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Q5JZY3

- EPHAA_HUMAN

UniProt

Q5JZY3 - EPHAA_HUMAN

Protein

Ephrin type-A receptor 10

Gene

EPHA10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (03 Apr 2013)
      Previous versions | rss
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    Functioni

    Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.1 Publication

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ephrin receptor activity Source: InterPro
    3. protein binding Source: UniProtKB
    4. transmembrane-ephrin receptor activity Source: UniProtKB

    GO - Biological processi

    1. ephrin receptor signaling pathway Source: GOC

    Keywords - Molecular functioni

    Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ephrin type-A receptor 10 (EC:2.7.10.1)
    Gene namesi
    Name:EPHA10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:19987. EPHA10.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB
    3. integral component of plasma membrane Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134938798.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 1008975Ephrin type-A receptor 10PRO_0000042157Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ5JZY3.
    PRIDEiQ5JZY3.

    Expressioni

    Tissue specificityi

    Mainly expressed in testis.1 Publication

    Gene expression databases

    ArrayExpressiQ5JZY3.
    BgeeiQ5JZY3.
    CleanExiHS_EPHA10.
    GenevestigatoriQ5JZY3.

    Organism-specific databases

    HPAiHPA027497.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000316395.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5JZY3.
    SMRiQ5JZY3. Positions 33-551, 619-907, 932-999.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini34 – 565532ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini587 – 1008422CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei566 – 58621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 216182Eph LBDPROSITE-ProRule annotationAdd
    BLAST
    Domaini340 – 452113Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini456 – 55499Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini645 – 900256Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini933 – 99765SAMPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The protein kinase domain is predicted to be catalytically inactive.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation
    Contains 1 Eph LBD (Eph ligand-binding) domain.PROSITE-ProRule annotation
    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233856.
    HOVERGENiHBG062180.
    InParanoidiQ5JZY3.
    KOiK08897.
    OrthoDBiEOG7VTDM6.
    TreeFamiTF314013.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    2.60.120.260. 1 hit.
    2.60.40.10. 2 hits.
    InterProiIPR027936. Eph_TM.
    IPR001090. Ephrin_rcpt_lig-bd_dom.
    IPR003961. Fibronectin_type3.
    IPR008979. Galactose-bd-like.
    IPR013783. Ig-like_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016257. Tyr_kinase_ephrin_rcpt.
    IPR001426. Tyr_kinase_rcpt_V_CS.
    [Graphical view]
    PfamiPF14575. EphA2_TM. 1 hit.
    PF01404. Ephrin_lbd. 1 hit.
    PF00041. fn3. 2 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00615. EPH_lbd. 1 hit.
    SM00060. FN3. 2 hits.
    SM00454. SAM. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF49265. SSF49265. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS01186. EGF_2. 1 hit.
    PS51550. EPH_LBD. 1 hit.
    PS50853. FN3. 2 hits.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
    PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5JZY3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    METCAGPHPL RLFLCRMQLC LALLLGPWRP GTAEEVILLD SKASQAELGW     50
    TALPSNGWEE ISGVDEHDRP IRTYQVCNVL EPNQDNWLQT GWISRGRGQR 100
    IFVELQFTLR DCSSIPGAAG TCKETFNVYY LETEADLGRG RPRLGGSRPR 150
    KIDTIAADES FTQGDLGERK MKLNTEVREI GPLSRRGFHL AFQDVGACVA 200
    LVSVRVYYKQ CRATVRGLAT FPATAAESAF STLVEVAGTC VAHSEGEPGS 250
    PPRMHCGADG EWLVPVGRCS CSAGFQERGD FCEACPPGFY KVSPRRPLCS 300
    PCPEHSRALE NASTFCVCQD SYARSPTDPP SASCTRPPSA PRDLQYSLSR 350
    SPLVLRLRWL PPADSGGRSD VTYSLLCLRC GREGPAGACE PCGPRVAFLP 400
    RQAGLRERAA TLLHLRPGAR YTVRVAALNG VSGPAAAAGT TYAQVTVSTG 450
    PGAPWEEDEI RRDRVEPQSV SLSWREPIPA GAPGANDTEY EIRYYEKGQS 500
    EQTYSMVKTG APTVTVTNLK PATRYVFQIR AASPGPSWEA QSFNPSIEVQ 550
    TLGEAASGSR DQSPAIVVTV VTISALLVLG SVMSVLAIWR RPCSYGKGGG 600
    DAHDEEELYF HFKVPTRRTF LDPQSCGDLL QAVHLFAKEL DAKSVTLERS 650
    LGGGRFGELC CGCLQLPGRQ ELLVAVHMLR DSASDSQRLG FLAEALTLGQ 700
    FDHSHIVRLE GVVTRGSTLM IVTEYMSHGA LDGFLRRHEG QLVAGQLMGL 750
    LPGLASAMKY LSEMGYVHRG LAARHVLVSS DLVCKISGFG RGPRDRSEAV 800
    YTTMSGRSPA LWAAPETLQF GHFSSASDVW SFGIIMWEVM AFGERPYWDM 850
    SGQDVIKAVE DGFRLPPPRN CPNLLHRLML DCWQKDPGER PRFSQIHSIL 900
    SKMVQDPEPP KCALTTCPRP PTPLADRAFS TFPSFGSVGA WLEALDLCRY 950
    KDSFAAAGYG SLEAVAEMTA QDLVSLGISL AEHREALLSG ISALQARVLQ 1000
    LQGQGVQV 1008
    Length:1,008
    Mass (Da):109,716
    Last modified:April 3, 2013 - v2
    Checksum:i82D60740B7B6B9BD
    GO
    Isoform 2 (identifier: Q5JZY3-2) [UniParc]FASTAAdd to Basket

