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Protein

Zinc finger protein 506

Gene

ZNF506

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri201 – 22323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 506
Gene namesi
Name:ZNF506
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23780. ZNF506.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134884301.

Polymorphism and mutation databases

BioMutaiZNF506.
DMDMi296453043.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Zinc finger protein 506PRO_0000047624Add
BLAST

Proteomic databases

EPDiQ5JVG8.
PaxDbiQ5JVG8.
PRIDEiQ5JVG8.

PTM databases

iPTMnetiQ5JVG8.
PhosphoSiteiQ5JVG8.

Expressioni

Gene expression databases

BgeeiQ5JVG8.
CleanExiHS_ZNF506.
ExpressionAtlasiQ5JVG8. baseline and differential.
GenevisibleiQ5JVG8. HS.

Interactioni

Protein-protein interaction databases

BioGridi136647. 1 interaction.
MINTiMINT-4718664.
STRINGi9606.ENSP00000393835.

Structurei

3D structure databases

ProteinModelPortaliQ5JVG8.
SMRiQ5JVG8. Positions 137-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri201 – 22323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5JVG8.
KOiK09228.
OMAiAYKQSSH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ5JVG8.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JVG8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPLQFRDVA IEFSLEEWHC LDAAQRNLYR DVMLENYRNL IFLGIVVSKP
60 70 80 90 100
NLITCLEQGK KPLTMKRHEM IAKPPVMYSH FAQDLWSEQS IKDSFQKVIL
110 120 130 140 150
RRYEKCRHDN LQLKKGCESV DECPVHKRGY NGLKQCLATT QRKIFQCDEY
160 170 180 190 200
VKFLHKFSNS NKHKIRDTGK KSFKCIEYGK TFNQSSTRTT YKKIDAGEKR
210 220 230 240 250
YKCEECGKAY KQSSHLTTHK KIHTGEKPYK CEECGKAYKQ SCNLTTHKII
260 270 280 290 300
HTGEKPYRCR ECGKAFNHPA TLFSHKKIHT GEKPYKCDKC GKAFISSSTL
310 320 330 340 350
TKHEIIHTGE KPYKCEECGK AFNRSSNLTK HKRIHTGDVP YKCDECGKTF
360 370 380 390 400
TWYSSLSKHK RAHTGEKPYK CEECGKAFTA FSTLTEHKII HTGEKPYKCE
410 420 430 440
ECGKAFNWSS ALNKHKKIHI RQKPCIVKNV ENLLNVPQPL ISIR
Length:444
Mass (Da):51,537
Last modified:May 18, 2010 - v2
Checksum:i4B8449C6B8B31FE0
GO
Isoform 2 (identifier: Q5JVG8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-75: Missing.

Show »
Length:412
Mass (Da):47,996
Checksum:iF557B8D3DBE933C7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti118 – 1181E → K in CAB66483 (PubMed:11230166).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti189 – 1891T → P.
Corresponds to variant rs16996376 [ dbSNP | Ensembl ].
VAR_057421

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei44 – 7532Missing in isoform 2. 1 PublicationVSP_040653Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136548 mRNA. Translation: CAB66483.1.
AK095575 mRNA. Translation: BAG53088.1.
AK122848 mRNA. No translation available.
AC011477 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84861.1.
CCDSiCCDS42531.1. [Q5JVG8-1]
CCDS46027.1. [Q5JVG8-2]
RefSeqiNP_001092739.1. NM_001099269.2. [Q5JVG8-1]
NP_001138876.1. NM_001145404.1. [Q5JVG8-2]
UniGeneiHs.351906.

Genome annotation databases

EnsembliENST00000443905; ENSP00000393835; ENSG00000081665. [Q5JVG8-1]
ENST00000450683; ENSP00000408892; ENSG00000081665. [Q5JVG8-2]
ENST00000540806; ENSP00000440625; ENSG00000081665. [Q5JVG8-1]
ENST00000591639; ENSP00000468150; ENSG00000081665. [Q5JVG8-1]
GeneIDi440515.
KEGGihsa:440515.
UCSCiuc002noh.4. human. [Q5JVG8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136548 mRNA. Translation: CAB66483.1.
AK095575 mRNA. Translation: BAG53088.1.
AK122848 mRNA. No translation available.
AC011477 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84861.1.
CCDSiCCDS42531.1. [Q5JVG8-1]
CCDS46027.1. [Q5JVG8-2]
RefSeqiNP_001092739.1. NM_001099269.2. [Q5JVG8-1]
NP_001138876.1. NM_001145404.1. [Q5JVG8-2]
UniGeneiHs.351906.

3D structure databases

ProteinModelPortaliQ5JVG8.
SMRiQ5JVG8. Positions 137-419.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136647. 1 interaction.
MINTiMINT-4718664.
STRINGi9606.ENSP00000393835.

PTM databases

iPTMnetiQ5JVG8.
PhosphoSiteiQ5JVG8.

Polymorphism and mutation databases

BioMutaiZNF506.
DMDMi296453043.

Proteomic databases

EPDiQ5JVG8.
PaxDbiQ5JVG8.
PRIDEiQ5JVG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000443905; ENSP00000393835; ENSG00000081665. [Q5JVG8-1]
ENST00000450683; ENSP00000408892; ENSG00000081665. [Q5JVG8-2]
ENST00000540806; ENSP00000440625; ENSG00000081665. [Q5JVG8-1]
ENST00000591639; ENSP00000468150; ENSG00000081665. [Q5JVG8-1]
GeneIDi440515.
KEGGihsa:440515.
UCSCiuc002noh.4. human. [Q5JVG8-1]

Organism-specific databases

CTDi440515.
GeneCardsiZNF506.
HGNCiHGNC:23780. ZNF506.
neXtProtiNX_Q5JVG8.
PharmGKBiPA134884301.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5JVG8.
KOiK09228.
OMAiAYKQSSH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ5JVG8.
TreeFamiTF342117.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF506. human.
GenomeRNAii440515.
PROiQ5JVG8.

Gene expression databases

BgeeiQ5JVG8.
CleanExiHS_ZNF506.
ExpressionAtlasiQ5JVG8. baseline and differential.
GenevisibleiQ5JVG8. HS.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZN506_HUMAN
AccessioniPrimary (citable) accession number: Q5JVG8
Secondary accession number(s): B3KTH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.