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Q5JZY3 (EPHAA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ephrin type-A receptor 10

EC=2.7.10.1
Gene names
Name:EPHA10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1008 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5. Ref.1

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Isoform 1: Cell membrane; Single-pass type I membrane protein Probable.

Isoform 3: Cell membrane; Single-pass type I membrane protein Probable.

Isoform 2: Secreted Probable.

Tissue specificity

Mainly expressed in testis. Ref.1

Domain

The protein kinase domain is predicted to be catalytically inactive.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.

Contains 1 Eph LBD (Eph ligand-binding) domain.

Contains 2 fibronectin type-III domains.

Contains 1 protein kinase domain.

Contains 1 SAM (sterile alpha motif) domain.

Sequence caution

The sequence AAI12934.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5JZY3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5JZY3-2)

Also known as: Epha10s;

The sequence of this isoform differs from the canonical sequence as follows:
     284-295: ACPPGFYKVSPR → GIQLAGGRGVGV
     296-1008: Missing.
Isoform 3 (identifier: Q5JZY3-3)

Also known as: Epha10*;

The sequence of this isoform differs from the canonical sequence as follows:
     889-892: ERPR → LPPH
     893-1008: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 1008975Ephrin type-A receptor 10
PRO_0000042157

Regions

Topological domain34 – 565532Extracellular Potential
Transmembrane566 – 58621Helical; Potential
Topological domain587 – 1008422Cytoplasmic Potential
Domain35 – 216182Eph LBD
Domain340 – 452113Fibronectin type-III 1
Domain456 – 55499Fibronectin type-III 2
Domain645 – 900256Protein kinase
Domain933 – 99765SAM

Amino acid modifications

Glycosylation3111N-linked (GlcNAc...) Potential
Glycosylation4861N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence284 – 29512ACPPG…KVSPR → GIQLAGGRGVGV in isoform 2.
VSP_015772
Alternative sequence296 – 1008713Missing in isoform 2.
VSP_015773
Alternative sequence889 – 8924ERPR → LPPH in isoform 3.
VSP_015774
Alternative sequence893 – 1008116Missing in isoform 3.
VSP_015775
Natural variant1031V → L.
Corresponds to variant rs34557762 [ dbSNP | Ensembl ].
VAR_055992
Natural variant1501R → H in a gastric adenocarcinoma sample; somatic mutation. Ref.4
VAR_042159
Natural variant2201T → K. Ref.4
Corresponds to variant rs56276182 [ dbSNP | Ensembl ].
VAR_042160
Natural variant2811F → I. Ref.4
Corresponds to variant rs4653328 [ dbSNP | Ensembl ].
VAR_042161
Natural variant6291L → P.
Corresponds to variant rs17511304 [ dbSNP | Ensembl ].
VAR_055993
Natural variant6301L → P. Ref.4
VAR_042162
Natural variant6451V → I.
Corresponds to variant rs12405650 [ dbSNP | Ensembl ].
VAR_055994
Natural variant7491G → E.
Corresponds to variant rs6671088 [ dbSNP | Ensembl ].
VAR_055995
Natural variant7751H → R in a breast infiltrating ductal carcinoma sample; somatic mutation. Ref.4
VAR_042163
Natural variant8071R → Q.
Corresponds to variant rs6670599 [ dbSNP | Ensembl ].
VAR_055996
Natural variant9561A → T. Ref.4
VAR_042164

Experimental info

Sequence conflict4581D → G in CAI43321. Ref.1
Sequence conflict5031T → A in CAI43321. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 3, 2013. Version 2.
Checksum: 82D60740B7B6B9BD

FASTA1,008109,716
        10         20         30         40         50         60 
METCAGPHPL RLFLCRMQLC LALLLGPWRP GTAEEVILLD SKASQAELGW TALPSNGWEE 

        70         80         90        100        110        120 
ISGVDEHDRP IRTYQVCNVL EPNQDNWLQT GWISRGRGQR IFVELQFTLR DCSSIPGAAG 

       130        140        150        160        170        180 
TCKETFNVYY LETEADLGRG RPRLGGSRPR KIDTIAADES FTQGDLGERK MKLNTEVREI 

       190        200        210        220        230        240 
GPLSRRGFHL AFQDVGACVA LVSVRVYYKQ CRATVRGLAT FPATAAESAF STLVEVAGTC 

       250        260        270        280        290        300 
VAHSEGEPGS PPRMHCGADG EWLVPVGRCS CSAGFQERGD FCEACPPGFY KVSPRRPLCS 

       310        320        330        340        350        360 
PCPEHSRALE NASTFCVCQD SYARSPTDPP SASCTRPPSA PRDLQYSLSR SPLVLRLRWL 

       370        380        390        400        410        420 
PPADSGGRSD VTYSLLCLRC GREGPAGACE PCGPRVAFLP RQAGLRERAA TLLHLRPGAR 

