Q5JVL4 (EFHC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
EF-hand domain-containing protein 1

Alternative name(s):
Myoclonin-1

Gene names

Name:

EFHC1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	640 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May enhance calcium influx through CACNA1E and stimulate programmed cell death. Ref.1
Subunit structure	Interacts with the C-terminus of CACNA1E. Ref.1
Tissue specificity	Widely expressed. Not detected in lymphocytes. Ref.1
Involvement in disease	Juvenile myoclonic epilepsy 1 (EJM1) [MIM:254770]: A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.1 Ref.6 Juvenile absence epilepsy 1 (JAE1) [MIM:607631]: A subtype of idiopathic generalized epilepsy characterized by onset occurring around puberty, absence seizures, generalized tonic-clonic seizures (GTCS), GTCS on awakening, and myoclonic seizures. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Sequence similarities	Contains 3 DM10 domains. Contains 1 EF-hand domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Epilepsy
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	axoneme Inferred from sequence or structural similarity. Source: UniProtKB cilium Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro protein C-terminus binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5JVL4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5JVL4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     243-278: LRFYAIWDDTDSMYGECRTYIIHYYLMDDTVEIREV → SDIGTTIGLLISKCDLHLLAKGLGSCIGNYFETLQL
     279-640: Missing.

Isoform 3 (identifier: Q5JVL4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MVSNPVHGLPFLPGTSFKDST → ML

