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Q5JY77

- GASP1_HUMAN

UniProt

Q5JY77 - GASP1_HUMAN

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Protein

G-protein coupled receptor-associated sorting protein 1

Gene
GPRASP1, GASP, KIAA0443
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN1P1/BECN2.3 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. endosome to lysosome transport Source: UniProtKB
  2. G-protein coupled receptor catabolic process Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor-associated sorting protein 1
Short name:
GASP-1
Gene namesi
Name:GPRASP1
Synonyms:GASP, KIAA0443
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:24834. GPRASP1.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134970616.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13951395G-protein coupled receptor-associated sorting protein 1PRO_0000239050Add
BLAST

Proteomic databases

MaxQBiQ5JY77.
PaxDbiQ5JY77.
PRIDEiQ5JY77.

PTM databases

PhosphoSiteiQ5JY77.

Expressioni

Tissue specificityi

Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra.2 Publications

Gene expression databases

BgeeiQ5JY77.
CleanExiHS_GPRASP1.
GenevestigatoriQ5JY77.

Organism-specific databases

HPAiHPA000161.

Interactioni

Subunit structurei

Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as D2 dopamine receptor/DRD2 By similarity, delta opioid receptor/OPRD1, beta-2 adrenergic receptor/ADRB2 and D4 dopamine receptor/DRD4. Interacts with PER1. Interacts with BECN1P1/BECN2; the interaction is direct.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BECN1P1A8MW954EBI-2514717,EBI-8839517
OPRD1P411432EBI-2514717,EBI-2624456

Protein-protein interaction databases

BioGridi115086. 29 interactions.
IntActiQ5JY77. 18 interactions.
MINTiMINT-1413443.
STRINGi9606.ENSP00000355146.

Structurei

3D structure databases

ProteinModelPortaliQ5JY77.
SMRiQ5JY77. Positions 1157-1212.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni899 – 1395497OPRD1-bindingAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi506 – 978473Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the GPRASP family.

Phylogenomic databases

eggNOGiNOG136667.
HOGENOMiHOG000231409.
HOVERGENiHBG057167.
InParanoidiQ5JY77.
OMAiMIQTYVC.
OrthoDBiEOG70PBZ0.
PhylomeDBiQ5JY77.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5JY77-1 [UniParc]FASTAAdd to Basket

« Hide

MTGAEIESGA QVKPEKKPGE EVVGGAEIEN DVPLVVRPKV RTQAQIMPGA     50
RPKNKSKVMP GASTKVETSA VGGARPKSKA KAIPVSRFKE EAQMWAQPRF 100
GAERLSKTER NSQTNIIASP LVSTDSVLVA KTKYLSEDRE LVNTDTESFP 150
RRKAHYQAGF QPSFRSKEET NMGSWCCPRP TSKQEASPNS DFKWVDKSVS 200
SLFWSGDEVT AKFHPGNRVK DSNRSMHMAN QEANTMSRSQ TNQELYIASS 250
SGSEDESVKT PWFWARDKTN TWSGPREDPN SRSRFRSKKE VYVESSSGSE 300
HEDHLESWFG AGKEAKFRSK MRAGKEANNR ARHRAKREAC IDFMPGSIDV 350
IKKESCFWPE ENANTFSRPM IKKEARARAM TKEEAKTKAR ARAKQEARSE 400
EEALIGTWFW ATDESSMADE ASIESSLQVE DESIIGSWFW TEEEASMGTG 450
ASSKSRPRTD GERIGDSLFG AREKTSMKTG AEATSESILA ADDEQVIIGS 500
WFWAGEEVNQ EAEEETIFGS WFWVIDAASV ESGVGVSCES RTRSEEEEVI 550
GPWFWSGEQV DIEAGIGEEA RPGAEEETIF GSWFWAENQT YMDCRAETSC 600
DTMQGAEEEE PIIGSWFWTR VEACVEGDVN SKSSLEDKEE AMIPCFGAKE 650
EVSMKHGTGV RCRFMAGAEE TNNKSCFWAE KEPCMYPAGG GSWKSRPEEE 700
EDIVNSWFWS RKYTKPEAII GSWLWATEES NIDGTGEKAK LLTEEETIIN 750
SWFWKEDEAI SEATDREESR PEAEEGDIIG SWFWAGEEDR LEPAAETREE 800
DRLAAEKEGI VGSWFGAREE TIRREAGSCS KSSPKAEEEE VIIGSWFWEE 850
EASPEAVAGV GFESKPGTEE EEITVGSWFW PEEEASIQAG SQAVEEMESE 900
TEEETIFGSW FWDGKEVSEE AGPCCVSKPE DDEEMIVESW FWSRDKAIKE 950
TGTVATCESK PENEEGAIVG SWFEAEDEVD NRTDNGSNCG SRTLADEDEA 1000
IVGSWFWAGD EAHFESNPSP VFRAICRSTC SVEQEPDPSR RPQSWEEVTV 1050
QFKPGPWGRV GFPSISPFRF PKEAASLFCE MFGGKPRNMV LSPEGEDQES 1100
LLQPDQPSPE FPFQYDPSYR SVQEIREHLR AKESTEPESS SCNCIQCELK 1150
IGSEEFEELL LLMEKIRDPF IHEISKIAMG MRSASQFTRD FIRDSGVVSL 1200
IETLLNYPSS RVRTSFLENM IRMAPPYPNL NIIQTYICKV CEETLAYSVD 1250
SPEQLSGIRM IRHLTTTTDY HTLVANYMSG FLSLLATGNA KTRFHVLKML 1300
LNLSENLFMT KELLSAEAVS EFIGLFNREE TNDNIQIVLA IFENIGNNIK 1350
KETVFSDDDF NIEPLISAFH KVEKFAKELQ GKTDNQNDPE GDQEN 1395
Length:1,395
Mass (Da):156,865
Last modified:February 20, 2007 - v3
Checksum:i89733CB9A59BC151
GO

Sequence cautioni

The sequence BAA23715.3 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti315 – 3151A → G.1 Publication
Corresponds to variant rs17339512 [ dbSNP | Ensembl ].
VAR_026579
Natural varianti779 – 7791I → V.
Corresponds to variant rs17292748 [ dbSNP | Ensembl ].
VAR_049263
Natural varianti1093 – 10931P → S.
Corresponds to variant rs2235804 [ dbSNP | Ensembl ].
VAR_049264

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB007903 mRNA. Translation: BAA23715.3. Different initiation.
AL035427 Genomic DNA. Translation: CAB55683.1.
BC114552 mRNA. Translation: AAI14553.1.
AY044233 mRNA. Translation: AAK95578.1.
CCDSiCCDS35352.1.
PIRiT00068.
RefSeqiNP_001092880.1. NM_001099410.1.
NP_001092881.1. NM_001099411.1.
NP_001171656.1. NM_001184727.1.
NP_055525.3. NM_014710.4.
UniGeneiHs.729265.
Hs.731996.

Genome annotation databases

EnsembliENST00000361600; ENSP00000355146; ENSG00000198932.
ENST00000415986; ENSP00000393691; ENSG00000198932.
ENST00000444152; ENSP00000409420; ENSG00000198932.
ENST00000537097; ENSP00000445683; ENSG00000198932.
GeneIDi9737.
KEGGihsa:9737.
UCSCiuc004eji.4. human.

Polymorphism databases

DMDMi126302546.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB007903 mRNA. Translation: BAA23715.3 . Different initiation.
AL035427 Genomic DNA. Translation: CAB55683.1 .
BC114552 mRNA. Translation: AAI14553.1 .
AY044233 mRNA. Translation: AAK95578.1 .
CCDSi CCDS35352.1.
PIRi T00068.
RefSeqi NP_001092880.1. NM_001099410.1.
NP_001092881.1. NM_001099411.1.
NP_001171656.1. NM_001184727.1.
NP_055525.3. NM_014710.4.
UniGenei Hs.729265.
Hs.731996.

3D structure databases

ProteinModelPortali Q5JY77.
SMRi Q5JY77. Positions 1157-1212.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115086. 29 interactions.
IntActi Q5JY77. 18 interactions.
MINTi MINT-1413443.
STRINGi 9606.ENSP00000355146.

PTM databases

PhosphoSitei Q5JY77.

Polymorphism databases

DMDMi 126302546.

Proteomic databases

MaxQBi Q5JY77.
PaxDbi Q5JY77.
PRIDEi Q5JY77.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361600 ; ENSP00000355146 ; ENSG00000198932 .
ENST00000415986 ; ENSP00000393691 ; ENSG00000198932 .
ENST00000444152 ; ENSP00000409420 ; ENSG00000198932 .
ENST00000537097 ; ENSP00000445683 ; ENSG00000198932 .
GeneIDi 9737.
KEGGi hsa:9737.
UCSCi uc004eji.4. human.

Organism-specific databases

CTDi 9737.
GeneCardsi GC0XP101906.
HGNCi HGNC:24834. GPRASP1.
HPAi HPA000161.
MIMi 300417. gene.
neXtProti NX_Q5JY77.
PharmGKBi PA134970616.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG136667.
HOGENOMi HOG000231409.
HOVERGENi HBG057167.
InParanoidi Q5JY77.
OMAi MIQTYVC.
OrthoDBi EOG70PBZ0.
PhylomeDBi Q5JY77.
TreeFami TF335652.

Miscellaneous databases

GeneWikii GPRASP1_(gene).
GenomeRNAii 9737.
NextBioi 36640.
PROi Q5JY77.
SOURCEi Search...

Gene expression databases

Bgeei Q5JY77.
CleanExi HS_GPRASP1.
Genevestigatori Q5JY77.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view ]
Pfami PF04826. Arm_2. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
    Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-315.
    Tissue: Brain.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Completely sequenced partial cDNA clone from a human heart library."
    Patzak D.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1362-1395.
    Tissue: Heart.
  5. "Modulation of postendocytic sorting of G protein-coupled receptors."
    Whistler J.L., Enquist J., Marley A., Fong J., Gladher F., Tsuruda P., Murray S.R., Von Zastrow M.
    Science 297:615-620(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH OPRD1; ADRB2 AND DRD4, DOMAIN OPRD1-BINDING, TISSUE SPECIFICITY.
  6. "A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP)."
    Heydorn A., Soendergaard B.P., Ersboell B., Holst B., Nielsen F.C., Haft C.R., Whistler J., Schwartz T.W.
    J. Biol. Chem. 279:54291-54303(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH G PROTEIN-COUPLED RECEPTORS, SUBCELLULAR LOCATION.
  7. "Identification of a novel family of G protein-coupled receptor associated sorting proteins."
    Simonin F., Karcher P., Boeuf J.J.-M., Matifas A., Kieffer B.L.
    J. Neurochem. 89:766-775(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INTERACTION WITH OPRD1.
  8. "Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism."
    He C., Wei Y., Sun K., Li B., Dong X., Zou Z., Liu Y., Kinch L.N., Khan S., Sinha S., Xavier R.J., Grishin N.V., Xiao G., Eskelinen E.L., Scherer P.E., Whistler J.L., Levine B.
    Cell 154:1085-1099(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH BECN1P1/BECN2.

Entry informationi

Entry nameiGASP1_HUMAN
AccessioniPrimary (citable) accession number: Q5JY77
Secondary accession number(s): O43168, Q96LA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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