Q5K0C7 (CO13_CONVR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Conotoxin 3
Organism	Conus virgo (Virgin cone)
Taxonomic identifier	89427 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Hypsogastropoda › Neogastropoda › Conoidea › Conidae › Conus

Protein attributes

Sequence length	79 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted By similarity.
Tissue specificity	Expressed by the venom duct.
Domain	The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity. The cysteine framework is VI/VII (C-C-CC-C-C).
Sequence similarities	Belongs to the conotoxin O1 superfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Knottin Signal
Molecular function	Toxin
PTM	Disulfide bond
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ion channel inhibitor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Propeptide	23 – 47	25	By similarity		PRO_0000034997
	Peptide	48 – 79	32	Conotoxin 3		PRO_0000034998
Amino acid modifications
	Disulfide bond	49 ↔ 62		By similarity
	Disulfide bond	56 ↔ 67		By similarity
	Disulfide bond	61 ↔ 77		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5K0C7 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 4C8947657E0E5C50	FASTA	79	8,536
	10 20 30 40 50 60 MKLTCVLIIT VLFLTASQLI TADYSRDQRQ YRAVRLGDEM RNFKGARDCG GQGEGCYTQP 70 CCPGLRCRGG GTGGGVCQL

References

[1]	"Direct cDNA cloning of novel conopeptide precursors of the O-superfamily." Kauferstein S., Melaun C., Mebs D. Peptides 26:361-367(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Venom duct.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ851181 mRNA. Translation: CAH64854.1. AJ851182 mRNA. Translation: CAH64855.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
ConoServer	1070. Conotoxin-1 precursor.
Family and domain databases
InterPro	IPR004214. Conotoxin. [Graphical view]
Pfam	PF02950. Conotoxin. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CO13_CONVR

Accession

Primary (citable) accession number: Q5K0C7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	February 15, 2005
Last modified:	October 3, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program