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Protein

G-protein coupled receptor-associated sorting protein 1

Gene

GPRASP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2.3 Publications

GO - Biological processi

  • endosome to lysosome transport Source: UniProtKB
  • G-protein coupled receptor catabolic process Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor-associated sorting protein 1
Short name:
GASP-1
Gene namesi
Name:GPRASP1
Synonyms:GASP, KIAA0443
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000198932.12
HGNCiHGNC:24834 GPRASP1
MIMi300417 gene
neXtProtiNX_Q5JY77

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi9737
OpenTargetsiENSG00000198932
PharmGKBiPA134970616

Polymorphism and mutation databases

BioMutaiGPRASP1
DMDMi126302546

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002390501 – 1395G-protein coupled receptor-associated sorting protein 1Add BLAST1395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei297PhosphoserineBy similarity1
Modified residuei631PhosphoserineBy similarity1
Modified residuei899PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5JY77
MaxQBiQ5JY77
PaxDbiQ5JY77
PeptideAtlasiQ5JY77
PRIDEiQ5JY77

PTM databases

iPTMnetiQ5JY77
PhosphoSitePlusiQ5JY77

Expressioni

Tissue specificityi

Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra.2 Publications

Gene expression databases

BgeeiENSG00000198932
CleanExiHS_GPRASP1
GenevisibleiQ5JY77 HS

Organism-specific databases

HPAiHPA000161
HPA031061

Interactioni

Subunit structurei

Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as D2 dopamine receptor/DRD2 (By similarity), delta opioid receptor/OPRD1, beta-2 adrenergic receptor/ADRB2 and D4 dopamine receptor/DRD4. Interacts with PER1. Interacts with BECN2; the interaction is direct.By similarity4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115086, 28 interactors
IntActiQ5JY77, 19 interactors
STRINGi9606.ENSP00000355146

Structurei

3D structure databases

ProteinModelPortaliQ5JY77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni899 – 1395OPRD1-bindingAdd BLAST497

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi506 – 978Glu-richAdd BLAST473

Sequence similaritiesi

Belongs to the GPRASP family.Curated

Phylogenomic databases

eggNOGiENOG410IIBK Eukaryota
ENOG410XUVQ LUCA
GeneTreeiENSGT00550000074488
HOGENOMiHOG000231409
HOVERGENiHBG057167
InParanoidiQ5JY77
OMAiFGSWFWA
OrthoDBiEOG091G01QA
PhylomeDBiQ5JY77
TreeFamiTF335652

Family and domain databases

InterProiView protein in InterPro
IPR006911 ARM-rpt_dom
IPR016024 ARM-type_fold
PfamiView protein in Pfam
PF04826 Arm_2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

