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Protein

Intracellular hyaluronan-binding protein 4

Gene

HABP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.
SIGNORiQ5JVS0.

Names & Taxonomyi

Protein namesi
Recommended name:
Intracellular hyaluronan-binding protein 4
Short name:
IHABP-4
Short name:
IHABP4
Alternative name(s):
Ki-1/57 intracellular antigen
Gene namesi
Name:HABP4Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:17062. HABP4.

Subcellular locationi

  • Cytoplasm
  • Nucleus

  • Note: Transported into the nuclear compartment in activated leukocytes.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22927.
OpenTargetsiENSG00000130956.
PharmGKBiPA38434.

Chemistry databases

DrugBankiDB08818. Hyaluronic acid.

Polymorphism and mutation databases

BioMutaiHABP4.
DMDMi74742472.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002579721 – 413Intracellular hyaluronan-binding protein 4Add BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei70Omega-N-methylarginineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei354Phosphothreonine; by PKC1 Publication1
Modified residuei375Phosphothreonine; by PKC1 Publication1

Post-translational modificationi

Phosphorylated by phorbol 12-myristate 13-acetate (PMA)-activated PKC isoforms at Thr-354 and Thr-375.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ5JVS0.
MaxQBiQ5JVS0.
PaxDbiQ5JVS0.
PeptideAtlasiQ5JVS0.
PRIDEiQ5JVS0.

PTM databases

iPTMnetiQ5JVS0.
PhosphoSitePlusiQ5JVS0.

Expressioni

Tissue specificityi

Highly expressed in brain, heart, and kidney, and moderately expressed in skeletal muscle. Also expressed in a variety of tumor cell lines and in activated but not resting leukocytes.2 Publications

Gene expression databases

BgeeiENSG00000130956.
CleanExiHS_HABP4.
GenevisibleiQ5JVS0. HS.

Organism-specific databases

HPAiHPA055969.

Interactioni

Subunit structurei

Interacts with SPIN1 (By similarity). Interacts with the C-terminus of CHD3. Interacts via its C-terminal region with RACK1. Interacts with p53/TP53.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PRMT1Q998732EBI-523625,EBI-78738
SRSF9Q132422EBI-523625,EBI-2949710
SYNCRIPO605062EBI-523625,EBI-1024357

Protein-protein interaction databases

BioGridi116587. 23 interactors.
IntActiQ5JVS0. 19 interactors.
MINTiMINT-1346616.
STRINGi9606.ENSP00000364398.

Structurei

3D structure databases

ProteinModelPortaliQ5JVS0.
SMRiQ5JVS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili40 – 64Sequence analysisAdd BLAST25

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2945. Eukaryota.
ENOG410YBHR. LUCA.
GeneTreeiENSGT00520000055591.
HOGENOMiHOG000220826.
HOVERGENiHBG056357.
InParanoidiQ5JVS0.
KOiK19019.
OMAiNEKIAIR.
OrthoDBiEOG091G0UA9.
PhylomeDBiQ5JVS0.
TreeFamiTF318374.

Family and domain databases

InterProiIPR006861. HABP4_PAIRBP1-bd.
IPR032381. IHABP4_N.
[Graphical view]
PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
PF16174. IHABP4_N. 1 hit.
[Graphical view]
SMARTiSM01233. HABP4_PAI-RBP1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 12 Publications (identifier: Q5JVS0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGALGSPVA AAGAAMQESF GCVVANRFHQ LLDDESDPFD ILREAERRRQ
60 70 80 90 100
QQLQRKRRDE AAAAAGAGPR GGRSPAGASG HRAGAGGRRE SQKERKSLPA
110 120 130 140 150
PVAQRPDSPG GGLQAPGQKR TPRRGEQQGW NDSRGPEGML ERAERRSYRE
160 170 180 190 200
YRPYETERQA DFTAEKFPDE KPGDRFDRDR PLRGRGGPRG GMRGRGRGGP
210 220 230 240 250
GNRVFDAFDQ RGKREFERYG GNDKIAVRTE DNMGGCGVRT WGSGKDTSDV
260 270 280 290 300
EPTAPMEEPT VVEESQGTPE EESPAKVPEL EVEEETQVQE MTLDEWKNLQ
310 320 330 340 350
EQTRPKPEFN IRKPESTVPS KAVVIHKSKY RDDMVKDDYE DDSHVFRKPA
360 370 380 390 400
NDITSQLEIN FGNLPRPGRG ARGGTRGGRG RIRRAENYGP RAEVVMQDVA
410
PNPDDPEDFP ALS
Length:413
Mass (Da):45,785
Last modified:February 15, 2005 - v1
Checksum:i98749EEC5CB92155
GO
Isoform 21 Publication (identifier: Q5JVS0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     172-276: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:308
Mass (Da):34,365
Checksum:iCFA9C86A34BF5514
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104Q → H in AAF62546 (PubMed:10887182).Curated1
Sequence conflicti115A → S in AAC31117 (PubMed:9523163).Curated1
Sequence conflicti388 – 389YG → NY in AAF62546 (PubMed:10887182).Curated2
Sequence conflicti388 – 389YG → NY in AAC31117 (PubMed:9523163).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052194172 – 276Missing in isoform 2. 1 PublicationAdd BLAST105

