Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5JTJ3 (COA6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase assembly factor 6 homolog
Gene names
Name:COA6
Synonyms:C1orf31
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length125 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with COA1. Ref.4

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 6B family.

Sequence caution

The sequence AAH25793.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence AAH25793.1 differs from that shown. Reason: Contaminating sequence.

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityAlternative splicing
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmitochondrion

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: InterPro

poly(A) RNA binding

Inferred from direct assay PubMed 22658674. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5JTJ3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5JTJ3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: MGPGGPLLSP...GPHTPVSTAL → MVARKGQKSP...KEAGRGRAES
Note: Gene prediction based on EST data.
Isoform 3 (identifier: Q5JTJ3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 125125Cytochrome c oxidase assembly factor 6 homolog
PRO_0000280399

Amino acid modifications

Disulfide bond58 ↔ 90 By similarity
Disulfide bond68 ↔ 79 By similarity

Natural variations

Alternative sequence1 – 4646Missing in isoform 3.
VSP_023655
Alternative sequence1 – 4040MGPGG…VSTAL → MVARKGQKSPRFRRVSCFLR LGRSTLLELEPAGRPCSGRT RHRALHRRLVACVTVSSRRH RKEAGRGRAES in isoform 2.
VSP_023656

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 69192034A460F462

FASTA12514,116
        10         20         30         40         50         60 
MGPGGPLLSP SRGFLLCKTG WHSNRLLGDC GPHTPVSTAL SFIAVGMAAP SMKERQVCWG 

        70         80         90        100        110        120 
ARDEYWKCLD ENLEDASQCK KLRSSFESSC PQQWIKYFDK RRDYLKFKEK FEAGQFEPSE 


TTAKS 

« Hide

Isoform 2 [UniParc].

Checksum: 9D5D3FA9B17E51E7
Show »

FASTA15618,094
Isoform 3 [UniParc].

Checksum: E743974EE94DA3FE
Show »

FASTA799,428

References

« Hide 'large scale' references
[1]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Ovary and Testis.
[3]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[4]"Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase."
Szklarczyk R., Wanschers B.F., Cuypers T.D., Esseling J.J., Riemersma M., van den Brand M.A., Gloerich J., Lasonder E., van den Heuvel L.P., Nijtmans L.G., Huynen M.A.
Genome Biol. 13:RESEARCH0012.1-RESEARCH0012.14(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH COA1.
[5]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL355472 Genomic DNA. Translation: CAI22928.1.
AL355472 Genomic DNA. Translation: CAI22929.1.
AL355472 Genomic DNA. Translation: CAI22930.1.
BC025793 mRNA. Translation: AAH25793.1. Sequence problems.
BC116455 mRNA. Translation: AAI16456.1.
CCDSCCDS31059.1. [Q5JTJ3-1]
CCDS55690.1. [Q5JTJ3-3]
RefSeqNP_001013003.1. NM_001012985.2. [Q5JTJ3-1]
NP_001193570.1. NM_001206641.1. [Q5JTJ3-3]
UniGeneHs.23198.

3D structure databases

ProteinModelPortalQ5JTJ3.
SMRQ5JTJ3. Positions 43-111.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid132839. 3 interactions.
IntActQ5JTJ3. 2 interactions.
STRING9606.ENSP00000355572.

PTM databases

PhosphoSiteQ5JTJ3.

Polymorphism databases

DMDM74742178.

Proteomic databases

MaxQBQ5JTJ3.
PaxDbQ5JTJ3.
PRIDEQ5JTJ3.

Protocols and materials databases

DNASU388753.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000366612; ENSP00000355571; ENSG00000168275. [Q5JTJ3-3]
ENST00000366613; ENSP00000355572; ENSG00000168275. [Q5JTJ3-1]
GeneID388753.
KEGGhsa:388753.
UCSCuc001hwb.3. human. [Q5JTJ3-1]

Organism-specific databases

CTD388753.
GeneCardsGC01P234510.
HGNCHGNC:18025. COA6.
HPAHPA028588.
MIM614772. gene.
neXtProtNX_Q5JTJ3.
PharmGKBPA25617.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG80742.
HOGENOMHOG000196422.
HOVERGENHBG056284.
KOK18179.
OMAVECESFL.
OrthoDBEOG74R1T7.
PhylomeDBQ5JTJ3.
TreeFamTF335992.

Gene expression databases

BgeeQ5JTJ3.
CleanExHS_C1orf31.
GenevestigatorQ5JTJ3.

Family and domain databases

Gene3D1.10.10.140. 1 hit.
InterProIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamPF02297. COX6B. 1 hit.
[Graphical view]
SUPFAMSSF47694. SSF47694. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi388753.
NextBio102341.
SOURCESearch...

Entry information

Entry nameCOA6_HUMAN
AccessionPrimary (citable) accession number: Q5JTJ3
Secondary accession number(s): Q5JTJ2, Q5JTJ4, Q8TA88
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: February 15, 2005
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM