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Protein

Putative ubiquitin-conjugating enzyme E2 N-like

Gene

UBE2NL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Could be inactive as a ligase. The potential active site Cys residue in position 88 is replaced by a Ser.Curated

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ5JXB2

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ubiquitin-conjugating enzyme E2 N-like
Alternative name(s):
Epididymis tissue protein Li 174
Gene namesi
Name:UBE2NL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:31710 UBE2NL
neXtProtiNX_Q5JXB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134943659

Polymorphism and mutation databases

DMDMi74742728

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710871 – 153Putative ubiquitin-conjugating enzyme E2 N-likeAdd BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ5JXB2
MaxQBiQ5JXB2
PaxDbiQ5JXB2
PeptideAtlasiQ5JXB2
PRIDEiQ5JXB2

PTM databases

iPTMnetiQ5JXB2
PhosphoSitePlusiQ5JXB2
SwissPalmiQ5JXB2

Expressioni

Tissue specificityi

Expressed in epididymis (at protein level).1 Publication

Gene expression databases

CleanExiHS_UBE2NL

Organism-specific databases

HPAiHPA044976

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1333173 interactors.
IntActiQ5JXB2 2 interactors.
STRINGi9606.ENSP00000359525

Structurei

3D structure databases

ProteinModelPortaliQ5JXB2
SMRiQ5JXB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0417 Eukaryota
COG5078 LUCA
HOGENOMiHOG000233455
HOVERGENiHBG063308
InParanoidiQ5JXB2
KOiK10580
PhylomeDBiQ5JXB2
TreeFamiTF101126

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.101 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5JXB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELPHRIIK ETQRLLAEPV PGIKAEPDES NARYFHVVIA GESKDSPFEG
60 70 80 90 100
GTFKRELLLA EEYPMAAPKV RFMTKIYHPN VDKLERISLD ILKDKWSPAL
110 120 130 140 150
QIRTVLLSIQ ALLNAPNPDD PLANDVVEQW KTNEAQAIET ARAWTRLYAM

NSI
Length:153
Mass (Da):17,377
Last modified:February 15, 2005 - v1
Checksum:i462536F5533F2230
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU727624 mRNA Translation: ADU87626.1
AL109622 Genomic DNA Translation: CAB72341.1
RefSeqiNP_001013007.1, NM_001012989.2
UniGeneiHs.585177

Genome annotation databases

GeneIDi389898
KEGGihsa:389898

Similar proteinsi

Entry informationi

Entry nameiUE2NL_HUMAN
AccessioniPrimary (citable) accession number: Q5JXB2
Secondary accession number(s): E9KL27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 15, 2005
Last modified: February 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome