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Q5JTN6 (WDR38_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WD repeat-containing protein 38
Gene names
Name:WDR38
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 7 WD repeats.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainRepeat
WD repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314WD repeat-containing protein 38
PRO_0000294440

Regions

Repeat19 – 5840WD 1
Repeat61 – 10040WD 2
Repeat103 – 14240WD 3
Repeat145 – 18440WD 4
Repeat190 – 22839WD 5
Repeat231 – 27242WD 6
Repeat274 – 31239WD 7

Natural variations

Natural variant1721H → R. Ref.2
Corresponds to variant rs2274970 [ dbSNP | Ensembl ].
VAR_053431
Natural variant1931A → G. Ref.2
Corresponds to variant rs10760381 [ dbSNP | Ensembl ].
VAR_053432

Sequences

Sequence LengthMass (Da)Tools
Q5JTN6 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 216533C331A83776

FASTA31434,312
        10         20         30         40         50         60 
MNSGVPATLA VRRVKFFGQH GGEVNSSAFS PDGQMLLTGS EDGCVYGWET RSGQLLWRLG 

        70         80         90        100        110        120 
GHTGPVKFCR FSPDGHLFAS ASCDCTVRLW DVARAKCLRV LKGHQRSVET VSFSPDSRQL 

       130        140        150        160        170        180 
ASGGWDKRVM LWDVQSGQML RLLVGHRDSI QSSDFSPTVN CLATGSWDST VHIWDLRMVT 

       190        200        210        220        230        240 
PAVSHQALEG HSANISCLCY SASGLLASGS WDKTIHIWKP TTSSLLIQLK GHVTWVKSIA 

       250        260        270        280        290        300 
FSPDELWLAS AGYSRMVKVW DCNTGKCLET LKGVLDVAHT CAFTPDGKIL VSGAADQTRR 

       310 
QISRTSKSPR DPQT 

« Hide

References

[1]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-172 AND GLY-193.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL354928 Genomic DNA. Translation: CAI39637.1.
BC127949 mRNA. Translation: AAI27950.1.
CCDSCCDS43876.1.
RefSeqNP_001038941.1. NM_001045476.2.
UniGeneHs.343383.

3D structure databases

ProteinModelPortalQ5JTN6.
SMRQ5JTN6. Positions 15-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000362677.

Polymorphism databases

DMDM74755676.

Proteomic databases

PaxDbQ5JTN6.
PRIDEQ5JTN6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373574; ENSP00000362677; ENSG00000136918.
GeneID401551.
KEGGhsa:401551.
UCSCuc004box.4. human.

Organism-specific databases

CTD401551.
GeneCardsGC09P127615.
HGNCHGNC:23745. WDR38.
HPAHPA056607.
neXtProtNX_Q5JTN6.
PharmGKBPA162409138.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2319.
HOVERGENHBG106736.
InParanoidQ5JTN6.
OMAITWVKSI.
OrthoDBEOG7WQ7SS.
PhylomeDBQ5JTN6.
TreeFamTF328741.

Enzyme and pathway databases

SignaLinkQ5JTN6.

Gene expression databases

BgeeQ5JTN6.
CleanExHS_WDR38.
GenevestigatorQ5JTN6.

Family and domain databases

Gene3D2.130.10.10. 2 hits.
InterProIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 7 hits.
[Graphical view]
PRINTSPR00320. GPROTEINBRPT.
SMARTSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi401551.
NextBio106977.
PROQ5JTN6.

Entry information

Entry nameWDR38_HUMAN
AccessionPrimary (citable) accession number: Q5JTN6
Secondary accession number(s): A0PK24
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 15, 2005
Last modified: July 9, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM