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Protein

KRAB domain-containing protein 4

Gene

KRBOX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
KRAB domain-containing protein 4
Alternative name(s):
KRAB box domain-containing protein 4
Gene namesi
Name:KRBOX4
Synonyms:ZNF673
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:26007. KRBOX4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi55634.
OpenTargetsiENSG00000147121.
PharmGKBiPA142670474.

Polymorphism and mutation databases

BioMutaiKRBOX4.
DMDMi74742348.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339941 – 171KRAB domain-containing protein 4Add BLAST171

Proteomic databases

MaxQBiQ5JUW0.
PaxDbiQ5JUW0.
PeptideAtlasiQ5JUW0.
PRIDEiQ5JUW0.

PTM databases

iPTMnetiQ5JUW0.
PhosphoSitePlusiQ5JUW0.

Expressioni

Tissue specificityi

Expressed in brain, ovary, testis, prostate, tonsil, heart, bone marrow, colon, breast and kidney.1 Publication

Gene expression databases

BgeeiENSG00000147121.
CleanExiHS_ZNF673.
ExpressionAtlasiQ5JUW0. baseline and differential.
GenevisibleiQ5JUW0. HS.

Interactioni

Protein-protein interaction databases

BioGridi120773. 15 interactors.
IntActiQ5JUW0. 15 interactors.
STRINGi9606.ENSP00000345797.

Structurei

3D structure databases

ProteinModelPortaliQ5JUW0.
SMRiQ5JUW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 1 KRAB domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133984.
HOGENOMiHOG000231475.
HOVERGENiHBG067759.
InParanoidiQ5JUW0.
OrthoDBiEOG091G0P6J.
PhylomeDBiQ5JUW0.
TreeFamiTF342644.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiIPR001909. KRAB.
IPR026613. KRAB_dom_C2H2_Znf_fam.
[Graphical view]
PANTHERiPTHR23232. PTHR23232. 1 hit.
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JUW0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMSQESLTF KDVFVDFTLE EWQQLDSAQK NLYRDVMLEN YSHLVSVGYL
60 70 80 90 100
VAKPDVIFRL GPGEESWMAD GGTPVRTCAG EDRPEVWQVD EQIDHYKESQ
110 120 130 140 150
DKLPWQAAFI GKETLKDESG QESRTCRKSI YLSTEFDSVR QRLPKYYSWE
160 170
KAFKTSFKLS WSKWKLCKKE R
Note: Gene prediction based on EST data.
Length:171
Mass (Da):20,100
Last modified:February 15, 2005 - v1
Checksum:iEA51AFEFDB5CEE9F
GO
Isoform 2 (identifier: Q5JUW0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-84: Missing.

Show »
Length:166
Mass (Da):19,545
Checksum:i0A378FF50E0C8458
GO
Isoform 3 (identifier: Q5JUW0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-98: EVWQVDEQIDHYKE → DVSIFASCILKCCY
     99-171: Missing.

Note: No experimental confirmation available.
Show »
Length:98
Mass (Da):11,065
Checksum:i68DA07E408A8D7D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64E → G in BAA91104 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01816380 – 84Missing in isoform 2. 2 Publications5
Alternative sequenceiVSP_01816485 – 98EVWQV…DHYKE → DVSIFASCILKCCY in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_01816599 – 171Missing in isoform 3. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000351 mRNA. Translation: BAA91104.1.
AK096413 mRNA. Translation: BAG53284.1.
AK289703 mRNA. Translation: BAF82392.1.
AL139811 Genomic DNA. Translation: CAI41302.1.
AL139811 Genomic DNA. Translation: CAI41301.1.
CH471164 Genomic DNA. Translation: EAW59263.1.
BC012569 mRNA. Translation: AAH12569.1.
CCDSiCCDS14267.1. [Q5JUW0-2]
CCDS48097.1. [Q5JUW0-1]
CCDS48098.1. [Q5JUW0-3]
RefSeqiNP_001123370.1. NM_001129898.1. [Q5JUW0-1]
NP_001123371.1. NM_001129899.1. [Q5JUW0-3]
NP_001123372.1. NM_001129900.1.
NP_060246.2. NM_017776.2. [Q5JUW0-2]
UniGeneiHs.632800.

