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Q5JTN6

- WDR38_HUMAN

UniProt

Q5JTN6 - WDR38_HUMAN

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Protein
WD repeat-containing protein 38
Gene
WDR38
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ5JTN6.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 38
Gene namesi
Name:WDR38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:23745. WDR38.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409138.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314WD repeat-containing protein 38
PRO_0000294440Add
BLAST

Proteomic databases

PaxDbiQ5JTN6.
PRIDEiQ5JTN6.

Expressioni

Gene expression databases

BgeeiQ5JTN6.
CleanExiHS_WDR38.
GenevestigatoriQ5JTN6.

Organism-specific databases

HPAiHPA056607.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362677.

Structurei

3D structure databases

ProteinModelPortaliQ5JTN6.
SMRiQ5JTN6. Positions 15-307.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati19 – 5840WD 1
Add
BLAST
Repeati61 – 10040WD 2
Add
BLAST
Repeati103 – 14240WD 3
Add
BLAST
Repeati145 – 18440WD 4
Add
BLAST
Repeati190 – 22839WD 5
Add
BLAST
Repeati231 – 27242WD 6
Add
BLAST
Repeati274 – 31239WD 7
Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOVERGENiHBG106736.
InParanoidiQ5JTN6.
OMAiITWVKSI.
OrthoDBiEOG7WQ7SS.
PhylomeDBiQ5JTN6.
TreeFamiTF328741.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JTN6-1 [UniParc]FASTAAdd to Basket

« Hide

MNSGVPATLA VRRVKFFGQH GGEVNSSAFS PDGQMLLTGS EDGCVYGWET    50
RSGQLLWRLG GHTGPVKFCR FSPDGHLFAS ASCDCTVRLW DVARAKCLRV 100
LKGHQRSVET VSFSPDSRQL ASGGWDKRVM LWDVQSGQML RLLVGHRDSI 150
QSSDFSPTVN CLATGSWDST VHIWDLRMVT PAVSHQALEG HSANISCLCY 200
SASGLLASGS WDKTIHIWKP TTSSLLIQLK GHVTWVKSIA FSPDELWLAS 250
AGYSRMVKVW DCNTGKCLET LKGVLDVAHT CAFTPDGKIL VSGAADQTRR 300
QISRTSKSPR DPQT 314
Length:314
Mass (Da):34,312
Last modified:February 15, 2005 - v1
Checksum:i216533C331A83776
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti172 – 1721H → R.1 Publication
Corresponds to variant rs2274970 [ dbSNP | Ensembl ].
VAR_053431
Natural varianti193 – 1931A → G.1 Publication
Corresponds to variant rs10760381 [ dbSNP | Ensembl ].
VAR_053432

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL354928 Genomic DNA. Translation: CAI39637.1.
BC127949 mRNA. Translation: AAI27950.1.
CCDSiCCDS43876.1.
RefSeqiNP_001038941.1. NM_001045476.2.
UniGeneiHs.343383.

Genome annotation databases

EnsembliENST00000373574; ENSP00000362677; ENSG00000136918.
GeneIDi401551.
KEGGihsa:401551.
UCSCiuc004box.4. human.

Polymorphism databases

DMDMi74755676.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL354928 Genomic DNA. Translation: CAI39637.1 .
BC127949 mRNA. Translation: AAI27950.1 .
CCDSi CCDS43876.1.
RefSeqi NP_001038941.1. NM_001045476.2.
UniGenei Hs.343383.

3D structure databases

ProteinModelPortali Q5JTN6.
SMRi Q5JTN6. Positions 15-307.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000362677.

Polymorphism databases

DMDMi 74755676.

Proteomic databases

PaxDbi Q5JTN6.
PRIDEi Q5JTN6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373574 ; ENSP00000362677 ; ENSG00000136918 .
GeneIDi 401551.
KEGGi hsa:401551.
UCSCi uc004box.4. human.

Organism-specific databases

CTDi 401551.
GeneCardsi GC09P127615.
HGNCi HGNC:23745. WDR38.
HPAi HPA056607.
neXtProti NX_Q5JTN6.
PharmGKBi PA162409138.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
HOVERGENi HBG106736.
InParanoidi Q5JTN6.
OMAi ITWVKSI.
OrthoDBi EOG7WQ7SS.
PhylomeDBi Q5JTN6.
TreeFami TF328741.

Enzyme and pathway databases

SignaLinki Q5JTN6.

Miscellaneous databases

GenomeRNAii 401551.
NextBioi 106977.
PROi Q5JTN6.

Gene expression databases

Bgeei Q5JTN6.
CleanExi HS_WDR38.
Genevestigatori Q5JTN6.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 7 hits.
[Graphical view ]
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-172 AND GLY-193.

Entry informationi

Entry nameiWDR38_HUMAN
AccessioniPrimary (citable) accession number: Q5JTN6
Secondary accession number(s): A0PK24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 15, 2005
Last modified: July 9, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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