Q5JTN6 (WDR38_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 38

Gene names

Name:

WDR38

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 7 WD repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	WD repeat-containing protein 38		PRO_0000294440
Regions
	Repeat	19 – 58	40	WD 1
	Repeat	61 – 100	40	WD 2
	Repeat	103 – 142	40	WD 3
	Repeat	145 – 184	40	WD 4
	Repeat	190 – 228	39	WD 5
	Repeat	231 – 272	42	WD 6
	Repeat	274 – 312	39	WD 7
Natural variations
	Natural variant	172	1	H → R. Ref.2 Corresponds to variant rs2274970 [ dbSNP | Ensembl ].		VAR_053431
	Natural variant	193	1	A → G. Ref.2 Corresponds to variant rs10760381 [ dbSNP | Ensembl ].		VAR_053432

Sequences

	Sequence		Length	Mass (Da)
	Q5JTN6 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 216533C331A83776	FASTA	314	34,312
	10 20 30 40 50 60 MNSGVPATLA VRRVKFFGQH GGEVNSSAFS PDGQMLLTGS EDGCVYGWET RSGQLLWRLG 70 80 90 100 110 120 GHTGPVKFCR FSPDGHLFAS ASCDCTVRLW DVARAKCLRV LKGHQRSVET VSFSPDSRQL 130 140 150 160 170 180 ASGGWDKRVM LWDVQSGQML RLLVGHRDSI QSSDFSPTVN CLATGSWDST VHIWDLRMVT 190 200 210 220 230 240 PAVSHQALEG HSANISCLCY SASGLLASGS WDKTIHIWKP TTSSLLIQLK GHVTWVKSIA 250 260 270 280 290 300 FSPDELWLAS AGYSRMVKVW DCNTGKCLET LKGVLDVAHT CAFTPDGKIL VSGAADQTRR 310 QISRTSKSPR DPQT

References

[1]

"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-172 AND GLY-193.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL354928 Genomic DNA. Translation: CAI39637.1. BC127949 mRNA. Translation: AAI27950.1.
IPI	IPI00740620.
RefSeq	NP_001038941.1. NM_001045476.1.
UniGene	Hs.343383.
3D structure databases
HSSP	HSSP built from PDB template 1ERJ based on UniProtKB P16649.
ProteinModelPortal	Q5JTN6.
SMR	Q5JTN6. Positions 11-309.
ModBase	Search...
Polymorphism databases
DMDM	74755676.
Proteomic databases
PRIDE	Q5JTN6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373574; ENSP00000362677; ENSG00000136918.
GeneID	401551.
KEGG	hsa:401551.
UCSC	uc004box.1. human.
Organism-specific databases
CTD	401551.
GeneCards	GC09P127615.
HGNC	HGNC:23745. WDR38.
neXtProt	NX_Q5JTN6.
PharmGKB	PA162409138.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13678.
GeneTree	ENSGT00600000084025.
HOVERGEN	HBG106736.
InParanoid	Q5JTN6.
OMA	KGHQRSV.
OrthoDB	EOG4ZW5BD.
PhylomeDB	Q5JTN6.
Gene expression databases
ArrayExpress	Q5JTN6.
Bgee	Q5JTN6.
CleanEx	HS_WDR38.
Genevestigator	Q5JTN6.
Family and domain databases
InterPro	IPR020472. G-protein_beta_WD-40_rep. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 2 hits.
Pfam	PF00400. WD40. 7 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00320. WD40. 7 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 3 hits. PS50082. WD_REPEATS_2. 6 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	106977.

Entry information

Entry name

WDR38_HUMAN

Accession

Primary (citable) accession number: Q5JTN6
Secondary accession number(s): A0PK24

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	February 15, 2005
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.