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Q5JY77

- GASP1_HUMAN

UniProt

Q5JY77 - GASP1_HUMAN

Protein

G-protein coupled receptor-associated sorting protein 1

Gene

GPRASP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 3 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN1P1/BECN2.3 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. endosome to lysosome transport Source: UniProtKB
    2. G-protein coupled receptor catabolic process Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor-associated sorting protein 1
    Short name:
    GASP-1
    Gene namesi
    Name:GPRASP1
    Synonyms:GASP, KIAA0443
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:24834. GPRASP1.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134970616.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13951395G-protein coupled receptor-associated sorting protein 1PRO_0000239050Add
    BLAST

    Proteomic databases

    MaxQBiQ5JY77.
    PaxDbiQ5JY77.
    PRIDEiQ5JY77.

    PTM databases

    PhosphoSiteiQ5JY77.

    Expressioni

    Tissue specificityi

    Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra.2 Publications

    Gene expression databases

    BgeeiQ5JY77.
    CleanExiHS_GPRASP1.
    GenevestigatoriQ5JY77.

    Organism-specific databases

    HPAiHPA000161.

    Interactioni

    Subunit structurei

    Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as D2 dopamine receptor/DRD2 By similarity, delta opioid receptor/OPRD1, beta-2 adrenergic receptor/ADRB2 and D4 dopamine receptor/DRD4. Interacts with PER1. Interacts with BECN1P1/BECN2; the interaction is direct.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BECN1P1A8MW954EBI-2514717,EBI-8839517
    OPRD1P411432EBI-2514717,EBI-2624456

    Protein-protein interaction databases

    BioGridi115086. 29 interactions.
    IntActiQ5JY77. 18 interactions.
    MINTiMINT-1413443.
    STRINGi9606.ENSP00000355146.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5JY77.
    SMRiQ5JY77. Positions 1157-1212.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni899 – 1395497OPRD1-bindingAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi506 – 978473Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GPRASP family.Curated