    Also known as: Epha10s

    The sequence of this isoform differs from the canonical sequence as follows:
         284-295: ACPPGFYKVSPR → GIQLAGGRGVGV
         296-1008: Missing.

    Show »
    Length:295
    Mass (Da):32,120
    Checksum:iC5818C0D8C4444D1
    GO
    Isoform 3 (identifier: Q5JZY3-3) [UniParc]FASTAAdd to Basket

    Also known as: Epha10*

    The sequence of this isoform differs from the canonical sequence as follows:
         889-892: ERPR → LPPH
         893-1008: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:892
    Mass (Da):97,293
    Checksum:iD91B200D8B705F89
    GO

    Sequence cautioni

    The sequence AAI12934.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti458 – 4581D → G in CAI43321. (PubMed:15777695)Curated
    Sequence conflicti503 – 5031T → A in CAI43321. (PubMed:15777695)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti103 – 1031V → L.
    Corresponds to variant rs34557762 [ dbSNP | Ensembl ].
    VAR_055992
    Natural varianti150 – 1501R → H in a gastric adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_042159
    Natural varianti220 – 2201T → K.1 Publication
    Corresponds to variant rs56276182 [ dbSNP | Ensembl ].
    VAR_042160
    Natural varianti281 – 2811F → I.1 Publication
    Corresponds to variant rs4653328 [ dbSNP | Ensembl ].
    VAR_042161
    Natural varianti629 – 6291L → P.
    Corresponds to variant rs17511304 [ dbSNP | Ensembl ].
    VAR_055993
    Natural varianti630 – 6301L → P.1 Publication
    VAR_042162
    Natural varianti645 – 6451V → I.
    Corresponds to variant rs12405650 [ dbSNP | Ensembl ].
    VAR_055994
    Natural varianti749 – 7491G → E.
    Corresponds to variant rs6671088 [ dbSNP | Ensembl ].
    VAR_055995
    Natural varianti775 – 7751H → R in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication
    VAR_042163
    Natural varianti807 – 8071R → Q.
    Corresponds to variant rs6670599 [ dbSNP | Ensembl ].
    VAR_055996
    Natural varianti956 – 9561A → T.1 Publication
    VAR_042164

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei284 – 29512ACPPG…KVSPR → GIQLAGGRGVGV in isoform 2. 2 PublicationsVSP_015772Add
    BLAST
    Alternative sequencei296 – 1008713Missing in isoform 2. 2 PublicationsVSP_015773Add
    BLAST
    Alternative sequencei889 – 8924ERPR → LPPH in isoform 3. 1 PublicationVSP_015774
    Alternative sequencei893 – 1008116Missing in isoform 3. 1 PublicationVSP_015775Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ872185 Genomic DNA. Translation: CAI43321.1.
    AJ781169 mRNA. Translation: CAG77605.1.
    AC104336 Genomic DNA. No translation available.
    BC067734 mRNA. Translation: AAH67734.1.
    BC112933 mRNA. Translation: AAI12934.1. Different initiation.
    CCDSiCCDS41305.1. [Q5JZY3-1]
    CCDS425.1. [Q5JZY3-2]
    RefSeqiNP_001092909.1. NM_001099439.1. [Q5JZY3-1]
    NP_775912.2. NM_173641.2. [Q5JZY3-2]
    UniGeneiHs.129435.

