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Q5K2C1 (TPS2_APHAV) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2

EC=2.4.1.15
Alternative name(s):
Trehalose-6-phosphate synthase 2
UDP-glucose-glucosephosphate glucosyltransferase 2
Gene names
Name:tps-2
OrganismAphelenchus avenae (Mycophagous nematode worm)
Taxonomic identifier70226 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaTylenchidaAphelenchinaAphelenchoideaAphelenchidaeAphelenchus

Protein attributes

Sequence length1303 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a 2 step process By similarity.

Catalytic activity

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

Sequence similarities

In the N-terminal section; belongs to the glycosyltransferase 20 family.

In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Molecular functionGlycosyltransferase
Transferase
Gene Ontology (GO)
   Biological_processtrehalose biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionalpha,alpha-trehalose-phosphate synthase (UDP-forming) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform a (identifier: Q5K2C1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform b (identifier: Q5K2C1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     349-364: Missing.
     420-420: R → RWGHSSAGEAGVEPSQPW
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13031303Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2
PRO_0000385174

Natural variations

Alternative sequence349 – 36416Missing in isoform b.
VSP_038110
Alternative sequence4201R → RWGHSSAGEAGVEPSQPW in isoform b.
VSP_038111

Experimental info

Sequence conflict1801Y → C in CAH18871. Ref.1
Sequence conflict2161G → A in CAH18871. Ref.1
Sequence conflict228 – 2292SG → A in CAH18871. Ref.1
Sequence conflict2321G → S in CAH18871. Ref.1
Sequence conflict2691I → T in CAH18869. Ref.1
Sequence conflict381 – 3833ATN → TTY in CAH18871. Ref.1
Sequence conflict4411P → A in CAH18871. Ref.1
Sequence conflict9951I → T in CAH18869. Ref.1
Sequence conflict10571L → P in CAH18871. Ref.1
Sequence conflict10841F → L in CAH18869. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: ACF8CF07481DE669

FASTA1,303147,741
        10         20         30         40         50         60 
MTVVPGETQC EEAQPAANGS SSPVLLQPFR RPRTDSRSRL DSGSNNTTLS EDCARKSILR 

        70         80         90        100        110        120 
TLKSLGVEID ESASFEAIID SGGIEKLADF WRKRDSSSEI AFQGLLSVLE YCLQHSFDTN 

       130        140        150        160        170        180 
EFFEKFVNAL GYHTVQFWRA GVPYVFDSDM SHGTKYRDAL LFSLTLYDVN TGKSRLKELY 

       190        200        210        220        230        240 
AAVPGIRKSL LGVHAKRFGE QYHHLQRRRS VSSRGGSLRG SMDSLNDSGQ NGAEDVIGVE 

       250        260        270        280        290        300 
DEEEAQKFRG KRTSISLDPA AAGEVMFTIE DGACFPSGGL ANTHFQQRVI NVSNAPPVSL 

       310        320        330        340        350        360 
KREKSGEWEI KQGSGGLVSC VDPIMSVNQE NMWLANLGMN IDKKKMLRYD DCLRSQEHTL 

       370        380        390        400        410        420 
ENMRSTELLN VTDDSAPLAP ATNTLGLPLM RQALADVLFH VIADDDIKEQ NEDEQSRNVR 

       430        440        450        460        470        480 
EEMSLLGVLN QYNRSNYKLN PVVVQEQDYN VYYGGISNGL LWPALHNLPE YIVADYDDPK 

       490        500        510        520        530        540 
VLYEHWCAYV RVNYQFAIDA VRNSRPQDFI WIHDYHLMLT GMIMQSLDSS LEIGFFLHIP 

       550        560        570        580        590        600 
FLPPDNFFTK YRLCAFPIMR GLLRFTKVGF QTHRDRAKFV ELVGIHLPTA RVTYDEKMDI 

       610        620        630        640        650        660 
HTVTYQGWSC SLGVFPVSIK NEDFLKVAQS AETIKKADDI RKEILGETPV DSARLLFSVE 

       670        680        690        700        710        720 
RFDYTKGIKE KLLAYRRYFE RHPDRIGKDV LYQVAVTNRR SVDTYRMYQD ECIQMAEDIN 

       730        740        750        760        770        780 
KEFATDEYPN WKPLIFRTDG LQRADLVAHY LAMDVGVVTP KKDGMNLVAK EMLVCNPSAG 

       790        800        810        820        830        840 
LVLSTGAGSE IQFTMAGLHP DDGDKCYHRV VDVYDADHYA DAFYEAAVEP EAERAAHGQR 

       850        860        870        880        890        900 
LNEFIMNNDI ERWSTAFLDP GWSHLVIRQS EIKDLDDFYS LMMRTRDVRR QIVERVLKGI 

       910        920        930        940        950        960 
PIRSHFSISL SNAKESLLLA CQPGTRTLHL KPSLEEDEQT EPAHFDIANE LDEFEKDLNF 

       970        980        990       1000       1010       1020 
MKFIQSDDVY NVEQFINSLQ EYHPVSADKF RDEVIELGDM LTEADHFNFF FTDRDGTLKS 

      1030       1040       1050       1060       1070       1080 
YSCSYPASIQ PAYSGVIQAQ FARRCAQTCA IVTTAPLMRI GVLDVSTIPE GYYYFGASAG 

      1090       1100       1110       1120       1130       1140 
REWFIDPANK FKDQSIPEED LELLERVFAA ISDLLEEPKF KHFTWVGSGL QKHYGHITIA 

      1150       1160       1170       1180       1190       1200 
HQDAFNSVPR HQVRAIDQKI KDIIHRIDPD QHTLKVKETE TDIKIFLKSE SGEIFDKGQG 

      1210       1220       1230       1240       1250       1260 
IRLLVEHMKC DISNGTILVC GDSSTDLPML QACLEANPSG VYTVWVTRSD ELKTTVRELC 

      1270       1280       1290       1300 
ERFGNKNFVF VSCPEVLLGG MAQATIREIS IGRPGPRASH DSE 

« Hide

Isoform b [UniParc].

Checksum: 0D28003A90F61398
Show »

FASTA1,304147,513

References

[1]"Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins."
Goyal K., Browne J.A., Burnell A.M., Tunnacliffe A.
Biochimie 87:565-574(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ811571 mRNA. Translation: CAH18870.1.
AJ811570 mRNA. Translation: CAH18869.1.
AJ811572 mRNA. Translation: CAH18871.1.

3D structure databases

ProteinModelPortalQ5K2C1.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT20. Glycosyltransferase Family 20.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.1000. 2 hits.
InterProIPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
[Graphical view]
PfamPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTPS2_APHAV
AccessionPrimary (citable) accession number: Q5K2C1
Secondary accession number(s): Q5K2C0, Q5K2C2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: February 15, 2005
Last modified: October 16, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families