Q5K4L6 (S27A3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Long-chain fatty acid transport protein 3
Short name=FATP-3
Short name=Fatty acid transport protein 3
EC=6.2.1.-

Alternative name(s):
Solute carrier family 27 member 3
Very long-chain acyl-CoA synthetase homolog 3
Short name=VLCS-3

Gene names

Name:	SLC27A3
Synonyms:	ACSVL3, FATP3
ORF Names:	PSEC0067, UNQ367/PRO703

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	730 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity By similarity.
Subcellular location	Mitochondrion membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.
Caution	It is uncertain whether Met-1 or Met-48 is the initiator.
Sequence caution	The sequence AAH29792.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB55156.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB84960.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC86050.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC86050.1 differs from that shown. Reason: Frameshift at position 540. The sequence CAE12159.1 differs from that shown. Reason: Erroneous initiation. The sequence CAH71420.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Membrane Mitochondrion
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	fatty-acyl-CoA synthase activity Inferred from electronic annotation. Source: Compara ligase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5K4L6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5K4L6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     673-707: Missing.

Isoform 3 (identifier: Q5K4L6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     270-276: EFLESLE → GKAGAPN
     277-730: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 730	730	Long-chain fatty acid transport protein 3		PRO_0000193207
Regions
	Transmembrane	50 – 70	21	Helical; Potential
	Transmembrane	369 – 389	21	Helical; Potential
	Nucleotide binding	332 – 343	12	AMP Potential
Natural variations
	Alternative sequence	270 – 276	7	EFLESLE → GKAGAPN in isoform 3.		VSP_036534
	Alternative sequence	277 – 730	454	Missing in isoform 3.		VSP_036535
	Alternative sequence	673 – 707	35	Missing in isoform 2.		VSP_016218
	Natural variant	110	1	G → A. Corresponds to variant rs34527123 [ dbSNP | Ensembl ].		VAR_048241
	Natural variant	439	1	R → H. Corresponds to variant rs35102232 [ dbSNP | Ensembl ].		VAR_048242
Experimental info
	Sequence conflict	12	1	K → E in BAB55156. Ref.4
	Sequence conflict	66	1	K → M in CAE12159. Ref.1
	Sequence conflict	472	1	Y → F in AAH03654. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: E8CC4E9463A534A0	FASTA	730	78,644
	10 20 30 40 50 60 MGVCQRTRAP WKEKSQLERA ALGFRKGGSG MFASGWNQTV PIEEAGSMAA LLLLPLLLLL 70 80 90 100 110 120 PLLLLKLHLW PQLRWLPADL AFAVRALCCK RALRARALAA AAADPEGPEG GCSLAWRLAE 130 140 150 160 170 180 LAQQRAAHTF LIHGSRRFSY SEAERESNRA ARAFLRALGW DWGPDGGDSG EGSAGEGERA 190 200 210 220 230 240 APGAGDAAAG SGAEFAGGDG AARGGGAAAP LSPGATVALL LPAGPEFLWL WFGLAKAGLR 250 260 270 280 290 300 TAFVPTALRR GPLLHCLRSC GARALVLAPE FLESLEPDLP ALRAMGLHLW AAGPGTHPAG 310 320 330 340 350 360 ISDLLAEVSA EVDGPVPGYL SSPQSITDTC LYIFTSGTTG LPKAARISHL KILQCQGFYQ 370 380 390 400 410 420 LCGVHQEDVI YLALPLYHMS GSLLGIVGCM GIGATVVLKS KFSAGQFWED CQQHRVTVFQ 430 440 450 460 470 480 YIGELCRYLV NQPPSKAERG HKVRLAVGSG LRPDTWERFV RRFGPLQVLE TYGLTEGNVA 490 500 510 520 530 540 TINYTGQRGA VGRASWLYKH IFPFSLIRYD VTTGEPIRDP QGHCMATSPG EPGLLVAPVS 550 560 570 580 590 600 QQSPFLGYAG GPELAQGKLL KDVFRPGDVF FNTGDLLVCD DQGFLRFHDR TGDTFRWKGE 610 620 630 640 650 660 NVATTEVAEV FEALDFLQEV NVYGVTVPGH EGRAGMAALV LRPPHALDLM QLYTHVSENL 670 680 690 700 710 720 PPYARPRFLR LQESLATTET FKQQKVRMAN EGFDPSTLSD PLYVLDQAVG AYLPLTTARY 730 SALLAGNLRI
	Isoform 2 [UniParc]. Checksum: C92234E76758019E	FASTA	695	74,702
