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Q5K2C1

- TPS2_APHAV

UniProt

Q5K2C1 - TPS2_APHAV

Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2

Gene

tps-2

Organism
Aphelenchus avenae (Mycophagous nematode worm)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a 2 step process.By similarity

    Catalytic activityi

    UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

    GO - Molecular functioni

    1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

    GO - Biological processi

    1. trehalose biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT20. Glycosyltransferase Family 20.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2 (EC:2.4.1.15)
    Alternative name(s):
    Trehalose-6-phosphate synthase 2
    UDP-glucose-glucosephosphate glucosyltransferase 2
    Gene namesi
    Name:tps-2
    OrganismiAphelenchus avenae (Mycophagous nematode worm)
    Taxonomic identifieri70226 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaTylenchidaAphelenchinaAphelenchoideaAphelenchidaeAphelenchus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13031303Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2PRO_0000385174Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ5K2C1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    In the N-terminal section; belongs to the glycosyltransferase 20 family.Curated
    In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.Curated

    Family and domain databases

    Gene3Di3.40.50.1000. 2 hits.
    InterProiIPR001830. Glyco_trans_20.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00982. Glyco_transf_20. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: Q5K2C1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTVVPGETQC EEAQPAANGS SSPVLLQPFR RPRTDSRSRL DSGSNNTTLS     50
    EDCARKSILR TLKSLGVEID ESASFEAIID SGGIEKLADF WRKRDSSSEI 100
    AFQGLLSVLE YCLQHSFDTN EFFEKFVNAL GYHTVQFWRA GVPYVFDSDM 150
    SHGTKYRDAL LFSLTLYDVN TGKSRLKELY AAVPGIRKSL LGVHAKRFGE 200
    QYHHLQRRRS VSSRGGSLRG SMDSLNDSGQ NGAEDVIGVE DEEEAQKFRG 250
    KRTSISLDPA AAGEVMFTIE DGACFPSGGL ANTHFQQRVI NVSNAPPVSL 300
    KREKSGEWEI KQGSGGLVSC VDPIMSVNQE NMWLANLGMN IDKKKMLRYD 350
    DCLRSQEHTL ENMRSTELLN VTDDSAPLAP ATNTLGLPLM RQALADVLFH 400
    VIADDDIKEQ NEDEQSRNVR EEMSLLGVLN QYNRSNYKLN PVVVQEQDYN 450
    VYYGGISNGL LWPALHNLPE YIVADYDDPK VLYEHWCAYV RVNYQFAIDA 500
    VRNSRPQDFI WIHDYHLMLT GMIMQSLDSS LEIGFFLHIP FLPPDNFFTK 550
    YRLCAFPIMR GLLRFTKVGF QTHRDRAKFV ELVGIHLPTA RVTYDEKMDI 600
    HTVTYQGWSC SLGVFPVSIK NEDFLKVAQS AETIKKADDI RKEILGETPV 650
    DSARLLFSVE RFDYTKGIKE KLLAYRRYFE RHPDRIGKDV LYQVAVTNRR 700
    SVDTYRMYQD ECIQMAEDIN KEFATDEYPN WKPLIFRTDG LQRADLVAHY 750
    LAMDVGVVTP KKDGMNLVAK EMLVCNPSAG LVLSTGAGSE IQFTMAGLHP 800
    DDGDKCYHRV VDVYDADHYA DAFYEAAVEP EAERAAHGQR LNEFIMNNDI 850
    ERWSTAFLDP GWSHLVIRQS EIKDLDDFYS LMMRTRDVRR QIVERVLKGI 900
    PIRSHFSISL SNAKESLLLA CQPGTRTLHL KPSLEEDEQT EPAHFDIANE 950
    LDEFEKDLNF MKFIQSDDVY NVEQFINSLQ EYHPVSADKF RDEVIELGDM 1000
    LTEADHFNFF FTDRDGTLKS YSCSYPASIQ PAYSGVIQAQ FARRCAQTCA 1050
    IVTTAPLMRI GVLDVSTIPE GYYYFGASAG REWFIDPANK FKDQSIPEED 1100
    LELLERVFAA ISDLLEEPKF KHFTWVGSGL QKHYGHITIA HQDAFNSVPR 1150
    HQVRAIDQKI KDIIHRIDPD QHTLKVKETE TDIKIFLKSE SGEIFDKGQG 1200
    IRLLVEHMKC DISNGTILVC GDSSTDLPML QACLEANPSG VYTVWVTRSD 1250
    ELKTTVRELC ERFGNKNFVF VSCPEVLLGG MAQATIREIS IGRPGPRASH 1300
    DSE 1303

    Note: No experimental confirmation available.

    Length:1,303
    Mass (Da):147,741
    Last modified:February 15, 2005 - v1
    Checksum:iACF8CF07481DE669
    GO
    Isoform b (identifier: Q5K2C1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         349-364: Missing.
         420-420: R → RWGHSSAGEAGVEPSQPW

    Note: No experimental confirmation available.

    Show »
    Length:1,304
    Mass (Da):147,513
    Checksum:i0D28003A90F61398
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti180 – 1801Y → C in CAH18871. (PubMed:15935281)Curated
    Sequence conflicti216 – 2161G → A in CAH18871. (PubMed:15935281)Curated
    Sequence conflicti228 – 2292SG → A in CAH18871. (PubMed:15935281)Curated
    Sequence conflicti232 – 2321G → S in CAH18871. (PubMed:15935281)Curated
    Sequence conflicti269 – 2691I → T in CAH18869. (PubMed:15935281)Curated
    Sequence conflicti381 – 3833ATN → TTY in CAH18871. (PubMed:15935281)Curated
    Sequence conflicti441 – 4411P → A in CAH18871. (PubMed:15935281)Curated
    Sequence conflicti995 – 9951I → T in CAH18869. (PubMed:15935281)Curated
    Sequence conflicti1057 – 10571L → P in CAH18871. (PubMed:15935281)Curated
    Sequence conflicti1084 – 10841F → L in CAH18869. (PubMed:15935281)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei349 – 36416Missing in isoform b. 1 PublicationVSP_038110Add
    BLAST
    Alternative sequencei420 – 4201R → RWGHSSAGEAGVEPSQPW in isoform b. 1 PublicationVSP_038111

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ811571 mRNA. Translation: CAH18870.1.
    AJ811570 mRNA. Translation: CAH18869.1.
    AJ811572 mRNA. Translation: CAH18871.1.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ811571 mRNA. Translation: CAH18870.1 .
    AJ811570 mRNA. Translation: CAH18869.1 .
    AJ811572 mRNA. Translation: CAH18871.1 .

    3D structure databases

    ProteinModelPortali Q5K2C1.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT20. Glycosyltransferase Family 20.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.1000. 2 hits.
    InterProi IPR001830. Glyco_trans_20.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00982. Glyco_transf_20. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins."
      Goyal K., Browne J.A., Burnell A.M., Tunnacliffe A.
      Biochimie 87:565-574(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).

    Entry informationi

    Entry nameiTPS2_APHAV
    AccessioniPrimary (citable) accession number: Q5K2C1
    Secondary accession number(s): Q5K2C0, Q5K2C2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3