    Genome annotation databases

    EnsembliENST00000319637; ENSP00000316395; ENSG00000183317. [Q5JZY3-2]
    ENST00000373048; ENSP00000362139; ENSG00000183317. [Q5JZY3-1]
    GeneIDi284656.
    KEGGihsa:284656.
    UCSCiuc001cbw.4. human. [Q5JZY3-2]

    Polymorphism databases

    DMDMi476007830.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ872185 Genomic DNA. Translation: CAI43321.1 .
    AJ781169 mRNA. Translation: CAG77605.1 .
    AC104336 Genomic DNA. No translation available.
    BC067734 mRNA. Translation: AAH67734.1 .
    BC112933 mRNA. Translation: AAI12934.1 . Different initiation.
    CCDSi CCDS41305.1. [Q5JZY3-1 ]
    CCDS425.1. [Q5JZY3-2 ]
    RefSeqi NP_001092909.1. NM_001099439.1. [Q5JZY3-1 ]
    NP_775912.2. NM_173641.2. [Q5JZY3-2 ]
    UniGenei Hs.129435.

    3D structure databases

    ProteinModelPortali Q5JZY3.
    SMRi Q5JZY3. Positions 33-551, 619-907, 932-999.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000316395.

    Chemistry

    ChEMBLi CHEMBL2363043.

    Polymorphism databases

    DMDMi 476007830.

    Proteomic databases

    PaxDbi Q5JZY3.
    PRIDEi Q5JZY3.

    Protocols and materials databases

    DNASUi 284656.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000319637 ; ENSP00000316395 ; ENSG00000183317 . [Q5JZY3-2 ]
    ENST00000373048 ; ENSP00000362139 ; ENSG00000183317 . [Q5JZY3-1 ]
    GeneIDi 284656.
    KEGGi hsa:284656.
    UCSCi uc001cbw.4. human. [Q5JZY3-2 ]

    Organism-specific databases

    CTDi 284656.
    GeneCardsi GC01M038181.
    HGNCi HGNC:19987. EPHA10.
    HPAi HPA027497.
    MIMi 611123. gene.
    neXtProti NX_Q5JZY3.
    PharmGKBi PA134938798.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233856.
    HOVERGENi HBG062180.
    InParanoidi Q5JZY3.
    KOi K08897.
    OrthoDBi EOG7VTDM6.
    TreeFami TF314013.

    Miscellaneous databases

    GeneWikii EPHA10.
    GenomeRNAii 284656.
    NextBioi 35535096.
    PROi Q5JZY3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5JZY3.
    Bgeei Q5JZY3.
    CleanExi HS_EPHA10.
    Genevestigatori Q5JZY3.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    2.60.120.260. 1 hit.
    2.60.40.10. 2 hits.
    InterProi IPR027936. Eph_TM.
    IPR001090. Ephrin_rcpt_lig-bd_dom.
    IPR003961. Fibronectin_type3.
    IPR008979. Galactose-bd-like.
    IPR013783. Ig-like_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016257. Tyr_kinase_ephrin_rcpt.
    IPR001426. Tyr_kinase_rcpt_V_CS.
    [Graphical view ]
    Pfami PF14575. EphA2_TM. 1 hit.
    PF01404. Ephrin_lbd. 1 hit.
    PF00041. fn3. 2 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000666. TyrPK_ephrin_receptor. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00615. EPH_lbd. 1 hit.
    SM00060. FN3. 2 hits.
    SM00454. SAM. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF49265. SSF49265. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS01186. EGF_2. 1 hit.
    PS51550. EPH_LBD. 1 hit.
    PS50853. FN3. 2 hits.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
    PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis."
      Aasheim H.-C., Patzke S., Hjorthaug H.S., Finne E.F.
      Biochim. Biophys. Acta 1723:1-7(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING, FUNCTION, TISSUE SPECIFICITY.
      Tissue: Testis.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 501-1008 (ISOFORM 3).
      Tissue: Brain.
    4. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-150; LYS-220; ILE-281; PRO-630; ARG-775 AND THR-956.

    Entry informationi

    Entry nameiEPHAA_HUMAN
    AccessioniPrimary (citable) accession number: Q5JZY3
    Secondary accession number(s): A4FU89, J3KPB5, Q6NW42
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: April 3, 2013
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3