    Phylogenomic databases

    eggNOGiNOG136667.
    HOGENOMiHOG000231409.
    HOVERGENiHBG057167.
    InParanoidiQ5JY77.
    OMAiMIQTYVC.
    OrthoDBiEOG70PBZ0.
    PhylomeDBiQ5JY77.
    TreeFamiTF335652.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    InterProiIPR011989. ARM-like.
    IPR006911. ARM-rpt_dom.
    IPR016024. ARM-type_fold.
    [Graphical view]
    PfamiPF04826. Arm_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5JY77-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGAEIESGA QVKPEKKPGE EVVGGAEIEN DVPLVVRPKV RTQAQIMPGA     50
    RPKNKSKVMP GASTKVETSA VGGARPKSKA KAIPVSRFKE EAQMWAQPRF 100
    GAERLSKTER NSQTNIIASP LVSTDSVLVA KTKYLSEDRE LVNTDTESFP 150
    RRKAHYQAGF QPSFRSKEET NMGSWCCPRP TSKQEASPNS DFKWVDKSVS 200
    SLFWSGDEVT AKFHPGNRVK DSNRSMHMAN QEANTMSRSQ TNQELYIASS 250
    SGSEDESVKT PWFWARDKTN TWSGPREDPN SRSRFRSKKE VYVESSSGSE 300
    HEDHLESWFG AGKEAKFRSK MRAGKEANNR ARHRAKREAC IDFMPGSIDV 350
    IKKESCFWPE ENANTFSRPM IKKEARARAM TKEEAKTKAR ARAKQEARSE 400
    EEALIGTWFW ATDESSMADE ASIESSLQVE DESIIGSWFW TEEEASMGTG 450
    ASSKSRPRTD GERIGDSLFG AREKTSMKTG AEATSESILA ADDEQVIIGS 500
    WFWAGEEVNQ EAEEETIFGS WFWVIDAASV ESGVGVSCES RTRSEEEEVI 550
    GPWFWSGEQV DIEAGIGEEA RPGAEEETIF GSWFWAENQT YMDCRAETSC 600
    DTMQGAEEEE PIIGSWFWTR VEACVEGDVN SKSSLEDKEE AMIPCFGAKE 650
    EVSMKHGTGV RCRFMAGAEE TNNKSCFWAE KEPCMYPAGG GSWKSRPEEE 700
    EDIVNSWFWS RKYTKPEAII GSWLWATEES NIDGTGEKAK LLTEEETIIN 750
    SWFWKEDEAI SEATDREESR PEAEEGDIIG SWFWAGEEDR LEPAAETREE 800
    DRLAAEKEGI VGSWFGAREE TIRREAGSCS KSSPKAEEEE VIIGSWFWEE 850
    EASPEAVAGV GFESKPGTEE EEITVGSWFW PEEEASIQAG SQAVEEMESE 900
    TEEETIFGSW FWDGKEVSEE AGPCCVSKPE DDEEMIVESW FWSRDKAIKE 950
    TGTVATCESK PENEEGAIVG SWFEAEDEVD NRTDNGSNCG SRTLADEDEA 1000
    IVGSWFWAGD EAHFESNPSP VFRAICRSTC SVEQEPDPSR RPQSWEEVTV 1050
    QFKPGPWGRV GFPSISPFRF PKEAASLFCE MFGGKPRNMV LSPEGEDQES 1100
    LLQPDQPSPE FPFQYDPSYR SVQEIREHLR AKESTEPESS SCNCIQCELK 1150
    IGSEEFEELL LLMEKIRDPF IHEISKIAMG MRSASQFTRD FIRDSGVVSL 1200
    IETLLNYPSS RVRTSFLENM IRMAPPYPNL NIIQTYICKV CEETLAYSVD 1250
    SPEQLSGIRM IRHLTTTTDY HTLVANYMSG FLSLLATGNA KTRFHVLKML 1300
    LNLSENLFMT KELLSAEAVS EFIGLFNREE TNDNIQIVLA IFENIGNNIK 1350
    KETVFSDDDF NIEPLISAFH KVEKFAKELQ GKTDNQNDPE GDQEN 1395
    Length:1,395
    Mass (Da):156,865
    Last modified:February 20, 2007 - v3
    Checksum:i89733CB9A59BC151
    GO

    Sequence cautioni

    The sequence BAA23715.3 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti315 – 3151A → G.1 Publication
    Corresponds to variant rs17339512 [ dbSNP | Ensembl ].
    VAR_026579
    Natural varianti779 – 7791I → V.
    Corresponds to variant rs17292748 [ dbSNP | Ensembl ].
    VAR_049263
    Natural varianti1093 – 10931P → S.
    Corresponds to variant rs2235804 [ dbSNP | Ensembl ].
    VAR_049264

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB007903 mRNA. Translation: BAA23715.3. Different initiation.
    AL035427 Genomic DNA. Translation: CAB55683.1.
    BC114552 mRNA. Translation: AAI14553.1.
    AY044233 mRNA. Translation: AAK95578.1.
    CCDSiCCDS35352.1.
    PIRiT00068.
    RefSeqiNP_001092880.1. NM_001099410.1.
    NP_001092881.1. NM_001099411.1.
    NP_001171656.1. NM_001184727.1.
    NP_055525.3. NM_014710.4.
    UniGeneiHs.729265.
    Hs.731996.

    Genome annotation databases

    EnsembliENST00000361600; ENSP00000355146; ENSG00000198932.
    ENST00000415986; ENSP00000393691; ENSG00000198932.
    ENST00000444152; ENSP00000409420; ENSG00000198932.
    ENST00000537097; ENSP00000445683; ENSG00000198932.
    GeneIDi9737.
    KEGGihsa:9737.
    UCSCiuc004eji.4. human.

    Polymorphism databases

    DMDMi126302546.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB007903 mRNA. Translation: BAA23715.3 . Different initiation.
    AL035427 Genomic DNA. Translation: CAB55683.1 .
    BC114552 mRNA. Translation: AAI14553.1 .
    AY044233 mRNA. Translation: AAK95578.1 .
    CCDSi CCDS35352.1.
    PIRi T00068.
    RefSeqi NP_001092880.1. NM_001099410.1.
    NP_001092881.1. NM_001099411.1.
    NP_001171656.1. NM_001184727.1.
    NP_055525.3. NM_014710.4.
    UniGenei Hs.729265.
    Hs.731996.

