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Q5K2C4 (TPS1_APHAV) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1

EC=2.4.1.15
Alternative name(s):
Trehalose-6-phosphate synthase 1
UDP-glucose-glucosephosphate glucosyltransferase 1
Gene names
Name:tps-1
OrganismAphelenchus avenae (Mycophagous nematode worm)
Taxonomic identifier70226 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaTylenchidaAphelenchinaAphelenchoideaAphelenchidaeAphelenchus

Protein attributes

Sequence length1155 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a 2 step process By similarity.

Catalytic activity

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

Sequence similarities

In the N-terminal section; belongs to the glycosyltransferase 20 family.

In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Molecular functionGlycosyltransferase
Transferase
Gene Ontology (GO)
   Biological_processtrehalose biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionalpha,alpha-trehalose-phosphate synthase (UDP-forming) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform a (identifier: Q5K2C4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform b (identifier: Q5K2C4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11551155Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1
PRO_0000385173

Natural variations

Alternative sequence1 – 175175Missing in isoform b.
VSP_038109

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 5D15061B15C32E47

FASTA1,155130,891
        10         20         30         40         50         60 
MSHGTKYRDA LLFSLTLYDV NTGKSRLKEL YAAVPGIRKS LLGVHAKRFG EQYHHLQRRR 

        70         80         90        100        110        120 
SVSSRGGSLR GSMDSLNDSG QNGAEDVIGV EDEEEAQKFR GKRTSISLDP AAAGEVMFTI 

       130        140        150        160        170        180 
EDGACFPSGG LANTHFQQRV INVSNAPPVS LKREKSGEWE IKQGSGGLVS CVDPIMSVNQ 

       190        200        210        220        230        240 
ENMWLANLGM NIDKKKMLRS TELLNVTDDS APLAPATNTL GLPLMRQALA DVLFHVIADD 

       250        260        270        280        290        300 
DIKEQNEDEQ SRNVRWGHSS VEAGGVAPSQ PWEEMSLLGV LNQYNRSNYK LNPVVVQEQD 

       310        320        330        340        350        360 
YNVYYGGISN GLLWPALHNL PEYIVADYDD PKVLYEHWCA YVRVNYQFAI DAVRNSRPQD 

       370        380        390        400        410        420 
FIWIHDYHLM LTGMIMQSLD SSLEIGFFLH IPFLPPDNFF TKYRLCAFPI MRGLLRFTKV 

       430        440        450        460        470        480 
GFQTHRDRAK FVELVGIHLP TARVTYDEKM DIHTVTYQGW SCSLGVFPVS IKNEDFLKVA 

       490        500        510        520        530        540 
QSAETIKKAD DIRKEILGET PVDSARLLFS VERFDYTKGI KEKLLAYRRY FERHPDRIGK 

       550        560        570        580        590        600 
DVLYQVAVTN RRSVDTYRMY QDECIQMAED INREFATDEY PNWKPLIFRT DGLQRADLVA 

       610        620        630        640        650        660 
HYLAMDVGVV TPKKDGMNLV AKEMLVCNPS AGLVLSTGAG SEIQFTMAGL HPDDGDKCYH 

       670        680        690        700        710        720 
RVVDVYDADH YADAFYEAAV EPEGERAAHG QRLNEFIMNN DIERWSTAFL DPGWSHLVIR 

       730        740        750        760        770        780 
QSEIKDLDDF YSLMMRTRDV RRQIVERVLK GIPIRSHFSI SLSNTKESLL LACQPGTRTL 

       790        800        810        820        830        840 
HLKPSLEEDE QTEPAHFDIA NELDEFEKDL NFMKFIQSDD VYNVEQFINS LQEYHPVSAD 

       850        860        870        880        890        900 
KFRDEVIELG DVLTEADHFN FFFTDRDGTL KSYSCSYPAS IQPAYSGVIQ AQFARRCAQT 

       910        920        930        940        950        960 
CAIVTTAPLM RIGVLDVSTI PEGYYYFGAS AGREWFIDPA NKFKDQSIPE EDLELLERVF 

       970        980        990       1000       1010       1020 
AAISDLLEEP KFKHFTWVGS GLQKHYGHIT IAHQDAFNSV PRHQVRAIDQ KIKDIIHRID 

      1030       1040       1050       1060       1070       1080 
PDQHTLKVKE TETDIKIFLK SESGEIFDKG QGIRLLVEHM KCDISNGTIL VCGDSSTDLP 

      1090       1100       1110       1120       1130       1140 
MLQACLEANP SGVYTVWVTR SDELKTTVRE LCERFGNKNF VFVSCPEVLL GGMAQATIRE 

      1150 
ISIGRPGPRA SHDSE 

« Hide

Isoform b [UniParc].

Checksum: 747939ABD0ED22FF
Show »

FASTA980111,888

References

[1]"Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins."
Goyal K., Browne J.A., Burnell A.M., Tunnacliffe A.
Biochimie 87:565-574(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ811568 mRNA. Translation: CAH18873.1.
AJ811569 mRNA. Translation: CAH18874.1.

3D structure databases

ProteinModelPortalQ5K2C4.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT20. Glycosyltransferase Family 20.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.1000. 2 hits.
InterProIPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
[Graphical view]
PfamPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTPS1_APHAV
AccessionPrimary (citable) accession number: Q5K2C4
Secondary accession number(s): Q5K2C3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: February 15, 2005
Last modified: October 16, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families