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Protein

WD repeat-containing protein 38

Gene

WDR38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ5JTN6.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 38
Gene namesi
Name:WDR38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23745. WDR38.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409138.

Polymorphism and mutation databases

DMDMi74755676.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314WD repeat-containing protein 38PRO_0000294440Add
BLAST

Proteomic databases

PaxDbiQ5JTN6.
PRIDEiQ5JTN6.

Expressioni

Gene expression databases

BgeeiQ5JTN6.
CleanExiHS_WDR38.
ExpressionAtlasiQ5JTN6. baseline and differential.
GenevisibleiQ5JTN6. HS.

Organism-specific databases

HPAiHPA056607.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362677.

Structurei

3D structure databases

ProteinModelPortaliQ5JTN6.
SMRiQ5JTN6. Positions 15-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati19 – 5840WD 1Add
BLAST
Repeati61 – 10040WD 2Add
BLAST
Repeati103 – 14240WD 3Add
BLAST
Repeati145 – 18440WD 4Add
BLAST
Repeati190 – 22839WD 5Add
BLAST
Repeati231 – 27242WD 6Add
BLAST
Repeati274 – 31239WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00760000118869.
HOVERGENiHBG106736.
InParanoidiQ5JTN6.
OMAiHACTFTP.
OrthoDBiEOG7WQ7SS.
PhylomeDBiQ5JTN6.
TreeFamiTF328741.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JTN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSGVPATLA VRRVKFFGQH GGEVNSSAFS PDGQMLLTGS EDGCVYGWET
60 70 80 90 100
RSGQLLWRLG GHTGPVKFCR FSPDGHLFAS ASCDCTVRLW DVARAKCLRV
110 120 130 140 150
LKGHQRSVET VSFSPDSRQL ASGGWDKRVM LWDVQSGQML RLLVGHRDSI
160 170 180 190 200
QSSDFSPTVN CLATGSWDST VHIWDLRMVT PAVSHQALEG HSANISCLCY
210 220 230 240 250
SASGLLASGS WDKTIHIWKP TTSSLLIQLK GHVTWVKSIA FSPDELWLAS
260 270 280 290 300
AGYSRMVKVW DCNTGKCLET LKGVLDVAHT CAFTPDGKIL VSGAADQTRR
310
QISRTSKSPR DPQT
Length:314
Mass (Da):34,312
Last modified:February 15, 2005 - v1
Checksum:i216533C331A83776
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti172 – 1721H → R.1 Publication
Corresponds to variant rs2274970 [ dbSNP | Ensembl ].
VAR_053431
Natural varianti193 – 1931A → G.1 Publication
Corresponds to variant rs10760381 [ dbSNP | Ensembl ].
VAR_053432

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL354928 Genomic DNA. Translation: CAI39637.1.
BC127949 mRNA. Translation: AAI27950.1.
CCDSiCCDS43876.1.
RefSeqiNP_001038941.1. NM_001045476.2.
UniGeneiHs.343383.

Genome annotation databases

EnsembliENST00000373574; ENSP00000362677; ENSG00000136918.
GeneIDi401551.
KEGGihsa:401551.
UCSCiuc004box.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL354928 Genomic DNA. Translation: CAI39637.1.
BC127949 mRNA. Translation: AAI27950.1.
CCDSiCCDS43876.1.
RefSeqiNP_001038941.1. NM_001045476.2.
UniGeneiHs.343383.

3D structure databases

ProteinModelPortaliQ5JTN6.
SMRiQ5JTN6. Positions 15-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000362677.

Polymorphism and mutation databases

DMDMi74755676.

Proteomic databases

PaxDbiQ5JTN6.
PRIDEiQ5JTN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373574; ENSP00000362677; ENSG00000136918.
GeneIDi401551.
KEGGihsa:401551.
UCSCiuc004box.4. human.

Organism-specific databases

CTDi401551.
GeneCardsiGC09P127615.
HGNCiHGNC:23745. WDR38.
HPAiHPA056607.
neXtProtiNX_Q5JTN6.
PharmGKBiPA162409138.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00760000118869.
HOVERGENiHBG106736.
InParanoidiQ5JTN6.
OMAiHACTFTP.
OrthoDBiEOG7WQ7SS.
PhylomeDBiQ5JTN6.
TreeFamiTF328741.

Enzyme and pathway databases

SignaLinkiQ5JTN6.

Miscellaneous databases

GenomeRNAii401551.
NextBioi106977.
PROiQ5JTN6.

Gene expression databases

BgeeiQ5JTN6.
CleanExiHS_WDR38.
ExpressionAtlasiQ5JTN6. baseline and differential.
GenevisibleiQ5JTN6. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-172 AND GLY-193.

Entry informationi

Entry nameiWDR38_HUMAN
AccessioniPrimary (citable) accession number: Q5JTN6
Secondary accession number(s): A0PK24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 15, 2005
Last modified: June 24, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.