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Protein

Signal-regulatory protein beta-2

Gene

SIRPB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-regulatory protein beta-2
Short name:
SIRP-beta-2
Alternative name(s):
Protein tyrosine phosphatase non-receptor type substrate 1-like 3
Protein tyrosine phosphatase non-receptor type substrate protein
Gene namesi
Name:SIRPB2
Synonyms:PTPN1L, PTPNS1L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16247. SIRPB2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 287ExtracellularSequence analysisAdd BLAST255
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Topological domaini309 – 342CytoplasmicSequence analysisAdd BLAST34

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196209.
PharmGKBiPA164742382.

Polymorphism and mutation databases

BioMutaiSIRPB2.
DMDMi74762205.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000033862933 – 342Signal-regulatory protein beta-2Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60 ↔ 127PROSITE-ProRule annotation
Glycosylationi116N-linked (GlcNAc...)Sequence analysis1
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi180 ↔ 242PROSITE-ProRule annotation
Glycosylationi231N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5JXA9.
PeptideAtlasiQ5JXA9.
PRIDEiQ5JXA9.

PTM databases

iPTMnetiQ5JXA9.
PhosphoSitePlusiQ5JXA9.

Expressioni

Gene expression databases

BgeeiENSG00000196209.
ExpressionAtlasiQ5JXA9. baseline and differential.
GenevisibleiQ5JXA9. HS.

Organism-specific databases

HPAiHPA011548.
HPA048032.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352849.

Structurei

3D structure databases

ProteinModelPortaliQ5JXA9.
SMRiQ5JXA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 143Ig-like V-type 1Add BLAST111
Domaini157 – 258Ig-like V-type 2Add BLAST102

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0R4. Eukaryota.
ENOG410ZC9B. LUCA.
GeneTreeiENSGT00440000033339.
HOGENOMiHOG000154328.
HOVERGENiHBG102811.
InParanoidiQ5JXA9.
KOiK16826.
OMAiEHTGTYH.
OrthoDBiEOG091G0ASC.
PhylomeDBiQ5JXA9.
TreeFamiTF341862.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JXA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCSTMSAPTC LAHLPPCFLL LALVLVPSDA SGQSSRNDWQ VLQPEGPMLV
60 70 80 90 100
AEGETLLLRC MVVGSCTDGM IKWVKVSTQD QQEIYNFKRG SFPGVMPMIQ
110 120 130 140 150
RTSEPLNCDY SIYIHNVTRE HTGTYHCVRF DGLSEHSEMK SDEGTSVLVK
160 170 180 190 200
GAGDPEPDLW IIQPQELVLG TTGDTVFLNC TVLGDGPPGP IRWFQGAGLS
210 220 230 240 250
REAIYNFGGI SHPKETAVQA SNNDFSILLQ NVSSEDAGTY YCVKFQRKPN
260 270 280 290 300
RQYLSGQGTS LKVKAKSTSS KEAEFTSEPA TEMSPTGLLV VFAPVVLGLK
310 320 330 340
AITLAALLLA LATSRRSPGQ EDVKTTGPAG AMNTLAWSKG QE
Length:342
Mass (Da):36,968
Last modified:February 15, 2005 - v1
Checksum:i5D0B35E6FD8E29B9
GO
Isoform 2 (identifier: Q5JXA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-150: Missing.
     290-342: Missing.

Note: No experimental confirmation available.
Show »
Length:191
Mass (Da):20,435
Checksum:i2AFCF082F1DD42D8
GO
Isoform 3 (identifier: Q5JXA9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-150: Missing.

Note: No experimental confirmation available.
Show »
Length:244
Mass (Da):25,837
Checksum:iC51D91A02EC4826E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289L → Q in AAR04783 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043814153G → E.Corresponds to variant rs6033876dbSNPEnsembl.1
Natural variantiVAR_043815215E → A.2 PublicationsCorresponds to variant rs6042507dbSNPEnsembl.1
Natural variantiVAR_043816304L → F.Corresponds to variant rs8119290dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03406553 – 150Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST98
Alternative sequenceiVSP_034066290 – 342Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424277 mRNA. Translation: AAR04783.1.
AK297072 mRNA. Translation: BAG59591.1.
AL109658 Genomic DNA. Translation: CAI22734.1.
CCDSiCCDS42849.1. [Q5JXA9-1]
CCDS46570.1. [Q5JXA9-3]
RefSeqiNP_001116434.1. NM_001122962.1. [Q5JXA9-1]
NP_001128308.1. NM_001134836.1. [Q5JXA9-3]
UniGeneiHs.721685.

Genome annotation databases

EnsembliENST00000359801; ENSP00000352849; ENSG00000196209. [Q5JXA9-1]
ENST00000444444; ENSP00000402438; ENSG00000196209. [Q5JXA9-3]
GeneIDi284759.
KEGGihsa:284759.
UCSCiuc002wfg.3. human. [Q5JXA9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424277 mRNA. Translation: AAR04783.1.
AK297072 mRNA. Translation: BAG59591.1.
AL109658 Genomic DNA. Translation: CAI22734.1.
CCDSiCCDS42849.1. [Q5JXA9-1]
CCDS46570.1. [Q5JXA9-3]
RefSeqiNP_001116434.1. NM_001122962.1. [Q5JXA9-1]
NP_001128308.1. NM_001134836.1. [Q5JXA9-3]
UniGeneiHs.721685.

3D structure databases

ProteinModelPortaliQ5JXA9.
SMRiQ5JXA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000352849.

PTM databases

iPTMnetiQ5JXA9.
PhosphoSitePlusiQ5JXA9.

Polymorphism and mutation databases

BioMutaiSIRPB2.
DMDMi74762205.

Proteomic databases

PaxDbiQ5JXA9.
PeptideAtlasiQ5JXA9.
PRIDEiQ5JXA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359801; ENSP00000352849; ENSG00000196209. [Q5JXA9-1]
ENST00000444444; ENSP00000402438; ENSG00000196209. [Q5JXA9-3]
GeneIDi284759.
KEGGihsa:284759.
UCSCiuc002wfg.3. human. [Q5JXA9-1]

Organism-specific databases

CTDi284759.
GeneCardsiSIRPB2.
HGNCiHGNC:16247. SIRPB2.
HPAiHPA011548.
HPA048032.
neXtProtiNX_Q5JXA9.
OpenTargetsiENSG00000196209.
PharmGKBiPA164742382.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0R4. Eukaryota.
ENOG410ZC9B. LUCA.
GeneTreeiENSGT00440000033339.
HOGENOMiHOG000154328.
HOVERGENiHBG102811.
InParanoidiQ5JXA9.
KOiK16826.
OMAiEHTGTYH.
OrthoDBiEOG091G0ASC.
PhylomeDBiQ5JXA9.
TreeFamiTF341862.

Miscellaneous databases

ChiTaRSiSIRPB2. human.
GenomeRNAii284759.
PROiQ5JXA9.

Gene expression databases

BgeeiENSG00000196209.
ExpressionAtlasiQ5JXA9. baseline and differential.
GenevisibleiQ5JXA9. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIRB2_HUMAN
AccessioniPrimary (citable) accession number: Q5JXA9
Secondary accession number(s): B4DLM9, E9PCW6, Q6TCH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.