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Protein

Spindlin-3

Gene

SPIN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Spindlin-3
Alternative name(s):
Spindlin-like protein 3
Short name:
SPIN-3
Gene namesi
Name:SPIN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:27272. SPIN3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134909757.

Polymorphism and mutation databases

BioMutaiSPIN3.
DMDMi74742352.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Spindlin-3PRO_0000259591Add
BLAST

Proteomic databases

MaxQBiQ5JUX0.
PaxDbiQ5JUX0.
PRIDEiQ5JUX0.

PTM databases

iPTMnetiQ5JUX0.
PhosphoSiteiQ5JUX0.

Expressioni

Gene expression databases

BgeeiQ5JUX0.
CleanExiHS_SPIN3.
GenevisibleiQ5JUX0. HS.

Organism-specific databases

HPAiHPA000727.

Interactioni

Protein-protein interaction databases

BioGridi127992. 7 interactions.
IntActiQ5JUX0. 1 interaction.
STRINGi9606.ENSP00000364054.

Structurei

Secondary structure

1
258
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi53 – 586Combined sources
Beta strandi66 – 7510Combined sources
Beta strandi83 – 875Combined sources
Beta strandi94 – 963Combined sources
Turni98 – 1003Combined sources
Beta strandi104 – 1096Combined sources
Helixi123 – 1286Combined sources
Beta strandi132 – 1387Combined sources
Beta strandi144 – 15411Combined sources
Beta strandi156 – 1583Combined sources
Beta strandi162 – 1665Combined sources
Beta strandi169 – 1757Combined sources
Helixi177 – 1837Combined sources
Beta strandi186 – 1883Combined sources
Beta strandi213 – 2175Combined sources
Beta strandi223 – 2319Combined sources
Beta strandi238 – 2436Combined sources
Beta strandi250 – 2534Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5A1HX-ray2.00A/B/C/D45-258[»]
ProteinModelPortaliQ5JUX0.
SMRiQ5JUX0. Positions 47-258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPIN/STSY family.Curated

Phylogenomic databases

eggNOGiENOG410IGUH. Eukaryota.
ENOG410XQI2. LUCA.
GeneTreeiENSGT00760000119261.
HOGENOMiHOG000293367.
HOVERGENiHBG000686.
InParanoidiQ5JUX0.
OMAiVSVTMMK.
OrthoDBiEOG7CK37K.
PhylomeDBiQ5JUX0.
TreeFamiTF332665.

Family and domain databases

InterProiIPR003671. SPIN/Ssty.
IPR029567. Spindlin-3.
[Graphical view]
PANTHERiPTHR10405. PTHR10405. 1 hit.
PTHR10405:SF18. PTHR10405:SF18. 1 hit.
PfamiPF02513. Spin-Ssty. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JUX0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTPFGKAAA GQRSRTGAGH GSVSVTMIKR KAAHKKHRSR PTSQPRGNIV
60 70 80 90 100
GCRIQHGWKD GDEPLTQWKG TVLDQVPVNP SLYLIKYDGF DCVYGLELHR
110 120 130 140 150
DERVSSLEVL PNRVASSRIS DTHLAEIMVG KAVEHIFETE EGSKNEWRGM
160 170 180 190 200
VLAQAPVMNT WFYITYEKDP VLYMYQLLDD YKDGDLRILQ DSNDSPLAER
210 220 230 240 250
EPGEVIDSLV GKQVEYAKDD GSKRTGMVIH QVEAKPSVYF IKFDDDFHIY

VYDLVKTS
Length:258
Mass (Da):29,207
Last modified:February 15, 2005 - v1
Checksum:i431F7EB61F5FBA81
GO
Isoform 2 (identifier: Q5JUX0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-77: VP → LL
     78-258: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:77
Mass (Da):8,416
Checksum:i4371BE72D7E97D64
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41P → A in BAH14098 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei76 – 772VP → LL in isoform 2. 1 PublicationVSP_021482
Alternative sequencei78 – 258181Missing in isoform 2. 1 PublicationVSP_021483Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304047 mRNA. Translation: BAH14098.1.
AL139397 Genomic DNA. Translation: CAI40751.1.
BC018073 mRNA. No translation available.
BC032490 mRNA. No translation available.
BC146899 mRNA. Translation: AAI46900.1.
BC146906 mRNA. Translation: AAI46907.1.
CCDSiCCDS43963.1. [Q5JUX0-1]
RefSeqiNP_001010862.2. NM_001010862.2. [Q5JUX0-1]
XP_006724640.1. XM_006724577.2. [Q5JUX0-1]
XP_006724641.1. XM_006724578.2. [Q5JUX0-1]
UniGeneiHs.522672.

