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Q5JTN6

- WDR38_HUMAN

UniProt

Q5JTN6 - WDR38_HUMAN

Protein

WD repeat-containing protein 38

Gene

WDR38

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    SignaLinkiQ5JTN6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WD repeat-containing protein 38
    Gene namesi
    Name:WDR38
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:23745. WDR38.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162409138.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314WD repeat-containing protein 38PRO_0000294440Add
    BLAST

    Proteomic databases

    PaxDbiQ5JTN6.
    PRIDEiQ5JTN6.

    Expressioni

    Gene expression databases

    BgeeiQ5JTN6.
    CleanExiHS_WDR38.
    GenevestigatoriQ5JTN6.

    Organism-specific databases

    HPAiHPA056607.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000362677.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5JTN6.
    SMRiQ5JTN6. Positions 15-307.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati19 – 5840WD 1Add
    BLAST
    Repeati61 – 10040WD 2Add
    BLAST
    Repeati103 – 14240WD 3Add
    BLAST
    Repeati145 – 18440WD 4Add
    BLAST
    Repeati190 – 22839WD 5Add
    BLAST
    Repeati231 – 27242WD 6Add
    BLAST
    Repeati274 – 31239WD 7Add
    BLAST

    Sequence similaritiesi

    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOVERGENiHBG106736.
    InParanoidiQ5JTN6.
    OMAiITWVKSI.
    OrthoDBiEOG7WQ7SS.
    PhylomeDBiQ5JTN6.
    TreeFamiTF328741.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 7 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 3 hits.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5JTN6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSGVPATLA VRRVKFFGQH GGEVNSSAFS PDGQMLLTGS EDGCVYGWET    50
    RSGQLLWRLG GHTGPVKFCR FSPDGHLFAS ASCDCTVRLW DVARAKCLRV 100
    LKGHQRSVET VSFSPDSRQL ASGGWDKRVM LWDVQSGQML RLLVGHRDSI 150
    QSSDFSPTVN CLATGSWDST VHIWDLRMVT PAVSHQALEG HSANISCLCY 200
    SASGLLASGS WDKTIHIWKP TTSSLLIQLK GHVTWVKSIA FSPDELWLAS 250
    AGYSRMVKVW DCNTGKCLET LKGVLDVAHT CAFTPDGKIL VSGAADQTRR 300
    QISRTSKSPR DPQT 314
    Length:314
    Mass (Da):34,312
    Last modified:February 15, 2005 - v1
    Checksum:i216533C331A83776
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti172 – 1721H → R.1 Publication
    Corresponds to variant rs2274970 [ dbSNP | Ensembl ].
    VAR_053431
    Natural varianti193 – 1931A → G.1 Publication
    Corresponds to variant rs10760381 [ dbSNP | Ensembl ].
    VAR_053432

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL354928 Genomic DNA. Translation: CAI39637.1.
    BC127949 mRNA. Translation: AAI27950.1.
    CCDSiCCDS43876.1.
    RefSeqiNP_001038941.1. NM_001045476.2.
    UniGeneiHs.343383.

    Genome annotation databases

    EnsembliENST00000373574; ENSP00000362677; ENSG00000136918.
    GeneIDi401551.
    KEGGihsa:401551.
    UCSCiuc004box.4. human.

    Polymorphism databases

    DMDMi74755676.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL354928 Genomic DNA. Translation: CAI39637.1 .
    BC127949 mRNA. Translation: AAI27950.1 .
    CCDSi CCDS43876.1.
    RefSeqi NP_001038941.1. NM_001045476.2.
    UniGenei Hs.343383.

    3D structure databases

    ProteinModelPortali Q5JTN6.
    SMRi Q5JTN6. Positions 15-307.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000362677.

    Polymorphism databases

    DMDMi 74755676.

    Proteomic databases

    PaxDbi Q5JTN6.
    PRIDEi Q5JTN6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373574 ; ENSP00000362677 ; ENSG00000136918 .
    GeneIDi 401551.
    KEGGi hsa:401551.
    UCSCi uc004box.4. human.

    Organism-specific databases

    CTDi 401551.
    GeneCardsi GC09P127615.
    HGNCi HGNC:23745. WDR38.
    HPAi HPA056607.
    neXtProti NX_Q5JTN6.
    PharmGKBi PA162409138.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOVERGENi HBG106736.
    InParanoidi Q5JTN6.
    OMAi ITWVKSI.
    OrthoDBi EOG7WQ7SS.
    PhylomeDBi Q5JTN6.
    TreeFami TF328741.

    Enzyme and pathway databases

    SignaLinki Q5JTN6.

    Miscellaneous databases

    GenomeRNAii 401551.
    NextBioi 106977.
    PROi Q5JTN6.

    Gene expression databases

    Bgeei Q5JTN6.
    CleanExi HS_WDR38.
    Genevestigatori Q5JTN6.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 7 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 3 hits.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-172 AND GLY-193.

    Entry informationi

    Entry nameiWDR38_HUMAN
    AccessioniPrimary (citable) accession number: Q5JTN6
    Secondary accession number(s): A0PK24
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3