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Protein

FERM and PDZ domain-containing protein 3

Gene

FRMPD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
FERM and PDZ domain-containing protein 3
Gene namesi
Name:FRMPD3
Synonyms:KIAA1817
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147234.10
HGNCiHGNC:29382 FRMPD3
MIMi301005 gene
neXtProtiNX_Q5JV73

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000147234
PharmGKBiPA143485474

Polymorphism and mutation databases

DMDMi118582027

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002546501 – 1810FERM and PDZ domain-containing protein 3Add BLAST1810

Proteomic databases

EPDiQ5JV73
MaxQBiQ5JV73
PaxDbiQ5JV73
PeptideAtlasiQ5JV73
PRIDEiQ5JV73
ProteomicsDBi63310

PTM databases

iPTMnetiQ5JV73
PhosphoSitePlusiQ5JV73

Expressioni

Gene expression databases

BgeeiENSG00000147234
CleanExiHS_FRMPD3
ExpressionAtlasiQ5JV73 baseline and differential
GenevisibleiQ5JV73 HS

Organism-specific databases

HPAiHPA003164

Interactioni

Protein-protein interaction databases

BioGridi124081, 1 interactor
IntActiQ5JV73, 1 interactor
STRINGi9606.ENSP00000276185

Structurei

3D structure databases

ProteinModelPortaliQ5JV73
SMRiQ5JV73
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 131PDZPROSITE-ProRule annotationAdd BLAST78
Domaini180 – 494FERMPROSITE-ProRule annotationAdd BLAST315

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi683 – 691Poly-Glu9
Compositional biasi779 – 784Poly-Pro6
Compositional biasi1584 – 1587Poly-Ser4
Compositional biasi1750 – 1776Gln-richAdd BLAST27
Compositional biasi1778 – 1784Poly-Ala7

Phylogenomic databases

eggNOGiKOG3552 Eukaryota
ENOG410YV8Z LUCA
GeneTreeiENSGT00530000063201
HOGENOMiHOG000112647
InParanoidiQ5JV73
OMAiRKCDMAD
OrthoDBiEOG091G00W9
PhylomeDBiQ5JV73
TreeFamiTF316497

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit

Sequencei

Sequence statusi: Complete.

Q5JV73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLDSQRVQ DRLLAAPGCS SPSGQQELFS SHVMQEESAN DMECEQLPAE
60 70 80 90 100
ILRQVTVHRD PIYGFGFVAG SERPVVVRSV RPGGPSENKL LAGDQIVAIN
110 120 130 140 150
EEDVSEAPRE RLIELIRSAK EFIVLTVLHT HQSPKSAFIS AAKKAKLRSN
160 170 180 190 200
PVKVRFSEQV AVGETDAKMM KKEALLLIPN VLKVFLENGQ IKSFTFDGRT
210 220 230 240 250
TVKDVMLTLQ DRLSLRFIEH FALVLEYAGP EQNHKFLLLQ DKQPLAYVVQ
260 270 280 290 300
RTHYHGMKCL FRISFFPKDP VELLRRDPAA FEYLYIQSRN DVIRERFGMD
310 320 330 340 350
PKPEMLLGLA ALHIYITVSA TRPSQKISLK NVEKEWGLEP FLPPSLLQVI
360 370 380 390 400
KEKNLRKSLS QQLKAHQTHP SCGTKGSAIQ AKLQYLRILN ELPTFTGVLF
410 420 430 440 450
NTVGLDEKQS ATTLLVGPRH GISHVIDLKT NLTTVLSEFS KISKIQLFRE
460 470 480 490 500
NQGVARVETS IMDAKPLVLL MEWPEATNFA CLIAGYCRLL LDSRKMVFSR
510 520 530 540 550
PASQPLPPPM IKADYMHSAH RPVTGGHLGK KESSYVGSVG TSPRKSSRCT
560 570 580 590 600
PPPADSELVS FCYLHMREQR KEQESRTDVN ENLIFFEETR PRTKSDPTSK
610 620 630 640 650
SSGQGYEVVP DDFDAASLDH EPCASRARSY TLDNSLGAEA LNFYCDSCKA
660 670 680 690 700
KLQEQLGPRK GGKPGSSRDN IVDLMSLPPP GSEEEEEEED ETTSLLPAIA
710 720 730 740 750
APPPGFRDNS SDEDDPKRRA VQSQEQGRHL RGLLYDEIPV TLIDSVQTRT
760 770 780 790 800
VRDHAQELDD ALVSTLQALE ALAASEDGPH PPPPQTAGLI VLATITPESS
810 820 830 840 850
LDSGHETNSS ELTDMSEMMS AMKQHQNTTY FLAQHLNKDS LLARKDLPFR
860 870 880 890 900
IQSCAAQAVL TAPYSLGRPD PNPSLQPIAT GQSPGPPGAR RKLPQSEGQV
910 920 930 940 950
QGERTYSLAV HPALSPQLSE QKNLSLLSPV PEDKGPGHTR AGLEMSLRAA
960 970 980 990 1000
TSSLSEEQVS ELRDNLPKEV RLSPKLILDP KSSVTPAIIS AALQQVVHNK
1010 1020 1030 1040 1050
SLVTAGGALG NPPSRGERRL EASMGRPEVS MMSSSASKNL KFKISPSAPE
1060 1070 1080 1090 1100
TSWNSQHQLG AEVSSSPRAP TGSRADSLHL SQQEDSLPVQ NFPPKSYLLR
1110 1120 1130 1140 1150
TSRESVGKQA TGEVAGKGGP VGGKPTLQKQ GTISSQGEKA QLESTPKRSK
1160 1170 1180 1190 1200
LEETSLVPRA TYPMALQSPS CQSRSHSPSC QPHGHSPSSQ SRGQSPSCQP
1210 1220 1230 1240 1250
RGQSPLRSQA ASRQVSTMPS RKLETTLNGA HSTSEGPAKP KSSRGPFRLR
1260 1270 1280 1290 1300
NLFSATFPTR QKKETDERQA QLQKVKQYEL EFLEELLKPP SQGELPGTEY
1310 1320 1330 1340 1350
LQPPAPGRCS CQLRSSPVQQ GPGMSREQRR SCDCKRICRG GRPQATQTPV
1360 1370 1380 1390 1400
PSLRGRERDR VLPSQRQPEA GPGVSLSSPI NVQRIRSTSL ESRECRSDPE
1410 1420 1430 1440 1450
SGVSCLTTCA SGGECLGAPN YRKLMRRYSI SELDQGDRAS LTSDVYPHPP
1460 1470 1480 1490 1500
LGMLPREAKE VEASLPIALG PKSRSLESPT LGDPSYVQVA PETKGPRQMA
1510 1520 1530 1540 1550
VFSLPEEVYR KPAELDEDSE SSKCCSIRYC FYYRKCDMAD DASDGKDELS
1560 1570 1580 1590 1600
YSIPMKILPG MKLDEQVVPV VSRTLQVLDA ATCSSSSPEA SRTQEIDLRV
1610 1620 1630 1640 1650
STFEGSLAKI NALRAHAYGL PDGFLAARLD TNELLTVLRQ CVASPEARAP
1660 1670 1680 1690 1700
KPYVSQISEY KLELALKFKE LRASCRRVAN VDKSPTHMLA AITGSFQVLS
1710 1720 1730 1740 1750
SLIETFVRLV FIVRSEAQRQ ELLAKVEEVV RNYTFLLRAA EESTARNLNQ
1760 1770 1780 1790 1800
QQQQQQQQQQ QQQQQQQQQQ QQQQQQVAAA AGAATEHPPG SPTSATVMST
1810
FTHSLKTLIK
Length:1,810
Mass (Da):199,209
Last modified:October 31, 2006 - v2
Checksum:i9FC42A38E6B682BB
GO

Sequence cautioni

The sequence CAI42175 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI42749 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti814 – 822DMSEMMSAM → ALKSWFHDL in BAB47446 (PubMed:11347906).Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137787, AL035088 Genomic DNA Translation: CAI42175.1 Sequence problems.
AL035088, AL137787 Genomic DNA Translation: CAI42749.1 Sequence problems.
AB058720 mRNA Translation: BAB47446.1
CCDSiCCDS76006.1
RefSeqiNP_115804.1, NM_032428.1
UniGeneiHs.496546

Genome annotation databases

EnsembliENST00000276185; ENSP00000276185; ENSG00000147234
GeneIDi84443
KEGGihsa:84443
UCSCiuc033eqj.1 human

Similar proteinsi

Entry informationi

Entry nameiFRPD3_HUMAN
AccessioniPrimary (citable) accession number: Q5JV73
Secondary accession number(s): Q96JK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: June 20, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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