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Q5K4L6

- S27A3_HUMAN

UniProt

Q5K4L6 - S27A3_HUMAN

Protein

Long-chain fatty acid transport protein 3

Gene

SLC27A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi332 – 34312AMPSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. fatty-acyl-CoA synthase activity Source: Ensembl
    2. ligase activity Source: UniProtKB-KW
    3. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. fatty acid metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    Nucleotide-binding

    Protein family/group databases

    TCDBi4.C.1.1.12. the proposed fatty acid transporter (fat) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain fatty acid transport protein 3 (EC:6.2.1.-)
    Short name:
    FATP-3
    Short name:
    Fatty acid transport protein 3
    Alternative name(s):
    Solute carrier family 27 member 3
    Very long-chain acyl-CoA synthetase homolog 3
    Short name:
    VLCS-3
    Gene namesi
    Name:SLC27A3
    Synonyms:ACSVL3, FATP3
    ORF Names:PSEC0067, UNQ367/PRO703
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10997. SLC27A3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: UniProtKB
    3. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35871.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 730730Long-chain fatty acid transport protein 3PRO_0000193207Add
    BLAST

    Proteomic databases

    MaxQBiQ5K4L6.
    PaxDbiQ5K4L6.
    PRIDEiQ5K4L6.

    PTM databases

    PhosphoSiteiQ5K4L6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5K4L6.
    BgeeiQ5K4L6.
    GenevestigatoriQ5K4L6.

    Organism-specific databases

    HPAiHPA006935.

    Interactioni

    Protein-protein interaction databases

    BioGridi116193. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5K4L6.
    SMRiQ5K4L6. Positions 201-691.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei50 – 7021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei369 – 38921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0318.
    HOVERGENiHBG005642.
    InParanoidiQ5K4L6.
    KOiK08772.
    PhylomeDBiQ5K4L6.
    TreeFamiTF313430.

    Family and domain databases

    InterProiIPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5K4L6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGVCQRTRAP WKEKSQLERA ALGFRKGGSG MFASGWNQTV PIEEAGSMAA    50
    LLLLPLLLLL PLLLLKLHLW PQLRWLPADL AFAVRALCCK RALRARALAA 100
    AAADPEGPEG GCSLAWRLAE LAQQRAAHTF LIHGSRRFSY SEAERESNRA 150
    ARAFLRALGW DWGPDGGDSG EGSAGEGERA APGAGDAAAG SGAEFAGGDG 200
    AARGGGAAAP LSPGATVALL LPAGPEFLWL WFGLAKAGLR TAFVPTALRR 250
    GPLLHCLRSC GARALVLAPE FLESLEPDLP ALRAMGLHLW AAGPGTHPAG 300
    ISDLLAEVSA EVDGPVPGYL SSPQSITDTC LYIFTSGTTG LPKAARISHL 350
    KILQCQGFYQ LCGVHQEDVI YLALPLYHMS GSLLGIVGCM GIGATVVLKS 400
    KFSAGQFWED CQQHRVTVFQ YIGELCRYLV NQPPSKAERG HKVRLAVGSG 450
    LRPDTWERFV RRFGPLQVLE TYGLTEGNVA TINYTGQRGA VGRASWLYKH 500
    IFPFSLIRYD VTTGEPIRDP QGHCMATSPG EPGLLVAPVS QQSPFLGYAG 550
    GPELAQGKLL KDVFRPGDVF FNTGDLLVCD DQGFLRFHDR TGDTFRWKGE 600
    NVATTEVAEV FEALDFLQEV NVYGVTVPGH EGRAGMAALV LRPPHALDLM 650
    QLYTHVSENL PPYARPRFLR LQESLATTET FKQQKVRMAN EGFDPSTLSD 700
    PLYVLDQAVG AYLPLTTARY SALLAGNLRI 730
    Length:730
    Mass (Da):78,644
    Last modified:November 25, 2008 - v3
    Checksum:iE8CC4E9463A534A0
    GO
    Isoform 2 (identifier: Q5K4L6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         673-707: Missing.

    Show »
    Length:695
    Mass (Da):74,702
    Checksum:iC92234E76758019E
    GO
    Isoform 3 (identifier: Q5K4L6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         270-276: EFLESLE → GKAGAPN
         277-730: Missing.

    Show »
    Length:276
    Mass (Da):28,670
    Checksum:i7FC81638A981ED34
    GO

    Sequence cautioni

    The sequence BAC86050.1 differs from that shown. Reason: Frameshift at position 540.
    The sequence AAH29792.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB55156.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB84960.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC86050.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAE12159.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAH71420.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121K → E in BAB55156. (PubMed:14702039)Curated
    Sequence conflicti66 – 661K → M in CAE12159. 1 PublicationCurated
    Sequence conflicti472 – 4721Y → F in AAH03654. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti110 – 1101G → A.
    Corresponds to variant rs34527123 [ dbSNP | Ensembl ].
    VAR_048241
    Natural varianti439 – 4391R → H.
    Corresponds to variant rs35102232 [ dbSNP | Ensembl ].
    VAR_048242

