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Protein

Protein FAM26D

Gene

FAM26D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Pore-forming subunit of a voltage-gated ion channel.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.84.1.5. the calcium homeostasis modulator ca(2+) channel (calhm-c) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM26D
Gene namesi
Name:FAM26D
Synonyms:C6orf78
ORF Names:UNQ6481/PRO21277
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21094. FAM26D.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence analysisAdd
BLAST
Transmembranei49 – 6921HelicalSequence analysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence analysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162387625.

Polymorphism and mutation databases

BioMutaiFAM26D.
DMDMi67460441.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Protein FAM26DPRO_0000186724Add
BLAST

Proteomic databases

PaxDbiQ5JW98.
PeptideAtlasiQ5JW98.
PRIDEiQ5JW98.

PTM databases

PhosphoSiteiQ5JW98.

Expressioni

Gene expression databases

BgeeiENSG00000164451.
CleanExiHS_FAM26D.
ExpressionAtlasiQ5JW98. baseline and differential.

Organism-specific databases

HPAiHPA019178.
HPA048014.

Interactioni

Protein-protein interaction databases

BioGridi128707. 15 interactions.
STRINGi9606.ENSP00000357586.

Structurei

3D structure databases

ProteinModelPortaliQ5JW98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM26 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KCWY. Eukaryota.
ENOG4110NTE. LUCA.
GeneTreeiENSGT00530000062796.
HOGENOMiHOG000294134.
HOVERGENiHBG099442.
InParanoidiQ5JW98.
OMAiCPCQVGK.
OrthoDBiEOG091G0BN1.
PhylomeDBiQ5JW98.

Family and domain databases

InterProiIPR029569. FAM26.
IPR029574. FAM26D.
[Graphical view]
PANTHERiPTHR32261. PTHR32261. 1 hit.
PTHR32261:SF5. PTHR32261:SF5. 1 hit.
PfamiPF14798. Ca_hom_mod. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JW98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCPTLNNIVS SLQRNGIFIN SLIAALTIGG QQLFSSSTFS CPCQVGKNFY
60 70 80 90 100
YGSAFLVIPA LILLVAGFAL RSQMWTITGE YCCSCAPPYR RISPLECKLA
110 120 130 140 150
CLRFFSITGR AVIAPLTWLA VTLLTGTYYE CAASEFASVD HYPMFDNVSA
160 170 180 190 200
SKREEILAGF PCCRSAPSDV ILVRDEIALL HRYQSQMLGW ILITLATIAA
210 220 230 240 250
LVSCCVAKCC SPLTSLQHCY WTSHLQNERE LFEQAAEQHS RLLMMHRIKK
260 270 280 290 300
LFGFIPGSED VKHIRIPSCQ DWKDISVPTL LCMGDDLQGH YSFLGNRVDE
310
DNEEDRSRGI ELKP
Length:314
Mass (Da):35,060
Last modified:February 15, 2005 - v1
Checksum:i2CF5DB1741A2E64E
GO
Isoform 2 (identifier: Q5JW98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-186: Missing.

Show »
Length:128
Mass (Da):14,630
Checksum:iA311918A8255050E
GO
Isoform 3 (identifier: Q5JW98-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.

Show »
Length:171
Mass (Da):19,478
Checksum:i9EB1F62C7AF6ACA9
GO
Isoform 4 (identifier: Q5JW98-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: MCPTLNNIVS...EILAGFPCCR → MAPRSAKETFRINPNVAANL

Show »
Length:170
Mass (Da):19,305
Checksum:i78873AC1E830269E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 186186Missing in isoform 2. 2 PublicationsVSP_013817Add
BLAST
Alternative sequencei1 – 164164MCPTL…FPCCR → MAPRSAKETFRINPNVAANL in isoform 4. 1 PublicationVSP_045216Add
BLAST
Alternative sequencei1 – 143143Missing in isoform 3. 1 PublicationVSP_018252Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358252 mRNA. Translation: AAQ88619.1.
AK056801 mRNA. Translation: BAB71288.1.
AK300309 mRNA. Translation: BAG62062.1.
AL121953 Genomic DNA. Translation: CAI21552.1.
AL121953 Genomic DNA. Translation: CAQ06529.1.
AL121953 Genomic DNA. Translation: CAQ06531.1.
CH471051 Genomic DNA. Translation: EAW48223.1.
CH471051 Genomic DNA. Translation: EAW48224.1.
BC057769 mRNA. Translation: AAH57769.2.
CCDSiCCDS5109.1. [Q5JW98-2]
CCDS59031.1. [Q5JW98-4]
CCDS59032.1. [Q5JW98-3]
RefSeqiNP_001243816.1. NM_001256887.2. [Q5JW98-3]
NP_001243817.1. NM_001256888.2. [Q5JW98-4]
NP_001243818.1. NM_001256889.2. [Q5JW98-2]
NP_694581.1. NM_153036.4. [Q5JW98-2]
XP_005266917.1. XM_005266860.3. [Q5JW98-1]
UniGeneiHs.350750.

