Q5JX71 (F209A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM209A

Gene names

Name:	FAM209A
Synonyms:	C20orf106

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the FAM209 family.
Sequence caution	The sequence AAH29411.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Coiled coil Signal Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 171	152	Protein FAM209A		PRO_0000264155
Regions
	Topological domain	20 – 52	33	Extracellular Potential
	Transmembrane	53 – 73	21	Helical; Potential
	Topological domain	74 – 171	98	Cytoplasmic Potential
	Coiled coil	114 – 139	26	Potential
Natural variations
	Natural variant	66	1	V → A. Corresponds to variant rs707554 [ dbSNP | Ensembl ].		VAR_029621
	Natural variant	95	1	L → F. Corresponds to variant rs1054343 [ dbSNP | Ensembl ].		VAR_033761
	Natural variant	117	1	M → K. Corresponds to variant rs1054349 [ dbSNP | Ensembl ].		VAR_029622
	Natural variant	135	1	R → G. Corresponds to variant rs1054358 [ dbSNP | Ensembl ].		VAR_029623
	Natural variant	146	1	R → K. Corresponds to variant rs1054361 [ dbSNP | Ensembl ].		VAR_029624
Experimental info
	Sequence conflict	98	1	P → L in AAH29411. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q5JX71 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 2CBB21C35AF9623A	FASTA	171	19,603
	10 20 30 40 50 60 MWTLKSSLVL LLCLTCSYAF MFSSLRQKTS EPQGKVQYGE HFRIRQNLPE HTQGWLGSKW 70 80 90 100 110 120 LWLLFVVVPF VILQCQRDSE KNKEQSPPGL RGGQLHSPLK KKRNASPNKD CAFNTLMELE 130 140 150 160 170 VELMKFVSKV RNLKRAMATG SGSNLRLRKS EMPADPYHVT ICEIWGEESS S

References

[1]

"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL109806 Genomic DNA. Translation: CAI19289.1. BC029411 mRNA. Translation: AAH29411.1. Sequence problems. BC107704 mRNA. Translation: AAI07705.1.
IPI	IPI00303732.
RefSeq	NP_001012989.2. NM_001012971.3.
UniGene	Hs.504907.
3D structure databases
ProteinModelPortal	Q5JX71.
ModBase	Search...
Polymorphism databases
DMDM	74742707.
Proteomic databases
PRIDE	Q5JX71.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371328; ENSP00000360379; ENSG00000124103.
GeneID	200232.
KEGG	hsa:200232.
UCSC	uc002xxx.1. human.
Organism-specific databases
CTD	200232.
GeneCards	GC20P055092.
HGNC	HGNC:16100. FAM209A.
HPA	HPA042756.
neXtProt	NX_Q5JX71.
PharmGKB	PA134974173.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20136.
GeneTree	ENSGT00390000005057.
HOGENOM	HBG281842.
HOVERGEN	HBG056390.
InParanoid	Q5JX71.
OMA	TIYEIWG.
OrthoDB	EOG4THVVB.
Gene expression databases
CleanEx	HS_C20orf106.
Genevestigator	Q5JX71.
GermOnline	ENSG00000124103. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	89874.

Entry information

Entry name

F209A_HUMAN

Accession

Primary (citable) accession number: Q5JX71
Secondary accession number(s): Q05C43

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	February 15, 2005
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.