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Q5K2C4

- TPS1_APHAV

UniProt

Q5K2C4 - TPS1_APHAV

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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1

Gene

tps-1

Organism
Aphelenchus avenae (Mycophagous nematode worm)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a 2 step process.By similarity

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

  1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. trehalose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1 (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase 1
UDP-glucose-glucosephosphate glucosyltransferase 1
Gene namesi
Name:tps-1
OrganismiAphelenchus avenae (Mycophagous nematode worm)
Taxonomic identifieri70226 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaTylenchidaAphelenchinaAphelenchoideaAphelenchidaeAphelenchus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11551155Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1PRO_0000385173Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5K2C4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 20 family.Curated
In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.Curated

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: Q5K2C4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSHGTKYRDA LLFSLTLYDV NTGKSRLKEL YAAVPGIRKS LLGVHAKRFG
60 70 80 90 100
EQYHHLQRRR SVSSRGGSLR GSMDSLNDSG QNGAEDVIGV EDEEEAQKFR
110 120 130 140 150
GKRTSISLDP AAAGEVMFTI EDGACFPSGG LANTHFQQRV INVSNAPPVS
160 170 180 190 200
LKREKSGEWE IKQGSGGLVS CVDPIMSVNQ ENMWLANLGM NIDKKKMLRS
210 220 230 240 250
TELLNVTDDS APLAPATNTL GLPLMRQALA DVLFHVIADD DIKEQNEDEQ
260 270 280 290 300
SRNVRWGHSS VEAGGVAPSQ PWEEMSLLGV LNQYNRSNYK LNPVVVQEQD
310 320 330 340 350
YNVYYGGISN GLLWPALHNL PEYIVADYDD PKVLYEHWCA YVRVNYQFAI
360 370 380 390 400
DAVRNSRPQD FIWIHDYHLM LTGMIMQSLD SSLEIGFFLH IPFLPPDNFF
410 420 430 440 450
TKYRLCAFPI MRGLLRFTKV GFQTHRDRAK FVELVGIHLP TARVTYDEKM
460 470 480 490 500
DIHTVTYQGW SCSLGVFPVS IKNEDFLKVA QSAETIKKAD DIRKEILGET
510 520 530 540 550
PVDSARLLFS VERFDYTKGI KEKLLAYRRY FERHPDRIGK DVLYQVAVTN
560 570 580 590 600
RRSVDTYRMY QDECIQMAED INREFATDEY PNWKPLIFRT DGLQRADLVA
610 620 630 640 650
HYLAMDVGVV TPKKDGMNLV AKEMLVCNPS AGLVLSTGAG SEIQFTMAGL
660 670 680 690 700
HPDDGDKCYH RVVDVYDADH YADAFYEAAV EPEGERAAHG QRLNEFIMNN
710 720 730 740 750
DIERWSTAFL DPGWSHLVIR QSEIKDLDDF YSLMMRTRDV RRQIVERVLK
760 770 780 790 800
GIPIRSHFSI SLSNTKESLL LACQPGTRTL HLKPSLEEDE QTEPAHFDIA
810 820 830 840 850
NELDEFEKDL NFMKFIQSDD VYNVEQFINS LQEYHPVSAD KFRDEVIELG
860 870 880 890 900
DVLTEADHFN FFFTDRDGTL KSYSCSYPAS IQPAYSGVIQ AQFARRCAQT
910 920 930 940 950
CAIVTTAPLM RIGVLDVSTI PEGYYYFGAS AGREWFIDPA NKFKDQSIPE
960 970 980 990 1000
EDLELLERVF AAISDLLEEP KFKHFTWVGS GLQKHYGHIT IAHQDAFNSV
1010 1020 1030 1040 1050
PRHQVRAIDQ KIKDIIHRID PDQHTLKVKE TETDIKIFLK SESGEIFDKG
1060 1070 1080 1090 1100
QGIRLLVEHM KCDISNGTIL VCGDSSTDLP MLQACLEANP SGVYTVWVTR
1110 1120 1130 1140 1150
SDELKTTVRE LCERFGNKNF VFVSCPEVLL GGMAQATIRE ISIGRPGPRA

SHDSE

Note: No experimental confirmation available.

Length:1,155
Mass (Da):130,891
Last modified:February 15, 2005 - v1
Checksum:i5D15061B15C32E47
GO
Isoform b (identifier: Q5K2C4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.

Note: No experimental confirmation available.

Show »
Length:980
Mass (Da):111,888
Checksum:i747939ABD0ED22FF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 175175Missing in isoform b. 1 PublicationVSP_038109Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ811568 mRNA. Translation: CAH18873.1.
AJ811569 mRNA. Translation: CAH18874.1.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ811568 mRNA. Translation: CAH18873.1 .
AJ811569 mRNA. Translation: CAH18874.1 .

3D structure databases

ProteinModelPortali Q5K2C4.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT20. Glycosyltransferase Family 20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1000. 2 hits.
InterProi IPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00982. Glyco_transf_20. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins."
    Goyal K., Browne J.A., Burnell A.M., Tunnacliffe A.
    Biochimie 87:565-574(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).

Entry informationi

Entry nameiTPS1_APHAV
AccessioniPrimary (citable) accession number: Q5K2C4
Secondary accession number(s): Q5K2C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: February 15, 2005
Last modified: October 1, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3