Q5JX69 (F209B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM209B

Gene names

Name:	FAM209B
Synonyms:	C20orf107

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the FAM209 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 171	152	Protein FAM209B		PRO_0000236040
Regions
	Topological domain	20 – 52	33	Extracellular Potential
	Transmembrane	53 – 73	21	Helical; Potential
	Topological domain	74 – 171	98	Cytoplasmic Potential
Amino acid modifications
	Modified residue	141	1	Phosphoserine Ref.3
	Modified residue	143	1	Phosphoserine Ref.3
Natural variations
	Natural variant	74	1	Q → K. Ref.2 Corresponds to variant rs3209183 [ dbSNP | Ensembl ].		VAR_050918
	Natural variant	84	1	E → K. Corresponds to variant rs61440263 [ dbSNP | Ensembl ].		VAR_061633
	Natural variant	129	1	E → A. Corresponds to variant rs2296129 [ dbSNP | Ensembl ].		VAR_033762
Experimental info
	Sequence conflict	37 – 38	2	PC → QY in AAI05793. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q5JX69 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 8B24B54EB89505A8	FASTA	171	19,499
	10 20 30 40 50 60 MWTLKSSLVL LLCLTCSYAF MFSSLRQKTS EPQGKVPCGE HFRIRQNLPE HTQGWLGSKW 70 80 90 100 110 120 LWLLFAVVPF VILQCQRDSE KNKEQSPPGL RGFPFRTPLK KNQNASLYKD CVFNTLNELE 130 140 150 160 170 VELLKFVSEV QNLKGAMATG SGSNLKLRRS EMPADPYHVT ICKIWGEESS S

References

[1]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-74. Tissue: Testis.
[3]	"Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation." Ficarro S., Chertihin O., Westbrook V.A., White F., Jayes F., Kalab P., Marto J.A., Shabanowitz J., Herr J.C., Hunt D.F., Visconti P.E. J. Biol. Chem. 278:11579-11589(2003) [PubMed: 12509440] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141 AND SER-143, MASS SPECTROMETRY. Tissue: Sperm.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL109806 Genomic DNA. Translation: CAI19291.1. BC105792 mRNA. Translation: AAI05793.1.
IPI	IPI00374077.
RefSeq	NP_001013668.2. NM_001013646.2.
UniGene	Hs.287759.
3D structure databases
ProteinModelPortal	Q5JX69.
ModBase	Search...
PTM databases
PhosphoSite	Q5JX69.
Polymorphism databases
DMDM	74742706.
Proteomic databases
PRIDE	Q5JX69.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371325; ENSP00000360376; ENSG00000213714.
GeneID	388799.
KEGG	hsa:388799.
UCSC	uc002xxy.1. human.
Organism-specific databases
CTD	388799.
GeneCards	GC20P055108.
HGNC	HGNC:16101. FAM209B.
HPA	HPA042144.
neXtProt	NX_Q5JX69.
PharmGKB	PA25646.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000005057.
HOGENOM	HBG281842.
HOVERGEN	HBG056390.
InParanoid	Q5JX69.
OMA	LPEYAQG.
OrthoDB	EOG4THVVB.
Gene expression databases
ArrayExpress	Q5JX69.
Bgee	Q5JX69.
CleanEx	HS_C20orf107.
Genevestigator	Q5JX69.
GermOnline	ENSG00000124103. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	102369.

Entry information

Entry name

F209B_HUMAN

Accession

Primary (citable) accession number: Q5JX69
Secondary accession number(s): Q3KRB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	February 15, 2005
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.