Ephrin type-A receptor 10 precursor

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Names and origin

Protein names

Recommended name:
Ephrin type-A receptor 10
EC=2.7.10.1

Gene names

Name:

EPHA10

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	1008 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5. Ref.1
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subcellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein Probable. Isoform 3: Cell membrane; Single-pass type I membrane protein Probable. Isoform 2: Secreted Probable.
Tissue specificity	Mainly expressed in testis. Ref.1
Domain	The protein kinase domain is predicted to be catalytically inactive.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain.

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Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ephrin receptor activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5JZY3-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5JZY3-2) Also known as: Epha10s; The sequence of this isoform differs from the canonical sequence as follows: 284-295: ACPPGFYKVSPR → GIQLAGGRGVGV 296-1008: Missing.

Isoform 3 (identifier: Q5JZY3-3) Also known as: Epha10; The sequence of this isoform differs from the canonical sequence as follows:* 889-892: ERPR → LPPH 893-1008: Missing.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 33

33

Potential

Chain

34 – 1008

975

Ephrin type-A receptor 10

PRO_0000042157

Regions

Topological domain

34 – 565

532

Extracellular Potential

Transmembrane

566 – 586

21

Potential

Topological domain

587 – 1008

422

Cytoplasmic Potential

Domain

337 – 443

107

Fibronectin type-III 1

Domain

454 – 552

99

Fibronectin type-III 2

Domain

645 – 900

256

Protein kinase

Domain

933 – 997

65

SAM

Amino acid modifications

Glycosylation

311

1

N-linked (GlcNAc...) Potential

Glycosylation

486

1

N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence

284 – 295

12

ACPPG…KVSPR → GIQLAGGRGVGV in isoform 2.

VSP_015772

Alternative sequence

296 – 1008

713

Missing in isoform 2.

VSP_015773

Alternative sequence

889 – 892

4

ERPR → LPPH in isoform 3.

VSP_015774

Alternative sequence

893 – 1008

116

Missing in isoform 3.

VSP_015775

Natural variant

103

1

V → L: dbSNP rs34557762.

VAR_055992

Natural variant

150

1

R → H in a gastric adenocarcinoma sample; somatic mutation. Ref.3

VAR_042159

Natural variant

220

1

T → K: dbSNP rs56276182. Ref.3

VAR_042160

Natural variant

281

1

F → I: dbSNP rs4653328. Ref.3

VAR_042161

Natural variant

629

1

L → P: dbSNP rs17511304.

VAR_055993

Natural variant

630

1

L → P

VAR_042162

Natural variant

645

1

V → I: dbSNP rs12405650.

VAR_055994

Natural variant

749

1

G → E: dbSNP rs6671088.

VAR_055995

Natural variant

775

1

H → R in a breast infiltrating ductal carcinoma sample; somatic mutation. Ref.3

VAR_042163

Natural variant

807

1

R → Q: dbSNP rs6670599.

VAR_055996

Natural variant

956

1

A → T

VAR_042164

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Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: AF5AA9AAB7B6B962 Show »	FASTA	1,008	109,628
10 20 30 40 50 60 METCAGPHPL RLFLCRMQLC LALLLGPWRP GTAEEVILLD SKASQAELGW TALPSNGWEE 70 80 90 100 110 120 ISGVDEHDRP IRTYQVCNVL EPNQDNWLQT GWISRGRGQR IFVELQFTLR DCSSIPGAAG 130 140 150 160 170 180 TCKETFNVYY LETEADLGRG RPRLGGSRPR KIDTIAADES FTQGDLGERK MKLNTEVREI 190 200 210 220 230 240 GPLSRRGFHL AFQDVGACVA LVSVRVYYKQ CRATVRGLAT FPATAAESAF STLVEVAGTC 250 260 270 280 290 300 VAHSEGEPGS PPRMHCGADG EWLVPVGRCS CSAGFQERGD FCEACPPGFY KVSPRRPLCS 310 320 330 340 350 360 PCPEHSRALE NASTFCVCQD SYARSPTDPP SASCTRPPSA PRDLQYSLSR SPLVLRLRWL 370 380 390 400 410 420 PPADSGGRSD VTYSLLCLRC GREGPAGACE PCGPRVAFLP RQAGLRERAA TLLHLRPGAR 430 440 450 460 470 480 YTVRVAALNG VSGPAAAAGT TYAQVTVSTG PGAPWEEGEI RRDRVEPQSV SLSWREPIPA 490 500 510 520 530 540 GAPGANDTEY EIRYYEKGQS EQAYSMVKTG APTVTVTNLK PATRYVFQIR AASPGPSWEA 550 560 570 580 590 600 QSFNPSIEVQ TLGEAASGSR DQSPAIVVTV VTISALLVLG SVMSVLAIWR RPCSYGKGGG 610 620 630 640 650 660 DAHDEEELYF HFKVPTRRTF LDPQSCGDLL QAVHLFAKEL DAKSVTLERS LGGGRFGELC 670 680 690 700 710 720 CGCLQLPGRQ ELLVAVHMLR DSASDSQRLG FLAEALTLGQ FDHSHIVRLE GVVTRGSTLM 730 740 750 760 770 780 IVTEYMSHGA LDGFLRRHEG QLVAGQLMGL LPGLASAMKY LSEMGYVHRG LAARHVLVSS 790 800 810 820 830 840 DLVCKISGFG RGPRDRSEAV YTTMSGRSPA LWAAPETLQF GHFSSASDVW SFGIIMWEVM 850 860 870 880 890 900 AFGERPYWDM SGQDVIKAVE DGFRLPPPRN CPNLLHRLML DCWQKDPGER PRFSQIHSIL 910 920 930 940 950 960 SKMVQDPEPP KCALTTCPRP PTPLADRAFS TFPSFGSVGA WLEALDLCRY KDSFAAAGYG 970 980 990 1000 SLEAVAEMTA QDLVSLGISL AEHREALLSG ISALQARVLQ LQGQGVQV « Hide
Isoform 2 (Epha10s). Checksum: C5818C0D8C4444D1 Show »	FASTA	295	32,120
10 20 30 40 50 60 METCAGPHPL RLFLCRMQLC LALLLGPWRP GTAEEVILLD SKASQAELGW TALPSNGWEE 70 80 90 100 110 120 ISGVDEHDRP IRTYQVCNVL EPNQDNWLQT GWISRGRGQR IFVELQFTLR DCSSIPGAAG 130 140 150 160 170 180 TCKETFNVYY LETEADLGRG RPRLGGSRPR KIDTIAADES FTQGDLGERK MKLNTEVREI 190 200 210 220 230 240 GPLSRRGFHL AFQDVGACVA LVSVRVYYKQ CRATVRGLAT FPATAAESAF STLVEVAGTC 250 260 270 280 290 VAHSEGEPGS PPRMHCGADG EWLVPVGRCS CSAGFQERGD FCEGIQLAGG RGVGV « Hide
Isoform 3 (Epha10*). Checksum: A661A0DFB6679E41 Show »	FASTA	892	97,205
10 20 30 40 50 60 METCAGPHPL RLFLCRMQLC LALLLGPWRP GTAEEVILLD SKASQAELGW TALPSNGWEE 70 80 90 100 110 120 ISGVDEHDRP IRTYQVCNVL EPNQDNWLQT GWISRGRGQR IFVELQFTLR DCSSIPGAAG 130 140 150 160 170 180 TCKETFNVYY LETEADLGRG RPRLGGSRPR KIDTIAADES FTQGDLGERK MKLNTEVREI 190 200 210 220 230 240 GPLSRRGFHL AFQDVGACVA LVSVRVYYKQ CRATVRGLAT FPATAAESAF STLVEVAGTC 250 260 270 280 290 300 VAHSEGEPGS PPRMHCGADG EWLVPVGRCS CSAGFQERGD FCEACPPGFY KVSPRRPLCS 310 320 330 340 350 360 PCPEHSRALE NASTFCVCQD SYARSPTDPP SASCTRPPSA PRDLQYSLSR SPLVLRLRWL 370 380 390 400 410 420 PPADSGGRSD VTYSLLCLRC GREGPAGACE PCGPRVAFLP RQAGLRERAA TLLHLRPGAR 430 440 450 460 470 480 YTVRVAALNG VSGPAAAAGT TYAQVTVSTG PGAPWEEGEI RRDRVEPQSV SLSWREPIPA 490 500 510 520 530 540 GAPGANDTEY EIRYYEKGQS EQAYSMVKTG APTVTVTNLK PATRYVFQIR AASPGPSWEA 550 560 570 580 590 600 QSFNPSIEVQ TLGEAASGSR DQSPAIVVTV VTISALLVLG SVMSVLAIWR RPCSYGKGGG 610 620 630 640 650 660 DAHDEEELYF HFKVPTRRTF LDPQSCGDLL QAVHLFAKEL DAKSVTLERS LGGGRFGELC 670 680 690 700 710 720 CGCLQLPGRQ ELLVAVHMLR DSASDSQRLG FLAEALTLGQ FDHSHIVRLE GVVTRGSTLM 730 740 750 760 770 780 IVTEYMSHGA LDGFLRRHEG QLVAGQLMGL LPGLASAMKY LSEMGYVHRG LAARHVLVSS 790 800 810 820 830 840 DLVCKISGFG RGPRDRSEAV YTTMSGRSPA LWAAPETLQF GHFSSASDVW SFGIIMWEVM 850 860 870 880 890 AFGERPYWDM SGQDVIKAVE DGFRLPPPRN CPNLLHRLML DCWQKDPGLP PH « Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis." Aasheim H.-C., Patzke S., Hjorthaug H.S., Finne E.F. Biochim. Biophys. Acta 1723:1-7(2005) [PubMed: 15777695] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING, FUNCTION, TISSUE SPECIFICITY. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-150; LYS-220; ILE-281; PRO-630; ARG-775 AND THR-956.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ872185 Genomic DNA. Translation: CAI43321.1. AJ781169 mRNA. Translation: CAG77605.1. BC067734 mRNA. Translation: AAH67734.1.
IPI	IPI00166339. IPI00651637. IPI00651751.
RefSeq	NP_775912.2.
UniGene	Hs.129435
3D structure databases
SMR	Q5JZY3. Positions 33-212, 334-551, 916-1000.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5JZY3.
Proteomic databases
PRIDE	Q5JZY3.
Genome annotation databases
Ensembl	ENST00000373048; ENSP00000362139; ENSG00000183317; Homo sapiens. [Genome view]
GeneID	284656.
KEGG	hsa:284656.
UCSC	uc001cbw.2. human. uc009vvi.1. human.
Organism-specific databases
CTD	284656.
GeneCards	GC01M037952.
H-InvDB	HIX0028650.
HGNC	HGNC:19987. EPHA10.
MIM	611123. gene.
PharmGKB	PA134938798.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG755340.
HOVERGEN	Q5JZY3.
InParanoid	Q5JZY3.
Enzyme and pathway databases
BRENDA	2.7.10.1. 247.
Gene expression databases
ArrayExpress	Q5JZY3.
Bgee	Q5JZY3.
CleanEx	HS_EPHA10.
Genevestigator	Q5JZY3.
GermOnline	ENSG00000183317. Homo sapiens.
Family and domain databases
InterPro	IPR001090. Ephrin_rcpt_lig-bd. IPR008957. Fibronectin_typ-III-like_fold. IPR003961. FN_III. IPR008979. Galactose-bd-like. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR001660. SAM. IPR010993. SAM_homology. IPR013761. SAM_type. IPR021129. SAM_type1. IPR020635. Tyr_Pkinase_cat_dom. IPR020685. Tyr_prot_kinase. IPR016257. Tyr_prot_kinase_ephrin_rcpt. IPR001426. Tyr_prot_kinase_rcpt_V_CS. [Graphical view]
Gene3D	G3DSA:2.60.40.30. FN_III-like. 1 hit. G3DSA:1.10.150.50. SAM_type. 1 hit.
PANTHER	PTHR23256. Tyr_prot_kinase. 1 hit.
Pfam	PF01404. Ephrin_lbd. 1 hit. PF00041. fn3. 2 hits. PF00536. SAM_1. 1 hit. [Graphical view]
PIRSF	PIRSF000666. TyrPK_ephrin_receptor. 1 hit.
SMART	SM00615. EPH_lbd. 1 hit. SM00060. FN3. 2 hits. SM00454. SAM. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS01186. EGF_2. 1 hit. Uncertain. PS50853. FN3. 2 hits. PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. False negative. PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit. PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit. PS50105. SAM_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	95031.
SOURCE	Search...

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Entry information

Entry name

EPHAA_HUMAN

Accession

Primary (citable) accession number: Q5JZY3
Secondary accession number(s): Q6NW42

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	February 15, 2005
Last modified:	February 9, 2010
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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