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Protein

Protein dopey-1

Gene

DOPEY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in protein traffic between late Golgi and early endosomes.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein dopey-1
Gene namesi
Name:DOPEY1
Synonyms:KIAA1117
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21194. DOPEY1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134924787.

Polymorphism and mutation databases

BioMutaiDOPEY1.
DMDMi156630499.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24652465Protein dopey-1PRO_0000297947Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1266 – 12661PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5JWR5.
MaxQBiQ5JWR5.
PaxDbiQ5JWR5.
PeptideAtlasiQ5JWR5.
PRIDEiQ5JWR5.

PTM databases

iPTMnetiQ5JWR5.
PhosphoSiteiQ5JWR5.

Expressioni

Gene expression databases

BgeeiQ5JWR5.
CleanExiHS_DOPEY1.
ExpressionAtlasiQ5JWR5. baseline and differential.
GenevisibleiQ5JWR5. HS.

Organism-specific databases

HPAiHPA027902.
HPA027904.

Interactioni

Protein-protein interaction databases

BioGridi116672. 1 interaction.
STRINGi9606.ENSP00000195654.

Structurei

3D structure databases

ProteinModelPortaliQ5JWR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dopey family.Curated

Phylogenomic databases

eggNOGiKOG3613. Eukaryota.
COG5221. LUCA.
GeneTreeiENSGT00390000016421.
HOGENOMiHOG000043862.
HOVERGENiHBG051222.
InParanoidiQ5JWR5.
OrthoDBiEOG7992PM.
PhylomeDBiQ5JWR5.
TreeFamiTF316855.

