterPro
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-KW
  5. maintenance of DNA trinucleotide repeats Source: EnsemblFungi
  6. nucleotide-excision repair Source: EnsemblFungi
  7. Okazaki fragment processing involved in mitotic DNA replication Source: EnsemblFungi
  8. telomere maintenance Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:CNI04170Imported
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)Imported
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000002149 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiFungiDB:CNI04170.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: EnsemblFungi
  2. nucleus Source: EnsemblFungi
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi214684.CNI04170.

Structurei

3D structure databases

ProteinModelPortaliQ5KB11.
SMRiQ5KB11. Positions 164-787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

InParanoidiQ5KB11.
KOiK10747.
OMAiPQVVIEV.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5KB11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDIEYPVKS NIRKKRTVIL SDDEDEGLGP SVIKEQVSSP KHSHLSDEET
60 70 80 90 100
EPPRKVAKTS SKVAPIFAPK EKKEKPSPKT SSALSKAPAK KIEVKSKGEK
110 120 130 140 150
PLASIFTKAT RKPEPKDDDE MSDEVKQKGK DEEEEDEIYD EVEDKQEGEA
160 170 180 190 200
AVKLASIFTK NQKSVPVADK GWKDGEAVPY PALVSTFEKI EATTKRLEIL
210 220 230 240 250
EFLTQFLLVV AKRDTATDAK GSMLLKVVYL CINRLCPDYM GIELGIGESL
260 270 280 290 300
LIKAIAESTG RAMPKIKEDL KKEGDLGKVA MNSRNTQSTM FKPKPLTVPY
310 320 330 340 350
VFQCLTDIAK ASGNASQAKK VGIIKKLLAA CQGTEAKFII RSLEGKLRIG
360 370 380 390 400
LADKTVVVAL AHAIVLKTIG DKKPPPEKLA IMLEQGAETV KAVYSELPSY
410 420 430 440 450
DLVIPALLQG GVEGLRERCK LTPGVPLKPM LAKPTKAITE VLDRFEGKEF
460 470 480 490 500
TCEYKYDGER AQVHLLEDGT ISVFSRNSEN MSAKYPDLVD QIPRSMKPTA
510 520 530 540 550
KTFVIDAEAV AYDLETKKIL PFQDLSRRKR KDVKAEDITV RVHIFAFDLL
560 570 580 590 600
YLNGESLLAK ELKERRQLLQ EHFQPVESEF AFAKSSDGST TEEIQALLEE
610 620 630 640 650
SVKDGCEGLM VKMLTSESST YEPSRRSMNW LKLKKDYLSG VGDSLDLVVV
660 670 680 690 700
GAYHGKGKRT AVYGAFLLAC YDPDSEHYQT ICKIGTGFSE EILTQFYELL
710 720 730 740 750
KPLELEVVRG DIEVGGAKPD VWFEPRVVWE VLTADLSLSP IYAAAHGVID
760 770 780 790 800
SRGISLRFPR FIRIRDDKSA DEATTAEQVS EFYQRQISAG GKKGAGADVD

DFW
Length:803
Mass (Da):89,050
Last modified:February 15, 2005 - v1
Checksum:i8F400926CE1B836A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017349 Genomic DNA. Translation: AAW45295.1.
RefSeqiXP_572602.1. XM_572602.1.
UniGeneiFne.3837.

Genome annotation databases

EnsemblFungiiAAW45295; AAW45295; CNI04170.
GeneIDi3259559.
KEGGicne:CNI04170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017349 Genomic DNA. Translation: AAW45295.1.
RefSeqiXP_572602.1. XM_572602.1.
UniGeneiFne.3837.

3D structure databases

ProteinModelPortaliQ5KB11.
SMRiQ5KB11. Positions 164-787.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214684.CNI04170.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAW45295; AAW45295; CNI04170.
GeneIDi3259559.
KEGGicne:CNI04170.

Organism-specific databases

EuPathDBiFungiDB:CNI04170.

Phylogenomic databases

InParanoidiQ5KB11.
KOiK10747.
OMAiPQVVIEV.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JEC21 / ATCC MYA-565Imported.

Entry informationi

Entry nameiQ5KB11_CRYNJ
AccessioniPrimary (citable) accession number: Q5KB11
Secondary accession number(s): Q55MN6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: April 29, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.