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Q5JUX0

- SPIN3_HUMAN

UniProt

Q5JUX0 - SPIN3_HUMAN

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Protein

Spindlin-3

Gene

SPIN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. gamete generation Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Spindlin-3
Alternative name(s):
Spindlin-like protein 3
Short name:
SPIN-3
Gene namesi
Name:SPIN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:27272. SPIN3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134909757.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Spindlin-3PRO_0000259591Add
BLAST

Proteomic databases

MaxQBiQ5JUX0.
PaxDbiQ5JUX0.
PRIDEiQ5JUX0.

PTM databases

PhosphoSiteiQ5JUX0.

Expressioni

Gene expression databases

BgeeiQ5JUX0.
CleanExiHS_SPIN3.
GenevestigatoriQ5JUX0.

Organism-specific databases

HPAiHPA000727.

Interactioni

Protein-protein interaction databases

BioGridi127992. 4 interactions.
IntActiQ5JUX0. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ5JUX0.
SMRiQ5JUX0. Positions 46-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPIN/STSY family.Curated

Phylogenomic databases

eggNOGiNOG40069.
GeneTreeiENSGT00760000119261.
HOGENOMiHOG000293367.
HOVERGENiHBG000686.
InParanoidiQ5JUX0.
OMAiVSVTMMK.
OrthoDBiEOG7CK37K.
PhylomeDBiQ5JUX0.
TreeFamiTF332665.

Family and domain databases

InterProiIPR003671. SPIN/Ssty.
IPR029567. Spindlin-3.
[Graphical view]
PANTHERiPTHR10405. PTHR10405. 1 hit.
PTHR10405:SF12. PTHR10405:SF12. 1 hit.
PfamiPF02513. Spin-Ssty. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5JUX0) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTPFGKAAA GQRSRTGAGH GSVSVTMIKR KAAHKKHRSR PTSQPRGNIV
60 70 80 90 100
GCRIQHGWKD GDEPLTQWKG TVLDQVPVNP SLYLIKYDGF DCVYGLELHR
110 120 130 140 150
DERVSSLEVL PNRVASSRIS DTHLAEIMVG KAVEHIFETE EGSKNEWRGM
160 170 180 190 200
VLAQAPVMNT WFYITYEKDP VLYMYQLLDD YKDGDLRILQ DSNDSPLAER
210 220 230 240 250
EPGEVIDSLV GKQVEYAKDD GSKRTGMVIH QVEAKPSVYF IKFDDDFHIY

VYDLVKTS
Length:258
Mass (Da):29,207
Last modified:February 15, 2005 - v1
Checksum:i431F7EB61F5FBA81
GO
Isoform 2 (identifier: Q5JUX0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-77: VP → LL
     78-258: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:77
Mass (Da):8,416
Checksum:i4371BE72D7E97D64
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41P → A in BAH14098. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei76 – 772VP → LL in isoform 2. 1 PublicationVSP_021482
Alternative sequencei78 – 258181Missing in isoform 2. 1 PublicationVSP_021483Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK304047 mRNA. Translation: BAH14098.1.
AL139397 Genomic DNA. Translation: CAI40751.1.
BC018073 mRNA. No translation available.
BC032490 mRNA. No translation available.
BC146899 mRNA. Translation: AAI46900.1.
BC146906 mRNA. Translation: AAI46907.1.
CCDSiCCDS43963.1. [Q5JUX0-1]
RefSeqiNP_001010862.2. NM_001010862.2. [Q5JUX0-1]
XP_006724640.1. XM_006724577.1. [Q5JUX0-1]
XP_006724641.1. XM_006724578.1. [Q5JUX0-1]
UniGeneiHs.522672.

Genome annotation databases

EnsembliENST00000374919; ENSP00000364054; ENSG00000204271. [Q5JUX0-1]
ENST00000475785; ENSP00000436805; ENSG00000204271. [Q5JUX0-2]
ENST00000478405; ENSP00000433337; ENSG00000204271. [Q5JUX0-2]
GeneIDi169981.
KEGGihsa:169981.
UCSCiuc004dux.1. human. [Q5JUX0-1]

Polymorphism databases

DMDMi74742352.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK304047 mRNA. Translation: BAH14098.1 .
AL139397 Genomic DNA. Translation: CAI40751.1 .
BC018073 mRNA. No translation available.
BC032490 mRNA. No translation available.
BC146899 mRNA. Translation: AAI46900.1 .
BC146906 mRNA. Translation: AAI46907.1 .
CCDSi CCDS43963.1. [Q5JUX0-1 ]
RefSeqi NP_001010862.2. NM_001010862.2. [Q5JUX0-1 ]
XP_006724640.1. XM_006724577.1. [Q5JUX0-1 ]
XP_006724641.1. XM_006724578.1. [Q5JUX0-1 ]
UniGenei Hs.522672.

3D structure databases

ProteinModelPortali Q5JUX0.
SMRi Q5JUX0. Positions 46-256.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127992. 4 interactions.
IntActi Q5JUX0. 1 interaction.

PTM databases

PhosphoSitei Q5JUX0.

Polymorphism databases

DMDMi 74742352.

Proteomic databases

MaxQBi Q5JUX0.
PaxDbi Q5JUX0.
PRIDEi Q5JUX0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374919 ; ENSP00000364054 ; ENSG00000204271 . [Q5JUX0-1 ]
ENST00000475785 ; ENSP00000436805 ; ENSG00000204271 . [Q5JUX0-2 ]
ENST00000478405 ; ENSP00000433337 ; ENSG00000204271 . [Q5JUX0-2 ]
GeneIDi 169981.
KEGGi hsa:169981.
UCSCi uc004dux.1. human. [Q5JUX0-1 ]

Organism-specific databases

CTDi 169981.
GeneCardsi GC0XM057019.
HGNCi HGNC:27272. SPIN3.
HPAi HPA000727.
neXtProti NX_Q5JUX0.
PharmGKBi PA134909757.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40069.
GeneTreei ENSGT00760000119261.
HOGENOMi HOG000293367.
HOVERGENi HBG000686.
InParanoidi Q5JUX0.
OMAi VSVTMMK.
OrthoDBi EOG7CK37K.
PhylomeDBi Q5JUX0.
TreeFami TF332665.

Miscellaneous databases

ChiTaRSi SPIN3. human.
GenomeRNAii 169981.
NextBioi 88854.
PROi Q5JUX0.

Gene expression databases

Bgeei Q5JUX0.
CleanExi HS_SPIN3.
Genevestigatori Q5JUX0.

Family and domain databases

InterProi IPR003671. SPIN/Ssty.
IPR029567. Spindlin-3.
[Graphical view ]
PANTHERi PTHR10405. PTHR10405. 1 hit.
PTHR10405:SF12. PTHR10405:SF12. 1 hit.
Pfami PF02513. Spin-Ssty. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Trachea.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain cortex.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPIN3_HUMAN
AccessioniPrimary (citable) accession number: Q5JUX0
Secondary accession number(s): B2RUW3, B7Z8W2, Q8N5D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3