Family and domain databases

InterProiIPR007249. Dopey_N.
[Graphical view]
PfamiPF04118. Dopey_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JWR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTEELELLS DSKYRNYVAA IDKALKNFEY SSEWADLISA LGKLNKVLQN
60 70 80 90 100
NAKYQVVPKK LTIGKRLAQC LHPALPGGVH RKALETYEII FKIIGPKRLA
110 120 130 140 150
KDLFLYSSGL FPLLANAAMS VKPTLLSLYE IYYLPLGKTL KPGLQGLLTG
160 170 180 190 200
ILPGLEEGSE YYERTNMLLE KVAAAVDQSA FYSALWGSLL TSPAVRLPGI
210 220 230 240 250
TYVLAHLNRK LSMEDQLYII GSDIELMVEA VSTSVQDSSV LVQRSTLDLI
260 270 280 290 300
LFCFPFHMSQ ATRPDMIRIL SAALHVVLRR DMSLNRRLYA WLLGFDNNGA
310 320 330 340 350
IIGPRSTRHS NPEEHATYYF TTFSKELLVQ AMVGILQVNG FGEENTLMQD
360 370 380 390 400
LKPFRILISL LDKPELGPVI LEDVLIEVFR TLYSQCKAEL DLQTEPPFSK
410 420 430 440 450
DHAQLSSKLR ENKKTAELIK TANLLFNSFE PYYMWDYVAR WFEECCRRTL
460 470 480 490 500
HVRLQIGPGD SNDSSELQLT NFCLLVDFLL DIVSLPTRSM RVLCQETYIE
510 520 530 540 550
IQTEHLPQLL LRMISALTSH LQTLHLSELT DSLRLCSKIL SKVQPPLLSA
560 570 580 590 600
STGGVLQFPS GQNNSVKEWE DKKVSSVSHE NPTEVFEDGE NPPSSRSSES
610 620 630 640 650
GFTEFIQYQA DRTDDIDREL SEGQGAAAIP IGSTSSETET ASTVGSEETI
660 670 680 690 700
IQTPSVVTQG TATRSRKTAQ KTAMQCCLEY VQQFLTRLIN LYIIQNNSFS
710 720 730 740 750
QSLATEHQGD LGREQGETSK WDRNSQGDVK EKNISKQKTS KEYLSAFLAA
760 770 780 790 800
CQLFLECSSF PVYIAEGNHT SELRSEKLET DCEHVQPPQW LQTLMNACSQ
810 820 830 840 850
ASDFSVQSVA ISLVMDLVGL TQSVAMVTGE NINSVEPAQP LSPNQGRVAV
860 870 880 890 900
VIRPPLTQGN LRYIAEKTEF FKHVALTLWD QLGDGTPQHH QKSVELFYQL
910 920 930 940 950
HNLVPSSSIC EDVISQQLTH KDKKIRMEAH AKFAVLWHLT RDLHINKSSS
960 970 980 990 1000
FVRSFDRSLF IMLDSLNSLD GSTSSVGQAW LNQVLQRHDI ARVLEPLLLL
1010 1020 1030 1040 1050
LLHPKTQRVS VQRVQAERYW NKSPCYPGEE SDKHFMQNFA CSNVSQVQLI
1060 1070 1080 1090 1100
TSKGNGEKPL TMDEIENFSL TVNPLSDRLS LLSTSSETIP MVVSDFDLPD
1110 1120 1130 1140 1150
QQIEILQSSD SGCSQSSAGD NLSYEVDPET VNAQEDSQMP KESSPDDDVQ
1160 1170 1180 1190 1200
QVVFDLICKV VSGLEVESAS VTSQLEIEAM PPKCSDIDPD EETIKIEDDS
1210 1220 1230 1240 1250
IQQSQNALLS NESSQFLSVS AEGGHECVAN GISRNSSSPC ISGTTHTLHD
1260 1270 1280 1290 1300
SSVASIETKS RQRSHSSIQF SFKEKLSEKV SEKETIVKES GKQPGAKPKV
1310 1320 1330 1340 1350
KLARKKDDDK KKSSNEKLKQ TSVFFSDGLD LENWYSCGEG DISEIESDMG
1360 1370 1380 1390 1400
SPGSRKSPNF NIHPLYQHVL LYLQLYDSSR TLYAFSAIKA ILKTNPIAFV
1410 1420 1430 1440 1450
NAISTTSVNN AYTPQLSLLQ NLLARHRISV MGKDFYSHIP VDSNHNFRSS
1460 1470 1480 1490 1500
MYIEILISLC LYYMRSHYPT HVKVTAQDLI GNRNMQMMSI EILTLLFTEL
1510 1520 1530 1540 1550
AKVIESSAKG FPSFISDMLS KCKVQKVILH CLLSSIFSAQ KWHSEKMAGK
1560 1570 1580 1590 1600
NLVAVEEGFS EDSLINFSED EFDNGSTLQS QLLKVLQRLI VLEHRVMTIP
1610 1620 1630 1640 1650
EENETGFDFV VSDLEHISPH QPMTSLQYLH AQPITCQGMF LCAVIRALHQ
1660 1670 1680 1690 1700
HCACKMHPQW IGLITSTLPY MGKVLQRVVV SVTLQLCRNL DNLIQQYKYE
1710 1720 1730 1740 1750
TGLSDSRPLW MASIIPPDMI LTLLEGITAI IHYCLLDPTT QYHQLLVSVD
1760 1770 1780 1790 1800
QKHLFEARSG ILSILHMIMS SVTLLWSILH QADSSEKMTI AASASLTTIN
1810 1820 1830 1840 1850
LGATKNLRQQ ILELLGPISM NHGVHFMAAI AFVWNERRQN KTTTRTKVIP
1860 1870 1880 1890 1900
AASEEQLLLV ELVRSISVMR AETVIQTVKE VLKQPPAIAK DKKHLSLEVC
1910 1920 1930 1940 1950
MLQFFYAYIQ RIPVPNLVDS WASLLILLKD SIQLSLPAPG QFLILGVLNE
1960 1970 1980 1990 2000
FIMKNPSLEN KKDQRDLQDV THKIVDAIGA IAGSSLEQTT WLRRNLEVKP
2010 2020 2030 2040 2050
SPKIMVDGTN LESDVEDMLS PAMETANITP SVYSVHALTL LSEVLAHLLD
2060 2070 2080 2090 2100
MVFYSDEKER VIPLLVNIMH YVVPYLRNHS AHNAPSYRAC VQLLSSLSGY
2110 2120 2130 2140 2150
QYTRRAWKKE AFDLFMDPSF FQMDASCVNH WRAIMDNLMT HDKTTFRDLM
2160 2170 2180 2190 2200
TRVAVAQSSS LNLFANRDVE LEQRAMLLKR LAFAIFSSEI DQYQKYLPDI
2210 2220 2230 2240 2250
QERLVESLRL PQVPTLHSQV FLFFRVLLLR MSPQHLTSLW PTMITELVQV
2260 2270 2280 2290 2300
FLLMEQELTA DEDISRTSGP SVAGLETTYT GGNGFSTSYN SQRWLNLYLS
2310 2320 2330 2340 2350
ACKFLDLALA LPSENLPQFQ MYRWAFIPEA SDDSGLEVRR QGIHQREFKP
2360 2370 2380 2390 2400
YVVRLAKLLR KRAKKNPEED NSGRTLGWEP GHLLLTICTV RSMEQLLPFF
2410 2420 2430 2440 2450
NVLSQVFNSK VTSRCGGHSG SPILYSNAFP NKDMKLENHK PCSSKARQKI
2460
EEMVEKDFLE GMIKT
Length:2,465
Mass (Da):277,355
Last modified:February 20, 2007 - v1
Checksum:i97C58882414BAA6E
GO

