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Q5K4L6 (S27A3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Long-chain fatty acid transport protein 3

Short name=FATP-3
Short name=Fatty acid transport protein 3
EC=6.2.1.-
Alternative name(s):
Solute carrier family 27 member 3
Very long-chain acyl-CoA synthetase homolog 3
Short name=VLCS-3
Gene names
Name:SLC27A3
Synonyms:ACSVL3, FATP3
ORF Names:PSEC0067, UNQ367/PRO703
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length730 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity By similarity.

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Caution

It is uncertain whether Met-1 or Met-48 is the initiator.

Sequence caution

The sequence AAH29792.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB55156.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB84960.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC86050.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC86050.1 differs from that shown. Reason: Frameshift at position 540.

The sequence CAE12159.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAH71420.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   Cellular componentMembrane
Mitochondrion
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   LigandNucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfatty acid metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfatty-acyl-CoA synthase activity

Inferred from electronic annotation. Source: Ensembl

ligase activity

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5K4L6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5K4L6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     673-707: Missing.
Isoform 3 (identifier: Q5K4L6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     270-276: EFLESLE → GKAGAPN
     277-730: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 730730Long-chain fatty acid transport protein 3
PRO_0000193207

Regions

Transmembrane50 – 7021Helical; Potential
Transmembrane369 – 38921Helical; Potential
Nucleotide binding332 – 34312AMP Potential

Natural variations

Alternative sequence270 – 2767EFLESLE → GKAGAPN in isoform 3.
VSP_036534
Alternative sequence277 – 730454Missing in isoform 3.
VSP_036535
Alternative sequence673 – 70735Missing in isoform 2.
VSP_016218
Natural variant1101G → A.
Corresponds to variant rs34527123 [ dbSNP | Ensembl ].
VAR_048241
Natural variant4391R → H.
Corresponds to variant rs35102232 [ dbSNP | Ensembl ].
VAR_048242

Experimental info

Sequence conflict121K → E in BAB55156. Ref.4
Sequence conflict661K → M in CAE12159. Ref.1
Sequence conflict4721Y → F in AAH03654. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 25, 2008. Version 3.
Checksum: E8CC4E9463A534A0

FASTA73078,644
        10         20         30         40         50         60 
MGVCQRTRAP WKEKSQLERA ALGFRKGGSG MFASGWNQTV PIEEAGSMAA LLLLPLLLLL 

        70         80         90        100        110        120 
PLLLLKLHLW PQLRWLPADL AFAVRALCCK RALRARALAA AAADPEGPEG GCSLAWRLAE 

       130        140        150        160        170        180 
LAQQRAAHTF LIHGSRRFSY SEAERESNRA ARAFLRALGW DWGPDGGDSG EGSAGEGERA 

       190        200        210        220        230        240 
APGAGDAAAG SGAEFAGGDG AARGGGAAAP LSPGATVALL LPAGPEFLWL WFGLAKAGLR 

       250        260        270        280        290        300 
TAFVPTALRR GPLLHCLRSC GARALVLAPE FLESLEPDLP ALRAMGLHLW AAGPGTHPAG 

       310        320        330        340        350        360 
ISDLLAEVSA EVDGPVPGYL SSPQSITDTC LYIFTSGTTG LPKAARISHL KILQCQGFYQ 

       370        380        390        400        410        420 
LCGVHQEDVI YLALPLYHMS GSLLGIVGCM GIGATVVLKS KFSAGQFWED CQQHRVTVFQ 

       430        440        450        460        470        480 
YIGELCRYLV NQPPSKAERG HKVRLAVGSG LRPDTWERFV RRFGPLQVLE TYGLTEGNVA 

       490        500        510        520        530        540 
TINYTGQRGA VGRASWLYKH IFPFSLIRYD VTTGEPIRDP QGHCMATSPG EPGLLVAPVS 

       550        560        570        580        590        600 
QQSPFLGYAG GPELAQGKLL KDVFRPGDVF FNTGDLLVCD DQGFLRFHDR TGDTFRWKGE 

       610        620        630        640        650        660 
NVATTEVAEV FEALDFLQEV NVYGVTVPGH EGRAGMAALV LRPPHALDLM QLYTHVSENL 

       670        680        690        700        710        720 
PPYARPRFLR LQESLATTET FKQQKVRMAN EGFDPSTLSD PLYVLDQAVG AYLPLTTARY 

       730 
SALLAGNLRI 

« Hide

Isoform 2 [UniParc].

