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Protein
Submitted name:

Four and a half LIM domains protein 1

Gene

FHL1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Four and a half LIM domains protein 1Imported
Gene namesi
Name:FHL1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:3702. FHL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000022267.

PTM / Processingi

Proteomic databases

MaxQBiQ5JXI8.
PaxDbiQ5JXI8.
PeptideAtlasiQ5JXI8.
PRIDEiQ5JXI8.

Expressioni

Gene expression databases

BgeeiENSG00000022267.
ExpressionAtlasiQ5JXI8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000071281.

Structurei

3D structure databases

ProteinModelPortaliQ5JXI8.
SMRiQ5JXI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 98LIM zinc-bindingInterPro annotationAdd BLAST61
Domaini99 – 160LIM zinc-bindingInterPro annotationAdd BLAST62
Domaini161 – 219LIM zinc-bindingInterPro annotationAdd BLAST59
Domaini220 – 257LIM zinc-bindingInterPro annotationAdd BLAST38

Sequence similaritiesi

Contains 4 LIM zinc-binding domains.UniRule annotation

Keywords - Domaini

LIM domainUniRule annotation

Phylogenomic databases

eggNOGiENOG410INGD. Eukaryota.
ENOG410YDMU. LUCA.
GeneTreeiENSGT00760000118910.
HOGENOMiHOG000231075.
HOVERGENiHBG074526.

Family and domain databases

Gene3Di2.10.110.10. 5 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 4 hits.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 3 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5JXI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKFDCHYC RDPLQGKKYV QKDGHHCCLK CFDKFCANTC VECRKPIGAD
60 70 80 90 100
SKEVHYKNRF WHDTCFRCAK CLHPLANETF VAKDNKILCN KCTTREDSPK
110 120 130 140 150
CKGCFKAIVA GDQNVEYKGT VWHKDCFTCS NCKQVIGTGS FFPKGEDFYC
160 170 180 190 200
VTCHETKFAK HCVKCNKAIT SGGITYQDQP WHADCFVCVT CSKKLAGQRF
210 220 230 240 250
TAVEDQYYCV DCYKNFVAKK CAGCKNPITG FGKGSSVVAY EGQSWHDYCF

HCKKCSV
Length:257
Mass (Da):29,161
Last modified:February 15, 2005 - v1
Checksum:i7A32C9D9264AC6F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei257Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078638 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000370674; ENSP00000359708; ENSG00000022267.
UCSCiuc065bhl.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078638 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliQ5JXI8.
SMRiQ5JXI8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000071281.

Proteomic databases

MaxQBiQ5JXI8.
PaxDbiQ5JXI8.
PeptideAtlasiQ5JXI8.
PRIDEiQ5JXI8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370674; ENSP00000359708; ENSG00000022267.
UCSCiuc065bhl.1. human.

Organism-specific databases

HGNCiHGNC:3702. FHL1.
OpenTargetsiENSG00000022267.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INGD. Eukaryota.
ENOG410YDMU. LUCA.
GeneTreeiENSGT00760000118910.
HOGENOMiHOG000231075.
HOVERGENiHBG074526.

Miscellaneous databases

ChiTaRSiFHL1. human.

Gene expression databases

BgeeiENSG00000022267.
ExpressionAtlasiQ5JXI8. baseline and differential.

Family and domain databases

Gene3Di2.10.110.10. 5 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 4 hits.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 3 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5JXI8_HUMAN
AccessioniPrimary (citable) accession number: Q5JXI8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: November 30, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.