Q5JVF3 (PCID2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PCI domain-containing protein 2

Alternative name(s):
CSN12-like protein

Gene names

Name:	PCID2
ORF Names:	HT004

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation By similarity.
Sequence similarities	Belongs to the CSN12 family. Contains 1 PCI domain.
Sequence caution	The sequence AAG09695.1 differs from that shown. Reason: Frameshift at position 48. The sequence BAB15768.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	negative regulation of apoptotic process Inferred from mutant phenotype. Source: UniProtKB negative regulation of cysteine-type endopeptidase activity Inferred from mutant phenotype. Source: UniProtKB positive regulation of mitotic cell cycle spindle assembly checkpoint Inferred from mutant phenotype. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from mutant phenotype. Source: UniProtKB regulation of mRNA stability Inferred from mutant phenotype. Source: UniProtKB spleen development Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5JVF3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5JVF3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MAHITINQYLQQ → MRLTDVVQQL

Note: No experimental confirmation available.

Isoform 3 (identifier: Q5JVF3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     92-114: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q5JVF3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     89-89: Q → QYPLSFMAAVPHRTHAVDYLGLETRKHWASCSFLQLERNDSVLEQKLVSALSLGT

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.5
	Chain	2 – 399	398	PCI domain-containing protein 2		PRO_0000121029
Regions
	Domain	277 – 388	112	PCI
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.5
	Modified residue	232	1	Phosphotyrosine Ref.6
Natural variations
	Alternative sequence	1 – 12	12	MAHIT…QYLQQ → MRLTDVVQQL in isoform 2.		VSP_016843
	Alternative sequence	89	1	Q → QYPLSFMAAVPHRTHAVDYL GLETRKHWASCSFLQLERND SVLEQKLVSALSLGT in isoform 4.		VSP_016844
	Alternative sequence	92 – 114	23	Missing in isoform 3.		VSP_016845
Experimental info
	Sequence conflict	74	1	N → D in AAH31246. Ref.4
	Sequence conflict	87	1	I → L in BAA91407. Ref.1
	Sequence conflict	106	1	P → L in AAG09695. Ref.2
	Sequence conflict	129	1	K → E in AAG09695. Ref.2
	Sequence conflict	145	1	L → M in BAA91407. Ref.1
	Sequence conflict	180	1	F → I in BAA91611. Ref.1
	Sequence conflict	313	1	I → T in BAA92118. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 10, 2006. Version 2. Checksum: 8D23273361F00E18	FASTA	399	46,030
	10 20 30 40 50 60 MAHITINQYL QQVYEAIDSR DGASCAELVS FKHPHVANPR LQMASPEEKC QQVLEPPYDE 70 80 90 100 110 120 MFAAHLRCTY AVGNHDFIEA YKCQTVIVQS FLRAFQAHKE ENWALPVMYA VALDLRVFAN 130 140 150 160 170 180 NADQQLVKKG KSKVGDMLEK AAELLMSCFR VCASDTRAGI EDSKKWGMLF LVNQLFKIYF 190 200 210 220 230 240 KINKLHLCKP LIRAIDSSNL KDDYSTAQRV TYKYYVGRKA MFDSDFKQAE EYLSFAFEHC 250 260 270 280 290 300 HRSSQKNKRM ILIYLLPVKM LLGHMPTVEL LKKYHLMQFA EVTRAVSEGN LLLLHEALAK 310 320 330 340 350 360 HEAFFIRCGI FLILEKLKII TYRNLFKKVY LLLKTHQLSL DAFLVALKFM QVEDVDIDEV 370 380 390 QCILANLIYM GHVKGYISHQ HQKLVVSKQN PFPPLSTVC
	Isoform 2 [UniParc]. Checksum: 785FD46B5D72AF70	FASTA	397	45,773
	10 20 30 40 50 60 MRLTDVVQQL VYEAIDSRDG ASCAELVSFK HPHVANPRLQ MASPEEKCQQ VLEPPYDEMF 70 80 90 100 110 120 AAHLRCTYAV GNHDFIEAYK CQTVIVQSFL RAFQAHKEEN WALPVMYAVA LDLRVFANNA 130 140 150 160 170 180 DQQLVKKGKS KVGDMLEKAA ELLMSCFRVC ASDTRAGIED SKKWGMLFLV NQLFKIYFKI 190 200 210 220 230 240 NKLHLCKPLI RAIDSSNLKD DYSTAQRVTY KYYVGRKAMF DSDFKQAEEY LSFAFEHCHR 250 260 270 280 290 300 SSQKNKRMIL IYLLPVKMLL GHMPTVELLK KYHLMQFAEV TRAVSEGNLL LLHEALAKHE 310 320 330 340 350 360 AFFIRCGIFL ILEKLKIITY RNLFKKVYLL LKTHQLSLDA FLVALKFMQV EDVDIDEVQC 370 380 390 ILANLIYMGH VKGYISHQHQ KLVVSKQNPF PPLSTVC
	Isoform 3 [UniParc]. Checksum: 039E8F8B8192F3C1	FASTA	376	43,375
	10 20 30 40 50 60 MAHITINQYL QQVYEAIDSR DGASCAELVS FKHPHVANPR LQMASPEEKC QQVLEPPYDE 70 80 90 100 110 120 MFAAHLRCTY AVGNHDFIEA YKCQTVIVQS FLRVFANNAD QQLVKKGKSK VGDMLEKAAE 130 140 150 160 170 180 LLMSCFRVCA SDTRAGIEDS KKWGMLFLVN QLFKIYFKIN KLHLCKPLIR AIDSSNLKDD 190 200 210 220 230 240 YSTAQRVTYK YYVGRKAMFD SDFKQAEEYL SFAFEHCHRS SQKNKRMILI YLLPVKMLLG 250 260 270 280 290 300 HMPTVELLKK YHLMQFAEVT RAVSEGNLLL LHEALAKHEA FFIRCGIFLI LEKLKIITYR 310 320 330 340 350 360 NLFKKVYLLL KTHQLSLDAF LVALKFMQVE DVDIDEVQCI LANLIYMGHV KGYISHQHQK 370 LVVSKQNPFP PLSTVC
