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Q5K2C4

- TPS1_APHAV

UniProt

Q5K2C4 - TPS1_APHAV

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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1

Gene
tps-1
Organism
Aphelenchus avenae (Mycophagous nematode worm)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a 2 step process By similarity.

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

  1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. trehalose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1 (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase 1
UDP-glucose-glucosephosphate glucosyltransferase 1
Gene namesi
Name:tps-1
OrganismiAphelenchus avenae (Mycophagous nematode worm)
Taxonomic identifieri70226 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaTylenchidaAphelenchinaAphelenchoideaAphelenchidaeAphelenchus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11551155Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1PRO_0000385173Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5K2C4.

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 20 family.
In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: Q5K2C4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSHGTKYRDA LLFSLTLYDV NTGKSRLKEL YAAVPGIRKS LLGVHAKRFG     50
EQYHHLQRRR SVSSRGGSLR GSMDSLNDSG QNGAEDVIGV EDEEEAQKFR 100
GKRTSISLDP AAAGEVMFTI EDGACFPSGG LANTHFQQRV INVSNAPPVS 150
LKREKSGEWE IKQGSGGLVS CVDPIMSVNQ ENMWLANLGM NIDKKKMLRS 200
TELLNVTDDS APLAPATNTL GLPLMRQALA DVLFHVIADD DIKEQNEDEQ 250
SRNVRWGHSS VEAGGVAPSQ PWEEMSLLGV LNQYNRSNYK LNPVVVQEQD 300
YNVYYGGISN GLLWPALHNL PEYIVADYDD PKVLYEHWCA YVRVNYQFAI 350
DAVRNSRPQD FIWIHDYHLM LTGMIMQSLD SSLEIGFFLH IPFLPPDNFF 400
TKYRLCAFPI MRGLLRFTKV GFQTHRDRAK FVELVGIHLP TARVTYDEKM 450
DIHTVTYQGW SCSLGVFPVS IKNEDFLKVA QSAETIKKAD DIRKEILGET 500
PVDSARLLFS VERFDYTKGI KEKLLAYRRY FERHPDRIGK DVLYQVAVTN 550
RRSVDTYRMY QDECIQMAED INREFATDEY PNWKPLIFRT DGLQRADLVA 600
HYLAMDVGVV TPKKDGMNLV AKEMLVCNPS AGLVLSTGAG SEIQFTMAGL 650
HPDDGDKCYH RVVDVYDADH YADAFYEAAV EPEGERAAHG QRLNEFIMNN 700
DIERWSTAFL DPGWSHLVIR QSEIKDLDDF YSLMMRTRDV RRQIVERVLK 750
GIPIRSHFSI SLSNTKESLL LACQPGTRTL HLKPSLEEDE QTEPAHFDIA 800
NELDEFEKDL NFMKFIQSDD VYNVEQFINS LQEYHPVSAD KFRDEVIELG 850
DVLTEADHFN FFFTDRDGTL KSYSCSYPAS IQPAYSGVIQ AQFARRCAQT 900
CAIVTTAPLM RIGVLDVSTI PEGYYYFGAS AGREWFIDPA NKFKDQSIPE 950
EDLELLERVF AAISDLLEEP KFKHFTWVGS GLQKHYGHIT IAHQDAFNSV 1000
PRHQVRAIDQ KIKDIIHRID PDQHTLKVKE TETDIKIFLK SESGEIFDKG 1050
QGIRLLVEHM KCDISNGTIL VCGDSSTDLP MLQACLEANP SGVYTVWVTR 1100
SDELKTTVRE LCERFGNKNF VFVSCPEVLL GGMAQATIRE ISIGRPGPRA 1150
SHDSE 1155

Note: No experimental confirmation available.

Length:1,155
Mass (Da):130,891
Last modified:February 15, 2005 - v1
Checksum:i5D15061B15C32E47
GO
Isoform b (identifier: Q5K2C4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.

Note: No experimental confirmation available.

Show »
Length:980
Mass (Da):111,888
Checksum:i747939ABD0ED22FF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 175175Missing in isoform b. VSP_038109Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ811568 mRNA. Translation: CAH18873.1.
AJ811569 mRNA. Translation: CAH18874.1.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ811568 mRNA. Translation: CAH18873.1 .
AJ811569 mRNA. Translation: CAH18874.1 .

3D structure databases

ProteinModelPortali Q5K2C4.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT20. Glycosyltransferase Family 20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1000. 2 hits.
InterProi IPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00982. Glyco_transf_20. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins."
    Goyal K., Browne J.A., Burnell A.M., Tunnacliffe A.
    Biochimie 87:565-574(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).

Entry informationi

Entry nameiTPS1_APHAV
AccessioniPrimary (citable) accession number: Q5K2C4
Secondary accession number(s): Q5K2C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: February 15, 2005
Last modified: October 16, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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