       430        440        450        460        470        480 
YTVRVAALNG VSGPAAAAGT TYAQVTVSTG PGAPWEEDEI RRDRVEPQSV SLSWREPIPA 

       490        500        510        520        530        540 
GAPGANDTEY EIRYYEKGQS EQTYSMVKTG APTVTVTNLK PATRYVFQIR AASPGPSWEA 

       550        560        570        580        590        600 
QSFNPSIEVQ TLGEAASGSR DQSPAIVVTV VTISALLVLG SVMSVLAIWR RPCSYGKGGG 

       610        620        630        640        650        660 
DAHDEEELYF HFKVPTRRTF LDPQSCGDLL QAVHLFAKEL DAKSVTLERS LGGGRFGELC 

       670        680        690        700        710        720 
CGCLQLPGRQ ELLVAVHMLR DSASDSQRLG FLAEALTLGQ FDHSHIVRLE GVVTRGSTLM 

       730        740        750        760        770        780 
IVTEYMSHGA LDGFLRRHEG QLVAGQLMGL LPGLASAMKY LSEMGYVHRG LAARHVLVSS 

       790        800        810        820        830        840 
DLVCKISGFG RGPRDRSEAV YTTMSGRSPA LWAAPETLQF GHFSSASDVW SFGIIMWEVM 

       850        860        870        880        890        900 
AFGERPYWDM SGQDVIKAVE DGFRLPPPRN CPNLLHRLML DCWQKDPGER PRFSQIHSIL 

       910        920        930        940        950        960 
SKMVQDPEPP KCALTTCPRP PTPLADRAFS TFPSFGSVGA WLEALDLCRY KDSFAAAGYG 

       970        980        990       1000 
SLEAVAEMTA QDLVSLGISL AEHREALLSG ISALQARVLQ LQGQGVQV 

« Hide

Isoform 2 (Epha10s) [UniParc].

Checksum: C5818C0D8C4444D1
Show »

FASTA29532,120
Isoform 3 (Epha10*) [UniParc].

Checksum: D91B200D8B705F89
Show »

FASTA89297,293

References

« Hide 'large scale' references
[1]"Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis."
Aasheim H.-C., Patzke S., Hjorthaug H.S., Finne E.F.
Biochim. Biophys. Acta 1723:1-7(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING, FUNCTION, TISSUE SPECIFICITY.
Tissue: Testis.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 501-1008 (ISOFORM 3).
Tissue: Brain.
[4]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-150; LYS-220; ILE-281; PRO-630; ARG-775 AND THR-956.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ872185 Genomic DNA. Translation: CAI43321.1.
AJ781169 mRNA. Translation: CAG77605.1.
AC104336 Genomic DNA. No translation available.
BC067734 mRNA. Translation: AAH67734.1.
BC112933 mRNA. Translation: AAI12934.1. Different initiation.
RefSeqNP_001092909.1. NM_001099439.1.
NP_775912.2. NM_173641.2.
UniGeneHs.129435.

3D structure databases

ProteinModelPortalQ5JZY3.
SMRQ5JZY3. Positions 33-551, 606-926, 932-999.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000316395.

Chemistry

ChEMBLCHEMBL2363043.

Polymorphism databases

DMDM476007830.

Proteomic databases

PaxDbQ5JZY3.
PRIDEQ5JZY3.

Protocols and materials databases

DNASU284656.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000319637; ENSP00000316395; ENSG00000183317. [Q5JZY3-2]
ENST00000373048; ENSP00000362139; ENSG00000183317. [Q5JZY3-1]
GeneID284656.
KEGGhsa:284656.
UCSCuc001cbw.4. human. [Q5JZY3-2]

Organism-specific databases

CTD284656.
GeneCardsGC01M038181.
HGNCHGNC:19987. EPHA10.
HPAHPA027497.
MIM611123. gene.
neXtProtNX_Q5JZY3.
PharmGKBPA134938798.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233856.
HOVERGENHBG062180.
InParanoidQ5JZY3.
KOK08897.
OrthoDBEOG7VTDM6.
TreeFamTF314013.

Gene expression databases

ArrayExpressQ5JZY3.
BgeeQ5JZY3.
CleanExHS_EPHA10.
GenevestigatorQ5JZY3.

Family and domain databases

Gene3D1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. Fibronectin_type3.
IPR008979. Galactose-bd-like.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PIRSFPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSPR00109. TYRKINASE.
SMARTSM00615. EPH_lbd. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS01186. EGF_2. 1 hit.
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiEPHA10.
GenomeRNAi284656.
NextBio35535096.
PROQ5JZY3.
SOURCESearch...

Entry information

Entry nameEPHAA_HUMAN
AccessionPrimary (citable) accession number: Q5JZY3
Secondary accession number(s): A4FU89, J3KPB5, Q6NW42
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: April 3, 2013
Last modified: April 16, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM