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Q5K920

- Q5K920_CRYNJ

UniProt

Q5K920 - Q5K920_CRYNJ

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Protein

Glutamate decarboxylase

Gene

CNH03700

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:CNH03700Imported, CNL03700Imported
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)Imported
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000002149: Chromosome 12, UP000002149: Chromosome 8

Interactioni

Protein-protein interaction databases

STRINGi214684.CNL03700.

Structurei

3D structure databases

ProteinModelPortaliQ5K920.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000070228.
InParanoidiQ5K920.
KOiK01580.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 2 hits.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5K920-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALSQHVDAD KLIEECKDHP IKRHLSHKAA LYDIPYTSRY EVEDEVPRYR
60 70 80 90 100
LPSKGVNGRA TYQLLHDELM LDGNPNMNLA SFVHTWVPDE CNRLVQENIN
110 120 130 140 150
KNLVDQDEYP AAQQIHERCI SMLSHLWHAP KEATAMGTAT TGSSEAIMLG
160 170 180 190 200
GLALKRRWQE KMKAAGKDIH NPGPNIVMGA EAQVALEKFA RYFEVEARLV
210 220 230 240 250
PIKPESSYVM DPKDVLKYVD ENTIGVFVIL GSTYTGAFES VKDVAQELDK
260 270 280 290 300
YEAETGISVP IHVDAASGGF VAPFAYPHYQ WDFQIPRVHS INASGHKYGM
310 320 330 340 350
STVGVGWIIW RSMEYLPKEL IFELHYLGAT DYSFNLNFSR PAHPILAQMF
360 370 380 390 400
TFLNLGFEGY KRIMDKNLTV ARLISRALEH SGYFICLSKI HHPKALTESS
410 420 430 440 450
SSAEQSNILP AVADAANTVL HGKKTTVDDA EYYCEGLPVV SFMFTDEIKK
460 470 480 490 500
KYPGVKQAWI QMQLRSIGWI VPNYPLAPDC EKTEILRVVV RESLSGDLAR
510 520 530 540 550
KLIHDILQVT EDLLNDAGPS YSMSTATRRH ENLDHGKLDN IDAVHIKQHT

STYSKPC
Length:557
Mass (Da):62,717
Last modified:February 15, 2005 - v1
Checksum:iA50822786EF33701
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017348 Genomic DNA. Translation: AAW45225.1.
AE017352 Genomic DNA. Translation: AAW46416.1.
RefSeqiXP_567933.1. XM_567933.1.
XP_572532.1. XM_572532.1.
UniGeneiFne.6965.
Fne.7297.

Genome annotation databases

EnsemblFungiiAAW45225; AAW45225; CNH03700.
AAW46416; AAW46416; CNL03700.
GeneIDi3254998.
3259079.
KEGGicne:CNH03700.
cne:CNL03700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017348 Genomic DNA. Translation: AAW45225.1 .
AE017352 Genomic DNA. Translation: AAW46416.1 .
RefSeqi XP_567933.1. XM_567933.1.
XP_572532.1. XM_572532.1.
UniGenei Fne.6965.
Fne.7297.

3D structure databases

ProteinModelPortali Q5K920.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 214684.CNL03700.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAW45225 ; AAW45225 ; CNH03700 .
AAW46416 ; AAW46416 ; CNL03700 .
GeneIDi 3254998.
3259079.
KEGGi cne:CNH03700.
cne:CNL03700.

Phylogenomic databases

HOGENOMi HOG000070228.
InParanoidi Q5K920.
KOi K01580.
OrthoDBi EOG7P2Z22.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
InterProi IPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11999:SF1. PTHR11999:SF1. 1 hit.
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 2 hits.
TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JEC21 / ATCC MYA-565Imported.

Entry informationi

Entry nameiQ5K920_CRYNJ
AccessioniPrimary (citable) accession number: Q5K920
Secondary accession number(s): Q55LQ3
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3