	Isoform 4 [UniParc]. Checksum: 57BB6C3A1E85A059	FASTA	453	52,100
	10 20 30 40 50 60 MAHITINQYL QQVYEAIDSR DGASCAELVS FKHPHVANPR LQMASPEEKC QQVLEPPYDE 70 80 90 100 110 120 MFAAHLRCTY AVGNHDFIEA YKCQTVIVQY PLSFMAAVPH RTHAVDYLGL ETRKHWASCS 130 140 150 160 170 180 FLQLERNDSV LEQKLVSALS LGTSFLRAFQ AHKEENWALP VMYAVALDLR VFANNADQQL 190 200 210 220 230 240 VKKGKSKVGD MLEKAAELLM SCFRVCASDT RAGIEDSKKW GMLFLVNQLF KIYFKINKLH 250 260 270 280 290 300 LCKPLIRAID SSNLKDDYST AQRVTYKYYV GRKAMFDSDF KQAEEYLSFA FEHCHRSSQK 310 320 330 340 350 360 NKRMILIYLL PVKMLLGHMP TVELLKKYHL MQFAEVTRAV SEGNLLLLHE ALAKHEAFFI 370 380 390 400 410 420 RCGIFLILEK LKIITYRNLF KKVYLLLKTH QLSLDAFLVA LKFMQVEDVD IDEVQCILAN 430 440 450 LIYMGHVKGY ISHQHQKLVV SKQNPFPPLS TVC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4). Tissue: Embryo, Ovary, Placenta, Spleen and Teratocarcinoma.
[2]	"A novel gene expressed in human hypothalamus." Peng Y., Li N., Jia J., Xu S., Han Z., Fu G., Chen Z. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Hypothalamus.
[3]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Eye and Testis.
[5]	Bienvenut W.V. Submitted (JAN-2010) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-20; 83-93; 117-128 AND 250-259, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: Ovarian carcinoma.
[6]	"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-232, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK000888 mRNA. Translation: BAA91407.1. AK001185 mRNA. Translation: BAA91542.1. AK001302 mRNA. Translation: BAA91611.1. AK002167 mRNA. Translation: BAA92118.1. AK023313 mRNA. Translation: BAB14521.1. AK024478 mRNA. Translation: BAB15768.1. Different initiation. AF183426 mRNA. Translation: AAG09695.1. Frameshift. AL137002 Genomic DNA. Translation: CAI41391.1. AL136221, AL137002 Genomic DNA. Translation: CAI13794.1. AL137002, AL136221 Genomic DNA. Translation: CAI41378.1. AL136221, AL137002 Genomic DNA. Translation: CAI13793.1. AL137002, AL136221 Genomic DNA. Translation: CAI41377.1. AL136221, AL137002 Genomic DNA. Translation: CAI13792.1. AL137002, AL136221 Genomic DNA. Translation: CAI41379.1. BC016614 mRNA. Translation: AAH16614.1. BC031246 mRNA. Translation: AAH31246.1.
IPI	IPI00072541. IPI00100313. IPI00941197. IPI01019111.
RefSeq	NP_001120674.1. NM_001127202.1. NP_001120675.1. NM_001127203.1. NP_060856.2. NM_018386.2.
UniGene	Hs.508769. Hs.729648.
3D structure databases
ProteinModelPortal	Q5JVF3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5JVF3. 1 interaction.
STRING	Q5JVF3.
PTM databases
PhosphoSite	Q5JVF3.
Polymorphism databases
DMDM	85681034.
Proteomic databases
PRIDE	Q5JVF3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000337344; ENSP00000337405; ENSG00000126226. ENST00000375477; ENSP00000364626; ENSG00000126226. ENST00000375479; ENSP00000364628; ENSG00000126226.
GeneID	55795.
KEGG	hsa:55795.
UCSC	uc001vtc.1. human.
Organism-specific databases
CTD	55795.
GeneCards	GC13M113831.
H-InvDB	HIX0011473.
HGNC	HGNC:25653. PCID2.
MIM	613713. gene.
neXtProt	NX_Q5JVF3.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06804.
GeneTree	ENSGT00390000001101.
HOVERGEN	HBG055800.
OMA	YFRINKL.
OrthoDB	EOG42821Q.
PhylomeDB	Q5JVF3.
Gene expression databases
ArrayExpress	Q5JVF3.
Bgee	Q5JVF3.
CleanEx	HS_PCID2.
Genevestigator	Q5JVF3.
GermOnline	ENSG00000126226. Homo sapiens.
Family and domain databases
InterPro	IPR013143. PAM. IPR000717. PCI_dom. [Graphical view]
Pfam	PF01399. PCI. 1 hit. [Graphical view]
SMART	SM00753. PAM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	60919.
SOURCE	Search...

Entry information

Entry name

PCID2_HUMAN

Accession

Primary (citable) accession number: Q5JVF3
Secondary accession number(s): A6NK09 , Q3ZCX1, Q5TC57, Q5TC58, Q9H7K1, Q9HBZ7, Q9NUK6, Q9NVY1, Q9NW44, Q9NWH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	January 10, 2006
Last modified:	January 25, 2012
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.