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei270 – 2767EFLESLE → GKAGAPN in isoform 3. 1 PublicationVSP_036534
    Alternative sequencei277 – 730454Missing in isoform 3. 1 PublicationVSP_036535Add
    BLAST
    Alternative sequencei673 – 70735Missing in isoform 2. 1 PublicationVSP_016218Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ577572 mRNA. Translation: CAE12159.1. Different initiation.
    AK074134 mRNA. Translation: BAB84960.1. Different initiation.
    AY358409 mRNA. Translation: AAQ88775.1.
    AK027499 mRNA. Translation: BAB55156.1. Different initiation.
    AK075377 mRNA. Translation: BAC11578.1.
    AK125102 mRNA. Translation: BAC86050.1. Sequence problems.
    AL513523 Genomic DNA. Translation: CAH71420.1. Different initiation.
    AL513523 Genomic DNA. Translation: CAH71421.1.
    AL513523 Genomic DNA. Translation: CAH71423.1.
    BC003041 mRNA. Translation: AAH03041.1.
    BC003654 mRNA. Translation: AAH03654.2.
    BC009916 mRNA. Translation: AAH09916.1.
    BC029792 mRNA. Translation: AAH29792.1. Different initiation.
    CCDSiCCDS1053.1. [Q5K4L6-1]
    RefSeqiNP_077306.1. NM_024330.1. [Q5K4L6-1]
    UniGeneiHs.438723.

    Genome annotation databases

    EnsembliENST00000368661; ENSP00000357650; ENSG00000143554. [Q5K4L6-1]
    ENST00000575439; ENSP00000458504; ENSG00000263163.
    GeneIDi11000.
    KEGGihsa:11000.
    UCSCiuc001fcz.3. human. [Q5K4L6-1]

    Polymorphism databases

    DMDMi215274206.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ577572 mRNA. Translation: CAE12159.1 . Different initiation.
    AK074134 mRNA. Translation: BAB84960.1 . Different initiation.
    AY358409 mRNA. Translation: AAQ88775.1 .
    AK027499 mRNA. Translation: BAB55156.1 . Different initiation.
    AK075377 mRNA. Translation: BAC11578.1 .
    AK125102 mRNA. Translation: BAC86050.1 . Sequence problems.
    AL513523 Genomic DNA. Translation: CAH71420.1 . Different initiation.
    AL513523 Genomic DNA. Translation: CAH71421.1 .
    AL513523 Genomic DNA. Translation: CAH71423.1 .
    BC003041 mRNA. Translation: AAH03041.1 .
    BC003654 mRNA. Translation: AAH03654.2 .
    BC009916 mRNA. Translation: AAH09916.1 .
    BC029792 mRNA. Translation: AAH29792.1 . Different initiation.
    CCDSi CCDS1053.1. [Q5K4L6-1 ]
    RefSeqi NP_077306.1. NM_024330.1. [Q5K4L6-1 ]
    UniGenei Hs.438723.

    3D structure databases

    ProteinModelPortali Q5K4L6.
    SMRi Q5K4L6. Positions 201-691.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116193. 3 interactions.

    Protein family/group databases

    TCDBi 4.C.1.1.12. the proposed fatty acid transporter (fat) family.

    PTM databases

    PhosphoSitei Q5K4L6.

    Polymorphism databases

    DMDMi 215274206.

    Proteomic databases

    MaxQBi Q5K4L6.
    PaxDbi Q5K4L6.
    PRIDEi Q5K4L6.

    Protocols and materials databases

    DNASUi 11000.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368661 ; ENSP00000357650 ; ENSG00000143554 . [Q5K4L6-1 ]
    ENST00000575439 ; ENSP00000458504 ; ENSG00000263163 .
    GeneIDi 11000.
    KEGGi hsa:11000.
    UCSCi uc001fcz.3. human. [Q5K4L6-1 ]

    Organism-specific databases

    CTDi 11000.
    GeneCardsi GC01P153746.
    HGNCi HGNC:10997. SLC27A3.
    HPAi HPA006935.
    MIMi 604193. gene.
    neXtProti NX_Q5K4L6.
    PharmGKBi PA35871.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0318.
    HOVERGENi HBG005642.
    InParanoidi Q5K4L6.
    KOi K08772.
    PhylomeDBi Q5K4L6.
    TreeFami TF313430.

    Miscellaneous databases

    GeneWikii SLC27A3.
    GenomeRNAii 11000.
    NextBioi 41791.
    PROi Q5K4L6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5K4L6.
    Bgeei Q5K4L6.
    Genevestigatori Q5K4L6.

    Family and domain databases

    InterProi IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Berger J.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver and Testis.
    2. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
      Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Spleen.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Neuron, Teratocarcinoma and Tongue.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 297-683 (ISOFORM 2).
      Tissue: Brain and Lung.

    Entry informationi

    Entry nameiS27A3_HUMAN
    AccessioniPrimary (citable) accession number: Q5K4L6
    Secondary accession number(s): Q5VUQ7
    , Q5VUQ8, Q5VUR3, Q6ZV16, Q8N2X7, Q8TEJ0, Q96SW5, Q9BTJ5, Q9BTY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-48 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3