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Q5K4L6

- S27A3_HUMAN

UniProt

Q5K4L6 - S27A3_HUMAN

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Protein
Long-chain fatty acid transport protein 3
Gene
SLC27A3, ACSVL3, FATP3, PSEC0067, UNQ367/PRO703
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi332 – 34312AMP Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. fatty-acyl-CoA synthase activity Source: Ensembl
  2. ligase activity Source: UniProtKB-KW
  3. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. fatty acid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

Nucleotide-binding

Protein family/group databases

TCDBi4.C.1.1.12. the proposed fatty acid transporter (fat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain fatty acid transport protein 3 (EC:6.2.1.-)
Short name:
FATP-3
Short name:
Fatty acid transport protein 3
Alternative name(s):
Solute carrier family 27 member 3
Very long-chain acyl-CoA synthetase homolog 3
Short name:
VLCS-3
Gene namesi
Name:SLC27A3
Synonyms:ACSVL3, FATP3
ORF Names:PSEC0067, UNQ367/PRO703
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10997. SLC27A3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei50 – 7021Helical; Reviewed prediction
Add
BLAST
Transmembranei369 – 38921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35871.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 730730Long-chain fatty acid transport protein 3
PRO_0000193207Add
BLAST

Proteomic databases

MaxQBiQ5K4L6.
PaxDbiQ5K4L6.
PRIDEiQ5K4L6.

PTM databases

PhosphoSiteiQ5K4L6.

Expressioni

Gene expression databases

ArrayExpressiQ5K4L6.
BgeeiQ5K4L6.
GenevestigatoriQ5K4L6.

Organism-specific databases

HPAiHPA006935.

Interactioni

Protein-protein interaction databases

BioGridi116193. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ5K4L6.
SMRiQ5K4L6. Positions 201-691.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0318.
HOVERGENiHBG005642.
InParanoidiQ5K4L6.
KOiK08772.
PhylomeDBiQ5K4L6.
TreeFamiTF313430.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5K4L6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGVCQRTRAP WKEKSQLERA ALGFRKGGSG MFASGWNQTV PIEEAGSMAA    50
LLLLPLLLLL PLLLLKLHLW PQLRWLPADL AFAVRALCCK RALRARALAA 100
AAADPEGPEG GCSLAWRLAE LAQQRAAHTF LIHGSRRFSY SEAERESNRA 150
ARAFLRALGW DWGPDGGDSG EGSAGEGERA APGAGDAAAG SGAEFAGGDG 200
AARGGGAAAP LSPGATVALL LPAGPEFLWL WFGLAKAGLR TAFVPTALRR 250
GPLLHCLRSC GARALVLAPE FLESLEPDLP ALRAMGLHLW AAGPGTHPAG 300
ISDLLAEVSA EVDGPVPGYL SSPQSITDTC LYIFTSGTTG LPKAARISHL 350
KILQCQGFYQ LCGVHQEDVI YLALPLYHMS GSLLGIVGCM GIGATVVLKS 400
KFSAGQFWED CQQHRVTVFQ YIGELCRYLV NQPPSKAERG HKVRLAVGSG 450
LRPDTWERFV RRFGPLQVLE TYGLTEGNVA TINYTGQRGA VGRASWLYKH 500
IFPFSLIRYD VTTGEPIRDP QGHCMATSPG EPGLLVAPVS QQSPFLGYAG 550
GPELAQGKLL KDVFRPGDVF FNTGDLLVCD DQGFLRFHDR TGDTFRWKGE 600
NVATTEVAEV FEALDFLQEV NVYGVTVPGH EGRAGMAALV LRPPHALDLM 650
QLYTHVSENL PPYARPRFLR LQESLATTET FKQQKVRMAN EGFDPSTLSD 700
PLYVLDQAVG AYLPLTTARY SALLAGNLRI 730
Length:730
Mass (Da):78,644
Last modified:November 25, 2008 - v3
Checksum:iE8CC4E9463A534A0
GO
Isoform 2 (identifier: Q5K4L6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     673-707: Missing.

Show »
Length:695
Mass (Da):74,702
Checksum:iC92234E76758019E
GO
Isoform 3 (identifier: Q5K4L6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     270-276: EFLESLE → GKAGAPN
     277-730: Missing.

