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Protein

FERM and PDZ domain-containing protein 3

Gene

FRMPD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
FERM and PDZ domain-containing protein 3
Gene namesi
Name:FRMPD3
Synonyms:KIAA1817
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:29382. FRMPD3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485474.

Polymorphism and mutation databases

DMDMi118582027.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18101810FERM and PDZ domain-containing protein 3PRO_0000254650Add
BLAST

Proteomic databases

EPDiQ5JV73.
MaxQBiQ5JV73.
PaxDbiQ5JV73.
PRIDEiQ5JV73.

PTM databases

iPTMnetiQ5JV73.
PhosphoSiteiQ5JV73.

Expressioni

Gene expression databases

BgeeiQ5JV73.
CleanExiHS_FRMPD3.
ExpressionAtlasiQ5JV73. baseline and differential.
GenevisibleiQ5JV73. HS.

Organism-specific databases

HPAiHPA003164.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000276185.

Structurei

3D structure databases

ProteinModelPortaliQ5JV73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 13178PDZPROSITE-ProRule annotationAdd
BLAST
Domaini180 – 494315FERMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi683 – 6919Poly-Glu
Compositional biasi779 – 7846Poly-Pro
Compositional biasi1584 – 15874Poly-Ser
Compositional biasi1750 – 177627Gln-richAdd
BLAST
Compositional biasi1778 – 17847Poly-Ala

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3552. Eukaryota.
ENOG410YV8Z. LUCA.
GeneTreeiENSGT00530000063201.
HOGENOMiHOG000112647.
InParanoidiQ5JV73.
OMAiRKCDMAD.
OrthoDBiEOG7W419W.
PhylomeDBiQ5JV73.
TreeFamiTF316497.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR001478. PDZ.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JV73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLDSQRVQ DRLLAAPGCS SPSGQQELFS SHVMQEESAN DMECEQLPAE
60 70 80 90 100
ILRQVTVHRD PIYGFGFVAG SERPVVVRSV RPGGPSENKL LAGDQIVAIN
110 120 130 140 150
EEDVSEAPRE RLIELIRSAK EFIVLTVLHT HQSPKSAFIS AAKKAKLRSN
160 170 180 190 200
PVKVRFSEQV AVGETDAKMM KKEALLLIPN VLKVFLENGQ IKSFTFDGRT
210 220 230 240 250
TVKDVMLTLQ DRLSLRFIEH FALVLEYAGP EQNHKFLLLQ DKQPLAYVVQ
260 270 280 290 300
RTHYHGMKCL FRISFFPKDP VELLRRDPAA FEYLYIQSRN DVIRERFGMD
310 320 330 340 350
PKPEMLLGLA ALHIYITVSA TRPSQKISLK NVEKEWGLEP FLPPSLLQVI
360 370 380 390 400
KEKNLRKSLS QQLKAHQTHP SCGTKGSAIQ AKLQYLRILN ELPTFTGVLF
410 420 430 440 450
NTVGLDEKQS ATTLLVGPRH GISHVIDLKT NLTTVLSEFS KISKIQLFRE
460 470 480 490 500
NQGVARVETS IMDAKPLVLL MEWPEATNFA CLIAGYCRLL LDSRKMVFSR
510 520 530 540 550
PASQPLPPPM IKADYMHSAH RPVTGGHLGK KESSYVGSVG TSPRKSSRCT
560 570 580 590 600
PPPADSELVS FCYLHMREQR KEQESRTDVN ENLIFFEETR PRTKSDPTSK
610 620 630 640 650
SSGQGYEVVP DDFDAASLDH EPCASRARSY TLDNSLGAEA LNFYCDSCKA
660 670 680 690 700
KLQEQLGPRK GGKPGSSRDN IVDLMSLPPP GSEEEEEEED ETTSLLPAIA
710 720 730 740 750
APPPGFRDNS SDEDDPKRRA VQSQEQGRHL RGLLYDEIPV TLIDSVQTRT
760 770 780 790 800
VRDHAQELDD ALVSTLQALE ALAASEDGPH PPPPQTAGLI VLATITPESS
810 820 830 840 850
LDSGHETNSS ELTDMSEMMS AMKQHQNTTY FLAQHLNKDS LLARKDLPFR
860 870 880 890 900
IQSCAAQAVL TAPYSLGRPD PNPSLQPIAT GQSPGPPGAR RKLPQSEGQV
910 920 930 940 950
QGERTYSLAV HPALSPQLSE QKNLSLLSPV PEDKGPGHTR AGLEMSLRAA
960 970 980 990 1000
TSSLSEEQVS ELRDNLPKEV RLSPKLILDP KSSVTPAIIS AALQQVVHNK
1010 1020 1030 1040 1050
SLVTAGGALG NPPSRGERRL EASMGRPEVS MMSSSASKNL KFKISPSAPE
1060 1070 1080 1090 1100
TSWNSQHQLG AEVSSSPRAP TGSRADSLHL SQQEDSLPVQ NFPPKSYLLR
1110 1120 1130 1140 1150
TSRESVGKQA TGEVAGKGGP VGGKPTLQKQ GTISSQGEKA QLESTPKRSK
1160 1170 1180 1190 1200
LEETSLVPRA TYPMALQSPS CQSRSHSPSC QPHGHSPSSQ SRGQSPSCQP
1210 1220 1230 1240 1250
RGQSPLRSQA ASRQVSTMPS RKLETTLNGA HSTSEGPAKP KSSRGPFRLR
1260 1270 1280 1290 1300
NLFSATFPTR QKKETDERQA QLQKVKQYEL EFLEELLKPP SQGELPGTEY
1310 1320 1330 1340 1350
LQPPAPGRCS CQLRSSPVQQ GPGMSREQRR SCDCKRICRG GRPQATQTPV
1360 1370 1380 1390 1400
PSLRGRERDR VLPSQRQPEA GPGVSLSSPI NVQRIRSTSL ESRECRSDPE
1410 1420 1430 1440 1450
SGVSCLTTCA SGGECLGAPN YRKLMRRYSI SELDQGDRAS LTSDVYPHPP
1460 1470 1480 1490 1500
LGMLPREAKE VEASLPIALG PKSRSLESPT LGDPSYVQVA PETKGPRQMA
1510 1520 1530 1540 1550
VFSLPEEVYR KPAELDEDSE SSKCCSIRYC FYYRKCDMAD DASDGKDELS
1560 1570 1580 1590 1600
YSIPMKILPG MKLDEQVVPV VSRTLQVLDA ATCSSSSPEA SRTQEIDLRV
1610 1620 1630 1640 1650
STFEGSLAKI NALRAHAYGL PDGFLAARLD TNELLTVLRQ CVASPEARAP
1660 1670 1680 1690 1700
KPYVSQISEY KLELALKFKE LRASCRRVAN VDKSPTHMLA AITGSFQVLS
1710 1720 1730 1740 1750
SLIETFVRLV FIVRSEAQRQ ELLAKVEEVV RNYTFLLRAA EESTARNLNQ
1760 1770 1780 1790 1800
QQQQQQQQQQ QQQQQQQQQQ QQQQQQVAAA AGAATEHPPG SPTSATVMST
1810
FTHSLKTLIK
Length:1,810
Mass (Da):199,209
Last modified:October 31, 2006 - v2
Checksum:i9FC42A38E6B682BB
GO

Sequence cautioni

The sequence CAI42175.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI42749.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti814 – 8229DMSEMMSAM → ALKSWFHDL in BAB47446 (PubMed:11347906).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137787, AL035088 Genomic DNA. Translation: CAI42175.1. Sequence problems.
AL035088, AL137787 Genomic DNA. Translation: CAI42749.1. Sequence problems.
AB058720 mRNA. Translation: BAB47446.1.
CCDSiCCDS76006.1.
RefSeqiNP_115804.1. NM_032428.1.
UniGeneiHs.496546.

Genome annotation databases

EnsembliENST00000276185; ENSP00000276185; ENSG00000147234.
GeneIDi84443.
KEGGihsa:84443.
UCSCiuc033eqj.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137787, AL035088 Genomic DNA. Translation: CAI42175.1. Sequence problems.
AL035088, AL137787 Genomic DNA. Translation: CAI42749.1. Sequence problems.
AB058720 mRNA. Translation: BAB47446.1.
CCDSiCCDS76006.1.
RefSeqiNP_115804.1. NM_032428.1.
UniGeneiHs.496546.

3D structure databases

ProteinModelPortaliQ5JV73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000276185.

PTM databases

iPTMnetiQ5JV73.
PhosphoSiteiQ5JV73.

Polymorphism and mutation databases

DMDMi118582027.

Proteomic databases

EPDiQ5JV73.
MaxQBiQ5JV73.
PaxDbiQ5JV73.
PRIDEiQ5JV73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276185; ENSP00000276185; ENSG00000147234.
GeneIDi84443.
KEGGihsa:84443.
UCSCiuc033eqj.1. human.

Organism-specific databases

CTDi84443.
GeneCardsiFRMPD3.
H-InvDBHIX0016975.
HGNCiHGNC:29382. FRMPD3.
HPAiHPA003164.
neXtProtiNX_Q5JV73.
PharmGKBiPA143485474.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3552. Eukaryota.
ENOG410YV8Z. LUCA.
GeneTreeiENSGT00530000063201.
HOGENOMiHOG000112647.
InParanoidiQ5JV73.
OMAiRKCDMAD.
OrthoDBiEOG7W419W.
PhylomeDBiQ5JV73.
TreeFamiTF316497.

Miscellaneous databases

ChiTaRSiFRMPD3. human.
GenomeRNAii84443.
NextBioi13621411.
PROiQ5JV73.

Gene expression databases

BgeeiQ5JV73.
CleanExiHS_FRMPD3.
ExpressionAtlasiQ5JV73. baseline and differential.
GenevisibleiQ5JV73. HS.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR001478. PDZ.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 814-1810.
    Tissue: Brain.

Entry informationi

Entry nameiFRPD3_HUMAN
AccessioniPrimary (citable) accession number: Q5JV73
Secondary accession number(s): Q96JK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: March 16, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.