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Protein

Putative ubiquitin-conjugating enzyme E2 N-like

Gene

UBE2NL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ5JXB2.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ubiquitin-conjugating enzyme E2 N-like
Alternative name(s):
Epididymis tissue protein Li 174
Gene namesi
Name:UBE2NL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:31710. UBE2NL.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • nucleus Source: GO_Central

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134943659.

Polymorphism and mutation databases

DMDMi74742728.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710871 – 153Putative ubiquitin-conjugating enzyme E2 N-likeAdd BLAST153

Proteomic databases

EPDiQ5JXB2.
MaxQBiQ5JXB2.
PaxDbiQ5JXB2.
PeptideAtlasiQ5JXB2.
PRIDEiQ5JXB2.

PTM databases

iPTMnetiQ5JXB2.
PhosphoSitePlusiQ5JXB2.
SwissPalmiQ5JXB2.

Expressioni

Tissue specificityi

Expressed in epididymis (at protein level).1 Publication

Gene expression databases

CleanExiHS_UBE2NL.

Organism-specific databases

HPAiHPA044976.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi133317. 3 interactors.
IntActiQ5JXB2. 2 interactors.
STRINGi9606.ENSP00000359525.

Structurei

3D structure databases

ProteinModelPortaliQ5JXB2.
SMRiQ5JXB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0417. Eukaryota.
COG5078. LUCA.
HOGENOMiHOG000233455.
HOVERGENiHBG063308.
InParanoidiQ5JXB2.
KOiK10580.
PhylomeDBiQ5JXB2.
TreeFamiTF101126.

Family and domain databases

CDDicd00195. UBCc. 1 hit.
Gene3Di3.10.110.10. 1 hit.
InterProiView protein in InterPro
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
PfamiView protein in Pfam
PF00179. UQ_con. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiView protein in PROSITE
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5JXB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELPHRIIK ETQRLLAEPV PGIKAEPDES NARYFHVVIA GESKDSPFEG
60 70 80 90 100
GTFKRELLLA EEYPMAAPKV RFMTKIYHPN VDKLERISLD ILKDKWSPAL
110 120 130 140 150
QIRTVLLSIQ ALLNAPNPDD PLANDVVEQW KTNEAQAIET ARAWTRLYAM

NSI
Length:153
Mass (Da):17,377
Last modified:February 15, 2005 - v1
Checksum:i462536F5533F2230
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU727624 mRNA. Translation: ADU87626.1.
AL109622 Genomic DNA. Translation: CAB72341.1.
RefSeqiNP_001013007.1. NM_001012989.2.
UniGeneiHs.585177.

Genome annotation databases

GeneIDi389898.
KEGGihsa:389898.

Similar proteinsi

Entry informationi

Entry nameiUE2NL_HUMAN
AccessioniPrimary (citable) accession number: Q5JXB2
Secondary accession number(s): E9KL27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 15, 2005
Last modified: August 30, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be inactive as a ligase. The potential active site Cys residue in position 88 is replaced by a Ser.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families