    3D structure databases

    ProteinModelPortali Q5JY77.
    SMRi Q5JY77. Positions 1157-1212.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115086. 29 interactions.
    IntActi Q5JY77. 18 interactions.
    MINTi MINT-1413443.
    STRINGi 9606.ENSP00000355146.

    PTM databases

    PhosphoSitei Q5JY77.

    Polymorphism databases

    DMDMi 126302546.

    Proteomic databases

    MaxQBi Q5JY77.
    PaxDbi Q5JY77.
    PRIDEi Q5JY77.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361600 ; ENSP00000355146 ; ENSG00000198932 .
    ENST00000415986 ; ENSP00000393691 ; ENSG00000198932 .
    ENST00000444152 ; ENSP00000409420 ; ENSG00000198932 .
    ENST00000537097 ; ENSP00000445683 ; ENSG00000198932 .
    GeneIDi 9737.
    KEGGi hsa:9737.
    UCSCi uc004eji.4. human.

    Organism-specific databases

    CTDi 9737.
    GeneCardsi GC0XP101906.
    HGNCi HGNC:24834. GPRASP1.
    HPAi HPA000161.
    MIMi 300417. gene.
    neXtProti NX_Q5JY77.
    PharmGKBi PA134970616.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG136667.
    HOGENOMi HOG000231409.
    HOVERGENi HBG057167.
    InParanoidi Q5JY77.
    OMAi MIQTYVC.
    OrthoDBi EOG70PBZ0.
    PhylomeDBi Q5JY77.
    TreeFami TF335652.

    Miscellaneous databases

    GeneWikii GPRASP1_(gene).
    GenomeRNAii 9737.
    NextBioi 36640.
    PROi Q5JY77.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5JY77.
    CleanExi HS_GPRASP1.
    Genevestigatori Q5JY77.

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    InterProi IPR011989. ARM-like.
    IPR006911. ARM-rpt_dom.
    IPR016024. ARM-type_fold.
    [Graphical view ]
    Pfami PF04826. Arm_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
      Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-315.
      Tissue: Brain.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Completely sequenced partial cDNA clone from a human heart library."
      Patzak D.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1362-1395.
      Tissue: Heart.
    5. "Modulation of postendocytic sorting of G protein-coupled receptors."
      Whistler J.L., Enquist J., Marley A., Fong J., Gladher F., Tsuruda P., Murray S.R., Von Zastrow M.
      Science 297:615-620(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH OPRD1; ADRB2 AND DRD4, DOMAIN OPRD1-BINDING, TISSUE SPECIFICITY.
    6. "A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP)."
      Heydorn A., Soendergaard B.P., Ersboell B., Holst B., Nielsen F.C., Haft C.R., Whistler J., Schwartz T.W.
      J. Biol. Chem. 279:54291-54303(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH G PROTEIN-COUPLED RECEPTORS, SUBCELLULAR LOCATION.
    7. "Identification of a novel family of G protein-coupled receptor associated sorting proteins."
      Simonin F., Karcher P., Boeuf J.J.-M., Matifas A., Kieffer B.L.
      J. Neurochem. 89:766-775(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INTERACTION WITH OPRD1.
    8. "Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism."
      He C., Wei Y., Sun K., Li B., Dong X., Zou Z., Liu Y., Kinch L.N., Khan S., Sinha S., Xavier R.J., Grishin N.V., Xiao G., Eskelinen E.L., Scherer P.E., Whistler J.L., Levine B.
      Cell 154:1085-1099(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH BECN1P1/BECN2.

    Entry informationi

    Entry nameiGASP1_HUMAN
    AccessioniPrimary (citable) accession number: Q5JY77
    Secondary accession number(s): O43168, Q96LA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 86 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3