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Q5K2C4

- TPS1_APHAV

UniProt

Q5K2C4 - TPS1_APHAV

Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1

Gene

tps-1

Organism
Aphelenchus avenae (Mycophagous nematode worm)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a 2 step process.By similarity

    Catalytic activityi

    UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

    GO - Molecular functioni

    1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

    GO - Biological processi

    1. trehalose biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT20. Glycosyltransferase Family 20.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1 (EC:2.4.1.15)
    Alternative name(s):
    Trehalose-6-phosphate synthase 1
    UDP-glucose-glucosephosphate glucosyltransferase 1
    Gene namesi
    Name:tps-1
    OrganismiAphelenchus avenae (Mycophagous nematode worm)
    Taxonomic identifieri70226 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaTylenchidaAphelenchinaAphelenchoideaAphelenchidaeAphelenchus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11551155Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1PRO_0000385173Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ5K2C4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    In the N-terminal section; belongs to the glycosyltransferase 20 family.Curated
    In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.Curated

    Family and domain databases

    Gene3Di3.40.50.1000. 2 hits.
    InterProiIPR001830. Glyco_trans_20.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00982. Glyco_transf_20. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: Q5K2C4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSHGTKYRDA LLFSLTLYDV NTGKSRLKEL YAAVPGIRKS LLGVHAKRFG     50
    EQYHHLQRRR SVSSRGGSLR GSMDSLNDSG QNGAEDVIGV EDEEEAQKFR 100
    GKRTSISLDP AAAGEVMFTI EDGACFPSGG LANTHFQQRV INVSNAPPVS 150
    LKREKSGEWE IKQGSGGLVS CVDPIMSVNQ ENMWLANLGM NIDKKKMLRS 200
    TELLNVTDDS APLAPATNTL GLPLMRQALA DVLFHVIADD DIKEQNEDEQ 250
    SRNVRWGHSS VEAGGVAPSQ PWEEMSLLGV LNQYNRSNYK LNPVVVQEQD 300
    YNVYYGGISN GLLWPALHNL PEYIVADYDD PKVLYEHWCA YVRVNYQFAI 350
    DAVRNSRPQD FIWIHDYHLM LTGMIMQSLD SSLEIGFFLH IPFLPPDNFF 400
    TKYRLCAFPI MRGLLRFTKV GFQTHRDRAK FVELVGIHLP TARVTYDEKM 450
    DIHTVTYQGW SCSLGVFPVS IKNEDFLKVA QSAETIKKAD DIRKEILGET 500
    PVDSARLLFS VERFDYTKGI KEKLLAYRRY FERHPDRIGK DVLYQVAVTN 550
    RRSVDTYRMY QDECIQMAED INREFATDEY PNWKPLIFRT DGLQRADLVA 600
    HYLAMDVGVV TPKKDGMNLV AKEMLVCNPS AGLVLSTGAG SEIQFTMAGL 650
    HPDDGDKCYH RVVDVYDADH YADAFYEAAV EPEGERAAHG QRLNEFIMNN 700
    DIERWSTAFL DPGWSHLVIR QSEIKDLDDF YSLMMRTRDV RRQIVERVLK 750
    GIPIRSHFSI SLSNTKESLL LACQPGTRTL HLKPSLEEDE QTEPAHFDIA 800
    NELDEFEKDL NFMKFIQSDD VYNVEQFINS LQEYHPVSAD KFRDEVIELG 850
    DVLTEADHFN FFFTDRDGTL KSYSCSYPAS IQPAYSGVIQ AQFARRCAQT 900
    CAIVTTAPLM RIGVLDVSTI PEGYYYFGAS AGREWFIDPA NKFKDQSIPE 950
    EDLELLERVF AAISDLLEEP KFKHFTWVGS GLQKHYGHIT IAHQDAFNSV 1000
    PRHQVRAIDQ KIKDIIHRID PDQHTLKVKE TETDIKIFLK SESGEIFDKG 1050
    QGIRLLVEHM KCDISNGTIL VCGDSSTDLP MLQACLEANP SGVYTVWVTR 1100
    SDELKTTVRE LCERFGNKNF VFVSCPEVLL GGMAQATIRE ISIGRPGPRA 1150
    SHDSE 1155

    Note: No experimental confirmation available.

    Length:1,155
    Mass (Da):130,891
    Last modified:February 15, 2005 - v1
    Checksum:i5D15061B15C32E47
    GO
    Isoform b (identifier: Q5K2C4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-175: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:980
    Mass (Da):111,888
    Checksum:i747939ABD0ED22FF
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 175175Missing in isoform b. 1 PublicationVSP_038109Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ811568 mRNA. Translation: CAH18873.1.
    AJ811569 mRNA. Translation: CAH18874.1.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ811568 mRNA. Translation: CAH18873.1 .
    AJ811569 mRNA. Translation: CAH18874.1 .

    3D structure databases

    ProteinModelPortali Q5K2C4.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT20. Glycosyltransferase Family 20.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.1000. 2 hits.
    InterProi IPR001830. Glyco_trans_20.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00982. Glyco_transf_20. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins."
      Goyal K., Browne J.A., Burnell A.M., Tunnacliffe A.
      Biochimie 87:565-574(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).

    Entry informationi

    Entry nameiTPS1_APHAV
    AccessioniPrimary (citable) accession number: Q5K2C4
    Secondary accession number(s): Q5K2C3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3