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Q5JTJ3

- COA6_HUMAN

UniProt

Q5JTJ3 - COA6_HUMAN

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Protein
Cytochrome c oxidase assembly factor 6 homolog
Gene
COA6, C1orf31
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro
  2. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly factor 6 homolog
Gene namesi
Name:COA6
Synonyms:C1orf31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18025. COA6.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25617.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 125125Cytochrome c oxidase assembly factor 6 homolog
PRO_0000280399Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 90 By similarity
Disulfide bondi68 ↔ 79 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ5JTJ3.
PaxDbiQ5JTJ3.
PRIDEiQ5JTJ3.

PTM databases

PhosphoSiteiQ5JTJ3.

Expressioni

Gene expression databases

BgeeiQ5JTJ3.
CleanExiHS_C1orf31.
GenevestigatoriQ5JTJ3.

Organism-specific databases

HPAiHPA028588.

Interactioni

Subunit structurei

Interacts with COA1.1 Publication

Protein-protein interaction databases

BioGridi132839. 3 interactions.
IntActiQ5JTJ3. 2 interactions.
STRINGi9606.ENSP00000355572.

Structurei

3D structure databases

ProteinModelPortaliQ5JTJ3.
SMRiQ5JTJ3. Positions 43-111.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG80742.
HOGENOMiHOG000196422.
HOVERGENiHBG056284.
KOiK18179.
OMAiVECESFL.
OrthoDBiEOG74R1T7.
PhylomeDBiQ5JTJ3.
TreeFamiTF335992.

Family and domain databases

Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
SUPFAMiSSF47694. SSF47694. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5JTJ3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGPGGPLLSP SRGFLLCKTG WHSNRLLGDC GPHTPVSTAL SFIAVGMAAP    50
SMKERQVCWG ARDEYWKCLD ENLEDASQCK KLRSSFESSC PQQWIKYFDK 100
RRDYLKFKEK FEAGQFEPSE TTAKS 125
Length:125
Mass (Da):14,116
Last modified:February 15, 2005 - v1
Checksum:i69192034A460F462
GO
Isoform 2 (identifier: Q5JTJ3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: MGPGGPLLSP...GPHTPVSTAL → MVARKGQKSP...KEAGRGRAES

Note: Gene prediction based on EST data.

Show »
Length:156
Mass (Da):18,094
Checksum:i9D5D3FA9B17E51E7
GO
Isoform 3 (identifier: Q5JTJ3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Note: Gene prediction based on EST data.

Show »
Length:79
Mass (Da):9,428
Checksum:iE743974EE94DA3FE
GO

Sequence cautioni

The sequence AAH25793.1 differs from that shown. Reason: Contaminating sequence.
The sequence AAH25793.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4646Missing in isoform 3.
VSP_023655Add
BLAST
Alternative sequencei1 – 4040MGPGG…VSTAL → MVARKGQKSPRFRRVSCFLR LGRSTLLELEPAGRPCSGRT RHRALHRRLVACVTVSSRRH RKEAGRGRAES in isoform 2.
VSP_023656Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL355472 Genomic DNA. Translation: CAI22928.1.
AL355472 Genomic DNA. Translation: CAI22929.1.
AL355472 Genomic DNA. Translation: CAI22930.1.
BC025793 mRNA. Translation: AAH25793.1. Sequence problems.
BC116455 mRNA. Translation: AAI16456.1.
CCDSiCCDS31059.1. [Q5JTJ3-1]
CCDS55690.1. [Q5JTJ3-3]
RefSeqiNP_001013003.1. NM_001012985.2. [Q5JTJ3-1]
NP_001193570.1. NM_001206641.1. [Q5JTJ3-3]
UniGeneiHs.23198.

Genome annotation databases

EnsembliENST00000366612; ENSP00000355571; ENSG00000168275. [Q5JTJ3-3]
ENST00000366613; ENSP00000355572; ENSG00000168275. [Q5JTJ3-1]
GeneIDi388753.
KEGGihsa:388753.
UCSCiuc001hwb.3. human. [Q5JTJ3-1]

Polymorphism databases

DMDMi74742178.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL355472 Genomic DNA. Translation: CAI22928.1 .
AL355472 Genomic DNA. Translation: CAI22929.1 .
AL355472 Genomic DNA. Translation: CAI22930.1 .
BC025793 mRNA. Translation: AAH25793.1 . Sequence problems.
BC116455 mRNA. Translation: AAI16456.1 .
CCDSi CCDS31059.1. [Q5JTJ3-1 ]
CCDS55690.1. [Q5JTJ3-3 ]
RefSeqi NP_001013003.1. NM_001012985.2. [Q5JTJ3-1 ]
NP_001193570.1. NM_001206641.1. [Q5JTJ3-3 ]
UniGenei Hs.23198.

3D structure databases

ProteinModelPortali Q5JTJ3.
SMRi Q5JTJ3. Positions 43-111.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 132839. 3 interactions.
IntActi Q5JTJ3. 2 interactions.
STRINGi 9606.ENSP00000355572.

PTM databases

PhosphoSitei Q5JTJ3.

Polymorphism databases

DMDMi 74742178.

Proteomic databases

MaxQBi Q5JTJ3.
PaxDbi Q5JTJ3.
PRIDEi Q5JTJ3.

Protocols and materials databases

DNASUi 388753.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000366612 ; ENSP00000355571 ; ENSG00000168275 . [Q5JTJ3-3 ]
ENST00000366613 ; ENSP00000355572 ; ENSG00000168275 . [Q5JTJ3-1 ]
GeneIDi 388753.
KEGGi hsa:388753.
UCSCi uc001hwb.3. human. [Q5JTJ3-1 ]

Organism-specific databases

CTDi 388753.
GeneCardsi GC01P234510.
HGNCi HGNC:18025. COA6.
HPAi HPA028588.
MIMi 614772. gene.
neXtProti NX_Q5JTJ3.
PharmGKBi PA25617.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG80742.
HOGENOMi HOG000196422.
HOVERGENi HBG056284.
KOi K18179.
OMAi VECESFL.
OrthoDBi EOG74R1T7.
PhylomeDBi Q5JTJ3.
TreeFami TF335992.

Miscellaneous databases

GenomeRNAii 388753.
NextBioi 102341.
SOURCEi Search...

Gene expression databases

Bgeei Q5JTJ3.
CleanExi HS_C1orf31.
Genevestigatori Q5JTJ3.

Family and domain databases

Gene3Di 1.10.10.140. 1 hit.
InterProi IPR003213. Cyt_c_oxidase_su6B.
[Graphical view ]
Pfami PF02297. COX6B. 1 hit.
[Graphical view ]
SUPFAMi SSF47694. SSF47694. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Ovary and Testis.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase."
    Szklarczyk R., Wanschers B.F., Cuypers T.D., Esseling J.J., Riemersma M., van den Brand M.A., Gloerich J., Lasonder E., van den Heuvel L.P., Nijtmans L.G., Huynen M.A.
    Genome Biol. 13:RESEARCH0012.1-RESEARCH0012.14(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH COA1.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOA6_HUMAN
AccessioniPrimary (citable) accession number: Q5JTJ3
Secondary accession number(s): Q5JTJ2, Q5JTJ4, Q8TA88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: February 15, 2005
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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