Q5JZY3 (EPHAA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ephrin type-A receptor 10
EC=2.7.10.1

Gene names

Name:

EPHA10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1008 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5. Ref.1
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subcellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein Probable. Isoform 3: Cell membrane; Single-pass type I membrane protein Probable. Isoform 2: Secreted Probable.
Tissue specificity	Mainly expressed in testis. Ref.1
Domain	The protein kinase domain is predicted to be catalytically inactive.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 1 Eph LBD (Eph ligand-binding) domain. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain.
Sequence caution	The sequence AAI12934.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB integral to plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ephrin receptor activity Inferred from electronic annotation. Source: InterPro transmembrane-ephrin receptor activity Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5JZY3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5JZY3-2)

Also known as: Epha10s;

The sequence of this isoform differs from the canonical sequence as follows:
     284-295: ACPPGFYKVSPR → GIQLAGGRGVGV
     296-1008: Missing.

Isoform 3 (identifier: Q5JZY3-3)

Also known as: Epha10*;

The sequence of this isoform differs from the canonical sequence as follows:
     889-892: ERPR → LPPH
     893-1008: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Potential
	Chain	34 – 1008	975	Ephrin type-A receptor 10		PRO_0000042157
Regions
	Topological domain	34 – 565	532	Extracellular Potential
	Transmembrane	566 – 586	21	Helical; Potential
	Topological domain	587 – 1008	422	Cytoplasmic Potential
	Domain	35 – 216	182	Eph LBD
	Domain	337 – 443	107	Fibronectin type-III 1
	Domain	454 – 552	99	Fibronectin type-III 2
	Domain	645 – 900	256	Protein kinase
	Domain	933 – 997	65	SAM
Amino acid modifications
	Glycosylation	311	1	N-linked (GlcNAc...) Potential
	Glycosylation	486	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	284 – 295	12	ACPPG…KVSPR → GIQLAGGRGVGV in isoform 2.		VSP_015772
	Alternative sequence	296 – 1008	713	Missing in isoform 2.		VSP_015773
	Alternative sequence	889 – 892	4	ERPR → LPPH in isoform 3.		VSP_015774
	Alternative sequence	893 – 1008	116	Missing in isoform 3.		VSP_015775
	Natural variant	103	1	V → L. Corresponds to variant rs34557762 [ dbSNP | Ensembl ].		VAR_055992
	Natural variant	150	1	R → H in a gastric adenocarcinoma sample; somatic mutation. Ref.4		VAR_042159
	Natural variant	220	1	T → K. Ref.4 Corresponds to variant rs56276182 [ dbSNP | Ensembl ].		VAR_042160
	Natural variant	281	1	F → I. Ref.4 Corresponds to variant rs4653328 [ dbSNP | Ensembl ].		VAR_042161
	Natural variant	629	1	L → P. Corresponds to variant rs17511304 [ dbSNP | Ensembl ].		VAR_055993
	Natural variant	630	1	L → P. Ref.4		VAR_042162
	Natural variant	645	1	V → I. Corresponds to variant rs12405650 [ dbSNP | Ensembl ].		VAR_055994
	Natural variant	749	1	G → E. Corresponds to variant rs6671088 [ dbSNP | Ensembl ].		VAR_055995
	Natural variant	775	1	H → R in a breast infiltrating ductal carcinoma sample; somatic mutation. Ref.4		VAR_042163
	Natural variant	807	1	R → Q. Corresponds to variant rs6670599 [ dbSNP | Ensembl ].		VAR_055996
	Natural variant	956	1	A → T. Ref.4		VAR_042164
Experimental info
	Sequence conflict	458	1	D → G in CAI43321. Ref.1