Genome annotation databases

EnsembliENST00000298190; ENSP00000298190; ENSG00000147121. [Q5JUW0-2]
ENST00000344302; ENSP00000345797; ENSG00000147121. [Q5JUW0-1]
ENST00000377919; ENSP00000367152; ENSG00000147121. [Q5JUW0-3]
ENST00000487081; ENSP00000418076; ENSG00000147121. [Q5JUW0-3]
GeneIDi55634.
KEGGihsa:55634.
UCSCiuc004dgm.5. human. [Q5JUW0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000351 mRNA. Translation: BAA91104.1.
AK096413 mRNA. Translation: BAG53284.1.
AK289703 mRNA. Translation: BAF82392.1.
AL139811 Genomic DNA. Translation: CAI41302.1.
AL139811 Genomic DNA. Translation: CAI41301.1.
CH471164 Genomic DNA. Translation: EAW59263.1.
BC012569 mRNA. Translation: AAH12569.1.
CCDSiCCDS14267.1. [Q5JUW0-2]
CCDS48097.1. [Q5JUW0-1]
CCDS48098.1. [Q5JUW0-3]
RefSeqiNP_001123370.1. NM_001129898.1. [Q5JUW0-1]
NP_001123371.1. NM_001129899.1. [Q5JUW0-3]
NP_001123372.1. NM_001129900.1.
NP_060246.2. NM_017776.2. [Q5JUW0-2]
UniGeneiHs.632800.

3D structure databases

ProteinModelPortaliQ5JUW0.
SMRiQ5JUW0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120773. 15 interactors.
IntActiQ5JUW0. 15 interactors.
STRINGi9606.ENSP00000345797.

PTM databases

iPTMnetiQ5JUW0.
PhosphoSitePlusiQ5JUW0.

Polymorphism and mutation databases

BioMutaiKRBOX4.
DMDMi74742348.

Proteomic databases

MaxQBiQ5JUW0.
PaxDbiQ5JUW0.
PeptideAtlasiQ5JUW0.
PRIDEiQ5JUW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298190; ENSP00000298190; ENSG00000147121. [Q5JUW0-2]
ENST00000344302; ENSP00000345797; ENSG00000147121. [Q5JUW0-1]
ENST00000377919; ENSP00000367152; ENSG00000147121. [Q5JUW0-3]
ENST00000487081; ENSP00000418076; ENSG00000147121. [Q5JUW0-3]
GeneIDi55634.
KEGGihsa:55634.
UCSCiuc004dgm.5. human. [Q5JUW0-1]

Organism-specific databases

CTDi55634.
DisGeNETi55634.
GeneCardsiKRBOX4.
HGNCiHGNC:26007. KRBOX4.
MIMi300585. gene.
neXtProtiNX_Q5JUW0.
OpenTargetsiENSG00000147121.
PharmGKBiPA142670474.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133984.
HOGENOMiHOG000231475.
HOVERGENiHBG067759.
InParanoidiQ5JUW0.
OrthoDBiEOG091G0P6J.
PhylomeDBiQ5JUW0.
TreeFamiTF342644.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii55634.
PROiQ5JUW0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147121.
CleanExiHS_ZNF673.
ExpressionAtlasiQ5JUW0. baseline and differential.
GenevisibleiQ5JUW0. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiIPR001909. KRAB.
IPR026613. KRAB_dom_C2H2_Znf_fam.
[Graphical view]
PANTHERiPTHR23232. PTHR23232. 1 hit.
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKRBX4_HUMAN
AccessioniPrimary (citable) accession number: Q5JUW0
Secondary accession number(s): A8K0Y8
, B3KU22, Q96EA3, Q9NXB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: February 15, 2005
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Despite its name, it does not contain a canonical C2H2-type zinc-finger, seems to be a partial inverted duplication of ZNF674.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.