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Q5K920

- Q5K920_CRYNJ

UniProt

Q5K920 - Q5K920_CRYNJ

Protein

Glutamate decarboxylase

Gene

CNH03700

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: InterPro
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glutamate metabolic process Source: InterPro

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, Lyase

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
    Gene namesi
    Ordered Locus Names:CNH03700Imported, CNL03700Imported
    OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)Imported
    Taxonomic identifieri214684 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
    ProteomesiUP000002149: Chromosome 12, UP000002149: Chromosome 8

    Interactioni

    Protein-protein interaction databases

    STRINGi214684.CNL03700.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000070228.
    KOiK01580.
    OrthoDBiEOG7P2Z22.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 2 hits.
    TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5K920-1 [UniParc]FASTAAdd to Basket

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    MALSQHVDAD KLIEECKDHP IKRHLSHKAA LYDIPYTSRY EVEDEVPRYR    50
    LPSKGVNGRA TYQLLHDELM LDGNPNMNLA SFVHTWVPDE CNRLVQENIN 100
    KNLVDQDEYP AAQQIHERCI SMLSHLWHAP KEATAMGTAT TGSSEAIMLG 150
    GLALKRRWQE KMKAAGKDIH NPGPNIVMGA EAQVALEKFA RYFEVEARLV 200
    PIKPESSYVM DPKDVLKYVD ENTIGVFVIL GSTYTGAFES VKDVAQELDK 250
    YEAETGISVP IHVDAASGGF VAPFAYPHYQ WDFQIPRVHS INASGHKYGM 300
    STVGVGWIIW RSMEYLPKEL IFELHYLGAT DYSFNLNFSR PAHPILAQMF 350
    TFLNLGFEGY KRIMDKNLTV ARLISRALEH SGYFICLSKI HHPKALTESS 400
    SSAEQSNILP AVADAANTVL HGKKTTVDDA EYYCEGLPVV SFMFTDEIKK 450
    KYPGVKQAWI QMQLRSIGWI VPNYPLAPDC EKTEILRVVV RESLSGDLAR 500
    KLIHDILQVT EDLLNDAGPS YSMSTATRRH ENLDHGKLDN IDAVHIKQHT 550
    STYSKPC 557
    Length:557
    Mass (Da):62,717
    Last modified:February 15, 2005 - v1
    Checksum:iA50822786EF33701
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017348 Genomic DNA. Translation: AAW45225.1.
    AE017352 Genomic DNA. Translation: AAW46416.1.
    RefSeqiXP_567933.1. XM_567933.1.
    XP_572532.1. XM_572532.1.
    UniGeneiFne.6965.
    Fne.7297.

    Genome annotation databases

    EnsemblFungiiAAW45225; AAW45225; CNH03700.
    AAW46416; AAW46416; CNL03700.
    GeneIDi3254998.
    3259079.
    KEGGicne:CNH03700.
    cne:CNL03700.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017348 Genomic DNA. Translation: AAW45225.1 .
    AE017352 Genomic DNA. Translation: AAW46416.1 .
    RefSeqi XP_567933.1. XM_567933.1.
    XP_572532.1. XM_572532.1.
    UniGenei Fne.6965.
    Fne.7297.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 214684.CNL03700.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii AAW45225 ; AAW45225 ; CNH03700 .
    AAW46416 ; AAW46416 ; CNL03700 .
    GeneIDi 3254998.
    3259079.
    KEGGi cne:CNH03700.
    cne:CNL03700.

    Phylogenomic databases

    HOGENOMi HOG000070228.
    KOi K01580.
    OrthoDBi EOG7P2Z22.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11999:SF1. PTHR11999:SF1. 1 hit.
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 2 hits.
    TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
      Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
      , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
      Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JEC21 / ATCC MYA-565Imported.

    Entry informationi

    Entry nameiQ5K920_CRYNJ
    AccessioniPrimary (citable) accession number: Q5K920
    Secondary accession number(s): Q55LQ3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 15, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3