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Protein

Signal-regulatory protein beta-2

Gene

SIRPB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-regulatory protein beta-2
Short name:
SIRP-beta-2
Alternative name(s):
Protein tyrosine phosphatase non-receptor type substrate 1-like 3
Protein tyrosine phosphatase non-receptor type substrate protein
Gene namesi
Name:SIRPB2
Synonyms:PTPN1L, PTPNS1L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16247. SIRPB2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 287255ExtracellularSequence analysisAdd
BLAST
Transmembranei288 – 30821HelicalSequence analysisAdd
BLAST
Topological domaini309 – 34234CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164742382.

Polymorphism and mutation databases

BioMutaiSIRPB2.
DMDMi74762205.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 342310Signal-regulatory protein beta-2PRO_0000338629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi60 ↔ 127PROSITE-ProRule annotation
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence analysis
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence analysis
Disulfide bondi180 ↔ 242PROSITE-ProRule annotation
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5JXA9.
PRIDEiQ5JXA9.

PTM databases

PhosphoSiteiQ5JXA9.

Expressioni

Gene expression databases

BgeeiQ5JXA9.
ExpressionAtlasiQ5JXA9. baseline and differential.
GenevisibleiQ5JXA9. HS.

Organism-specific databases

HPAiHPA011548.
HPA048032.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352849.

Structurei

3D structure databases

ProteinModelPortaliQ5JXA9.
SMRiQ5JXA9. Positions 40-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 143111Ig-like V-type 1Add
BLAST
Domaini157 – 258102Ig-like V-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0R4. Eukaryota.
ENOG410ZC9B. LUCA.
GeneTreeiENSGT00440000033339.
HOGENOMiHOG000154328.
HOVERGENiHBG102811.
InParanoidiQ5JXA9.
KOiK16826.
OMAiMKSDEGT.
OrthoDBiEOG7J70GW.
PhylomeDBiQ5JXA9.
TreeFamiTF341862.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JXA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCSTMSAPTC LAHLPPCFLL LALVLVPSDA SGQSSRNDWQ VLQPEGPMLV
60 70 80 90 100
AEGETLLLRC MVVGSCTDGM IKWVKVSTQD QQEIYNFKRG SFPGVMPMIQ
110 120 130 140 150
RTSEPLNCDY SIYIHNVTRE HTGTYHCVRF DGLSEHSEMK SDEGTSVLVK
160 170 180 190 200
GAGDPEPDLW IIQPQELVLG TTGDTVFLNC TVLGDGPPGP IRWFQGAGLS
210 220 230 240 250
REAIYNFGGI SHPKETAVQA SNNDFSILLQ NVSSEDAGTY YCVKFQRKPN
260 270 280 290 300
RQYLSGQGTS LKVKAKSTSS KEAEFTSEPA TEMSPTGLLV VFAPVVLGLK
310 320 330 340
AITLAALLLA LATSRRSPGQ EDVKTTGPAG AMNTLAWSKG QE
Length:342
Mass (Da):36,968
Last modified:February 15, 2005 - v1
Checksum:i5D0B35E6FD8E29B9
GO
Isoform 2 (identifier: Q5JXA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-150: Missing.
     290-342: Missing.

Note: No experimental confirmation available.
Show »
Length:191
Mass (Da):20,435
Checksum:i2AFCF082F1DD42D8
GO
Isoform 3 (identifier: Q5JXA9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-150: Missing.

Note: No experimental confirmation available.
Show »
Length:244
Mass (Da):25,837
Checksum:iC51D91A02EC4826E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti289 – 2891L → Q in AAR04783 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti153 – 1531G → E.
Corresponds to variant rs6033876 [ dbSNP | Ensembl ].
VAR_043814
Natural varianti215 – 2151E → A.2 Publications
Corresponds to variant rs6042507 [ dbSNP | Ensembl ].
VAR_043815
Natural varianti304 – 3041L → F.
Corresponds to variant rs8119290 [ dbSNP | Ensembl ].
VAR_043816

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei53 – 15098Missing in isoform 2 and isoform 3. 2 PublicationsVSP_034065Add
BLAST
Alternative sequencei290 – 34253Missing in isoform 2. 1 PublicationVSP_034066Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424277 mRNA. Translation: AAR04783.1.
AK297072 mRNA. Translation: BAG59591.1.
AL109658 Genomic DNA. Translation: CAI22734.1.
CCDSiCCDS42849.1. [Q5JXA9-1]
CCDS46570.1. [Q5JXA9-3]
RefSeqiNP_001116434.1. NM_001122962.1. [Q5JXA9-1]
NP_001128308.1. NM_001134836.1. [Q5JXA9-3]
UniGeneiHs.721685.

Genome annotation databases

EnsembliENST00000359801; ENSP00000352849; ENSG00000196209. [Q5JXA9-1]
ENST00000444444; ENSP00000402438; ENSG00000196209. [Q5JXA9-3]
GeneIDi284759.
KEGGihsa:284759.
UCSCiuc002wfg.3. human. [Q5JXA9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424277 mRNA. Translation: AAR04783.1.
AK297072 mRNA. Translation: BAG59591.1.
AL109658 Genomic DNA. Translation: CAI22734.1.
CCDSiCCDS42849.1. [Q5JXA9-1]
CCDS46570.1. [Q5JXA9-3]
RefSeqiNP_001116434.1. NM_001122962.1. [Q5JXA9-1]
NP_001128308.1. NM_001134836.1. [Q5JXA9-3]
UniGeneiHs.721685.

3D structure databases

ProteinModelPortaliQ5JXA9.
SMRiQ5JXA9. Positions 40-285.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000352849.

PTM databases

PhosphoSiteiQ5JXA9.

Polymorphism and mutation databases

BioMutaiSIRPB2.
DMDMi74762205.

Proteomic databases

PaxDbiQ5JXA9.
PRIDEiQ5JXA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359801; ENSP00000352849; ENSG00000196209. [Q5JXA9-1]
ENST00000444444; ENSP00000402438; ENSG00000196209. [Q5JXA9-3]
GeneIDi284759.
KEGGihsa:284759.
UCSCiuc002wfg.3. human. [Q5JXA9-1]

Organism-specific databases

CTDi284759.
GeneCardsiSIRPB2.
HGNCiHGNC:16247. SIRPB2.
HPAiHPA011548.
HPA048032.
neXtProtiNX_Q5JXA9.
PharmGKBiPA164742382.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0R4. Eukaryota.
ENOG410ZC9B. LUCA.
GeneTreeiENSGT00440000033339.
HOGENOMiHOG000154328.
HOVERGENiHBG102811.
InParanoidiQ5JXA9.
KOiK16826.
OMAiMKSDEGT.
OrthoDBiEOG7J70GW.
PhylomeDBiQ5JXA9.
TreeFamiTF341862.

Miscellaneous databases

ChiTaRSiSIRPB2. human.
GenomeRNAii284759.
NextBioi95105.
PROiQ5JXA9.

Gene expression databases

BgeeiQ5JXA9.
ExpressionAtlasiQ5JXA9. baseline and differential.
GenevisibleiQ5JXA9. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Li H., Zhong G., Zheng G., Ke R., Zhou G., Shen C., Lin L., Yang S.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ALA-215.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ALA-215.
    Tissue: Umbilical cord blood.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSIRB2_HUMAN
AccessioniPrimary (citable) accession number: Q5JXA9
Secondary accession number(s): B4DLM9, E9PCW6, Q6TCH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 15, 2005
Last modified: May 11, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.