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Protein

Ephrin type-A receptor 10

Gene

EPHA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ephrin receptor activity Source: InterPro
  • transmembrane-ephrin receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS10971-MONOMER.
ReactomeiR-HSA-2682334. EPH-Ephrin signaling.
R-HSA-3928663. EPHA-mediated growth cone collapse.
R-HSA-3928665. EPH-ephrin mediated repulsion of cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin type-A receptor 10 (EC:2.7.10.1)
Gene namesi
Name:EPHA10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19987. EPHA10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 565ExtracellularSequence analysisAdd BLAST532
Transmembranei566 – 586HelicalSequence analysisAdd BLAST21
Topological domaini587 – 1008CytoplasmicSequence analysisAdd BLAST422

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: InterPro
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi284656.
OpenTargetsiENSG00000183317.
PharmGKBiPA134938798.

Chemistry databases

ChEMBLiCHEMBL2363043.

Polymorphism and mutation databases

BioMutaiEPHA10.
DMDMi476007830.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000004215734 – 1008Ephrin type-A receptor 10Add BLAST975

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi311N-linked (GlcNAc...)Sequence analysis1
Glycosylationi486N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ5JZY3.
PaxDbiQ5JZY3.
PeptideAtlasiQ5JZY3.
PRIDEiQ5JZY3.

PTM databases

iPTMnetiQ5JZY3.
PhosphoSitePlusiQ5JZY3.

Expressioni

Tissue specificityi

Mainly expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000183317.
CleanExiHS_EPHA10.
ExpressionAtlasiQ5JZY3. baseline and differential.
GenevisibleiQ5JZY3. HS.

Organism-specific databases

HPAiHPA027497.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BANPQ8N9N53EBI-10244652,EBI-744695
CAMK2DQ135573EBI-10244652,EBI-351018
FHL3Q136433EBI-10244652,EBI-741101
TFCP2Q128003EBI-10244652,EBI-717422

Protein-protein interaction databases

BioGridi129927. 5 interactors.
IntActiQ5JZY3. 4 interactors.
STRINGi9606.ENSP00000362139.

Structurei

3D structure databases

ProteinModelPortaliQ5JZY3.
SMRiQ5JZY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 216Eph LBDPROSITE-ProRule annotationAdd BLAST182
Domaini340 – 452Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST113
Domaini456 – 554Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST99
Domaini645 – 900Protein kinasePROSITE-ProRule annotationAdd BLAST256
Domaini933 – 997SAMPROSITE-ProRule annotationAdd BLAST65

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation
Contains 1 Eph LBD (Eph ligand-binding) domain.PROSITE-ProRule annotation
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118975.
HOGENOMiHOG000233856.
HOVERGENiHBG062180.
InParanoidiQ5JZY3.
KOiK08897.
TreeFamiTF314013.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS01186. EGF_2. 1 hit.
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JZY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METCAGPHPL RLFLCRMQLC LALLLGPWRP GTAEEVILLD SKASQAELGW
60 70 80 90 100
TALPSNGWEE ISGVDEHDRP IRTYQVCNVL EPNQDNWLQT GWISRGRGQR
110 120 130 140 150
IFVELQFTLR DCSSIPGAAG TCKETFNVYY LETEADLGRG RPRLGGSRPR
160 170 180 190 200
KIDTIAADES FTQGDLGERK MKLNTEVREI GPLSRRGFHL AFQDVGACVA
210 220 230 240 250
LVSVRVYYKQ CRATVRGLAT FPATAAESAF STLVEVAGTC VAHSEGEPGS
260 270 280 290 300
PPRMHCGADG EWLVPVGRCS CSAGFQERGD FCEACPPGFY KVSPRRPLCS
310 320 330 340 350
PCPEHSRALE NASTFCVCQD SYARSPTDPP SASCTRPPSA PRDLQYSLSR
360 370 380 390 400
SPLVLRLRWL PPADSGGRSD VTYSLLCLRC GREGPAGACE PCGPRVAFLP
410 420 430 440 450
RQAGLRERAA TLLHLRPGAR YTVRVAALNG VSGPAAAAGT TYAQVTVSTG
460 470 480 490 500
PGAPWEEDEI RRDRVEPQSV SLSWREPIPA GAPGANDTEY EIRYYEKGQS
510 520 530 540 550
EQTYSMVKTG APTVTVTNLK PATRYVFQIR AASPGPSWEA QSFNPSIEVQ
560 570 580 590 600
TLGEAASGSR DQSPAIVVTV VTISALLVLG SVMSVLAIWR RPCSYGKGGG
610 620 630 640 650
DAHDEEELYF HFKVPTRRTF LDPQSCGDLL QAVHLFAKEL DAKSVTLERS
660 670 680 690 700
LGGGRFGELC CGCLQLPGRQ ELLVAVHMLR DSASDSQRLG FLAEALTLGQ
710 720 730 740 750
FDHSHIVRLE GVVTRGSTLM IVTEYMSHGA LDGFLRRHEG QLVAGQLMGL
760 770 780 790 800
LPGLASAMKY LSEMGYVHRG LAARHVLVSS DLVCKISGFG RGPRDRSEAV
810 820 830 840 850
YTTMSGRSPA LWAAPETLQF GHFSSASDVW SFGIIMWEVM AFGERPYWDM
860 870 880 890 900
SGQDVIKAVE DGFRLPPPRN CPNLLHRLML DCWQKDPGER PRFSQIHSIL
910 920 930 940 950
SKMVQDPEPP KCALTTCPRP PTPLADRAFS TFPSFGSVGA WLEALDLCRY
960 970 980 990 1000
KDSFAAAGYG SLEAVAEMTA QDLVSLGISL AEHREALLSG ISALQARVLQ

LQGQGVQV
Length:1,008
Mass (Da):109,716
Last modified:April 3, 2013 - v2
Checksum:i82D60740B7B6B9BD
GO
Isoform 2 (identifier: Q5JZY3-2) [UniParc]FASTAAdd to basket
Also known as: Epha10s

The sequence of this isoform differs from the canonical sequence as follows:
     284-295: ACPPGFYKVSPR → GIQLAGGRGVGV
     296-1008: Missing.

Show »
Length:295
Mass (Da):32,120
Checksum:iC5818C0D8C4444D1
GO
Isoform 3 (identifier: Q5JZY3-3) [UniParc]FASTAAdd to basket
Also known as: Epha10*

The sequence of this isoform differs from the canonical sequence as follows:
     889-892: ERPR → LPPH
     893-1008: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:892
Mass (Da):97,293
Checksum:iD91B200D8B705F89
GO

Sequence cautioni

The sequence AAI12934 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti458D → G in CAI43321 (PubMed:15777695).Curated1
Sequence conflicti503T → A in CAI43321 (PubMed:15777695).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055992103V → L.Corresponds to variant rs34557762dbSNPEnsembl.1
Natural variantiVAR_042159150R → H in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant rs771803475dbSNPEnsembl.1
Natural variantiVAR_042160220T → K.1 PublicationCorresponds to variant rs56276182dbSNPEnsembl.1
Natural variantiVAR_042161281F → I.1 PublicationCorresponds to variant rs4653328dbSNPEnsembl.1
Natural variantiVAR_055993629L → P.Corresponds to variant rs17511304dbSNPEnsembl.1
Natural variantiVAR_042162630L → P.1 Publication1
Natural variantiVAR_055994645V → I.Corresponds to variant rs12405650dbSNPEnsembl.1
Natural variantiVAR_055995749G → E.Corresponds to variant rs6671088dbSNPEnsembl.1
Natural variantiVAR_042163775H → R in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_055996807R → Q.Corresponds to variant rs6670599dbSNPEnsembl.1
Natural variantiVAR_042164956A → T.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015772284 – 295ACPPG…KVSPR → GIQLAGGRGVGV in isoform 2. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_015773296 – 1008Missing in isoform 2. 2 PublicationsAdd BLAST713
Alternative sequenceiVSP_015774889 – 892ERPR → LPPH in isoform 3. 1 Publication4
Alternative sequenceiVSP_015775893 – 1008Missing in isoform 3. 1 PublicationAdd BLAST116

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ872185 Genomic DNA. Translation: CAI43321.1.
AJ781169 mRNA. Translation: CAG77605.1.
AC104336 Genomic DNA. No translation available.
BC067734 mRNA. Translation: AAH67734.1.
BC112933 mRNA. Translation: AAI12934.1. Different initiation.
CCDSiCCDS41305.1. [Q5JZY3-1]
CCDS425.1. [Q5JZY3-2]
RefSeqiNP_001092909.1. NM_001099439.1. [Q5JZY3-1]
NP_775912.2. NM_173641.2. [Q5JZY3-2]
UniGeneiHs.129435.

Genome annotation databases

EnsembliENST00000319637; ENSP00000316395; ENSG00000183317. [Q5JZY3-2]
ENST00000373048; ENSP00000362139; ENSG00000183317. [Q5JZY3-1]
GeneIDi284656.
KEGGihsa:284656.
UCSCiuc001cbw.5. human. [Q5JZY3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ872185 Genomic DNA. Translation: CAI43321.1.
AJ781169 mRNA. Translation: CAG77605.1.
AC104336 Genomic DNA. No translation available.
BC067734 mRNA. Translation: AAH67734.1.
BC112933 mRNA. Translation: AAI12934.1. Different initiation.
CCDSiCCDS41305.1. [Q5JZY3-1]
CCDS425.1. [Q5JZY3-2]
RefSeqiNP_001092909.1. NM_001099439.1. [Q5JZY3-1]
NP_775912.2. NM_173641.2. [Q5JZY3-2]
UniGeneiHs.129435.

3D structure databases

ProteinModelPortaliQ5JZY3.
SMRiQ5JZY3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129927. 5 interactors.
IntActiQ5JZY3. 4 interactors.
STRINGi9606.ENSP00000362139.

Chemistry databases

ChEMBLiCHEMBL2363043.

PTM databases

iPTMnetiQ5JZY3.
PhosphoSitePlusiQ5JZY3.

Polymorphism and mutation databases

BioMutaiEPHA10.
DMDMi476007830.

Proteomic databases

EPDiQ5JZY3.
PaxDbiQ5JZY3.
PeptideAtlasiQ5JZY3.
PRIDEiQ5JZY3.

Protocols and materials databases

DNASUi284656.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319637; ENSP00000316395; ENSG00000183317. [Q5JZY3-2]
ENST00000373048; ENSP00000362139; ENSG00000183317. [Q5JZY3-1]
GeneIDi284656.
KEGGihsa:284656.
UCSCiuc001cbw.5. human. [Q5JZY3-1]

Organism-specific databases

CTDi284656.
DisGeNETi284656.
GeneCardsiEPHA10.
HGNCiHGNC:19987. EPHA10.
HPAiHPA027497.
MIMi611123. gene.
neXtProtiNX_Q5JZY3.
OpenTargetsiENSG00000183317.
PharmGKBiPA134938798.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118975.
HOGENOMiHOG000233856.
HOVERGENiHBG062180.
InParanoidiQ5JZY3.
KOiK08897.
TreeFamiTF314013.

Enzyme and pathway databases

BioCyciZFISH:HS10971-MONOMER.
ReactomeiR-HSA-2682334. EPH-Ephrin signaling.
R-HSA-3928663. EPHA-mediated growth cone collapse.
R-HSA-3928665. EPH-ephrin mediated repulsion of cells.

Miscellaneous databases

ChiTaRSiEPHA10. human.
GeneWikiiEPHA10.
GenomeRNAii284656.
PROiQ5JZY3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183317.
CleanExiHS_EPHA10.
ExpressionAtlasiQ5JZY3. baseline and differential.
GenevisibleiQ5JZY3. HS.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS01186. EGF_2. 1 hit.
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEPHAA_HUMAN
AccessioniPrimary (citable) accession number: Q5JZY3
Secondary accession number(s): A4FU89, J3KPB5, Q6NW42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: April 3, 2013
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.