	Sequence conflict	503	1	T → A in CAI43321. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 3, 2013. Version 2. Checksum: 82D60740B7B6B9BD	FASTA	1,008	109,716
	10 20 30 40 50 60 METCAGPHPL RLFLCRMQLC LALLLGPWRP GTAEEVILLD SKASQAELGW TALPSNGWEE 70 80 90 100 110 120 ISGVDEHDRP IRTYQVCNVL EPNQDNWLQT GWISRGRGQR IFVELQFTLR DCSSIPGAAG 130 140 150 160 170 180 TCKETFNVYY LETEADLGRG RPRLGGSRPR KIDTIAADES FTQGDLGERK MKLNTEVREI 190 200 210 220 230 240 GPLSRRGFHL AFQDVGACVA LVSVRVYYKQ CRATVRGLAT FPATAAESAF STLVEVAGTC 250 260 270 280 290 300 VAHSEGEPGS PPRMHCGADG EWLVPVGRCS CSAGFQERGD FCEACPPGFY KVSPRRPLCS 310 320 330 340 350 360 PCPEHSRALE NASTFCVCQD SYARSPTDPP SASCTRPPSA PRDLQYSLSR SPLVLRLRWL 370 380 390 400 410 420 PPADSGGRSD VTYSLLCLRC GREGPAGACE PCGPRVAFLP RQAGLRERAA TLLHLRPGAR 430 440 450 460 470 480 YTVRVAALNG VSGPAAAAGT TYAQVTVSTG PGAPWEEDEI RRDRVEPQSV SLSWREPIPA 490 500 510 520 530 540 GAPGANDTEY EIRYYEKGQS EQTYSMVKTG APTVTVTNLK PATRYVFQIR AASPGPSWEA 550 560 570 580 590 600 QSFNPSIEVQ TLGEAASGSR DQSPAIVVTV VTISALLVLG SVMSVLAIWR RPCSYGKGGG 610 620 630 640 650 660 DAHDEEELYF HFKVPTRRTF LDPQSCGDLL QAVHLFAKEL DAKSVTLERS LGGGRFGELC 670 680 690 700 710 720 CGCLQLPGRQ ELLVAVHMLR DSASDSQRLG FLAEALTLGQ FDHSHIVRLE GVVTRGSTLM 730 740 750 760 770 780 IVTEYMSHGA LDGFLRRHEG QLVAGQLMGL LPGLASAMKY LSEMGYVHRG LAARHVLVSS 790 800 810 820 830 840 DLVCKISGFG RGPRDRSEAV YTTMSGRSPA LWAAPETLQF GHFSSASDVW SFGIIMWEVM 850 860 870 880 890 900 AFGERPYWDM SGQDVIKAVE DGFRLPPPRN CPNLLHRLML DCWQKDPGER PRFSQIHSIL 910 920 930 940 950 960 SKMVQDPEPP KCALTTCPRP PTPLADRAFS TFPSFGSVGA WLEALDLCRY KDSFAAAGYG 970 980 990 1000 SLEAVAEMTA QDLVSLGISL AEHREALLSG ISALQARVLQ LQGQGVQV
	Isoform 2 (Epha10s) [UniParc]. Checksum: C5818C0D8C4444D1	FASTA	295	32,120
	10 20 30 40 50 60 METCAGPHPL RLFLCRMQLC LALLLGPWRP GTAEEVILLD SKASQAELGW TALPSNGWEE 70 80 90 100 110 120 ISGVDEHDRP IRTYQVCNVL EPNQDNWLQT GWISRGRGQR IFVELQFTLR DCSSIPGAAG 130 140 150 160 170 180 TCKETFNVYY LETEADLGRG RPRLGGSRPR KIDTIAADES FTQGDLGERK MKLNTEVREI 190 200 210 220 230 240 GPLSRRGFHL AFQDVGACVA LVSVRVYYKQ CRATVRGLAT FPATAAESAF STLVEVAGTC 250 260 270 280 290 VAHSEGEPGS PPRMHCGADG EWLVPVGRCS CSAGFQERGD FCEGIQLAGG RGVGV
	Isoform 3 (Epha10*) [UniParc]. Checksum: D91B200D8B705F89	FASTA	892	97,293
	10 20 30 40 50 60 METCAGPHPL RLFLCRMQLC LALLLGPWRP GTAEEVILLD SKASQAELGW TALPSNGWEE 70 80 90 100 110 120 ISGVDEHDRP IRTYQVCNVL EPNQDNWLQT GWISRGRGQR IFVELQFTLR DCSSIPGAAG 130 140 150 160 170 180 TCKETFNVYY LETEADLGRG RPRLGGSRPR KIDTIAADES FTQGDLGERK MKLNTEVREI 190 200 210 220 230 240 GPLSRRGFHL AFQDVGACVA LVSVRVYYKQ CRATVRGLAT FPATAAESAF STLVEVAGTC 250 260 270 280 290 300 VAHSEGEPGS PPRMHCGADG EWLVPVGRCS CSAGFQERGD FCEACPPGFY KVSPRRPLCS 310 320 330 340 350 360 PCPEHSRALE NASTFCVCQD SYARSPTDPP SASCTRPPSA PRDLQYSLSR SPLVLRLRWL 370 380 390 400 410 420 PPADSGGRSD VTYSLLCLRC GREGPAGACE PCGPRVAFLP RQAGLRERAA TLLHLRPGAR 430 440 450 460 470 480 YTVRVAALNG VSGPAAAAGT TYAQVTVSTG PGAPWEEDEI RRDRVEPQSV SLSWREPIPA 490 500 510 520 530 540 GAPGANDTEY EIRYYEKGQS EQTYSMVKTG APTVTVTNLK PATRYVFQIR AASPGPSWEA 550 560 570 580 590 600 QSFNPSIEVQ TLGEAASGSR DQSPAIVVTV VTISALLVLG SVMSVLAIWR RPCSYGKGGG 610 620 630 640 650 660 DAHDEEELYF HFKVPTRRTF LDPQSCGDLL QAVHLFAKEL DAKSVTLERS LGGGRFGELC 670 680 690 700 710 720 CGCLQLPGRQ ELLVAVHMLR DSASDSQRLG FLAEALTLGQ FDHSHIVRLE GVVTRGSTLM 730 740 750 760 770 780 IVTEYMSHGA LDGFLRRHEG QLVAGQLMGL LPGLASAMKY LSEMGYVHRG LAARHVLVSS 790 800 810 820 830 840 DLVCKISGFG RGPRDRSEAV YTTMSGRSPA LWAAPETLQF GHFSSASDVW SFGIIMWEVM 850 860 870 880 890 AFGERPYWDM SGQDVIKAVE DGFRLPPPRN CPNLLHRLML DCWQKDPGLP PH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis." Aasheim H.-C., Patzke S., Hjorthaug H.S., Finne E.F. Biochim. Biophys. Acta 1723:1-7(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING, FUNCTION, TISSUE SPECIFICITY. Tissue: Testis.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 501-1008 (ISOFORM 3). Tissue: Brain.
