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Protein

Methyltransferase-like protein 24

Gene

METTL24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 24 (EC:2.1.1.-)
Gene namesi
Name:METTL24
Synonyms:C6orf186
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21566. METTL24.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000053328.
PharmGKBiPA134906793.

Polymorphism and mutation databases

BioMutaiMETTL24.
DMDMi205830266.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000034374330 – 366Methyltransferase-like protein 24Add BLAST337

Proteomic databases

EPDiQ5JXM2.
PaxDbiQ5JXM2.
PeptideAtlasiQ5JXM2.
PRIDEiQ5JXM2.

PTM databases

PhosphoSitePlusiQ5JXM2.

Expressioni

Gene expression databases

BgeeiENSG00000053328.

Organism-specific databases

HPAiHPA037441.
HPA037442.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000344071.

Structurei

3D structure databases

ProteinModelPortaliQ5JXM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHCM. Eukaryota.
ENOG410Y3P7. LUCA.
GeneTreeiENSGT00390000002881.
HOGENOMiHOG000111577.
HOVERGENiHBG107658.
InParanoidiQ5JXM2.
OMAiPRWHIDL.
OrthoDBiEOG091G08NE.
PhylomeDBiQ5JXM2.
TreeFamiTF330614.

Family and domain databases

InterProiView protein in InterPro
IPR025714. Methyltranfer_dom.
IPR026913. METTL24.
PANTHERiPTHR32026:SF13. PTHR32026:SF13. 1 hit.
PfamiView protein in Pfam
PF13383. Methyltransf_22. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5JXM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARERPPGRG CGVLRRCLLG AVLLFGLRLC AELRRAGPGS PTRSAPPGPA
60 70 80 90 100
WRPPGPHLPP APGQPRGASR RQVTYVRSGR RAPPGGGGSG TPEPGCCAPR
110 120 130 140 150
GRPRRKGPRW HIDLQPWAGS AQSLDEEAWR FLRYISTTQI ACNHMNTDSL
160 170 180 190 200
ATDSSPTHKP WSVCLDDRFN LAHQIRNKQC RLYSLGLGSD DTHFEVSMAN
210 220 230 240 250
NGCEVHRFDP SVKSAHILES QHLWYHRLSI DWRDPHPAVA AQKPHSNTRK
260 270 280 290 300
LGSILNEFGH HKIDVLKADL ESAEWKVLEN LILEDVLEQI GQLIFEIHLH
310 320 330 340 350
WPGFEVSGSD SSVVRFWYSL LKELEQKDFR LFHSYKDLSK PQLFLKKDIF
360
NASSCYTLSW VNTRWK
Length:366
Mass (Da):41,330
Last modified:February 5, 2008 - v1
Checksum:i8B9A3DCE659A846D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti308G → V in BAC86851 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_044502281L → F. Corresponds to variant dbSNP:rs2334321Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445068, AL050350 Genomic DNA. Translation: CAI22520.1.
AL050350, AL445068 Genomic DNA. Translation: CAI42513.1.
AK127146 mRNA. Translation: BAC86851.1.
CCDSiCCDS43489.1.
RefSeqiNP_001116836.1. NM_001123364.1.
UniGeneiHs.722171.

Genome annotation databases

EnsembliENST00000338882; ENSP00000344071; ENSG00000053328.
GeneIDi728464.
KEGGihsa:728464.
UCSCiuc010kdu.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMET24_HUMAN
AccessioniPrimary (citable) accession number: Q5JXM2
Secondary accession number(s): Q6ZSU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: February 5, 2008
Last modified: May 10, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries