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Q5JTY5 (CBWD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
COBW domain-containing protein 3
Alternative name(s):
Cobalamin synthase W domain-containing protein 3
Gene names
Name:CBWD3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the CobW family.

Contains 1 cobW C-terminal domain.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395COBW domain-containing protein 3
PRO_0000317238

Regions

Domain274 – 377104CobW C-terminal
Nucleotide binding49 – 568ATP Potential
Nucleotide binding110 – 1145ATP Potential
Nucleotide binding203 – 2064ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q5JTY5 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 52EE727920F143DE

FASTA39544,038
        10         20         30         40         50         60 
MLPAVGSVDE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY LGAGKTTLLN 

        70         80         90        100        110        120 
YILTEQHSKR VAVILNESGE GSALEKSLAV SQGGELYEEW LELRNGCLCC SVKDNGLRAI 

       130        140        150        160        170        180 
ENLMQKKGKF DDILLETTGL ADPGAVASMF WVDAELGSDI YLDGIITIVD SKYGLKHLTE 

       190        200        210        220        230        240 
EKPDGLINEA TRQVALADII LINKTDLVPE EDVKKLRTTI RSINGLGQIL ETQRSRVDLS 

       250        260        270        280        290        300 
NVLDLHAFDS LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE 

       310        320        330        340        350        360 
KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD TERTNRLVLI 

       370        380        390 
GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT 

« Hide

References

« Hide 'large scale' references
[1]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions."
Fan Y., Newman T., Linardopoulou E., Trask B.J.
Genome Res. 12:1663-1672(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL353608 Genomic DNA. Translation: CAI41162.1.
RefSeqNP_958861.2. NM_201453.2.
UniGeneHs.645337.

3D structure databases

ProteinModelPortalQ5JTY5.
SMRQ5JTY5. Positions 42-373.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid138650. 1 interaction.
IntActQ5JTY5. 1 interaction.
STRING9606.ENSP00000353295.

PTM databases

PhosphoSiteQ5JTY5.

Polymorphism databases

DMDM74742238.

Proteomic databases

PaxDbQ5JTY5.
PRIDEQ5JTY5.

Protocols and materials databases

DNASU445571.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360171; ENSP00000353295; ENSG00000196873.
ENST00000578449; ENSP00000463867; ENSG00000265880.
GeneID445571.
KEGGhsa:445571.
UCSCuc004aga.4. human.

Organism-specific databases

CTD445571.
GeneCardsGC09P070849.
HGNCHGNC:18519. CBWD3.
MIM611080. gene.
neXtProtNX_Q5JTY5.
PharmGKBPA134863724.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0523.
HOGENOMHOG000182211.
HOVERGENHBG056297.
InParanoidQ5JTY5.
OMAEVTEWME.
PhylomeDBQ5JTY5.
TreeFamTF332679.

Gene expression databases

ArrayExpressQ5JTY5.
BgeeQ5JTY5.
GenevestigatorQ5JTY5.

Family and domain databases

Gene3D3.30.1220.10. 1 hit.
InterProIPR011629. Cbl_biosynth_CobW-like_C.
IPR003495. CobW/HypB/UreG_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF02492. cobW. 1 hit.
PF07683. CobW_C. 1 hit.
[Graphical view]
SMARTSM00833. CobW_C. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
SSF90002. SSF90002. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi445571.
NextBio111390.
PROQ5JTY5.
SOURCESearch...

Entry information

Entry nameCBWD3_HUMAN
AccessionPrimary (citable) accession number: Q5JTY5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 15, 2005
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM