Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 506

Gene

ZNF506

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri201 – 223C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 506
Gene namesi
Name:ZNF506
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000081665.13
HGNCiHGNC:23780 ZNF506
neXtProtiNX_Q5JVG8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000081665
PharmGKBiPA134884301

Polymorphism and mutation databases

BioMutaiZNF506
DMDMi296453043

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476241 – 444Zinc finger protein 506Add BLAST444

Proteomic databases

EPDiQ5JVG8
MaxQBiQ5JVG8
PaxDbiQ5JVG8
PeptideAtlasiQ5JVG8
PRIDEiQ5JVG8

PTM databases

iPTMnetiQ5JVG8
PhosphoSitePlusiQ5JVG8

Expressioni

Gene expression databases

BgeeiENSG00000081665
CleanExiHS_ZNF506
ExpressionAtlasiQ5JVG8 baseline and differential
GenevisibleiQ5JVG8 HS

Interactioni

Protein-protein interaction databases

BioGridi136647, 1 interactor
STRINGi9606.ENSP00000393835

Structurei

3D structure databases

ProteinModelPortaliQ5JVG8
SMRiQ5JVG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri201 – 223C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ5JVG8
KOiK09228
OMAiAYKQSSH
OrthoDBiEOG091G02KC
PhylomeDBiQ5JVG8
TreeFamiTF342117

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JVG8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPLQFRDVA IEFSLEEWHC LDAAQRNLYR DVMLENYRNL IFLGIVVSKP
60 70 80 90 100
NLITCLEQGK KPLTMKRHEM IAKPPVMYSH FAQDLWSEQS IKDSFQKVIL
110 120 130 140 150
RRYEKCRHDN LQLKKGCESV DECPVHKRGY NGLKQCLATT QRKIFQCDEY
160 170 180 190 200
VKFLHKFSNS NKHKIRDTGK KSFKCIEYGK TFNQSSTRTT YKKIDAGEKR
210 220 230 240 250
YKCEECGKAY KQSSHLTTHK KIHTGEKPYK CEECGKAYKQ SCNLTTHKII
260 270 280 290 300
HTGEKPYRCR ECGKAFNHPA TLFSHKKIHT GEKPYKCDKC GKAFISSSTL
310 320 330 340 350
TKHEIIHTGE KPYKCEECGK AFNRSSNLTK HKRIHTGDVP YKCDECGKTF
360 370 380 390 400
TWYSSLSKHK RAHTGEKPYK CEECGKAFTA FSTLTEHKII HTGEKPYKCE
410 420 430 440
ECGKAFNWSS ALNKHKKIHI RQKPCIVKNV ENLLNVPQPL ISIR
Length:444
Mass (Da):51,537
Last modified:May 18, 2010 - v2
Checksum:i4B8449C6B8B31FE0
GO
Isoform 2 (identifier: Q5JVG8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-75: Missing.

Show »
Length:412
Mass (Da):47,996
Checksum:iF557B8D3DBE933C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118E → K in CAB66483 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057421189T → P. Corresponds to variant dbSNP:rs16996376Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04065344 – 75Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136548 mRNA Translation: CAB66483.1
AK095575 mRNA Translation: BAG53088.1
AK122848 mRNA No translation available.
AC011477 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84861.1
CCDSiCCDS42531.1 [Q5JVG8-1]
CCDS46027.1 [Q5JVG8-2]
RefSeqiNP_001092739.1, NM_001099269.2 [Q5JVG8-1]
NP_001138876.1, NM_001145404.1 [Q5JVG8-2]
UniGeneiHs.351906

Genome annotation databases

EnsembliENST00000443905; ENSP00000393835; ENSG00000081665 [Q5JVG8-1]
ENST00000450683; ENSP00000408892; ENSG00000081665 [Q5JVG8-2]
ENST00000540806; ENSP00000440625; ENSG00000081665 [Q5JVG8-1]
ENST00000591639; ENSP00000468150; ENSG00000081665 [Q5JVG8-1]
GeneIDi440515
KEGGihsa:440515
UCSCiuc002noh.4 human [Q5JVG8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN506_HUMAN
AccessioniPrimary (citable) accession number: Q5JVG8
Secondary accession number(s): B3KTH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health