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Protein

Zinc finger protein 484

Gene

ZNF484

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri223 – 245C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 350C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri552 – 574C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri580 – 602C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri608 – 630C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri636 – 658C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri664 – 686C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri692 – 714C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri720 – 742C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri748 – 770C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri776 – 798C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 484
Gene namesi
Name:ZNF484
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23385. ZNF484.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127081.
PharmGKBiPA134992184.

Polymorphism and mutation databases

BioMutaiZNF484.
DMDMi74762200.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339861 – 852Zinc finger protein 484Add BLAST852

Proteomic databases

MaxQBiQ5JVG2.
PaxDbiQ5JVG2.
PeptideAtlasiQ5JVG2.
PRIDEiQ5JVG2.

PTM databases

iPTMnetiQ5JVG2.
PhosphoSitePlusiQ5JVG2.

Expressioni

Gene expression databases

BgeeiENSG00000127081.
CleanExiHS_ZNF484.

Organism-specific databases

HPAiHPA028973.

Interactioni

Protein-protein interaction databases

IntActiQ5JVG2. 2 interactors.
STRINGi9606.ENSP00000364645.

Structurei

Secondary structure

1852
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi379 – 381Combined sources3
Beta strandi387 – 389Combined sources3
Beta strandi392 – 394Combined sources3
Helixi396 – 402Combined sources7
Helixi403 – 405Combined sources3
Beta strandi411 – 413Combined sources3
Beta strandi415 – 417Combined sources3
Beta strandi420 – 425Combined sources6
Helixi426 – 434Combined sources9
Beta strandi443 – 445Combined sources3
Helixi452 – 459Combined sources8
Helixi460 – 462Combined sources3
Beta strandi463 – 465Combined sources3
Turni471 – 473Combined sources3
Helixi480 – 487Combined sources8
Turni488 – 490Combined sources3
Beta strandi495 – 497Combined sources3
Turni499 – 501Combined sources3
Beta strandi504 – 507Combined sources4
Helixi508 – 519Combined sources12
Beta strandi527 – 529Combined sources3
Helixi536 – 545Combined sources10
Beta strandi555 – 557Combined sources3
Beta strandi560 – 563Combined sources4
Helixi564 – 571Combined sources8
Helixi572 – 574Combined sources3
Beta strandi607 – 609Combined sources3
Beta strandi611 – 613Combined sources3
Beta strandi616 – 619Combined sources4
Helixi620 – 628Combined sources9
Beta strandi635 – 637Combined sources3
Beta strandi639 – 641Combined sources3
Beta strandi644 – 647Combined sources4
Helixi648 – 655Combined sources8
Turni656 – 660Combined sources5
Beta strandi667 – 669Combined sources3
Beta strandi672 – 675Combined sources4
Helixi676 – 686Combined sources11
Beta strandi695 – 697Combined sources3
Beta strandi700 – 703Combined sources4
Helixi704 – 711Combined sources8
Turni712 – 714Combined sources3
Beta strandi719 – 721Combined sources3
Beta strandi723 – 725Combined sources3
Beta strandi728 – 731Combined sources4
Helixi732 – 738Combined sources7
Helixi739 – 741Combined sources3
Beta strandi775 – 777Combined sources3
Beta strandi779 – 781Combined sources3
Beta strandi784 – 787Combined sources4
Helixi788 – 797Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EMFNMR-A379-411[»]
2EMGNMR-A463-495[»]
2EMHNMR-A491-523[»]
2EMINMR-A547-579[»]
2EOVNMR-A519-551[»]
2EP1NMR-A435-467[»]
2EP2NMR-A603-635[»]
2EP3NMR-A631-663[»]
2EQWNMR-A409-437[»]
2YTJNMR-A771-803[»]
2YTONMR-A659-691[»]
2YTPNMR-A687-719[»]
2YTSNMR-A715-747[»]
ProteinModelPortaliQ5JVG2.
SMRiQ5JVG2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5JVG2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 78KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri223 – 245C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 350C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri552 – 574C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri580 – 602C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri608 – 630C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri636 – 658C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri664 – 686C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri692 – 714C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri720 – 742C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri748 – 770C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri776 – 798C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133809.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5JVG2.
KOiK09228.
OMAiHVNTHLV.
OrthoDBiEOG091G02KC.
PhylomeDBiQ5JVG2.
TreeFamiTF350810.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JVG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTKSLESVSF KDVTVDFSRD EWQQLDLAQK SLYREVMLEN YFNLISVGCQ
60 70 80 90 100
VPKPEVIFSL EQEEPCMLDG EIPSQSRPDG DIGFGPLQQR MSEEVSFQSE
110 120 130 140 150
ININLFTRDD PYSILEELWK DDEHTRKCGE NQNKPLSRVV FINKKTLAND
160 170 180 190 200
SIFEYKDIGE IVHVNTHLVS SRKRPHNCNS CGKNLEPIIT LYNRNNATEN
210 220 230 240 250
SDKTIGDGDI FTHLNSHTEV TACECNQCGK PLHHKQALIQ QQKIHTRESL
260 270 280 290 300
YLFSDYVNVF SPKSHAFAHE SICAEEKQHE CHECEAVFTQ KSQLDGSQRV
310 320 330 340 350
YAGICTEYEK DFSLKSNRQK TPYEGNYYKC SDYGRAFIQK SDLFRCQRIH
360 370 380 390 400
SGEKPYEYSE CEKNLPQNSN LNIHKKIHTG GKHFECTECG KAFTRKSTLS
410 420 430 440 450
MHQKIHTGEK PYVCTECGKA FIRKSHFITH ERIHTGEKPY ECSDCGKSFI
460 470 480 490 500
KKSQLHVHQR IHTGENPFIC SECGKVFTHK TNLIIHQKIH TGERPYICTV
510 520 530 540 550
CGKAFTDRSN LIKHQKIHTG EKPYKCSDCG KSFTWKSRLR IHQKCHTGER
560 570 580 590 600
HYECSECGKA FIQKSTLSMH QRIHRGEKPY VCTECGKAFF HKSHFITHER
610 620 630 640 650
IHTGEKPYEC SICGKSFTKK SQLHVHQQIH TGEKPYRCAE CGKAFTDRSN
660 670 680 690 700
LFTHQKIHTG EKPYKCSDCG KAFTRKSGLH IHQQSHTGER HYECSECGKA
710 720 730 740 750
FARKSTLIMH QRIHTGEKPY ICNECGKSFI QKSHLNRHRR IHTGEKPYEC
760 770 780 790 800
SDCGKSFIKK SQLHEHHRIH TGEKPYICAE CGKAFTIRSN LIKHQKIHTK
810 820 830 840 850
QKPYKCSDLG KALNWKPQLS MPQKSDNGEV ECSMPQLWCG DSEGDQGQLS

