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Q5JTY5

- CBWD3_HUMAN

UniProt

Q5JTY5 - CBWD3_HUMAN

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Protein

COBW domain-containing protein 3

Gene

CBWD3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi49 – 568ATPSequence Analysis
Nucleotide bindingi110 – 1145ATPSequence Analysis
Nucleotide bindingi203 – 2064ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
COBW domain-containing protein 3
Alternative name(s):
Cobalamin synthase W domain-containing protein 3
Gene namesi
Name:CBWD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:18519. CBWD3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134863724.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395COBW domain-containing protein 3PRO_0000317238Add
BLAST

Proteomic databases

MaxQBiQ5JTY5.
PaxDbiQ5JTY5.
PRIDEiQ5JTY5.

PTM databases

PhosphoSiteiQ5JTY5.

Expressioni

Gene expression databases

BgeeiQ5JTY5.
ExpressionAtlasiQ5JTY5. baseline.
GenevestigatoriQ5JTY5.

Interactioni

Protein-protein interaction databases

BioGridi138650. 10 interactions.
IntActiQ5JTY5. 1 interaction.
STRINGi9606.ENSP00000353295.

Structurei

3D structure databases

ProteinModelPortaliQ5JTY5.
SMRiQ5JTY5. Positions 42-373.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini274 – 377104CobW C-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the CobW family.Curated
Contains 1 cobW C-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0523.
GeneTreeiENSGT00640000091523.
HOGENOMiHOG000182211.
HOVERGENiHBG056297.
InParanoidiQ5JTY5.
OMAiTETEKRW.
PhylomeDBiQ5JTY5.
TreeFamiTF332679.

Family and domain databases

Gene3Di3.30.1220.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR011629. Cbl_biosynth_CobW-like_C.
IPR003495. CobW/HypB/UreG_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02492. cobW. 1 hit.
PF07683. CobW_C. 1 hit.
[Graphical view]
SMARTiSM00833. CobW_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90002. SSF90002. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5JTY5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPAVGSVDE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY
60 70 80 90 100
LGAGKTTLLN YILTEQHSKR VAVILNESGE GSALEKSLAV SQGGELYEEW
110 120 130 140 150
LELRNGCLCC SVKDNGLRAI ENLMQKKGKF DDILLETTGL ADPGAVASMF
160 170 180 190 200
WVDAELGSDI YLDGIITIVD SKYGLKHLTE EKPDGLINEA TRQVALADII
210 220 230 240 250
LINKTDLVPE EDVKKLRTTI RSINGLGQIL ETQRSRVDLS NVLDLHAFDS
260 270 280 290 300
LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE
310 320 330 340 350
KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD
360 370 380 390
TERTNRLVLI GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT
Length:395
Mass (Da):44,038
Last modified:February 15, 2005 - v1
Checksum:i52EE727920F143DE
GO
Isoform 2 (identifier: Q5JTY5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-164: Missing.

Note: No experimental confirmation available.

Show »
Length:375
Mass (Da):41,897
Checksum:iD2D4CD5D9A8D3963
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321D → Y in AAQ76870. (PubMed:15233989)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei145 – 16420Missing in isoform 2. 1 PublicationVSP_055975Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY344633 mRNA. Translation: AAQ76870.1.
AK297912 mRNA. Translation: BAG60231.1.
AL353608 Genomic DNA. Translation: CAI41162.1.
BX284632 Genomic DNA. No translation available.
CCDSiCCDS35038.2. [Q5JTY5-1]
RefSeqiNP_001278750.1. NM_001291821.1. [Q5JTY5-2]
NP_958861.2. NM_201453.3. [Q5JTY5-1]
XP_005272807.1. XM_005272750.1. [Q5JTY5-2]
UniGeneiHs.355950.
Hs.531330.
Hs.635227.
Hs.645337.
Hs.645504.

Genome annotation databases

EnsembliENST00000360171; ENSP00000353295; ENSG00000196873. [Q5JTY5-1]
GeneIDi220869.
445571.
KEGGihsa:220869.
hsa:445571.
UCSCiuc004aga.4. human. [Q5JTY5-1]

Polymorphism databases

DMDMi74742238.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY344633 mRNA. Translation: AAQ76870.1 .
AK297912 mRNA. Translation: BAG60231.1 .
AL353608 Genomic DNA. Translation: CAI41162.1 .
BX284632 Genomic DNA. No translation available.
CCDSi CCDS35038.2. [Q5JTY5-1 ]
RefSeqi NP_001278750.1. NM_001291821.1. [Q5JTY5-2 ]
NP_958861.2. NM_201453.3. [Q5JTY5-1 ]
XP_005272807.1. XM_005272750.1. [Q5JTY5-2 ]
UniGenei Hs.355950.
Hs.531330.
Hs.635227.
Hs.645337.
Hs.645504.

3D structure databases

ProteinModelPortali Q5JTY5.
SMRi Q5JTY5. Positions 42-373.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 138650. 10 interactions.
IntActi Q5JTY5. 1 interaction.
STRINGi 9606.ENSP00000353295.

PTM databases

PhosphoSitei Q5JTY5.

Polymorphism databases

DMDMi 74742238.

Proteomic databases

MaxQBi Q5JTY5.
PaxDbi Q5JTY5.
PRIDEi Q5JTY5.

Protocols and materials databases

DNASUi 445571.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360171 ; ENSP00000353295 ; ENSG00000196873 . [Q5JTY5-1 ]
GeneIDi 220869.
445571.
KEGGi hsa:220869.
hsa:445571.
UCSCi uc004aga.4. human. [Q5JTY5-1 ]

Organism-specific databases

CTDi 220869.
445571.
GeneCardsi GC09P070849.
HGNCi HGNC:18519. CBWD3.
MIMi 611080. gene.
neXtProti NX_Q5JTY5.
PharmGKBi PA134863724.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0523.
GeneTreei ENSGT00640000091523.
HOGENOMi HOG000182211.
HOVERGENi HBG056297.
InParanoidi Q5JTY5.
OMAi TETEKRW.
PhylomeDBi Q5JTY5.
TreeFami TF332679.

Miscellaneous databases

GenomeRNAii 445571.
NextBioi 111390.
PROi Q5JTY5.
SOURCEi Search...

Gene expression databases

Bgeei Q5JTY5.
ExpressionAtlasi Q5JTY5. baseline.
Genevestigatori Q5JTY5.

Family and domain databases

Gene3Di 3.30.1220.10. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR011629. Cbl_biosynth_CobW-like_C.
IPR003495. CobW/HypB/UreG_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF02492. cobW. 1 hit.
PF07683. CobW_C. 1 hit.
[Graphical view ]
SMARTi SM00833. CobW_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF90002. SSF90002. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Diverse fates of paralogs following segmental duplication of telomeric genes."
    Wong A., Vallender E.J., Heretis K., Ilkin Y., Lahn B.T., Lese Martin C., Ledbetter D.H.
    Genomics 84:239-247(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryo.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions."
    Fan Y., Newman T., Linardopoulou E., Trask B.J.
    Genome Res. 12:1663-1672(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiCBWD3_HUMAN
AccessioniPrimary (citable) accession number: Q5JTY5
Secondary accession number(s): B4DNG9, Q6VB91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 15, 2005
Last modified: November 26, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3