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241831 mRNA. Translation: AAF62546.1.
AL133477 Genomic DNA. Translation: CAI39620.1.
AL133477 Genomic DNA. Translation: CAI39621.1.
BC018788 mRNA. Translation: AAH18788.1.
U77327 mRNA. Translation: AAC31117.1.
CCDSiCCDS6719.1. [Q5JVS0-1]
RefSeqiNP_055097.2. NM_014282.3. [Q5JVS0-1]
UniGeneiHs.494567.

Genome annotation databases

EnsembliENST00000375249; ENSP00000364398; ENSG00000130956. [Q5JVS0-1]
ENST00000375251; ENSP00000364400; ENSG00000130956. [Q5JVS0-2]
GeneIDi22927.
KEGGihsa:22927.
UCSCiuc010msg.5. human. [Q5JVS0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241831 mRNA. Translation: AAF62546.1.
AL133477 Genomic DNA. Translation: CAI39620.1.
AL133477 Genomic DNA. Translation: CAI39621.1.
BC018788 mRNA. Translation: AAH18788.1.
U77327 mRNA. Translation: AAC31117.1.
CCDSiCCDS6719.1. [Q5JVS0-1]
RefSeqiNP_055097.2. NM_014282.3. [Q5JVS0-1]
UniGeneiHs.494567.

3D structure databases

ProteinModelPortaliQ5JVS0.
SMRiQ5JVS0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116587. 23 interactors.
IntActiQ5JVS0. 19 interactors.
MINTiMINT-1346616.
STRINGi9606.ENSP00000364398.

Chemistry databases

DrugBankiDB08818. Hyaluronic acid.

PTM databases

iPTMnetiQ5JVS0.
PhosphoSitePlusiQ5JVS0.

Polymorphism and mutation databases

BioMutaiHABP4.
DMDMi74742472.

Proteomic databases

EPDiQ5JVS0.
MaxQBiQ5JVS0.
PaxDbiQ5JVS0.
PeptideAtlasiQ5JVS0.
PRIDEiQ5JVS0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375249; ENSP00000364398; ENSG00000130956. [Q5JVS0-1]
ENST00000375251; ENSP00000364400; ENSG00000130956. [Q5JVS0-2]
GeneIDi22927.
KEGGihsa:22927.
UCSCiuc010msg.5. human. [Q5JVS0-1]

Organism-specific databases

CTDi22927.
DisGeNETi22927.
GeneCardsiHABP4.
HGNCiHGNC:17062. HABP4.
HPAiHPA055969.
neXtProtiNX_Q5JVS0.
OpenTargetsiENSG00000130956.
PharmGKBiPA38434.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2945. Eukaryota.
ENOG410YBHR. LUCA.
GeneTreeiENSGT00520000055591.
HOGENOMiHOG000220826.
HOVERGENiHBG056357.
InParanoidiQ5JVS0.
KOiK19019.
OMAiNEKIAIR.
OrthoDBiEOG091G0UA9.
PhylomeDBiQ5JVS0.
TreeFamiTF318374.

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.
SIGNORiQ5JVS0.

Miscellaneous databases

ChiTaRSiHABP4. human.
GeneWikiiHABP4.
GenomeRNAii22927.
PROiQ5JVS0.

Gene expression databases

BgeeiENSG00000130956.
CleanExiHS_HABP4.
GenevisibleiQ5JVS0. HS.

Family and domain databases

InterProiIPR006861. HABP4_PAIRBP1-bd.
IPR032381. IHABP4_N.
[Graphical view]
PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
PF16174. IHABP4_N. 1 hit.
[Graphical view]
SMARTiSM01233. HABP4_PAI-RBP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHABP4_HUMAN
AccessioniPrimary (citable) accession number: Q5JVS0
Secondary accession number(s): O75804, Q8WV33, Q9NYJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Able to bind hyaluronan. However, its intracellular localization suggests that this interaction may not be relevant in vivo.
The interaction with RACK1 is abolished upon activation of L540 tumor cells with PMA, which results in phosphorylation and exit of HABP4 from the nucleus.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.