Reviewed, UniProtKB/Swiss-Prot Q5JX69 (CT107_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C20orf107

Gene names

Name:

C20orf107

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 171	152	Uncharacterized protein C20orf107		PRO_0000236040
Regions
	Topological domain	20 – 52	33	Extracellular Potential
	Transmembrane	53 – 73	21	Potential
	Topological domain	74 – 171	98	Cytoplasmic Potential
Amino acid modifications
	Modified residue	141	1	Phosphoserine Ref.3
	Modified residue	143	1	Phosphoserine Ref.3
Natural variations
	Natural variant	74	1	Q → K: dbSNP rs3209183. Ref.2		VAR_050918
	Natural variant	129	1	E → A: dbSNP rs2296129.		VAR_033762
Experimental info
	Sequence conflict	37 – 38	2	PC → QY in AAI05793. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q5JX69-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 8B24B54EB89505A8	FASTA	171	19,499
	10 20 30 40 50 60 MWTLKSSLVL LLCLTCSYAF MFSSLRQKTS EPQGKVPCGE HFRIRQNLPE HTQGWLGSKW 70 80 90 100 110 120 LWLLFAVVPF VILQCQRDSE KNKEQSPPGL RGFPFRTPLK KNQNASLYKD CVFNTLNELE 130 140 150 160 170 VELLKFVSEV QNLKGAMATG SGSNLKLRRS EMPADPYHVT ICKIWGEESS S

References

[1]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-74. Tissue: Testis.
[3]	"Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation." Ficarro S., Chertihin O., Westbrook V.A., White F., Jayes F., Kalab P., Marto J.A., Shabanowitz J., Herr J.C., Hunt D.F., Visconti P.E. J. Biol. Chem. 278:11579-11589(2003) [PubMed: 12509440] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141 AND SER-143, MASS SPECTROMETRY. Tissue: Sperm.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL109806 Genomic DNA. Translation: CAI19291.1. BC105792 mRNA. Translation: AAI05793.1.
IPI	IPI00374077.
RefSeq	NP_001013668.2.
UniGene	Hs.287759
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q5JX69.
Genome annotation databases
Ensembl	ENST00000371325; ENSP00000360376; ENSG00000213714; Homo sapiens. [Genome view]
GeneID	388799.
KEGG	hsa:388799.
UCSC	uc002xxy.1. human.
Organism-specific databases
CTD	388799.
GeneCards	GC20P054541.
HGNC	HGNC:16101. C20orf107.
PharmGKB	PA25646.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q5JX69.
OMA	LPEYAQG
OrthoDB	EOG9D81SD
Gene expression databases
ArrayExpress	Q5JX69.
Bgee	Q5JX69.
CleanEx	HS_C20orf107.
Genevestigator	Q5JX69.
GermOnline	ENSG00000124103. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	102369.

Entry information

Entry name

CT107_HUMAN

Accession

Primary (citable) accession number: Q5JX69
Secondary accession number(s): Q3KRB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	February 15, 2005
Last modified:	November 24, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.