Q5K2C1 (TPS2_APHAV) Reviewed, UniProtKB/Swiss-Prot
Last modified
March 6, 2013.
Version 24.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2 EC=2.4.1.15 Alternative name(s): Trehalose-6-phosphate synthase 2 UDP-glucose-glucosephosphate glucosyltransferase 2 | ||
| Gene names |
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| Organism | Aphelenchus avenae (Mycophagous nematode worm) | ||
| Taxonomic identifier | 70226 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Tylenchida › Aphelenchina › Aphelenchoidea › Aphelenchidae › Aphelenchus |
Protein attributes
| Sequence length | 1303 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a 2 step process By similarity. |
| Catalytic activity | UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate. |
| Sequence similarities | In the N-terminal section; belongs to the glycosyltransferase 20 family. In the C-terminal section; belongs to the gob-1 trehalose phosphatase family. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Molecular function | Glycosyltransferase Transferase |
| Gene Ontology (GO) | |
| Biological_process | trehalose biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Molecular_function | alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform a (identifier: Q5K2C1-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform b (identifier: Q5K2C1-2) The sequence of this isoform differs from the canonical sequence as follows: 349-364: Missing. 420-420: R → RWGHSSAGEAGVEPSQPW | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1303 | 1303 | Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2 | PRO_0000385174 | |||||
Natural variations | |||||||||
| Alternative sequence | 349 – 364 | 16 | Missing in isoform b. | VSP_038110 | |||||
| Alternative sequence | 420 | 1 | R → RWGHSSAGEAGVEPSQPW in isoform b. | VSP_038111 | |||||
Experimental info | |||||||||
| Sequence conflict | 180 | 1 | Y → C in CAH18871. Ref.1 | ||||||
| Sequence conflict | 216 | 1 | G → A in CAH18871. Ref.1 | ||||||
| Sequence conflict | 228 – 229 | 2 | SG → A in CAH18871. Ref.1 | ||||||
| Sequence conflict | 232 | 1 | G → S in CAH18871. Ref.1 | ||||||
| Sequence conflict | 269 | 1 | I → T in CAH18869. Ref.1 | ||||||
| Sequence conflict | 381 – 383 | 3 | ATN → TTY in CAH18871. Ref.1 | ||||||
| Sequence conflict | 441 | 1 | P → A in CAH18871. Ref.1 | ||||||
| Sequence conflict | 995 | 1 | I → T in CAH18869. Ref.1 | ||||||
| Sequence conflict | 1057 | 1 | L → P in CAH18871. Ref.1 | ||||||
| Sequence conflict | 1084 | 1 | F → L in CAH18869. Ref.1 | ||||||
Sequences
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References
| [1] | "Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins." Goyal K., Browne J.A., Burnell A.M., Tunnacliffe A. Biochimie 87:565-574(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B). |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ811571 mRNA. Translation: CAH18870.1. AJ811570 mRNA. Translation: CAH18869.1. AJ811572 mRNA. Translation: CAH18871.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1UQT based on UniProtKB P31677. |
| ProteinModelPortal | Q5K2C1. |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GT20. Glycosyltransferase Family 20. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| Gene3D | 3.40.50.1000. 2 hits. |
| InterPro | IPR001830. Glyco_trans_20. IPR023214. HAD-like_dom. [Graphical view] |
| Pfam | PF00982. Glyco_transf_20. 1 hit. [Graphical view] |
| SUPFAM | SSF56784. HAD-like_dom. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | TPS2_APHAV | ||||||||
| Accession | Primary (citable) accession number: Q5K2C1 Secondary accession number(s): Q5K2C0, Q5K2C2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |