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Protein

Centrosomal protein of 78 kDa

Gene

CEP78

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles.1 Publication

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 78 kDa
Short name:
Cep78
Gene namesi
Name:CEP78
Synonyms:C9orf81
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:25740. CEP78.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148019.
PharmGKBiPA134937066.

Polymorphism and mutation databases

BioMutaiCEP78.
DMDMi74742229.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002919521 – 689Centrosomal protein of 78 kDaAdd BLAST689

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei325PhosphoserineCombined sources1
Modified residuei327PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5JTW2.
MaxQBiQ5JTW2.
PaxDbiQ5JTW2.
PeptideAtlasiQ5JTW2.
PRIDEiQ5JTW2.

PTM databases

iPTMnetiQ5JTW2.
PhosphoSitePlusiQ5JTW2.

Expressioni

Developmental stagei

Expression is cell cycle-dependent, with low levels in mitosis. The expression starts to increase during late G1 until the S/G2 transition (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000148019.
CleanExiHS_CEP78.
ExpressionAtlasiQ5JTW2. baseline and differential.
GenevisibleiQ5JTW2. HS.

Organism-specific databases

HPAiHPA048846.

Interactioni

Subunit structurei

Interacts with PLK4.1 Publication

Protein-protein interaction databases

BioGridi123903. 24 interactors.
IntActiQ5JTW2. 15 interactors.
STRINGi9606.ENSP00000365782.

Structurei

3D structure databases

ProteinModelPortaliQ5JTW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili450 – 505Sequence analysisAdd BLAST56

Sequence similaritiesi

Belongs to the CEP78 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00390000013287.
HOGENOMiHOG000015235.
HOVERGENiHBG056294.
InParanoidiQ5JTW2.
KOiK16765.
OMAiMMKAVIK.
OrthoDBiEOG091G0AYV.
PhylomeDBiQ5JTW2.
TreeFamiTF328928.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR026212. Cep78.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 2 hits.
[Graphical view]
PRINTSiPR02062. CENTROSOME78.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JTW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIDSVKLRRD SAADFFSHYE YLCALQNSVP LPAVRACLRE GVLDFNADRL
60 70 80 90 100
RGVDWAPLLS TLKINKDLPL VSIKSFFQPW LGDTGSDMNK FCRSRVPAIR
110 120 130 140 150
YKDVTFQLCK ALKGCLSISS VLKNLELNGL ILRERDLTIL AKGLNKSASL
160 170 180 190 200
VHLSLANCPI GDGGLEIICQ GIKSSITLKT VNFTGCNLTW QGADHMAKIL
210 220 230 240 250
KYQTMRRHEE TWAESLRYRR PDLDCMAGLR RITLNCNTLI GDLGACAFAD
260 270 280 290 300
SLSEDLWLRA LDLQQCGLTN EGAKALLEAL ETNTTLVVLD IRKNPLIDHS
310 320 330 340 350
MMKAVIKKVL QNGRSAKSEY QWITSPSVKE PSKTAKQKRR TIILGSGHKG
360 370 380 390 400
KATIRIGLAT KKPVSSGRKH SLGKEYYAPA PLPPGVSGFL PWRTAERAKR
410 420 430 440 450
HRGFPLIKTR DICNQLQQPG FPVTVTVESP SSSEVEEVDD SSESVHEVPE
460 470 480 490 500
KTSIEQEALQ EKLEECLKQL KEERVIRLKV DKRVSELEHE NAQLRNINFS
510 520 530 540 550
LSEALHAQSL TNMILDDEGV LGSIENSFQK FHAFLDLLKD AGLGQLATMA
560 570 580 590 600
GIDQSDFQLL GHPQMTSTVS NPPKEEKKAL EDEKPEPKQN ALGQMQNIQF
610 620 630 640 650
QKITGDARIP LPLDSFPVPV STPEGLGTSS NNLGVPATEQ RQESFEGFIA
660 670 680
RMCSPSPDAT SGTGSQRKEE ELSRNSRSSS EKKTKTESH
Length:689
Mass (Da):76,396
Last modified:February 15, 2005 - v1
Checksum:i5FEEE6542F8E4F5F
GO
Isoform 2 (identifier: Q5JTW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-356: I → IV
     599-599: Q → QVSICMQSAYNEGTLMK
     687-689: ESH → GEYTKKHSDKQHPGKDLHS

Note: No experimental confirmation available.
Show »
Length:722
Mass (Da):80,074
Checksum:i747ACCD87DB5D60E
GO
Isoform 3 (identifier: Q5JTW2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     599-599: Q → QVSICMQSAYNEGTLMK

Note: Gene prediction based on EST data. No experimental confirmation available.
Show »
Length:705
Mass (Da):78,153
Checksum:i96D85522FD74506A
GO
Isoform 4 (identifier: Q5JTW2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-356: I → IV
     687-689: ESH → GEYTKKHSDKQHPGKDLHS

Note: No experimental confirmation available.
Show »
Length:706
Mass (Da):78,317
Checksum:i4D194C3FE5E69CB7
GO