[4]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-150; LYS-220; ILE-281; PRO-630; ARG-775 AND THR-956.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ872185 Genomic DNA. Translation: CAI43321.1. AJ781169 mRNA. Translation: CAG77605.1. AC104336 Genomic DNA. No translation available. BC067734 mRNA. Translation: AAH67734.1. BC112933 mRNA. Translation: AAI12934.1. Different initiation.
IPI	IPI00166339. IPI00651637. IPI00651751.
RefSeq	NP_001092909.1. NM_001099439.1. NP_775912.2. NM_173641.2.
UniGene	Hs.129435.
3D structure databases
ProteinModelPortal	Q5JZY3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000316395.
Polymorphism databases
DMDM	74762207.
Proteomic databases
PaxDb	Q5JZY3.
PRIDE	Q5JZY3.
Protocols and materials databases
DNASU	284656.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000319637; ENSP00000316395; ENSG00000183317. ENST00000373048; ENSP00000362139; ENSG00000183317.
GeneID	284656.
KEGG	hsa:284656.
UCSC	uc001cbw.4. human. uc009vvi.3. human.
Organism-specific databases
CTD	284656.
GeneCards	GC01M038181.
HGNC	HGNC:19987. EPHA10.
HPA	HPA027497.
MIM	611123. gene.
neXtProt	NX_Q5JZY3.
PharmGKB	PA134938798.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000233856.
HOVERGEN	HBG062180.
InParanoid	Q5JZY3.
KO	K08897.
Gene expression databases
ArrayExpress	Q5JZY3.
Bgee	Q5JZY3.
CleanEx	HS_EPHA10.
Genevestigator	Q5JZY3.
GermOnline	ENSG00000183317. Homo sapiens.
Family and domain databases
Gene3D	1.10.150.50. 1 hit. 2.60.40.10. 2 hits.
InterPro	IPR001090. Ephrin_rcpt_lig-bd_dom. IPR003961. Fibronectin_type3. IPR008979. Galactose-bd-like. IPR013783. Ig-like_fold. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR001660. SAM. IPR013761. SAM/pointed. IPR021129. SAM_type1. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR020635. Tyr_kinase_cat_dom. IPR016257. Tyr_kinase_ephrin_rcpt. IPR001426. Tyr_kinase_rcpt_V_CS. [Graphical view]
Pfam	PF01404. Ephrin_lbd. 1 hit. PF00041. fn3. 2 hits. PF07714. Pkinase_Tyr. 1 hit. PF00536. SAM_1. 1 hit. [Graphical view]
PIRSF	PIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTS	PR00109. TYRKINASE.
SMART	SM00615. EPH_lbd. 1 hit. SM00060. FN3. 2 hits. SM00454. SAM. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 2 hits. SSF49785. Gal_bind_like. 1 hit. SSF56112. Kinase_like. 1 hit. SSF47769. SAM_homology. 1 hit.
PROSITE	PS01186. EGF_2. 1 hit. Uncertain. PS51550. EPH_LBD. 1 hit. PS50853. FN3. 2 hits. PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. False negative. PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit. PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit. PS50105. SAM_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	284656.
NextBio	35535096.
SOURCE	Search...

Entry information

Entry name

EPHAA_HUMAN

Accession

Primary (citable) accession number: Q5JZY3
Secondary accession number(s): A4FU89, J3KPB5, Q6NW42

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	April 3, 2013
Last modified:	May 1, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.