Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

COBW domain-containing protein 3

Gene

CBWD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi49 – 568ATPSequence Analysis
Nucleotide bindingi110 – 1145ATPSequence Analysis
Nucleotide bindingi203 – 2064ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
COBW domain-containing protein 3
Alternative name(s):
Cobalamin synthase W domain-containing protein 3
Gene namesi
Name:CBWD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:18519. CBWD3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134863724.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395COBW domain-containing protein 3PRO_0000317238Add
BLAST

Proteomic databases

MaxQBiQ5JTY5.
PaxDbiQ5JTY5.
PRIDEiQ5JTY5.

PTM databases

PhosphoSiteiQ5JTY5.

Expressioni

Gene expression databases

BgeeiQ5JTY5.
ExpressionAtlasiQ5JTY5. baseline and differential.
GenevestigatoriQ5JTY5.

Interactioni

Protein-protein interaction databases

BioGridi138650. 10 interactions.
IntActiQ5JTY5. 1 interaction.
STRINGi9606.ENSP00000353295.

Structurei

3D structure databases

ProteinModelPortaliQ5JTY5.
SMRiQ5JTY5. Positions 42-373.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini274 – 377104CobW C-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the CobW family.Curated
Contains 1 cobW C-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0523.
GeneTreeiENSGT00640000091523.
HOGENOMiHOG000182211.
HOVERGENiHBG056297.
InParanoidiQ5JTY5.
OMAiETEKRWT.
PhylomeDBiQ5JTY5.
TreeFamiTF332679.

Family and domain databases

Gene3Di3.30.1220.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR011629. Cbl_biosynth_CobW-like_C.
IPR003495. CobW/HypB/UreG_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02492. cobW. 1 hit.
PF07683. CobW_C. 1 hit.
[Graphical view]
SMARTiSM00833. CobW_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90002. SSF90002. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5JTY5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPAVGSVDE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY
60 70 80 90 100
LGAGKTTLLN YILTEQHSKR VAVILNESGE GSALEKSLAV SQGGELYEEW
110 120 130 140 150
LELRNGCLCC SVKDNGLRAI ENLMQKKGKF DDILLETTGL ADPGAVASMF
160 170 180 190 200
WVDAELGSDI YLDGIITIVD SKYGLKHLTE EKPDGLINEA TRQVALADII
210 220 230 240 250
LINKTDLVPE EDVKKLRTTI RSINGLGQIL ETQRSRVDLS NVLDLHAFDS
260 270 280 290 300
LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE
310 320 330 340 350
KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD
360 370 380 390
TERTNRLVLI GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT
Length:395
Mass (Da):44,038
Last modified:February 15, 2005 - v1
Checksum:i52EE727920F143DE
GO
Isoform 2 (identifier: Q5JTY5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-164: Missing.

Note: No experimental confirmation available.

Show »
Length:375
Mass (Da):41,897
Checksum:iD2D4CD5D9A8D3963
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321D → Y in AAQ76870. (PubMed:15233989)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei145 – 16420Missing in isoform 2. 1 PublicationVSP_055975Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY344633 mRNA. Translation: AAQ76870.1.
AK297912 mRNA. Translation: BAG60231.1.
AL353608 Genomic DNA. Translation: CAI41162.1.
BX284632 Genomic DNA. No translation available.
CCDSiCCDS35038.2. [Q5JTY5-1]
RefSeqiNP_001278750.1. NM_001291821.1. [Q5JTY5-2]
NP_958861.2. NM_201453.3. [Q5JTY5-1]
XP_005272807.1. XM_005272750.1. [Q5JTY5-2]
UniGeneiHs.355950.
Hs.531330.
Hs.635227.
Hs.645337.
Hs.645504.

Genome annotation databases

EnsembliENST00000360171; ENSP00000353295; ENSG00000196873. [Q5JTY5-1]
GeneIDi220869.
445571.
KEGGihsa:220869.
hsa:445571.
UCSCiuc004aga.4. human. [Q5JTY5-1]

Polymorphism databases

DMDMi74742238.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY344633 mRNA. Translation: AAQ76870.1.
AK297912 mRNA. Translation: BAG60231.1.
AL353608 Genomic DNA. Translation: CAI41162.1.
BX284632 Genomic DNA. No translation available.
CCDSiCCDS35038.2. [Q5JTY5-1]
RefSeqiNP_001278750.1. NM_001291821.1. [Q5JTY5-2]
NP_958861.2. NM_201453.3. [Q5JTY5-1]
XP_005272807.1. XM_005272750.1. [Q5JTY5-2]
UniGeneiHs.355950.
Hs.531330.
Hs.635227.
Hs.645337.
Hs.645504.

3D structure databases

ProteinModelPortaliQ5JTY5.
SMRiQ5JTY5. Positions 42-373.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi138650. 10 interactions.
IntActiQ5JTY5. 1 interaction.
STRINGi9606.ENSP00000353295.

PTM databases

PhosphoSiteiQ5JTY5.

Polymorphism databases

DMDMi74742238.

Proteomic databases

MaxQBiQ5JTY5.
PaxDbiQ5JTY5.
PRIDEiQ5JTY5.

Protocols and materials databases

DNASUi445571.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360171; ENSP00000353295; ENSG00000196873. [Q5JTY5-1]
GeneIDi220869.
445571.
KEGGihsa:220869.
hsa:445571.
UCSCiuc004aga.4. human. [Q5JTY5-1]

Organism-specific databases

CTDi220869.
445571.
GeneCardsiGC09P070849.
HGNCiHGNC:18519. CBWD3.
MIMi611080. gene.
neXtProtiNX_Q5JTY5.
PharmGKBiPA134863724.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0523.
GeneTreeiENSGT00640000091523.
HOGENOMiHOG000182211.
HOVERGENiHBG056297.
InParanoidiQ5JTY5.
OMAiETEKRWT.
PhylomeDBiQ5JTY5.
TreeFamiTF332679.

Miscellaneous databases

GenomeRNAii445571.
NextBioi111390.
PROiQ5JTY5.
SOURCEiSearch...

Gene expression databases

BgeeiQ5JTY5.
ExpressionAtlasiQ5JTY5. baseline and differential.
GenevestigatoriQ5JTY5.

Family and domain databases

Gene3Di3.30.1220.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR011629. Cbl_biosynth_CobW-like_C.
IPR003495. CobW/HypB/UreG_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02492. cobW. 1 hit.
PF07683. CobW_C. 1 hit.
[Graphical view]
SMARTiSM00833. CobW_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90002. SSF90002. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Diverse fates of paralogs following segmental duplication of telomeric genes."
    Wong A., Vallender E.J., Heretis K., Ilkin Y., Lahn B.T., Lese Martin C., Ledbetter D.H.
    Genomics 84:239-247(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryo.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions."
    Fan Y., Newman T., Linardopoulou E., Trask B.J.
    Genome Res. 12:1663-1672(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiCBWD3_HUMAN
AccessioniPrimary (citable) accession number: Q5JTY5
Secondary accession number(s): B4DNG9, Q6VB91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 15, 2005
Last modified: February 4, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.