Show »
Length:276
Mass (Da):28,670
Checksum:i7FC81638A981ED34
GO

Sequence cautioni

The sequence BAC86050.1 differs from that shown. Reason: Frameshift at position 540.
The sequence AAH29792.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB55156.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB84960.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC86050.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAE12159.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAH71420.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101G → A.
Corresponds to variant rs34527123 [ dbSNP | Ensembl ].
VAR_048241
Natural varianti439 – 4391R → H.
Corresponds to variant rs35102232 [ dbSNP | Ensembl ].
VAR_048242

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei270 – 2767EFLESLE → GKAGAPN in isoform 3.
VSP_036534
Alternative sequencei277 – 730454Missing in isoform 3.
VSP_036535Add
BLAST
Alternative sequencei673 – 70735Missing in isoform 2.
VSP_016218Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121K → E in BAB55156. 1 Publication
Sequence conflicti66 – 661K → M in CAE12159. 1 Publication
Sequence conflicti472 – 4721Y → F in AAH03654. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ577572 mRNA. Translation: CAE12159.1. Different initiation.
AK074134 mRNA. Translation: BAB84960.1. Different initiation.
AY358409 mRNA. Translation: AAQ88775.1.
AK027499 mRNA. Translation: BAB55156.1. Different initiation.
AK075377 mRNA. Translation: BAC11578.1.
AK125102 mRNA. Translation: BAC86050.1. Sequence problems.
AL513523 Genomic DNA. Translation: CAH71420.1. Different initiation.
AL513523 Genomic DNA. Translation: CAH71421.1.
AL513523 Genomic DNA. Translation: CAH71423.1.
BC003041 mRNA. Translation: AAH03041.1.
BC003654 mRNA. Translation: AAH03654.2.
BC009916 mRNA. Translation: AAH09916.1.
BC029792 mRNA. Translation: AAH29792.1. Different initiation.
CCDSiCCDS1053.1. [Q5K4L6-1]
RefSeqiNP_077306.1. NM_024330.1. [Q5K4L6-1]
UniGeneiHs.438723.

Genome annotation databases

EnsembliENST00000368661; ENSP00000357650; ENSG00000143554. [Q5K4L6-1]
ENST00000575439; ENSP00000458504; ENSG00000263163.
GeneIDi11000.
KEGGihsa:11000.
UCSCiuc001fcz.3. human. [Q5K4L6-1]

Polymorphism databases

DMDMi215274206.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ577572 mRNA. Translation: CAE12159.1 . Different initiation.
AK074134 mRNA. Translation: BAB84960.1 . Different initiation.
AY358409 mRNA. Translation: AAQ88775.1 .
AK027499 mRNA. Translation: BAB55156.1 . Different initiation.
AK075377 mRNA. Translation: BAC11578.1 .
AK125102 mRNA. Translation: BAC86050.1 . Sequence problems.
AL513523 Genomic DNA. Translation: CAH71420.1 . Different initiation.
AL513523 Genomic DNA. Translation: CAH71421.1 .
AL513523 Genomic DNA. Translation: CAH71423.1 .
BC003041 mRNA. Translation: AAH03041.1 .
BC003654 mRNA. Translation: AAH03654.2 .
BC009916 mRNA. Translation: AAH09916.1 .
BC029792 mRNA. Translation: AAH29792.1 . Different initiation.
CCDSi CCDS1053.1. [Q5K4L6-1 ]
RefSeqi NP_077306.1. NM_024330.1. [Q5K4L6-1 ]
UniGenei Hs.438723.

3D structure databases

ProteinModelPortali Q5K4L6.
SMRi Q5K4L6. Positions 201-691.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116193. 3 interactions.

Protein family/group databases

TCDBi 4.C.1.1.12. the proposed fatty acid transporter (fat) family.

PTM databases

PhosphoSitei Q5K4L6.

Polymorphism databases

DMDMi 215274206.

Proteomic databases

MaxQBi Q5K4L6.
PaxDbi Q5K4L6.
PRIDEi Q5K4L6.

Protocols and materials databases

DNASUi 11000.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368661 ; ENSP00000357650 ; ENSG00000143554 . [Q5K4L6-1 ]
ENST00000575439 ; ENSP00000458504 ; ENSG00000263163 .
GeneIDi 11000.
KEGGi hsa:11000.
UCSCi uc001fcz.3. human. [Q5K4L6-1 ]

Organism-specific databases

CTDi 11000.
GeneCardsi GC01P153746.
HGNCi HGNC:10997. SLC27A3.
HPAi HPA006935.
MIMi 604193. gene.
neXtProti NX_Q5K4L6.
PharmGKBi PA35871.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0318.
HOVERGENi HBG005642.
InParanoidi Q5K4L6.
KOi K08772.
PhylomeDBi Q5K4L6.
TreeFami TF313430.

Miscellaneous databases

GeneWikii SLC27A3.
GenomeRNAii 11000.
NextBioi 41791.
PROi Q5K4L6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q5K4L6.
Bgeei Q5K4L6.
Genevestigatori Q5K4L6.

Family and domain databases

InterProi IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Berger J.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver and Testis.
  2. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Spleen.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Neuron, Teratocarcinoma and Tongue.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 297-683 (ISOFORM 2).
    Tissue: Brain and Lung.

Entry informationi

Entry nameiS27A3_HUMAN
AccessioniPrimary (citable) accession number: Q5K4L6
Secondary accession number(s): Q5VUQ7
, Q5VUQ8, Q5VUR3, Q6ZV16, Q8N2X7, Q8TEJ0, Q96SW5, Q9BTJ5, Q9BTY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-48 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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