	10 20 30 40 50 60 MGVCQRTRAP WKEKSQLERA ALGFRKGGSG MFASGWNQTV PIEEAGSMAA LLLLPLLLLL 70 80 90 100 110 120 PLLLLKLHLW PQLRWLPADL AFAVRALCCK RALRARALAA AAADPEGPEG GCSLAWRLAE 130 140 150 160 170 180 LAQQRAAHTF LIHGSRRFSY SEAERESNRA ARAFLRALGW DWGPDGGDSG EGSAGEGERA 190 200 210 220 230 240 APGAGDAAAG SGAEFAGGDG AARGGGAAAP LSPGATVALL LPAGPEFLWL WFGLAKAGLR 250 260 270 280 290 300 TAFVPTALRR GPLLHCLRSC GARALVLAPE FLESLEPDLP ALRAMGLHLW AAGPGTHPAG 310 320 330 340 350 360 ISDLLAEVSA EVDGPVPGYL SSPQSITDTC LYIFTSGTTG LPKAARISHL KILQCQGFYQ 370 380 390 400 410 420 LCGVHQEDVI YLALPLYHMS GSLLGIVGCM GIGATVVLKS KFSAGQFWED CQQHRVTVFQ 430 440 450 460 470 480 YIGELCRYLV NQPPSKAERG HKVRLAVGSG LRPDTWERFV RRFGPLQVLE TYGLTEGNVA 490 500 510 520 530 540 TINYTGQRGA VGRASWLYKH IFPFSLIRYD VTTGEPIRDP QGHCMATSPG EPGLLVAPVS 550 560 570 580 590 600 QQSPFLGYAG GPELAQGKLL KDVFRPGDVF FNTGDLLVCD DQGFLRFHDR TGDTFRWKGE 610 620 630 640 650 660 NVATTEVAEV FEALDFLQEV NVYGVTVPGH EGRAGMAALV LRPPHALDLM QLYTHVSENL 670 680 690 PPYARPRFLR LQAVGAYLPL TTARYSALLA GNLRI
	Isoform 3 [UniParc]. Checksum: 7FC81638A981ED34	FASTA	276	28,670
	10 20 30 40 50 60 MGVCQRTRAP WKEKSQLERA ALGFRKGGSG MFASGWNQTV PIEEAGSMAA LLLLPLLLLL 70 80 90 100 110 120 PLLLLKLHLW PQLRWLPADL AFAVRALCCK RALRARALAA AAADPEGPEG GCSLAWRLAE 130 140 150 160 170 180 LAQQRAAHTF LIHGSRRFSY SEAERESNRA ARAFLRALGW DWGPDGGDSG EGSAGEGERA 190 200 210 220 230 240 APGAGDAAAG SGAEFAGGDG AARGGGAAAP LSPGATVALL LPAGPEFLWL WFGLAKAGLR 250 260 270 TAFVPTALRR GPLLHCLRSC GARALVLAPG KAGAPN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Berger J. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Liver and Testis.
[2]	"The nucleotide sequence of a long cDNA clone isolated from human spleen." Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Spleen.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Neuron, Teratocarcinoma and Tongue.
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 297-683 (ISOFORM 2). Tissue: Brain and Lung.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ577572 mRNA. Translation: CAE12159.1. Different initiation. AK074134 mRNA. Translation: BAB84960.1. Different initiation. AY358409 mRNA. Translation: AAQ88775.1. AK027499 mRNA. Translation: BAB55156.1. Different initiation. AK075377 mRNA. Translation: BAC11578.1. AK125102 mRNA. Translation: BAC86050.1. Sequence problems. AL513523 Genomic DNA. Translation: CAH71420.1. Different initiation. AL513523 Genomic DNA. Translation: CAH71421.1. AL513523 Genomic DNA. Translation: CAH71423.1. BC003041 mRNA. Translation: AAH03041.1. BC003654 mRNA. Translation: AAH03654.2. BC009916 mRNA. Translation: AAH09916.1. BC029792 mRNA. Translation: AAH29792.1. Different initiation.
IPI	IPI00013623. IPI00645636. IPI00922217.
RefSeq	NP_077306.1. NM_024330.1.
UniGene	Hs.438723.
3D structure databases
ProteinModelPortal	Q5K4L6.
ModBase	Search...
PTM databases
PhosphoSite	Q5K4L6.
Polymorphism databases
DMDM	215274206.
Proteomic databases
PaxDb	Q5K4L6.
PRIDE	Q5K4L6.
Protocols and materials databases
DNASU	11000.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000271857; ENSP00000271857; ENSG00000143554. ENST00000368661; ENSP00000357650; ENSG00000143554. ENST00000575439; ENSP00000458504; ENSG00000263163.
GeneID	11000.
KEGG	hsa:11000.
UCSC	uc001fcz.3. human.
Organism-specific databases
CTD	11000.
GeneCards	GC01P153746.
HGNC	HGNC:10997. SLC27A3.
HPA	HPA006935.
MIM	604193. gene.
neXtProt	NX_Q5K4L6.
PharmGKB	PA35871.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0318.
HOVERGEN	HBG005642.
InParanoid	Q5K4L6.
KO	K08772.
OrthoDB	EOG4RXXZN.
PhylomeDB	Q5K4L6.
Gene expression databases
ArrayExpress	Q5K4L6.
Bgee	Q5K4L6.
Genevestigator	Q5K4L6.
GermOnline	ENSG00000143554. Homo sapiens.
Family and domain databases
InterPro	IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	11000.
NextBio	41791.
SOURCE	Search...

Entry information

Entry name

S27A3_HUMAN

Accession

Primary (citable) accession number: Q5K4L6
Secondary accession number(s): Q5VUQ7 , Q5VUQ8, Q5VUR3, Q6ZV16, Q8N2X7, Q8TEJ0, Q96SW5, Q9BTJ5, Q9BTY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 84 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.