Sequence cautioni

The sequence AAH91515 differs from that shown. Probable intron retention.Curated
The sequence AAH91515 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49R → G in AAI28059 (PubMed:15489334).Curated1
Sequence conflicti173K → R in AAI28059 (PubMed:15489334).Curated1
Sequence conflicti236 – 237CN → GY in BAB14190 (PubMed:14702039).Curated2
Sequence conflicti451K → R in BAB14190 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026321356I → IV in isoform 2 and isoform 4. 1 Publication1
Alternative sequenceiVSP_026322599Q → QVSICMQSAYNEGTLMK in isoform 2 and isoform 3. 1 Publication1
Alternative sequenceiVSP_026323687 – 689ESH → GEYTKKHSDKQHPGKDLHS in isoform 2 and isoform 4. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353705 Genomic DNA. No translation available.
BC091515 mRNA. Translation: AAH91515.1. Sequence problems.
BC128058 mRNA. Translation: AAI28059.1.
AK022705 mRNA. Translation: BAB14190.1.
CCDSiCCDS47984.1. [Q5JTW2-2]
CCDS47985.1. [Q5JTW2-5]
CCDS83376.1. [Q5JTW2-3]
CCDS83377.1. [Q5JTW2-1]
RefSeqiNP_001092272.1. NM_001098802.1. [Q5JTW2-2]
NP_001317620.1. NM_001330691.1.
NP_001317622.1. NM_001330693.1.
NP_001317623.1. NM_001330694.1.
NP_115547.1. NM_032171.1. [Q5JTW2-5]
UniGeneiHs.374421.

Genome annotation databases

EnsembliENST00000376597; ENSP00000365782; ENSG00000148019. [Q5JTW2-2]
ENST00000376598; ENSP00000365783; ENSG00000148019. [Q5JTW2-3]
ENST00000415759; ENSP00000399286; ENSG00000148019. [Q5JTW2-5]
ENST00000424347; ENSP00000411284; ENSG00000148019. [Q5JTW2-1]
GeneIDi84131.
KEGGihsa:84131.
UCSCiuc004akx.3. human. [Q5JTW2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353705 Genomic DNA. No translation available.
BC091515 mRNA. Translation: AAH91515.1. Sequence problems.
BC128058 mRNA. Translation: AAI28059.1.
AK022705 mRNA. Translation: BAB14190.1.
CCDSiCCDS47984.1. [Q5JTW2-2]
CCDS47985.1. [Q5JTW2-5]
CCDS83376.1. [Q5JTW2-3]
CCDS83377.1. [Q5JTW2-1]
RefSeqiNP_001092272.1. NM_001098802.1. [Q5JTW2-2]
NP_001317620.1. NM_001330691.1.
NP_001317622.1. NM_001330693.1.
NP_001317623.1. NM_001330694.1.
NP_115547.1. NM_032171.1. [Q5JTW2-5]
UniGeneiHs.374421.

3D structure databases

ProteinModelPortaliQ5JTW2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123903. 24 interactors.
IntActiQ5JTW2. 15 interactors.
STRINGi9606.ENSP00000365782.

PTM databases

iPTMnetiQ5JTW2.
PhosphoSitePlusiQ5JTW2.

Polymorphism and mutation databases

BioMutaiCEP78.
DMDMi74742229.

Proteomic databases

EPDiQ5JTW2.
MaxQBiQ5JTW2.
PaxDbiQ5JTW2.
PeptideAtlasiQ5JTW2.
PRIDEiQ5JTW2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376597; ENSP00000365782; ENSG00000148019. [Q5JTW2-2]
ENST00000376598; ENSP00000365783; ENSG00000148019. [Q5JTW2-3]
ENST00000415759; ENSP00000399286; ENSG00000148019. [Q5JTW2-5]
ENST00000424347; ENSP00000411284; ENSG00000148019. [Q5JTW2-1]
GeneIDi84131.
KEGGihsa:84131.
UCSCiuc004akx.3. human. [Q5JTW2-1]

Organism-specific databases

CTDi84131.
GeneCardsiCEP78.
HGNCiHGNC:25740. CEP78.
HPAiHPA048846.
MIMi617110. gene.
neXtProtiNX_Q5JTW2.
OpenTargetsiENSG00000148019.
PharmGKBiPA134937066.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00390000013287.
HOGENOMiHOG000015235.
HOVERGENiHBG056294.
InParanoidiQ5JTW2.
KOiK16765.
OMAiMMKAVIK.
OrthoDBiEOG091G0AYV.
PhylomeDBiQ5JTW2.
TreeFamiTF328928.

Enzyme and pathway databases

ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Miscellaneous databases

ChiTaRSiCEP78. human.
GeneWikiiCEP78.
GenomeRNAii84131.
PROiQ5JTW2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148019.
CleanExiHS_CEP78.
ExpressionAtlasiQ5JTW2. baseline and differential.
GenevisibleiQ5JTW2. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR026212. Cep78.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 2 hits.
[Graphical view]
PRINTSiPR02062. CENTROSOME78.
ProtoNetiSearch...

Entry informationi

Entry nameiCEP78_HUMAN
AccessioniPrimary (citable) accession number: Q5JTW2
Secondary accession number(s): A1A4S8
, E9PHX5, Q5BJE3, Q5JTW0, Q5JTW1, Q9H9N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 15, 2005
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.