ID Q5JVC1_HUMAN Unreviewed; 147 AA. AC Q5JVC1; DT 15-FEB-2005, integrated into UniProtKB/TrEMBL. DT 15-FEB-2005, sequence version 1. DT 27-MAR-2024, entry version 110. DE SubName: Full=Citramalyl-CoA lyase {ECO:0000313|Ensembl:ENSP00000401586.1}; DE Flags: Fragment; GN Name=CLYBL {ECO:0000313|Ensembl:ENSP00000401586.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000401586.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000401586.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057823; DOI=10.1038/nature02379; RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L., RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., RA Frankish A.G., Frankland J., French L., Garner P., Garnett J., RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., RA Coulson A., Durbin R., Hubbard T., Sulston J.E., Beck S., Bentley D.R., RA Rogers J., Ross M.T.; RT "The DNA sequence and analysis of human chromosome 13."; RL Nature 428:522-528(2004). RN [2] {ECO:0007829|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [3] {ECO:0007829|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [4] {ECO:0000313|Ensembl:ENSP00000401586.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL137139; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL139035; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL359748; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL445184; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF455818; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; Q5JVC1; -. DR SMR; Q5JVC1; -. DR MassIVE; Q5JVC1; -. DR MaxQB; Q5JVC1; -. DR PeptideAtlas; Q5JVC1; -. DR ProteomicsDB; 63319; -. DR Antibodypedia; 25197; 67 antibodies from 17 providers. DR Ensembl; ENST00000443887.1; ENSP00000401586.1; ENSG00000125246.16. DR UCSC; uc058xzy.1; human. DR HGNC; HGNC:18355; CLYBL. DR VEuPathDB; HostDB:ENSG00000125246; -. DR GeneTree; ENSGT00390000017163; -. DR ChiTaRS; CLYBL; human. DR Proteomes; UP000005640; Chromosome 13. DR Bgee; ENSG00000125246; Expressed in kidney epithelium and 168 other cell types or tissues. DR ExpressionAtlas; Q5JVC1; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0003824; F:catalytic activity; IEA:InterPro. DR Gene3D; 3.20.20.60; Phosphoenolpyruvate-binding domains; 1. DR InterPro; IPR005000; Aldolase/citrate-lyase_domain. DR InterPro; IPR040186; Citramalyl-CoA_lyase. DR InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom. DR InterPro; IPR040442; Pyrv_Kinase-like_dom_sf. DR PANTHER; PTHR11105:SF0; CITRAMALYL-COA LYASE, MITOCHONDRIAL; 1. DR PANTHER; PTHR11105; CITRATE LYASE SUBUNIT BETA-RELATED; 1. DR Pfam; PF03328; HpcH_HpaI; 1. DR SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1. PE 1: Evidence at protein level; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|EPD:Q5JVC1, KW ECO:0007829|MaxQB:Q5JVC1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 101..120 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 2..64 FT /note="HpcH/HpaI aldolase/citrate lyase" FT /evidence="ECO:0000259|Pfam:PF03328" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSP00000401586.1" SQ SEQUENCE 147 AA; 16280 MW; FB3B439BFE70B95C CRC64; NEARLRIVKT LEDIDLGPTE KCVRVNSVSS GLAEEDLETL LQSRVLPSSL MLPKVESPEE IQWAVCEETL KVGPQVGLFL DAVVFGGEDF RASIGVKDIS LSLFLCVCVY MCVYIFSLPL KDGHLHNNVY LPTMTMVFHD NGMDTTS //