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Protein

Protein FAM209A

Gene

FAM209A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM209A
Gene namesi
Name:FAM209A
Synonyms:C20orf106
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000124103.8.
HGNCiHGNC:16100. FAM209A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 52ExtracellularSequence analysisAdd BLAST33
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 171CytoplasmicSequence analysisAdd BLAST98

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124103.
PharmGKBiPA134974173.

Polymorphism and mutation databases

BioMutaiFAM209A.
DMDMi74742707.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000026415520 – 171Protein FAM209AAdd BLAST152

Proteomic databases

PaxDbiQ5JX71.
PeptideAtlasiQ5JX71.
PRIDEiQ5JX71.

PTM databases

PhosphoSitePlusiQ5JX71.

Expressioni

Gene expression databases

BgeeiENSG00000124103.
CleanExiHS_C20orf106.

Interactioni

Protein-protein interaction databases

BioGridi128313. 1 interactor.
STRINGi9606.ENSP00000360379.

Structurei

3D structure databases

ProteinModelPortaliQ5JX71.
SMRiQ5JX71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili114 – 139Sequence analysisAdd BLAST26

Sequence similaritiesi

Belongs to the FAM209 family.Curated

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWYA. Eukaryota.
ENOG4111CPN. LUCA.
GeneTreeiENSGT00390000005057.
HOGENOMiHOG000115798.
HOVERGENiHBG056390.
InParanoidiQ5JX71.
OMAiNKDCAFN.
OrthoDBiEOG091G0TAG.
PhylomeDBiQ5JX71.
TreeFamiTF338191.

Family and domain databases

InterProiView protein in InterPro
IPR027943. FAM209.
PANTHERiPTHR35157. PTHR35157. 1 hit.
PfamiView protein in Pfam
PF15206. FAM209. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5JX71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTLKSSLVL LLCLTCSYAF MFSSLRQKTS EPQGKVQYGE HFRIRQNLPE
60 70 80 90 100
HTQGWLGSKW LWLLFVVVPF VILQCQRDSE KNKEQSPPGL RGGQLHSPLK
110 120 130 140 150
KKRNASPNKD CAFNTLMELE VELMKFVSKV RNLKRAMATG SGSNLRLRKS
160 170
EMPADPYHVT ICEIWGEESS S
Length:171
Mass (Da):19,603
Last modified:February 15, 2005 - v1
Checksum:i2CBB21C35AF9623A
GO

Sequence cautioni

The sequence AAH29411 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98P → L in AAH29411 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02962166V → A. Corresponds to variant dbSNP:rs707554Ensembl.1
Natural variantiVAR_03376195L → F. Corresponds to variant dbSNP:rs1054343Ensembl.1
Natural variantiVAR_029622117M → K. Corresponds to variant dbSNP:rs1054349Ensembl.1
Natural variantiVAR_029623135R → G. Corresponds to variant dbSNP:rs1054358Ensembl.1
Natural variantiVAR_029624146R → K. Corresponds to variant dbSNP:rs1054361Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109806 Genomic DNA. No translation available.
BC029411 mRNA. Translation: AAH29411.1. Sequence problems.
BC107704 mRNA. Translation: AAI07705.1.
CCDSiCCDS33493.1.
RefSeqiNP_001012989.2. NM_001012971.3.
UniGeneiHs.504907.

Genome annotation databases

EnsembliENST00000371328; ENSP00000360379; ENSG00000124103.
GeneIDi200232.
KEGGihsa:200232.
UCSCiuc002xxx.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF209A_HUMAN
AccessioniPrimary (citable) accession number: Q5JX71
Secondary accession number(s): Q05C43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: February 15, 2005
Last modified: November 22, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families