Genome annotation databases

EnsembliENST00000374919; ENSP00000364054; ENSG00000204271. [Q5JUX0-1]
ENST00000475785; ENSP00000436805; ENSG00000204271. [Q5JUX0-2]
ENST00000478405; ENSP00000433337; ENSG00000204271. [Q5JUX0-2]
GeneIDi169981.
KEGGihsa:169981.
UCSCiuc004dux.1. human. [Q5JUX0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304047 mRNA. Translation: BAH14098.1.
AL139397 Genomic DNA. Translation: CAI40751.1.
BC018073 mRNA. No translation available.
BC032490 mRNA. No translation available.
BC146899 mRNA. Translation: AAI46900.1.
BC146906 mRNA. Translation: AAI46907.1.
CCDSiCCDS43963.1. [Q5JUX0-1]
RefSeqiNP_001010862.2. NM_001010862.2. [Q5JUX0-1]
XP_006724640.1. XM_006724577.2. [Q5JUX0-1]
XP_006724641.1. XM_006724578.2. [Q5JUX0-1]
UniGeneiHs.522672.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5A1HX-ray2.00A/B/C/D45-258[»]
ProteinModelPortaliQ5JUX0.
SMRiQ5JUX0. Positions 47-258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127992. 7 interactions.
IntActiQ5JUX0. 1 interaction.
STRINGi9606.ENSP00000364054.

PTM databases

iPTMnetiQ5JUX0.
PhosphoSiteiQ5JUX0.

Polymorphism and mutation databases

BioMutaiSPIN3.
DMDMi74742352.

Proteomic databases

MaxQBiQ5JUX0.
PaxDbiQ5JUX0.
PRIDEiQ5JUX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374919; ENSP00000364054; ENSG00000204271. [Q5JUX0-1]
ENST00000475785; ENSP00000436805; ENSG00000204271. [Q5JUX0-2]
ENST00000478405; ENSP00000433337; ENSG00000204271. [Q5JUX0-2]
GeneIDi169981.
KEGGihsa:169981.
UCSCiuc004dux.1. human. [Q5JUX0-1]

Organism-specific databases

CTDi169981.
GeneCardsiSPIN3.
HGNCiHGNC:27272. SPIN3.
HPAiHPA000727.
neXtProtiNX_Q5JUX0.
PharmGKBiPA134909757.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGUH. Eukaryota.
ENOG410XQI2. LUCA.
GeneTreeiENSGT00760000119261.
HOGENOMiHOG000293367.
HOVERGENiHBG000686.
InParanoidiQ5JUX0.
OMAiVSVTMMK.
OrthoDBiEOG7CK37K.
PhylomeDBiQ5JUX0.
TreeFamiTF332665.

Miscellaneous databases

ChiTaRSiSPIN3. human.
GenomeRNAii169981.
NextBioi88854.
PROiQ5JUX0.

Gene expression databases

BgeeiQ5JUX0.
CleanExiHS_SPIN3.
GenevisibleiQ5JUX0. HS.

Family and domain databases

InterProiIPR003671. SPIN/Ssty.
IPR029567. Spindlin-3.
[Graphical view]
PANTHERiPTHR10405. PTHR10405. 1 hit.
PTHR10405:SF18. PTHR10405:SF18. 1 hit.
PfamiPF02513. Spin-Ssty. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Trachea.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain cortex.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPIN3_HUMAN
AccessioniPrimary (citable) accession number: Q5JUX0
Secondary accession number(s): B2RUW3, B7Z8W2, Q8N5D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 15, 2005
Last modified: January 20, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.