Genome annotation databases

EnsembliENST00000368596; ENSP00000357585; ENSG00000164451. [Q5JW98-1]
ENST00000368597; ENSP00000357586; ENSG00000164451. [Q5JW98-2]
ENST00000405399; ENSP00000385836; ENSG00000164451. [Q5JW98-3]
ENST00000628083; ENSP00000487169; ENSG00000164451. [Q5JW98-4]
GeneIDi221301.
KEGGihsa:221301.
UCSCiuc003pwz.5. human. [Q5JW98-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358252 mRNA. Translation: AAQ88619.1.
AK056801 mRNA. Translation: BAB71288.1.
AK300309 mRNA. Translation: BAG62062.1.
AL121953 Genomic DNA. Translation: CAI21552.1.
AL121953 Genomic DNA. Translation: CAQ06529.1.
AL121953 Genomic DNA. Translation: CAQ06531.1.
CH471051 Genomic DNA. Translation: EAW48223.1.
CH471051 Genomic DNA. Translation: EAW48224.1.
BC057769 mRNA. Translation: AAH57769.2.
CCDSiCCDS5109.1. [Q5JW98-2]
CCDS59031.1. [Q5JW98-4]
CCDS59032.1. [Q5JW98-3]
RefSeqiNP_001243816.1. NM_001256887.2. [Q5JW98-3]
NP_001243817.1. NM_001256888.2. [Q5JW98-4]
NP_001243818.1. NM_001256889.2. [Q5JW98-2]
NP_694581.1. NM_153036.4. [Q5JW98-2]
XP_005266917.1. XM_005266860.3. [Q5JW98-1]
UniGeneiHs.350750.

3D structure databases

ProteinModelPortaliQ5JW98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128707. 15 interactions.
STRINGi9606.ENSP00000357586.

Protein family/group databases

TCDBi1.A.84.1.5. the calcium homeostasis modulator ca(2+) channel (calhm-c) family.

PTM databases

PhosphoSiteiQ5JW98.

Polymorphism and mutation databases

BioMutaiFAM26D.
DMDMi67460441.

Proteomic databases

PaxDbiQ5JW98.
PeptideAtlasiQ5JW98.
PRIDEiQ5JW98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368596; ENSP00000357585; ENSG00000164451. [Q5JW98-1]
ENST00000368597; ENSP00000357586; ENSG00000164451. [Q5JW98-2]
ENST00000405399; ENSP00000385836; ENSG00000164451. [Q5JW98-3]
ENST00000628083; ENSP00000487169; ENSG00000164451. [Q5JW98-4]
GeneIDi221301.
KEGGihsa:221301.
UCSCiuc003pwz.5. human. [Q5JW98-1]

Organism-specific databases

CTDi221301.
GeneCardsiFAM26D.
H-InvDBHIX0200851.
HGNCiHGNC:21094. FAM26D.
HPAiHPA019178.
HPA048014.
neXtProtiNX_Q5JW98.
PharmGKBiPA162387625.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCWY. Eukaryota.
ENOG4110NTE. LUCA.
GeneTreeiENSGT00530000062796.
HOGENOMiHOG000294134.
HOVERGENiHBG099442.
InParanoidiQ5JW98.
OMAiCPCQVGK.
OrthoDBiEOG091G0BN1.
PhylomeDBiQ5JW98.

Miscellaneous databases

GenomeRNAii221301.
PROiQ5JW98.

Gene expression databases

BgeeiENSG00000164451.
CleanExiHS_FAM26D.
ExpressionAtlasiQ5JW98. baseline and differential.

Family and domain databases

InterProiIPR029569. FAM26.
IPR029574. FAM26D.
[Graphical view]
PANTHERiPTHR32261. PTHR32261. 1 hit.
PTHR32261:SF5. PTHR32261:SF5. 1 hit.
PfamiPF14798. Ca_hom_mod. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFA26D_HUMAN
AccessioniPrimary (citable) accession number: Q5JW98
Secondary accession number(s): B0QZ25
, B0QZ27, B4DTQ0, Q96MK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: February 15, 2005
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.