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Q5K2C1

- TPS2_APHAV

UniProt

Q5K2C1 - TPS2_APHAV

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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2

Gene
tps-2
Organism
Aphelenchus avenae (Mycophagous nematode worm)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a 2 step process By similarity.

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

  1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. trehalose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2 (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase 2
UDP-glucose-glucosephosphate glucosyltransferase 2
Gene namesi
Name:tps-2
OrganismiAphelenchus avenae (Mycophagous nematode worm)
Taxonomic identifieri70226 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaTylenchidaAphelenchinaAphelenchoideaAphelenchidaeAphelenchus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13031303Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2PRO_0000385174Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5K2C1.

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 20 family.
In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: Q5K2C1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTVVPGETQC EEAQPAANGS SSPVLLQPFR RPRTDSRSRL DSGSNNTTLS     50
EDCARKSILR TLKSLGVEID ESASFEAIID SGGIEKLADF WRKRDSSSEI 100
AFQGLLSVLE YCLQHSFDTN EFFEKFVNAL GYHTVQFWRA GVPYVFDSDM 150
SHGTKYRDAL LFSLTLYDVN TGKSRLKELY AAVPGIRKSL LGVHAKRFGE 200
QYHHLQRRRS VSSRGGSLRG SMDSLNDSGQ NGAEDVIGVE DEEEAQKFRG 250
KRTSISLDPA AAGEVMFTIE DGACFPSGGL ANTHFQQRVI NVSNAPPVSL 300
KREKSGEWEI KQGSGGLVSC VDPIMSVNQE NMWLANLGMN IDKKKMLRYD 350
DCLRSQEHTL ENMRSTELLN VTDDSAPLAP ATNTLGLPLM RQALADVLFH 400
VIADDDIKEQ NEDEQSRNVR EEMSLLGVLN QYNRSNYKLN PVVVQEQDYN 450
VYYGGISNGL LWPALHNLPE YIVADYDDPK VLYEHWCAYV RVNYQFAIDA 500
VRNSRPQDFI WIHDYHLMLT GMIMQSLDSS LEIGFFLHIP FLPPDNFFTK 550
YRLCAFPIMR GLLRFTKVGF QTHRDRAKFV ELVGIHLPTA RVTYDEKMDI 600
HTVTYQGWSC SLGVFPVSIK NEDFLKVAQS AETIKKADDI RKEILGETPV 650
DSARLLFSVE RFDYTKGIKE KLLAYRRYFE RHPDRIGKDV LYQVAVTNRR 700
SVDTYRMYQD ECIQMAEDIN KEFATDEYPN WKPLIFRTDG LQRADLVAHY 750
LAMDVGVVTP KKDGMNLVAK EMLVCNPSAG LVLSTGAGSE IQFTMAGLHP 800
DDGDKCYHRV VDVYDADHYA DAFYEAAVEP EAERAAHGQR LNEFIMNNDI 850
ERWSTAFLDP GWSHLVIRQS EIKDLDDFYS LMMRTRDVRR QIVERVLKGI 900
PIRSHFSISL SNAKESLLLA CQPGTRTLHL KPSLEEDEQT EPAHFDIANE 950
LDEFEKDLNF MKFIQSDDVY NVEQFINSLQ EYHPVSADKF RDEVIELGDM 1000
LTEADHFNFF FTDRDGTLKS YSCSYPASIQ PAYSGVIQAQ FARRCAQTCA 1050
IVTTAPLMRI GVLDVSTIPE GYYYFGASAG REWFIDPANK FKDQSIPEED 1100
LELLERVFAA ISDLLEEPKF KHFTWVGSGL QKHYGHITIA HQDAFNSVPR 1150
HQVRAIDQKI KDIIHRIDPD QHTLKVKETE TDIKIFLKSE SGEIFDKGQG 1200
IRLLVEHMKC DISNGTILVC GDSSTDLPML QACLEANPSG VYTVWVTRSD 1250
ELKTTVRELC ERFGNKNFVF VSCPEVLLGG MAQATIREIS IGRPGPRASH 1300
DSE 1303

Note: No experimental confirmation available.

Length:1,303
Mass (Da):147,741
Last modified:February 15, 2005 - v1
Checksum:iACF8CF07481DE669
GO
Isoform b (identifier: Q5K2C1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     349-364: Missing.
     420-420: R → RWGHSSAGEAGVEPSQPW

Note: No experimental confirmation available.

Show »
Length:1,304
Mass (Da):147,513
Checksum:i0D28003A90F61398
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei349 – 36416Missing in isoform b. VSP_038110Add
BLAST
Alternative sequencei420 – 4201R → RWGHSSAGEAGVEPSQPW in isoform b. VSP_038111

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1801Y → C in CAH18871. 1 Publication
Sequence conflicti216 – 2161G → A in CAH18871. 1 Publication
Sequence conflicti228 – 2292SG → A in CAH18871. 1 Publication
Sequence conflicti232 – 2321G → S in CAH18871. 1 Publication
Sequence conflicti269 – 2691I → T in CAH18869. 1 Publication
Sequence conflicti381 – 3833ATN → TTY in CAH18871. 1 Publication
Sequence conflicti441 – 4411P → A in CAH18871. 1 Publication
Sequence conflicti995 – 9951I → T in CAH18869. 1 Publication
Sequence conflicti1057 – 10571L → P in CAH18871. 1 Publication
Sequence conflicti1084 – 10841F → L in CAH18869. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ811571 mRNA. Translation: CAH18870.1.
AJ811570 mRNA. Translation: CAH18869.1.
AJ811572 mRNA. Translation: CAH18871.1.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ811571 mRNA. Translation: CAH18870.1 .
AJ811570 mRNA. Translation: CAH18869.1 .
AJ811572 mRNA. Translation: CAH18871.1 .

3D structure databases

ProteinModelPortali Q5K2C1.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT20. Glycosyltransferase Family 20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1000. 2 hits.
InterProi IPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00982. Glyco_transf_20. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins."
    Goyal K., Browne J.A., Burnell A.M., Tunnacliffe A.
    Biochimie 87:565-574(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).

Entry informationi

Entry nameiTPS2_APHAV
AccessioniPrimary (citable) accession number: Q5K2C1
Secondary accession number(s): Q5K2C0, Q5K2C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: February 15, 2005
Last modified: October 16, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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