Checksum: C92234E76758019E
Show »

FASTA69574,702
Isoform 3 [UniParc].

Checksum: 7FC81638A981ED34
Show »

FASTA27628,670

References

« Hide 'large scale' references
[1]Berger J.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Liver and Testis.
[2]"The nucleotide sequence of a long cDNA clone isolated from human spleen."
Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Spleen.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Neuron, Teratocarcinoma and Tongue.
[5]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 297-683 (ISOFORM 2).
Tissue: Brain and Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ577572 mRNA. Translation: CAE12159.1. Different initiation.
AK074134 mRNA. Translation: BAB84960.1. Different initiation.
AY358409 mRNA. Translation: AAQ88775.1.
AK027499 mRNA. Translation: BAB55156.1. Different initiation.
AK075377 mRNA. Translation: BAC11578.1.
AK125102 mRNA. Translation: BAC86050.1. Sequence problems.
AL513523 Genomic DNA. Translation: CAH71420.1. Different initiation.
AL513523 Genomic DNA. Translation: CAH71421.1.
AL513523 Genomic DNA. Translation: CAH71423.1.
BC003041 mRNA. Translation: AAH03041.1.
BC003654 mRNA. Translation: AAH03654.2.
BC009916 mRNA. Translation: AAH09916.1.
BC029792 mRNA. Translation: AAH29792.1. Different initiation.
CCDSCCDS1053.1. [Q5K4L6-1]
RefSeqNP_077306.1. NM_024330.1. [Q5K4L6-1]
UniGeneHs.438723.

3D structure databases

ProteinModelPortalQ5K4L6.
SMRQ5K4L6. Positions 201-691.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116193. 3 interactions.

Protein family/group databases

TCDB4.C.1.1.12. the proposed fatty acid transporter (fat) family.

PTM databases

PhosphoSiteQ5K4L6.

Polymorphism databases

DMDM215274206.

Proteomic databases

MaxQBQ5K4L6.
PaxDbQ5K4L6.
PRIDEQ5K4L6.

Protocols and materials databases

DNASU11000.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000368661; ENSP00000357650; ENSG00000143554. [Q5K4L6-1]
ENST00000575439; ENSP00000458504; ENSG00000263163.
GeneID11000.
KEGGhsa:11000.
UCSCuc001fcz.3. human. [Q5K4L6-1]

Organism-specific databases

CTD11000.
GeneCardsGC01P153746.
HGNCHGNC:10997. SLC27A3.
HPAHPA006935.
MIM604193. gene.
neXtProtNX_Q5K4L6.
PharmGKBPA35871.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0318.
HOVERGENHBG005642.
InParanoidQ5K4L6.
KOK08772.
PhylomeDBQ5K4L6.
TreeFamTF313430.

Gene expression databases

ArrayExpressQ5K4L6.
BgeeQ5K4L6.
GenevestigatorQ5K4L6.

Family and domain databases

InterProIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLC27A3.
GenomeRNAi11000.
NextBio41791.
PROQ5K4L6.
SOURCESearch...

Entry information

Entry nameS27A3_HUMAN
AccessionPrimary (citable) accession number: Q5K4L6
Secondary accession number(s): Q5VUQ7 expand/collapse secondary AC list , Q5VUQ8, Q5VUR3, Q6ZV16, Q8N2X7, Q8TEJ0, Q96SW5, Q9BTJ5, Q9BTY5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM