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Q5JUX0

- SPIN3_HUMAN

UniProt

Q5JUX0 - SPIN3_HUMAN

Protein

Spindlin-3

Gene

SPIN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. gamete generation Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Spindlin-3
    Alternative name(s):
    Spindlin-like protein 3
    Short name:
    SPIN-3
    Gene namesi
    Name:SPIN3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:27272. SPIN3.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134909757.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 258258Spindlin-3PRO_0000259591Add
    BLAST

    Proteomic databases

    MaxQBiQ5JUX0.
    PaxDbiQ5JUX0.
    PRIDEiQ5JUX0.

    PTM databases

    PhosphoSiteiQ5JUX0.

    Expressioni

    Gene expression databases

    BgeeiQ5JUX0.
    CleanExiHS_SPIN3.
    GenevestigatoriQ5JUX0.

    Organism-specific databases

    HPAiHPA000727.

    Interactioni

    Protein-protein interaction databases

    BioGridi127992. 3 interactions.
    IntActiQ5JUX0. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5JUX0.
    SMRiQ5JUX0. Positions 46-256.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SPIN/STSY family.Curated

    Phylogenomic databases

    eggNOGiNOG40069.
    HOGENOMiHOG000293367.
    HOVERGENiHBG000686.
    InParanoidiQ5JUX0.
    OMAiVSVTMMK.
    OrthoDBiEOG7CK37K.
    PhylomeDBiQ5JUX0.
    TreeFamiTF332665.

    Family and domain databases

    InterProiIPR003671. SPIN/Ssty.
    IPR029567. Spindlin-3.
    [Graphical view]
    PANTHERiPTHR10405. PTHR10405. 1 hit.
    PTHR10405:SF12. PTHR10405:SF12. 1 hit.
    PfamiPF02513. Spin-Ssty. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5JUX0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKTPFGKAAA GQRSRTGAGH GSVSVTMIKR KAAHKKHRSR PTSQPRGNIV    50
    GCRIQHGWKD GDEPLTQWKG TVLDQVPVNP SLYLIKYDGF DCVYGLELHR 100
    DERVSSLEVL PNRVASSRIS DTHLAEIMVG KAVEHIFETE EGSKNEWRGM 150
    VLAQAPVMNT WFYITYEKDP VLYMYQLLDD YKDGDLRILQ DSNDSPLAER 200
    EPGEVIDSLV GKQVEYAKDD GSKRTGMVIH QVEAKPSVYF IKFDDDFHIY 250
    VYDLVKTS 258
    Length:258
    Mass (Da):29,207
    Last modified:February 15, 2005 - v1
    Checksum:i431F7EB61F5FBA81
    GO
    Isoform 2 (identifier: Q5JUX0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         76-77: VP → LL
         78-258: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:77
    Mass (Da):8,416
    Checksum:i4371BE72D7E97D64
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 41P → A in BAH14098. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei76 – 772VP → LL in isoform 2. 1 PublicationVSP_021482
    Alternative sequencei78 – 258181Missing in isoform 2. 1 PublicationVSP_021483Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK304047 mRNA. Translation: BAH14098.1.
    AL139397 Genomic DNA. Translation: CAI40751.1.
    BC018073 mRNA. No translation available.
    BC032490 mRNA. No translation available.
    BC146899 mRNA. Translation: AAI46900.1.
    BC146906 mRNA. Translation: AAI46907.1.
    CCDSiCCDS43963.1. [Q5JUX0-1]
    RefSeqiNP_001010862.2. NM_001010862.2. [Q5JUX0-1]
    XP_006724640.1. XM_006724577.1. [Q5JUX0-1]
    XP_006724641.1. XM_006724578.1. [Q5JUX0-1]
    UniGeneiHs.522672.

    Genome annotation databases

    EnsembliENST00000374919; ENSP00000364054; ENSG00000204271. [Q5JUX0-1]
    ENST00000475785; ENSP00000436805; ENSG00000204271. [Q5JUX0-2]
    ENST00000478405; ENSP00000433337; ENSG00000204271. [Q5JUX0-2]
    GeneIDi169981.
    KEGGihsa:169981.
    UCSCiuc004dux.1. human. [Q5JUX0-1]

    Polymorphism databases

    DMDMi74742352.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK304047 mRNA. Translation: BAH14098.1 .
    AL139397 Genomic DNA. Translation: CAI40751.1 .
    BC018073 mRNA. No translation available.
    BC032490 mRNA. No translation available.
    BC146899 mRNA. Translation: AAI46900.1 .
    BC146906 mRNA. Translation: AAI46907.1 .
    CCDSi CCDS43963.1. [Q5JUX0-1 ]
    RefSeqi NP_001010862.2. NM_001010862.2. [Q5JUX0-1 ]
    XP_006724640.1. XM_006724577.1. [Q5JUX0-1 ]
    XP_006724641.1. XM_006724578.1. [Q5JUX0-1 ]
    UniGenei Hs.522672.

    3D structure databases

    ProteinModelPortali Q5JUX0.
    SMRi Q5JUX0. Positions 46-256.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127992. 3 interactions.
    IntActi Q5JUX0. 1 interaction.

    PTM databases

    PhosphoSitei Q5JUX0.

    Polymorphism databases

    DMDMi 74742352.

    Proteomic databases

    MaxQBi Q5JUX0.
    PaxDbi Q5JUX0.
    PRIDEi Q5JUX0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374919 ; ENSP00000364054 ; ENSG00000204271 . [Q5JUX0-1 ]
    ENST00000475785 ; ENSP00000436805 ; ENSG00000204271 . [Q5JUX0-2 ]
    ENST00000478405 ; ENSP00000433337 ; ENSG00000204271 . [Q5JUX0-2 ]
    GeneIDi 169981.
    KEGGi hsa:169981.
    UCSCi uc004dux.1. human. [Q5JUX0-1 ]

    Organism-specific databases

    CTDi 169981.
    GeneCardsi GC0XM057019.
    HGNCi HGNC:27272. SPIN3.
    HPAi HPA000727.
    neXtProti NX_Q5JUX0.
    PharmGKBi PA134909757.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40069.
    HOGENOMi HOG000293367.
    HOVERGENi HBG000686.
    InParanoidi Q5JUX0.
    OMAi VSVTMMK.
    OrthoDBi EOG7CK37K.
    PhylomeDBi Q5JUX0.
    TreeFami TF332665.

    Miscellaneous databases

    ChiTaRSi SPIN3. human.
    GenomeRNAii 169981.
    NextBioi 88854.
    PROi Q5JUX0.

    Gene expression databases

    Bgeei Q5JUX0.
    CleanExi HS_SPIN3.
    Genevestigatori Q5JUX0.

    Family and domain databases

    InterProi IPR003671. SPIN/Ssty.
    IPR029567. Spindlin-3.
    [Graphical view ]
    PANTHERi PTHR10405. PTHR10405. 1 hit.
    PTHR10405:SF12. PTHR10405:SF12. 1 hit.
    Pfami PF02513. Spin-Ssty. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Trachea.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain cortex.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSPIN3_HUMAN
    AccessioniPrimary (citable) accession number: Q5JUX0
    Secondary accession number(s): B2RUW3, B7Z8W2, Q8N5D9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3