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Protein

COBW domain-containing protein 3

Gene

CBWD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 56ATPSequence analysis8
Nucleotide bindingi110 – 114ATPSequence analysis5
Nucleotide bindingi203 – 206ATPSequence analysis4

GO - Molecular functioni

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
COBW domain-containing protein 3
Alternative name(s):
Cobalamin synthase W domain-containing protein 3
Gene namesi
Name:CBWD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000196873.15
HGNCiHGNC:18519 CBWD3
MIMi611080 gene
neXtProtiNX_Q5JTY5

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000147996
ENSG00000196873
PharmGKBiPA134863724

Polymorphism and mutation databases

BioMutaiCBWD3
DMDMi74742238

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172381 – 395COBW domain-containing protein 3Add BLAST395

Proteomic databases

MaxQBiQ5JTY5
PaxDbiQ5JTY5
PeptideAtlasiQ5JTY5
PRIDEiQ5JTY5

PTM databases

iPTMnetiQ5JTY5
PhosphoSitePlusiQ5JTY5

Expressioni

Gene expression databases

BgeeiENSG00000196873
ExpressionAtlasiQ5JTY5 baseline and differential
GenevisibleiQ5JTY5 HS

Organism-specific databases

HPAiHPA042759
HPA042813

Interactioni

Protein-protein interaction databases

BioGridi128658, 1 interactor
138650, 24 interactors
IntActiQ5JTY5, 2 interactors
STRINGi9606.ENSP00000353295

Structurei

3D structure databases

ProteinModelPortaliQ5JTY5
SMRiQ5JTY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini274 – 377CobW C-terminalAdd BLAST104

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2743 Eukaryota
COG0523 LUCA
GeneTreeiENSGT00640000091523
HOGENOMiHOG000182211
HOVERGENiHBG056297
InParanoidiQ5JTY5
OMAiTFFMDDE
OrthoDBiEOG091G0JUI
PhylomeDBiQ5JTY5
TreeFamiTF332679

Family and domain databases

Gene3Di3.30.1220.10, 1 hit
InterProiView protein in InterPro
IPR011629 Cbl_biosynth_CobW-like_C
IPR036627 CobW-likC_sf
IPR003495 CobW/HypB/UreG_dom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF02492 cobW, 1 hit
PF07683 CobW_C, 1 hit
SMARTiView protein in SMART
SM00833 CobW_C, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JTY5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPAVGSVDE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY
60 70 80 90 100
LGAGKTTLLN YILTEQHSKR VAVILNESGE GSALEKSLAV SQGGELYEEW
110 120 130 140 150
LELRNGCLCC SVKDNGLRAI ENLMQKKGKF DDILLETTGL ADPGAVASMF
160 170 180 190 200
WVDAELGSDI YLDGIITIVD SKYGLKHLTE EKPDGLINEA TRQVALADII
210 220 230 240 250
LINKTDLVPE EDVKKLRTTI RSINGLGQIL ETQRSRVDLS NVLDLHAFDS
260 270 280 290 300
LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE
310 320 330 340 350
KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD
360 370 380 390
TERTNRLVLI GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT
Length:395
Mass (Da):44,038
Last modified:February 15, 2005 - v1
Checksum:i52EE727920F143DE
GO
Isoform 2 (identifier: Q5JTY5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-164: Missing.

Note: No experimental confirmation available.
Show »
Length:375
Mass (Da):41,897
Checksum:iD2D4CD5D9A8D3963
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132D → Y in AAQ76870 (PubMed:15233989).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055975145 – 164Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY344633 mRNA Translation: AAQ76870.1
AK297912 mRNA Translation: BAG60231.1
AL353608 Genomic DNA No translation available.
BX284632 Genomic DNA No translation available.
CCDSiCCDS35038.2 [Q5JTY5-1]
RefSeqiNP_001278750.1, NM_001291821.1 [Q5JTY5-2]
NP_958861.2, NM_201453.3 [Q5JTY5-1]
XP_005272807.1, XM_005272750.1 [Q5JTY5-2]
UniGeneiHs.355950
Hs.531330
Hs.635227
Hs.645337
Hs.645504

Genome annotation databases

EnsembliENST00000360171; ENSP00000353295; ENSG00000196873 [Q5JTY5-1]
GeneIDi220869
445571
KEGGihsa:445571
UCSCiuc004agi.6 human [Q5JTY5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCBWD3_HUMAN
AccessioniPrimary (citable) accession number: Q5JTY5
Secondary accession number(s): B4DNG9, Q6VB91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 15, 2005
Last modified: February 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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