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Q5JXX5

- GLRA4_HUMAN

UniProt

Q5JXX5 - GLRA4_HUMAN

Protein

Glycine receptor subunit alpha-4

Gene

GLRA4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 3 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).

    GO - Molecular functioni

    1. chloride channel activity Source: UniProtKB-KW
    2. extracellular ligand-gated ion channel activity Source: InterPro
    3. glycine binding Source: InterPro
    4. transmitter-gated ion channel activity Source: InterPro

    Keywords - Molecular functioni

    Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Enzyme and pathway databases

    ReactomeiREACT_25387. Ligand-gated ion channel transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine receptor subunit alpha-4
    Gene namesi
    Name:GLRA4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:31715. GLRA4.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. chloride channel complex Source: UniProtKB-KW
    3. integral component of plasma membrane Source: InterPro
    4. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671731.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 417389Glycine receptor subunit alpha-4PRO_0000338609Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi172 ↔ 186By similarity
    Disulfide bondi233 ↔ 244By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ5JXX5.
    PRIDEiQ5JXX5.

    PTM databases

    PhosphoSiteiQ5JXX5.

    Expressioni

    Gene expression databases

    BgeeiQ5JXX5.
    CleanExiHS_GLRA4.
    GenevestigatoriQ5JXX5.

    Organism-specific databases

    HPAiHPA044759.

    Interactioni

    Subunit structurei

    Pentamer composed of alpha and beta subunits.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000361700.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5JXX5.
    SMRiQ5JXX5. Positions 55-349.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 258230ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini280 – 32142CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini343 – 41775ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei259 – 27921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei322 – 34221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG265706.
    HOGENOMiHOG000231336.
    HOVERGENiHBG051707.
    InParanoidiQ5JXX5.
    KOiK05271.
    OMAiSYREYPD.
    OrthoDBiEOG712TVZ.
    PhylomeDBiQ5JXX5.
    TreeFamiTF315453.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006028. GABAA/Glycine_rcpt.
    IPR008127. Glycine_rcpt_A.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00253. GABAARECEPTR.
    PR01673. GLYRALPHA.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5JXX5-1 [UniParc]FASTAAdd to Basket

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    MTTLVPATLS FLLLWTLPGQ VLLRVALAKE EVKSGTKGSQ PMSPSDFLDK    50
    LMGRTSGYDA RIRPNFKGPP VNVTCNIFIN SFSSITKTTM DYRVNVFLRQ 100
    QWNDPRLSYR EYPDDSLDLD PSMLDSIWKP DLFFANEKGA NFHEVTTDNK 150
    LLRIFKNGNV LYSIRLTLIL SCLMDLKNFP MDIQTCTMQL ESFGYTMKDL 200
    VFEWLEDAPA VQVAEGLTLP QFILRDEKDL GCCTKHYNTG KFTCIEVKFH 250
    LERQMGYYLI QMYIPSLLIV ILSWVSFWIN MDAAPARVGL GITTVLTMTT 300
    QSSGSRASLP KVSYVKAIDI WMAVCLLFVF AALLEYAAIN FVSRQHKEFI 350
    RLRRRQRRQR LEEDIIQESR FYFRGYGLGH CLQARDGGPM EGSGIYSPQP 400
    PAPLLREGET TRKLYVD 417
    Length:417
    Mass (Da):47,728
    Last modified:November 3, 2009 - v3
    Checksum:i7F3B1A5B26B7F0E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z93848, AL049610 Genomic DNA. Translation: CAI41994.2.
    AL049610, Z93848 Genomic DNA. Translation: CAI42158.2.
    CCDSiCCDS43980.2.
    RefSeqiNP_001019623.2. NM_001024452.2.
    UniGeneiHs.533289.

    Genome annotation databases

    EnsembliENST00000372617; ENSP00000361700; ENSG00000188828.
    GeneIDi441509.
    KEGGihsa:441509.
    UCSCiuc010nou.2. human.

    Polymorphism databases

    DMDMi262527577.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z93848 , AL049610 Genomic DNA. Translation: CAI41994.2 .
    AL049610 , Z93848 Genomic DNA. Translation: CAI42158.2 .
    CCDSi CCDS43980.2.
    RefSeqi NP_001019623.2. NM_001024452.2.
    UniGenei Hs.533289.

    3D structure databases

    ProteinModelPortali Q5JXX5.
    SMRi Q5JXX5. Positions 55-349.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000361700.

    Chemistry

    GuidetoPHARMACOLOGYi 426.

    PTM databases

    PhosphoSitei Q5JXX5.

    Polymorphism databases

    DMDMi 262527577.

    Proteomic databases

    PaxDbi Q5JXX5.
    PRIDEi Q5JXX5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372617 ; ENSP00000361700 ; ENSG00000188828 .
    GeneIDi 441509.
    KEGGi hsa:441509.
    UCSCi uc010nou.2. human.

    Organism-specific databases

    CTDi 441509.
    GeneCardsi GC0XM102962.
    HGNCi HGNC:31715. GLRA4.
    HPAi HPA044759.
    neXtProti NX_Q5JXX5.
    PharmGKBi PA142671731.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG265706.
    HOGENOMi HOG000231336.
    HOVERGENi HBG051707.
    InParanoidi Q5JXX5.
    KOi K05271.
    OMAi SYREYPD.
    OrthoDBi EOG712TVZ.
    PhylomeDBi Q5JXX5.
    TreeFami TF315453.

    Enzyme and pathway databases

    Reactomei REACT_25387. Ligand-gated ion channel transport.

    Miscellaneous databases

    GeneWikii GLRA4.
    GenomeRNAii 441509.
    NextBioi 110250.
    PROi Q5JXX5.

    Gene expression databases

    Bgeei Q5JXX5.
    CleanExi HS_GLRA4.
    Genevestigatori Q5JXX5.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006028. GABAA/Glycine_rcpt.
    IPR008127. Glycine_rcpt_A.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00253. GABAARECEPTR.
    PR01673. GLYRALPHA.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiGLRA4_HUMAN
    AccessioniPrimary (citable) accession number: Q5JXX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 67 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The alpha subunit binds strychnine.By similarity

    Caution

    Is shorter at the N-terminus compared to its mouse ortholog due to the presence of a premature stop codon.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3