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 640	640	EF-hand domain-containing protein 1		PRO_0000073877
Regions
	Domain	93 – 198	106	DM10 1
	Domain	239 – 359	121	DM10 2
	Domain	416 – 520	105	DM10 3
	Domain	574 – 609	36	EF-hand
Natural variations
	Alternative sequence	1 – 21	21	MVSNP…FKDST → ML in isoform 3.		VSP_046107
	Alternative sequence	243 – 278	36	LRFYA…EIREV → SDIGTTIGLLISKCDLHLLA KGLGSCIGNYFETLQL in isoform 2.		VSP_015894
	Alternative sequence	279 – 640	362	Missing in isoform 2.		VSP_015895
	Natural variant	77	1	P → T in EJM1; associated with H-221; reduces substantially the cell death effect; reduces partly the calcium influx; binds to CACNA1E. Ref.1		VAR_023619
	Natural variant	159	1	R → W No effect on cell death; binds to CACNA1E. Ref.1 Ref.5 Corresponds to variant rs3804506 [ dbSNP | Ensembl ].		VAR_023620
	Natural variant	174	1	I → V Associated with susceptibility to JAE1. Ref.5		VAR_043154
	Natural variant	182	1	R → H No effect on cell death; binds to CACNA1E. Ref.1 Ref.5 Ref.6 Corresponds to variant rs3804505 [ dbSNP | Ensembl ].		VAR_023621
	Natural variant	210	1	D → N in EJM1; reduces substantially the cell death effect; reduces partly the calcium influx; binds to CACNA1E. Ref.1		VAR_023622
	Natural variant	221	1	R → H in EJM1; associated with T-77; reduces substantially the cell death effect; reduces partly the calcium influx; binds to CACNA1E. Ref.1		VAR_023623
	Natural variant	229	1	F → L in EJM1; uncertain pathological significance; reduces substantially the cell death effect; reduces significantly the calcium influx; binds to CACNA1E. Ref.1 Ref.5 Ref.6		VAR_023624
	Natural variant	253	1	D → Y in EJM1; reduces substantially the cell death effect; reduces partly the calcium influx; binds to CACNA1E. Ref.1		VAR_023625
	Natural variant	259	1	C → Y Associated with susceptibility to JAE1. Ref.5		VAR_043155
	Natural variant	285	1	R → I. Ref.4 Corresponds to variant rs17851771 [ dbSNP | Ensembl ].		VAR_026531
	Natural variant	294	1	R → H. Ref.5 Corresponds to variant rs1570624 [ dbSNP | Ensembl ].		VAR_043156
	Natural variant	353	1	R → W in EJM1. Ref.6		VAR_043157
	Natural variant	357	1	E → K. Corresponds to variant rs505760 [ dbSNP | Ensembl ].		VAR_048666
	Natural variant	394	1	A → S in a sporadic case of unclassified epilepsy.		VAR_043158
	Natural variant	448	1	M → T. Ref.5 Corresponds to variant rs1266787 [ dbSNP | Ensembl ].		VAR_043159
	Natural variant	619	1	I → L No effect on cell death; binds to CACNA1E. Ref.1 Ref.4 Corresponds to variant rs17851770 [ dbSNP | Ensembl ].		VAR_023626
Experimental info
	Sequence conflict	140	1	N → D in BAG60005. Ref.2
	Sequence conflict	399	1	A → T in BAA91628. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 08F9E8BFEC42FCF3	FASTA	640	73,990
	10 20 30 40 50 60 MVSNPVHGLP FLPGTSFKDS TKTAFHRSQT LSYRNGYAIV RRPTVGIGGD RLQFNQLSQA 70 80 90 100 110 120 ELDELASKAP VLTYGQPKQA PPADFIPAHV AFDKKVLKFD AYFQEDVPMS TEEQYRIRQV 130 140 150 160 170 180 NIYYYLEDDS MSVIEPVVEN SGILQGKLIK RQRLAKNDRG DHYHWKDLNR GINITIYGKT 190 200 210 220 230 240 FRVVDCDQFT QVFLESQGIE LNPPEKMALD PYTELRKQPL RKYVTPSDFD QLKQFLTFDK 250 260 270 280 290 300 QVLRFYAIWD DTDSMYGECR TYIIHYYLMD DTVEIREVHE RNDGRDPFPL LMNRQRVPKV 310 320 330 340 350 360 LVENAKNFPQ CVLEISDQEV LEWYTAKDFI VGKSLTILGR TFFIYDCDPF TRRYYKEKFG 370 380 390 400 410 420 ITDLPRIDVS KREPPPVKQE LPPYNGFGLV EDSAQNCFAL IPKAPKKDVI KMLVNDNKVL 430 440 450 460 470 480 RYLAVLESPI PEDKDRRFVF SYFLATDMIS IFEPPVRNSG IIGGKYLGRT KVVKPYSTVD 490 500 510 520 530 540 NPVYYGPSDF FIGAVIEVFG HRFIILDTDE YVLKYMESNA AQYSPEALAS IQNHVRKREA 550 560 570 580 590 600 PAPEAESKQT EKDPGVQELE ALIDTIQKQL KDHSCKDNIR EAFQIYDKEA SGYVDRDMFF 610 620 630 640 KICESLNVPV DDSLVKELIR MCSHGEGKIN YYNFVRAFSN
	Isoform 2 [UniParc]. Checksum: 806C5C56F5E294F9	FASTA	278	31,661
	10 20 30 40 50 60 MVSNPVHGLP FLPGTSFKDS TKTAFHRSQT LSYRNGYAIV RRPTVGIGGD RLQFNQLSQA 70 80 90 100 110 120 ELDELASKAP VLTYGQPKQA PPADFIPAHV AFDKKVLKFD AYFQEDVPMS TEEQYRIRQV 130 140 150 160 170 180 NIYYYLEDDS MSVIEPVVEN SGILQGKLIK RQRLAKNDRG DHYHWKDLNR GINITIYGKT 190 200 210 220 230 240 FRVVDCDQFT QVFLESQGIE LNPPEKMALD PYTELRKQPL RKYVTPSDFD QLKQFLTFDK 250 260 270 QVSDIGTTIG LLISKCDLHL LAKGLGSCIG NYFETLQL
	Isoform 3 [UniParc]. Checksum: C289DD7386FF510B	FASTA	621	72,021