Sequence cautioni

The sequence BAB15631.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti596 – 5961R → Q.
Corresponds to variant rs4706980 [ dbSNP | Ensembl ].
VAR_034690
Natural varianti1155 – 11551D → H in a breast cancer sample; somatic mutation. 1 Publication
VAR_036607
Natural varianti1781 – 17811Q → L.
Corresponds to variant rs9444039 [ dbSNP | Ensembl ].
VAR_034691

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121716, AL139333 Genomic DNA. Translation: CAI42425.2.
AL139333, AL121716 Genomic DNA. Translation: CAM21599.1.
AB029040 mRNA. Translation: BAA83069.2.
AL050080 mRNA. Translation: CAB43259.1.
AL162056 mRNA. Translation: CAB82395.1.
AK027030 mRNA. Translation: BAB15631.1. Different initiation.
BC048342 mRNA. Translation: AAH48342.1.
CCDSiCCDS4996.1.
PIRiT47141.
RefSeqiNP_055833.2. NM_015018.3.
UniGeneiHs.520246.
Hs.708998.

Genome annotation databases

EnsembliENST00000349129; ENSP00000195654; ENSG00000083097.
GeneIDi23033.
KEGGihsa:23033.
UCSCiuc003pjs.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121716, AL139333 Genomic DNA. Translation: CAI42425.2.
AL139333, AL121716 Genomic DNA. Translation: CAM21599.1.
AB029040 mRNA. Translation: BAA83069.2.
AL050080 mRNA. Translation: CAB43259.1.
AL162056 mRNA. Translation: CAB82395.1.
AK027030 mRNA. Translation: BAB15631.1. Different initiation.
BC048342 mRNA. Translation: AAH48342.1.
CCDSiCCDS4996.1.
PIRiT47141.
RefSeqiNP_055833.2. NM_015018.3.
UniGeneiHs.520246.
Hs.708998.

3D structure databases

ProteinModelPortaliQ5JWR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116672. 1 interaction.
STRINGi9606.ENSP00000195654.

PTM databases

iPTMnetiQ5JWR5.
PhosphoSiteiQ5JWR5.

Polymorphism and mutation databases

BioMutaiDOPEY1.
DMDMi156630499.

Proteomic databases

EPDiQ5JWR5.
MaxQBiQ5JWR5.
PaxDbiQ5JWR5.
PeptideAtlasiQ5JWR5.
PRIDEiQ5JWR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349129; ENSP00000195654; ENSG00000083097.
GeneIDi23033.
KEGGihsa:23033.
UCSCiuc003pjs.2. human.

Organism-specific databases

CTDi23033.
GeneCardsiDOPEY1.
H-InvDBHIX0006035.
HIX0033209.
HGNCiHGNC:21194. DOPEY1.
HPAiHPA027902.
HPA027904.
neXtProtiNX_Q5JWR5.
PharmGKBiPA134924787.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3613. Eukaryota.
COG5221. LUCA.
GeneTreeiENSGT00390000016421.
HOGENOMiHOG000043862.
HOVERGENiHBG051222.
InParanoidiQ5JWR5.
OrthoDBiEOG7992PM.
PhylomeDBiQ5JWR5.
TreeFamiTF316855.

Miscellaneous databases

ChiTaRSiDOPEY1. human.
GenomeRNAii23033.
PROiQ5JWR5.

Gene expression databases

BgeeiQ5JWR5.
CleanExiHS_DOPEY1.
ExpressionAtlasiQ5JWR5. baseline and differential.
GenevisibleiQ5JWR5. HS.

Family and domain databases

InterProiIPR007249. Dopey_N.
[Graphical view]
PfamiPF04118. Dopey_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 908-2465.
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1212-2465.
    Tissue: Amygdala.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1326-2465.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1910-2465.
    Tissue: Brain.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-1155.

Entry informationi

Entry nameiDOP1_HUMAN
AccessioniPrimary (citable) accession number: Q5JWR5
Secondary accession number(s): Q86XV1
, Q9H5J5, Q9NSL4, Q9UPN5, Q9Y414
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: February 20, 2007
Last modified: July 6, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.