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Protein

COBW domain-containing protein 3

Gene

CBWD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 56ATPSequence analysis8
Nucleotide bindingi110 – 114ATPSequence analysis5
Nucleotide bindingi203 – 206ATPSequence analysis4

GO - Molecular functioni

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
COBW domain-containing protein 3
Alternative name(s):
Cobalamin synthase W domain-containing protein 3
Gene namesi
Name:CBWD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000196873.15.
HGNCiHGNC:18519. CBWD3.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000147996.
ENSG00000196873.
PharmGKBiPA134863724.

Polymorphism and mutation databases

BioMutaiCBWD3.
DMDMi74742238.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172381 – 395COBW domain-containing protein 3Add BLAST395

Proteomic databases

MaxQBiQ5JTY5.
PaxDbiQ5JTY5.
PeptideAtlasiQ5JTY5.
PRIDEiQ5JTY5.

PTM databases

iPTMnetiQ5JTY5.
PhosphoSitePlusiQ5JTY5.

Expressioni

Gene expression databases

BgeeiENSG00000196873.
ExpressionAtlasiQ5JTY5. baseline and differential.
GenevisibleiQ5JTY5. HS.

Organism-specific databases

HPAiHPA042759.
HPA042813.

Interactioni

Protein-protein interaction databases

BioGridi128658. 1 interactor.
138650. 24 interactors.
IntActiQ5JTY5. 2 interactors.
STRINGi9606.ENSP00000353295.

Structurei

3D structure databases

ProteinModelPortaliQ5JTY5.
SMRiQ5JTY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini274 – 377CobW C-terminalAdd BLAST104

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2743. Eukaryota.
COG0523. LUCA.
GeneTreeiENSGT00640000091523.
HOGENOMiHOG000182211.
HOVERGENiHBG056297.
InParanoidiQ5JTY5.
OMAiTFFMDDE.
OrthoDBiEOG091G0JUI.
PhylomeDBiQ5JTY5.
TreeFamiTF332679.

Family and domain databases

Gene3Di3.30.1220.10. 1 hit.
InterProiView protein in InterPro
IPR011629. Cbl_biosynth_CobW-like_C.
IPR036627. CobW-likC_sf.
IPR003495. CobW/HypB/UreG_dom.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF02492. cobW. 1 hit.
PF07683. CobW_C. 1 hit.
SMARTiView protein in SMART
SM00833. CobW_C. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90002. SSF90002. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JTY5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPAVGSVDE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY
60 70 80 90 100
LGAGKTTLLN YILTEQHSKR VAVILNESGE GSALEKSLAV SQGGELYEEW
110 120 130 140 150
LELRNGCLCC SVKDNGLRAI ENLMQKKGKF DDILLETTGL ADPGAVASMF
160 170 180 190 200
WVDAELGSDI YLDGIITIVD SKYGLKHLTE EKPDGLINEA TRQVALADII
210 220 230 240 250
LINKTDLVPE EDVKKLRTTI RSINGLGQIL ETQRSRVDLS NVLDLHAFDS
260 270 280 290 300
LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE
310 320 330 340 350
KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD
360 370 380 390
TERTNRLVLI GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT
Length:395
Mass (Da):44,038
Last modified:February 15, 2005 - v1
Checksum:i52EE727920F143DE
GO
Isoform 2 (identifier: Q5JTY5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-164: Missing.

Note: No experimental confirmation available.
Show »
Length:375
Mass (Da):41,897
Checksum:iD2D4CD5D9A8D3963
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132D → Y in AAQ76870 (PubMed:15233989).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055975145 – 164Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY344633 mRNA. Translation: AAQ76870.1.
AK297912 mRNA. Translation: BAG60231.1.
AL353608 Genomic DNA. Translation: CAI41162.1.
BX284632 Genomic DNA. No translation available.
CCDSiCCDS35038.2. [Q5JTY5-1]
RefSeqiNP_001278750.1. NM_001291821.1. [Q5JTY5-2]
NP_958861.2. NM_201453.3. [Q5JTY5-1]
XP_005272807.1. XM_005272750.1. [Q5JTY5-2]
UniGeneiHs.355950.
Hs.531330.
Hs.635227.
Hs.645337.
Hs.645504.

Genome annotation databases

EnsembliENST00000360171; ENSP00000353295; ENSG00000196873. [Q5JTY5-1]
GeneIDi220869.
445571.
KEGGihsa:445571.
UCSCiuc004agi.6. human. [Q5JTY5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCBWD3_HUMAN
AccessioniPrimary (citable) accession number: Q5JTY5
Secondary accession number(s): B4DNG9, Q6VB91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 15, 2005
Last modified: October 25, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families