SI
Length:852
Mass (Da):98,221
Last modified:February 15, 2005 - v1
Checksum:i98A75F9C12877908
GO
Isoform 2 (identifier: Q5JVG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Note: No experimental confirmation available.
Show »
Length:816
Mass (Da):93,959
Checksum:iB5383CA9AB13B517
GO
Isoform 3 (identifier: Q5JVG2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MTKSL → MSVLSLP

Note: No experimental confirmation available.
Show »
Length:854
Mass (Da):98,388
Checksum:iDC702347BB90C166
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033570502G → D.Corresponds to variant rs3739602dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0430791 – 36Missing in isoform 2. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_0449221 – 5MTKSL → MSVLSLP in isoform 3. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091203 mRNA. Translation: BAG52305.1.
AK299274 mRNA. Translation: BAG61294.1.
AL136981 Genomic DNA. Translation: CAI41017.1.
AL136981 Genomic DNA. Translation: CAI41018.1.
CH471089 Genomic DNA. Translation: EAW62837.1.
BC112394 mRNA. Translation: AAI12395.1.
BC112396 mRNA. Translation: AAI12397.1.
CCDSiCCDS35066.1. [Q5JVG2-1]
CCDS35067.1. [Q5JVG2-2]
CCDS59136.1. [Q5JVG2-3]
RefSeqiNP_001007102.1. NM_001007101.2. [Q5JVG2-2]
NP_001248387.1. NM_001261458.1. [Q5JVG2-3]
NP_001248388.1. NM_001261459.1. [Q5JVG2-2]
NP_001248389.1. NM_001261460.1. [Q5JVG2-2]
NP_113674.1. NM_031486.2. [Q5JVG2-1]
XP_016870670.1. XM_017015181.1. [Q5JVG2-2]
UniGeneiHs.668378.

Genome annotation databases

EnsembliENST00000332591; ENSP00000364646; ENSG00000127081. [Q5JVG2-2]
ENST00000375495; ENSP00000364645; ENSG00000127081. [Q5JVG2-1]
ENST00000395505; ENSP00000378881; ENSG00000127081. [Q5JVG2-3]
ENST00000395506; ENSP00000378882; ENSG00000127081. [Q5JVG2-2]
GeneIDi83744.
KEGGihsa:83744.
UCSCiuc004asu.3. human. [Q5JVG2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091203 mRNA. Translation: BAG52305.1.
AK299274 mRNA. Translation: BAG61294.1.
AL136981 Genomic DNA. Translation: CAI41017.1.
AL136981 Genomic DNA. Translation: CAI41018.1.
CH471089 Genomic DNA. Translation: EAW62837.1.
BC112394 mRNA. Translation: AAI12395.1.
BC112396 mRNA. Translation: AAI12397.1.
CCDSiCCDS35066.1. [Q5JVG2-1]
CCDS35067.1. [Q5JVG2-2]
CCDS59136.1. [Q5JVG2-3]
RefSeqiNP_001007102.1. NM_001007101.2. [Q5JVG2-2]
NP_001248387.1. NM_001261458.1. [Q5JVG2-3]
NP_001248388.1. NM_001261459.1. [Q5JVG2-2]
NP_001248389.1. NM_001261460.1. [Q5JVG2-2]
NP_113674.1. NM_031486.2. [Q5JVG2-1]
XP_016870670.1. XM_017015181.1. [Q5JVG2-2]
UniGeneiHs.668378.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EMFNMR-A379-411[»]
2EMGNMR-A463-495[»]
2EMHNMR-A491-523[»]
2EMINMR-A547-579[»]
2EOVNMR-A519-551[»]
2EP1NMR-A435-467[»]
2EP2NMR-A603-635[»]
2EP3NMR-A631-663[»]
2EQWNMR-A409-437[»]
2YTJNMR-A771-803[»]
2YTONMR-A659-691[»]
2YTPNMR-A687-719[»]
2YTSNMR-A715-747[»]
ProteinModelPortaliQ5JVG2.
SMRiQ5JVG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5JVG2. 2 interactors.
STRINGi9606.ENSP00000364645.

PTM databases

iPTMnetiQ5JVG2.
PhosphoSitePlusiQ5JVG2.

Polymorphism and mutation databases

BioMutaiZNF484.
DMDMi74762200.

Proteomic databases

MaxQBiQ5JVG2.
PaxDbiQ5JVG2.
PeptideAtlasiQ5JVG2.
PRIDEiQ5JVG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332591; ENSP00000364646; ENSG00000127081. [Q5JVG2-2]
ENST00000375495; ENSP00000364645; ENSG00000127081. [Q5JVG2-1]
ENST00000395505; ENSP00000378881; ENSG00000127081. [Q5JVG2-3]
ENST00000395506; ENSP00000378882; ENSG00000127081. [Q5JVG2-2]
GeneIDi83744.
KEGGihsa:83744.
UCSCiuc004asu.3. human. [Q5JVG2-1]

Organism-specific databases

CTDi83744.
GeneCardsiZNF484.
HGNCiHGNC:23385. ZNF484.
HPAiHPA028973.
neXtProtiNX_Q5JVG2.
OpenTargetsiENSG00000127081.
PharmGKBiPA134992184.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133809.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5JVG2.
KOiK09228.
OMAiHVNTHLV.
OrthoDBiEOG091G02KC.
PhylomeDBiQ5JVG2.
TreeFamiTF350810.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

EvolutionaryTraceiQ5JVG2.
GenomeRNAii83744.
PROiQ5JVG2.

Gene expression databases

BgeeiENSG00000127081.
CleanExiHS_ZNF484.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN484_HUMAN
AccessioniPrimary (citable) accession number: Q5JVG2
Secondary accession number(s): B1AL89, B4DRI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: February 15, 2005
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.