	10 20 30 40 50 60 MLKTAFHRSQ TLSYRNGYAI VRRPTVGIGG DRLQFNQLSQ AELDELASKA PVLTYGQPKQ 70 80 90 100 110 120 APPADFIPAH VAFDKKVLKF DAYFQEDVPM STEEQYRIRQ VNIYYYLEDD SMSVIEPVVE 130 140 150 160 170 180 NSGILQGKLI KRQRLAKNDR GDHYHWKDLN RGINITIYGK TFRVVDCDQF TQVFLESQGI 190 200 210 220 230 240 ELNPPEKMAL DPYTELRKQP LRKYVTPSDF DQLKQFLTFD KQVLRFYAIW DDTDSMYGEC 250 260 270 280 290 300 RTYIIHYYLM DDTVEIREVH ERNDGRDPFP LLMNRQRVPK VLVENAKNFP QCVLEISDQE 310 320 330 340 350 360 VLEWYTAKDF IVGKSLTILG RTFFIYDCDP FTRRYYKEKF GITDLPRIDV SKREPPPVKQ 370 380 390 400 410 420 ELPPYNGFGL VEDSAQNCFA LIPKAPKKDV IKMLVNDNKV LRYLAVLESP IPEDKDRRFV 430 440 450 460 470 480 FSYFLATDMI SIFEPPVRNS GIIGGKYLGR TKVVKPYSTV DNPVYYGPSD FFIGAVIEVF 490 500 510 520 530 540 GHRFIILDTD EYVLKYMESN AAQYSPEALA SIQNHVRKRE APAPEAESKQ TEKDPGVQEL 550 560 570 580 590 600 EALIDTIQKQ LKDHSCKDNI REAFQIYDKE ASGYVDRDMF FKICESLNVP VDDSLVKELI 610 620 RMCSHGEGKI NYYNFVRAFS N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mutations in EFHC1 cause juvenile myoclonic epilepsy." Suzuki T., Delgado-Escueta A.V., Aguan K., Alonso M.E., Shi J., Hara Y., Nishida M., Numata T., Medina M.T., Takeuchi T., Morita R., Bai D., Ganesh S., Sugimoto Y., Inazawa J., Bailey J.N., Ochoa A., Jara-Prado A. , Rasmussen A., Ramos-Peek J., Cordova S., Rubio-Donnadieu F., Inoue Y., Osawa M., Kaneko S., Oguni H., Mori Y., Yamakawa K. Nat. Genet. 36:842-849(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [MRNA] OF 557-640 (ISOFORM 1), FUNCTION, INTERACTION WITH CACNA1E, TISSUE SPECIFICITY, VARIANTS EJM1 THR-77; ASN-210; HIS-221; LEU-229 AND TYR-253, CHARACTERIZATION OF VARIANTS EJM1 THR-77; ASN-210; HIS-221; LEU-229 AND TYR-253, VARIANTS TRP-159; HIS-182 AND LEU-619, CHARACTERIZATION OF VARIANTS TRP-159; HIS-182 AND LEU-619.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Brain.
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ILE-285 AND LEU-619. Tissue: Kidney.
[5]	"Idiopathic generalized epilepsy phenotypes associated with different EFHC1 mutations." Stogmann E., Lichtner P., Baumgartner C., Bonelli S., Assem-Hilger E., Leutmezer F., Schmied M., Hotzy C., Strom T.M., Meitinger T., Zimprich F., Zimprich A. Neurology 67:2029-2031(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO JUVENILE ABSENCE EPILEPSY, VARIANTS TRP-159; VAL-174; HIS-182; LEU-229; TYR-259; HIS-294; SER-394 AND THR-448.
[6]	"Mutational analysis of EFHC1 gene in Italian families with juvenile myoclonic epilepsy." Annesi F., Gambardella A., Michelucci R., Bianchi A., Marini C., Canevini M.P., Capovilla G., Elia M., Buti D., Chifari R., Striano P., Rocca F.E., Castellotti B., Cali F., Labate A., Lepiane E., Besana D., Sofia V. , Tabiadon G., Tortorella G., Vigliano P., Vignoli A., Beccaria F., Annesi G., Striano S., Aguglia U., Guerrini R., Quattrone A. Epilepsia 48:1686-1690(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS EJM1 LEU-229 AND TRP-353, VARIANT HIS-182.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY608689 mRNA. Translation: AAT67418.1. AY608690 mRNA. Translation: AAT67419.1. AK001328 mRNA. Translation: BAA91628.1. AK297632 mRNA. Translation: BAG60005.1. AL049611, AL136125 Genomic DNA. Translation: CAI19693.1. AL136125, AL049611 Genomic DNA. Translation: CAI20107.1. BC020210 mRNA. Translation: AAH20210.1.
IPI	IPI00018207. IPI00382418. IPI00956011.
RefSeq	NP_001165891.1. NM_001172420.1. NP_060570.2. NM_018100.3.
UniGene	Hs.403171.
3D structure databases
ProteinModelPortal	Q5JVL4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5JVL4. 1 interaction.
MINT	MINT-1484267.
STRING	9606.ENSP00000360107.
PTM databases
PhosphoSite	Q5JVL4.
Polymorphism databases
DMDM	74762202.
Proteomic databases
PaxDb	Q5JVL4.
PeptideAtlas	Q5JVL4.
PRIDE	Q5JVL4.
Protocols and materials databases
DNASU	114327.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371068; ENSP00000360107; ENSG00000096093. ENST00000480623; ENSP00000434498; ENSG00000096093. ENST00000538167; ENSP00000444521; ENSG00000096093.
GeneID	114327.
KEGG	hsa:114327.
UCSC	uc003pap.4. human.
Organism-specific databases
CTD	114327.
GeneCards	GC06P052284.
HGNC	HGNC:16406. EFHC1.
HPA	CAB020814.
MIM	254770. phenotype. 607631. phenotype. 608815. gene.
neXtProt	NX_Q5JVL4.
Orphanet	307. Juvenile myoclonic epilepsy.
PharmGKB	PA27654.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG282456.
HOGENOM	HOG000265451.
HOVERGEN	HBG059646.
InParanoid	Q5JVL4.
OMA	NAKNFPQ.
OrthoDB	EOG412M4X.
PhylomeDB	Q5JVL4.
Gene expression databases
ArrayExpress	Q5JVL4.
Bgee	Q5JVL4.
CleanEx	HS_EFHC1.
Genevestigator	Q5JVL4.
GermOnline	ENSG00000096093. Homo sapiens.
Family and domain databases
Gene3D	1.10.238.10. 1 hit.
InterPro	IPR010554. DUF1126. IPR011992. EF-hand-like_dom. IPR002048. EF_hand_dom. IPR006602. Uncharacterised_DM10. [Graphical view]
Pfam	PF06565. DUF1126. 3 hits. [Graphical view]
SMART	SM00676. DM10. 3 hits. [Graphical view]
PROSITE	PS51336. DM10. 3 hits. PS00018. EF_HAND_1. False negative. PS50222. EF_HAND_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	EFHC1. human.
GenomeRNAi	114327.
NextBio	79065.
SOURCE	Search...

Entry information

Entry name

EFHC1_HUMAN

Accession

Primary (citable) accession number: Q5JVL4
Secondary accession number(s): B4DMU3 , F5GZD8, Q5XKM4, Q6E1U7, Q6E1U8, Q8WUL2, Q9NVW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	February 15, 2005
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.