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Q5JTY5

- CBWD3_HUMAN

UniProt

Q5JTY5 - CBWD3_HUMAN

Protein

COBW domain-containing protein 3

Gene

CBWD3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi49 – 568ATPSequence Analysis
    Nucleotide bindingi110 – 1145ATPSequence Analysis
    Nucleotide bindingi203 – 2064ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    COBW domain-containing protein 3
    Alternative name(s):
    Cobalamin synthase W domain-containing protein 3
    Gene namesi
    Name:CBWD3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:18519. CBWD3.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134863724.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 395395COBW domain-containing protein 3PRO_0000317238Add
    BLAST

    Proteomic databases

    MaxQBiQ5JTY5.
    PaxDbiQ5JTY5.
    PRIDEiQ5JTY5.

    PTM databases

    PhosphoSiteiQ5JTY5.

    Expressioni

    Gene expression databases

    BgeeiQ5JTY5.
    GenevestigatoriQ5JTY5.

    Interactioni

    Protein-protein interaction databases

    BioGridi138650. 1 interaction.
    IntActiQ5JTY5. 1 interaction.
    STRINGi9606.ENSP00000353295.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5JTY5.
    SMRiQ5JTY5. Positions 42-373.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini274 – 377104CobW C-terminalAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CobW family.Curated
    Contains 1 cobW C-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0523.
    HOGENOMiHOG000182211.
    HOVERGENiHBG056297.
    InParanoidiQ5JTY5.
    OMAiTETEKRW.
    PhylomeDBiQ5JTY5.
    TreeFamiTF332679.

    Family and domain databases

    Gene3Di3.30.1220.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR011629. Cbl_biosynth_CobW-like_C.
    IPR003495. CobW/HypB/UreG_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF02492. cobW. 1 hit.
    PF07683. CobW_C. 1 hit.
    [Graphical view]
    SMARTiSM00833. CobW_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF90002. SSF90002. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5JTY5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLPAVGSVDE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY    50
    LGAGKTTLLN YILTEQHSKR VAVILNESGE GSALEKSLAV SQGGELYEEW 100
    LELRNGCLCC SVKDNGLRAI ENLMQKKGKF DDILLETTGL ADPGAVASMF 150
    WVDAELGSDI YLDGIITIVD SKYGLKHLTE EKPDGLINEA TRQVALADII 200
    LINKTDLVPE EDVKKLRTTI RSINGLGQIL ETQRSRVDLS NVLDLHAFDS 250
    LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE 300
    KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD 350
    TERTNRLVLI GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT 395
    Length:395
    Mass (Da):44,038
    Last modified:February 15, 2005 - v1
    Checksum:i52EE727920F143DE
    GO
    Isoform 2 (identifier: Q5JTY5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         145-164: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:375
    Mass (Da):41,897
    Checksum:iD2D4CD5D9A8D3963
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti132 – 1321D → Y in AAQ76870. (PubMed:15233989)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei145 – 16420Missing in isoform 2. 1 PublicationVSP_055975Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY344633 mRNA. Translation: AAQ76870.1.
    AK297912 mRNA. Translation: BAG60231.1.
    AL353608 Genomic DNA. Translation: CAI41162.1.
    BX284632 Genomic DNA. No translation available.
    CCDSiCCDS35038.1.
    RefSeqiNP_958861.2. NM_201453.3.
    UniGeneiHs.645337.

    Genome annotation databases

    EnsembliENST00000360171; ENSP00000353295; ENSG00000196873.
    GeneIDi445571.
    KEGGihsa:445571.
    UCSCiuc004aga.4. human.

    Polymorphism databases

    DMDMi74742238.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY344633 mRNA. Translation: AAQ76870.1 .
    AK297912 mRNA. Translation: BAG60231.1 .
    AL353608 Genomic DNA. Translation: CAI41162.1 .
    BX284632 Genomic DNA. No translation available.
    CCDSi CCDS35038.1.
    RefSeqi NP_958861.2. NM_201453.3.
    UniGenei Hs.645337.

    3D structure databases

    ProteinModelPortali Q5JTY5.
    SMRi Q5JTY5. Positions 42-373.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 138650. 1 interaction.
    IntActi Q5JTY5. 1 interaction.
    STRINGi 9606.ENSP00000353295.

    PTM databases

    PhosphoSitei Q5JTY5.

    Polymorphism databases

    DMDMi 74742238.

    Proteomic databases

    MaxQBi Q5JTY5.
    PaxDbi Q5JTY5.
    PRIDEi Q5JTY5.

    Protocols and materials databases

    DNASUi 445571.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360171 ; ENSP00000353295 ; ENSG00000196873 .
    GeneIDi 445571.
    KEGGi hsa:445571.
    UCSCi uc004aga.4. human.

    Organism-specific databases

    CTDi 445571.
    GeneCardsi GC09P070849.
    HGNCi HGNC:18519. CBWD3.
    MIMi 611080. gene.
    neXtProti NX_Q5JTY5.
    PharmGKBi PA134863724.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0523.
    HOGENOMi HOG000182211.
    HOVERGENi HBG056297.
    InParanoidi Q5JTY5.
    OMAi TETEKRW.
    PhylomeDBi Q5JTY5.
    TreeFami TF332679.

    Miscellaneous databases

    GenomeRNAii 445571.
    NextBioi 111390.
    PROi Q5JTY5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5JTY5.
    Genevestigatori Q5JTY5.

    Family and domain databases

    Gene3Di 3.30.1220.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR011629. Cbl_biosynth_CobW-like_C.
    IPR003495. CobW/HypB/UreG_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF02492. cobW. 1 hit.
    PF07683. CobW_C. 1 hit.
    [Graphical view ]
    SMARTi SM00833. CobW_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF90002. SSF90002. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Diverse fates of paralogs following segmental duplication of telomeric genes."
      Wong A., Vallender E.J., Heretis K., Ilkin Y., Lahn B.T., Lese Martin C., Ledbetter D.H.
      Genomics 84:239-247(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Embryo.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions."
      Fan Y., Newman T., Linardopoulou E., Trask B.J.
      Genome Res. 12:1663-1672(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiCBWD3_HUMAN
    AccessioniPrimary (citable) accession number: Q5JTY5
    Secondary accession number(s): B4DNG9, Q6VB91
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3