Q5JY77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGAEIESGA QVKPEKKPGE EVVGGAEIEN DVPLVVRPKV RTQAQIMPGA
60 70 80 90 100
RPKNKSKVMP GASTKVETSA VGGARPKSKA KAIPVSRFKE EAQMWAQPRF
110 120 130 140 150
GAERLSKTER NSQTNIIASP LVSTDSVLVA KTKYLSEDRE LVNTDTESFP
160 170 180 190 200
RRKAHYQAGF QPSFRSKEET NMGSWCCPRP TSKQEASPNS DFKWVDKSVS
210 220 230 240 250
SLFWSGDEVT AKFHPGNRVK DSNRSMHMAN QEANTMSRSQ TNQELYIASS
260 270 280 290 300
SGSEDESVKT PWFWARDKTN TWSGPREDPN SRSRFRSKKE VYVESSSGSE
310 320 330 340 350
HEDHLESWFG AGKEAKFRSK MRAGKEANNR ARHRAKREAC IDFMPGSIDV
360 370 380 390 400
IKKESCFWPE ENANTFSRPM IKKEARARAM TKEEAKTKAR ARAKQEARSE
410 420 430 440 450
EEALIGTWFW ATDESSMADE ASIESSLQVE DESIIGSWFW TEEEASMGTG
460 470 480 490 500
ASSKSRPRTD GERIGDSLFG AREKTSMKTG AEATSESILA ADDEQVIIGS
510 520 530 540 550
WFWAGEEVNQ EAEEETIFGS WFWVIDAASV ESGVGVSCES RTRSEEEEVI
560 570 580 590 600
GPWFWSGEQV DIEAGIGEEA RPGAEEETIF GSWFWAENQT YMDCRAETSC
610 620 630 640 650
DTMQGAEEEE PIIGSWFWTR VEACVEGDVN SKSSLEDKEE AMIPCFGAKE
660 670 680 690 700
EVSMKHGTGV RCRFMAGAEE TNNKSCFWAE KEPCMYPAGG GSWKSRPEEE
710 720 730 740 750
EDIVNSWFWS RKYTKPEAII GSWLWATEES NIDGTGEKAK LLTEEETIIN
760 770 780 790 800
SWFWKEDEAI SEATDREESR PEAEEGDIIG SWFWAGEEDR LEPAAETREE
810 820 830 840 850
DRLAAEKEGI VGSWFGAREE TIRREAGSCS KSSPKAEEEE VIIGSWFWEE
860 870 880 890 900
EASPEAVAGV GFESKPGTEE EEITVGSWFW PEEEASIQAG SQAVEEMESE
910 920 930 940 950
TEEETIFGSW FWDGKEVSEE AGPCCVSKPE DDEEMIVESW FWSRDKAIKE
960 970 980 990 1000
TGTVATCESK PENEEGAIVG SWFEAEDEVD NRTDNGSNCG SRTLADEDEA
1010 1020 1030 1040 1050
IVGSWFWAGD EAHFESNPSP VFRAICRSTC SVEQEPDPSR RPQSWEEVTV
1060 1070 1080 1090 1100
QFKPGPWGRV GFPSISPFRF PKEAASLFCE MFGGKPRNMV LSPEGEDQES
1110 1120 1130 1140 1150
LLQPDQPSPE FPFQYDPSYR SVQEIREHLR AKESTEPESS SCNCIQCELK
1160 1170 1180 1190 1200
IGSEEFEELL LLMEKIRDPF IHEISKIAMG MRSASQFTRD FIRDSGVVSL
1210 1220 1230 1240 1250
IETLLNYPSS RVRTSFLENM IRMAPPYPNL NIIQTYICKV CEETLAYSVD
1260 1270 1280 1290 1300
SPEQLSGIRM IRHLTTTTDY HTLVANYMSG FLSLLATGNA KTRFHVLKML
1310 1320 1330 1340 1350
LNLSENLFMT KELLSAEAVS EFIGLFNREE TNDNIQIVLA IFENIGNNIK
1360 1370 1380 1390
KETVFSDDDF NIEPLISAFH KVEKFAKELQ GKTDNQNDPE GDQEN
Length:1,395
Mass (Da):156,865
Last modified:February 20, 2007 - v3
Checksum:i89733CB9A59BC151
GO

Sequence cautioni

The sequence BAA23715 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026579315A → G1 PublicationCorresponds to variant dbSNP:rs17339512Ensembl.1
Natural variantiVAR_049263779I → V. Corresponds to variant dbSNP:rs17292748Ensembl.1
Natural variantiVAR_0492641093P → S. Corresponds to variant dbSNP:rs2235804Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007903 mRNA Translation: BAA23715.3 Different initiation.
AL035427 Genomic DNA No translation available.
BC114552 mRNA Translation: AAI14553.1
AY044233 mRNA Translation: AAK95578.1
CCDSiCCDS35352.1
PIRiT00068
RefSeqiNP_001092880.1, NM_001099410.1
NP_001092881.1, NM_001099411.1
NP_001171656.1, NM_001184727.1
NP_055525.3, NM_014710.4
XP_016885470.1, XM_017029981.1
XP_016885471.1, XM_017029982.1
UniGeneiHs.729265
Hs.731996

Genome annotation databases

EnsembliENST00000361600; ENSP00000355146; ENSG00000198932
ENST00000415986; ENSP00000393691; ENSG00000198932
ENST00000444152; ENSP00000409420; ENSG00000198932
ENST00000537097; ENSP00000445683; ENSG00000198932
GeneIDi9737
KEGGihsa:9737
UCSCiuc004eji.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGASP1_HUMAN
AccessioniPrimary (citable) accession number: Q5JY77
Secondary accession number(s): O43168, Q96LA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: February 20, 2007
Last modified: May 23, 2018
This is version 110 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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