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Protein

Zinc finger protein 506

Gene

ZNF506

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri201 – 223C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 506
Gene namesi
Name:ZNF506
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000081665.13.
HGNCiHGNC:23780. ZNF506.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000081665.
PharmGKBiPA134884301.

Polymorphism and mutation databases

BioMutaiZNF506.
DMDMi296453043.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476241 – 444Zinc finger protein 506Add BLAST444

Proteomic databases

EPDiQ5JVG8.
MaxQBiQ5JVG8.
PaxDbiQ5JVG8.
PeptideAtlasiQ5JVG8.
PRIDEiQ5JVG8.

PTM databases

iPTMnetiQ5JVG8.
PhosphoSitePlusiQ5JVG8.

Expressioni

Gene expression databases

BgeeiENSG00000081665.
CleanExiHS_ZNF506.
ExpressionAtlasiQ5JVG8. baseline and differential.
GenevisibleiQ5JVG8. HS.

Interactioni

Protein-protein interaction databases

BioGridi136647. 1 interactor.
MINTiMINT-4718664.
STRINGi9606.ENSP00000393835.

Structurei

3D structure databases

ProteinModelPortaliQ5JVG8.
SMRiQ5JVG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri201 – 223C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139354.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5JVG8.
KOiK09228.
OMAiAYKQSSH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ5JVG8.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 5 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JVG8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPLQFRDVA IEFSLEEWHC LDAAQRNLYR DVMLENYRNL IFLGIVVSKP
60 70 80 90 100
NLITCLEQGK KPLTMKRHEM IAKPPVMYSH FAQDLWSEQS IKDSFQKVIL
110 120 130 140 150
RRYEKCRHDN LQLKKGCESV DECPVHKRGY NGLKQCLATT QRKIFQCDEY
160 170 180 190 200
VKFLHKFSNS NKHKIRDTGK KSFKCIEYGK TFNQSSTRTT YKKIDAGEKR
210 220 230 240 250
YKCEECGKAY KQSSHLTTHK KIHTGEKPYK CEECGKAYKQ SCNLTTHKII
260 270 280 290 300
HTGEKPYRCR ECGKAFNHPA TLFSHKKIHT GEKPYKCDKC GKAFISSSTL
310 320 330 340 350
TKHEIIHTGE KPYKCEECGK AFNRSSNLTK HKRIHTGDVP YKCDECGKTF
360 370 380 390 400
TWYSSLSKHK RAHTGEKPYK CEECGKAFTA FSTLTEHKII HTGEKPYKCE
410 420 430 440
ECGKAFNWSS ALNKHKKIHI RQKPCIVKNV ENLLNVPQPL ISIR
Length:444
Mass (Da):51,537
Last modified:May 18, 2010 - v2
Checksum:i4B8449C6B8B31FE0
GO
Isoform 2 (identifier: Q5JVG8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-75: Missing.

Show »
Length:412
Mass (Da):47,996
Checksum:iF557B8D3DBE933C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118E → K in CAB66483 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057421189T → P. Corresponds to variant dbSNP:rs16996376Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04065344 – 75Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136548 mRNA. Translation: CAB66483.1.
AK095575 mRNA. Translation: BAG53088.1.
AK122848 mRNA. No translation available.
AC011477 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84861.1.
CCDSiCCDS42531.1. [Q5JVG8-1]
CCDS46027.1. [Q5JVG8-2]
RefSeqiNP_001092739.1. NM_001099269.2. [Q5JVG8-1]
NP_001138876.1. NM_001145404.1. [Q5JVG8-2]
UniGeneiHs.351906.

Genome annotation databases

EnsembliENST00000443905; ENSP00000393835; ENSG00000081665. [Q5JVG8-1]
ENST00000450683; ENSP00000408892; ENSG00000081665. [Q5JVG8-2]
ENST00000540806; ENSP00000440625; ENSG00000081665. [Q5JVG8-1]
ENST00000591639; ENSP00000468150; ENSG00000081665. [Q5JVG8-1]
GeneIDi440515.
KEGGihsa:440515.
UCSCiuc002noh.4. human. [Q5JVG8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN506_HUMAN
AccessioniPrimary (citable) accession number: Q5JVG8
Secondary accession number(s): B3KTH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 18, 2010
Last modified: September 27, 2017
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families