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Protein

Beta-galactoside alpha-2,6-sialyltransferase 2

Gene

st6gal2

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.By similarity

Catalytic activityi

CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.99.1. 3199.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactoside alpha-2,6-sialyltransferase 2 (EC:2.4.99.1)
Short name:
Alpha 2,6-ST 2
Alternative name(s):
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
ST6Gal II
Short name:
ST6GalII
Sialyltransferase 2
Gene namesi
Name:st6gal2
OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
Proteomesi
  • UP000001038 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence analysis
Transmembranei11 – 3121Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini32 – 509478LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Beta-galactoside alpha-2,6-sialyltransferase 2PRO_0000314792Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi237 ↔ 507By similarity
Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence analysis
Disulfide bondi284 ↔ 436By similarity
Glycosylationi352 – 3521N-linked (GlcNAc...)Sequence analysis
Disulfide bondi454 ↔ 465By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi8090.ENSORLP00000015721.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
HOGENOMiHOG000013206.
HOVERGENiHBG052853.
InParanoidiQ5K027.
KOiK00779.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5K027-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFSMRQWRK LVLAAILAWA LLFLGLLSYF LDNRVEEPLT PAGSLVSQHS
60 70 80 90 100
DTRRLTSIQS SQQQQQPVPG LRSEQGLNSI RTSHGNQPEA GVLSSSETPG
110 120 130 140 150
NMVNHIPSSS PYQTYGSQEA NHQNDLDPQS LAAWSSFGTQ NVDSNFNIAS
160 170 180 190 200
QHRERASQSI FSNNVEDEEL PNEISPLVER RADADNVVQH MWRGTVSSGM
210 220 230 240 250
LSPRLKRAMN DYINANKHHV SYQRHRKVAR SAKELLCQMK NQSQLRTVDG
260 270 280 290 300
SEQPFSSLGW ADFVPLVPLQ RWNKQRGGRS FRTCAVVSSA GAILHSGLGK
310 320 330 340 350
EIDSHDAVLR FNAAPTEGYE QDVGTKTTIR IINSQILANP KHEFKTSSIY
360 370 380 390 400
KNITLVAWDP APYTLNLDEW FASPDYDLFG PYVEHRKNHA EQLFYILHPS
410 420 430 440 450
YLWQLWDLIQ SNTQEKIQPN PPSSGFIGIL TMMALCDKLH VYEYIPSMRQ
460 470 480 490 500
TDLCHYHENY YDAACTLGAY HPLIYEKNLI RRINLGSEKD LLKKGRVTLP

GFSTLTCGA
Length:509
Mass (Da):57,528
Last modified:February 15, 2005 - v1
Checksum:i1748521D1688AE1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ871601 mRNA. Translation: CAI39644.1.
RefSeqiNP_001098242.1. NM_001104772.1.
XP_011487504.1. XM_011489202.1.
UniGeneiOla.9871.

Genome annotation databases

GeneIDi100049381.
KEGGiola:100049381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ871601 mRNA. Translation: CAI39644.1.
RefSeqiNP_001098242.1. NM_001104772.1.
XP_011487504.1. XM_011489202.1.
UniGeneiOla.9871.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8090.ENSORLP00000015721.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100049381.
KEGGiola:100049381.

Organism-specific databases

CTDi84620.

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
HOGENOMiHOG000013206.
HOVERGENiHBG052853.
InParanoidiQ5K027.
KOiK00779.

Enzyme and pathway databases

BRENDAi2.4.99.1. 3199.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach."
    Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R.
    Glycobiology 15:805-817(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSIAT2_ORYLA
AccessioniPrimary (citable) accession number: Q5K027
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 15, 2005
Last modified: November 11, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.