ID   WDR38_HUMAN             Reviewed;         314 AA.
AC   Q5JTN6; A0PK24;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   27-MAR-2024, entry version 123.
DE   RecName: Full=WD repeat-containing protein 38;
GN   Name=WDR38;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ARG-172 AND GLY-193.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; AL354928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC127949; AAI27950.1; -; mRNA.
DR   CCDS; CCDS43876.1; -.
DR   RefSeq; NP_001038941.1; NM_001045476.2.
DR   AlphaFoldDB; Q5JTN6; -.
DR   SMR; Q5JTN6; -.
DR   STRING; 9606.ENSP00000483312; -.
DR   iPTMnet; Q5JTN6; -.
DR   PhosphoSitePlus; Q5JTN6; -.
DR   BioMuta; WDR38; -.
DR   DMDM; 74755676; -.
DR   MassIVE; Q5JTN6; -.
DR   PeptideAtlas; Q5JTN6; -.
DR   ProteomicsDB; 63225; -.
DR   Antibodypedia; 64851; 24 antibodies from 12 providers.
DR   DNASU; 401551; -.
DR   Ensembl; ENST00000373574.2; ENSP00000362677.1; ENSG00000136918.8.
DR   GeneID; 401551; -.
DR   KEGG; hsa:401551; -.
DR   MANE-Select; ENST00000373574.2; ENSP00000362677.1; NM_001045476.3; NP_001038941.1.
DR   UCSC; uc004box.5; human.
DR   AGR; HGNC:23745; -.
DR   CTD; 401551; -.
DR   GeneCards; WDR38; -.
DR   HGNC; HGNC:23745; WDR38.
DR   HPA; ENSG00000136918; Group enriched (choroid plexus, fallopian tube).
DR   neXtProt; NX_Q5JTN6; -.
DR   OpenTargets; ENSG00000136918; -.
DR   PharmGKB; PA162409138; -.
DR   VEuPathDB; HostDB:ENSG00000136918; -.
DR   eggNOG; KOG0266; Eukaryota.
DR   eggNOG; KOG0273; Eukaryota.
DR   GeneTree; ENSGT00940000162358; -.
DR   HOGENOM; CLU_000288_57_33_1; -.
DR   InParanoid; Q5JTN6; -.
DR   OMA; ELCHHTE; -.
DR   OrthoDB; 4632138at2759; -.
DR   PhylomeDB; Q5JTN6; -.
DR   TreeFam; TF328741; -.
DR   PathwayCommons; Q5JTN6; -.
DR   SignaLink; Q5JTN6; -.
DR   BioGRID-ORCS; 401551; 23 hits in 1143 CRISPR screens.
DR   ChiTaRS; WDR38; human.
DR   GenomeRNAi; 401551; -.
DR   Pharos; Q5JTN6; Tdark.
DR   PRO; PR:Q5JTN6; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q5JTN6; Protein.
DR   Bgee; ENSG00000136918; Expressed in bronchial epithelial cell and 88 other cell types or tissues.
DR   ExpressionAtlas; Q5JTN6; baseline and differential.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR19879:SF1; CANNONBALL-RELATED; 1.
DR   PANTHER; PTHR19879; TRANSCRIPTION INITIATION FACTOR TFIID; 1.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR   Genevisible; Q5JTN6; HS.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..314
FT                   /note="WD repeat-containing protein 38"
FT                   /id="PRO_0000294440"
FT   REPEAT          19..58
FT                   /note="WD 1"
FT   REPEAT          61..100
FT                   /note="WD 2"
FT   REPEAT          103..142
FT                   /note="WD 3"
FT   REPEAT          145..184
FT                   /note="WD 4"
FT   REPEAT          190..228
FT                   /note="WD 5"
FT   REPEAT          231..272
FT                   /note="WD 6"
FT   REPEAT          274..312
FT                   /note="WD 7"
FT   REGION          294..314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        296..314
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         172
FT                   /note="H -> R (in dbSNP:rs2274970)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_053431"
FT   VARIANT         193
FT                   /note="A -> G (in dbSNP:rs10760381)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_053432"
SQ   SEQUENCE   314 AA;  34312 MW;  216533C331A83776 CRC64;
     MNSGVPATLA VRRVKFFGQH GGEVNSSAFS PDGQMLLTGS EDGCVYGWET RSGQLLWRLG
     GHTGPVKFCR FSPDGHLFAS ASCDCTVRLW DVARAKCLRV LKGHQRSVET VSFSPDSRQL
     ASGGWDKRVM LWDVQSGQML RLLVGHRDSI QSSDFSPTVN CLATGSWDST VHIWDLRMVT
     PAVSHQALEG HSANISCLCY SASGLLASGS WDKTIHIWKP TTSSLLIQLK GHVTWVKSIA
     FSPDELWLAS AGYSRMVKVW DCNTGKCLET LKGVLDVAHT CAFTPDGKIL VSGAADQTRR
     QISRTSKSPR DPQT
//