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Protein

Cytochrome c oxidase assembly factor 6 homolog

Gene

COA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly factor 6 homolog
Gene namesi
Name:COA6
Synonyms:C1orf31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18025. COA6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25617.

Polymorphism and mutation databases

BioMutaiCOA6.
DMDMi74742178.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 125125Cytochrome c oxidase assembly factor 6 homologPRO_0000280399Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 90By similarity
Disulfide bondi68 ↔ 79By similarity

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

MaxQBiQ5JTJ3.
PaxDbiQ5JTJ3.
PRIDEiQ5JTJ3.

PTM databases

PhosphoSiteiQ5JTJ3.

Expressioni

Gene expression databases

BgeeiQ5JTJ3.
CleanExiHS_C1orf31.
ExpressionAtlasiQ5JTJ3. baseline and differential.
GenevisibleiQ5JTJ3. HS.

Organism-specific databases

HPAiHPA028588.

Interactioni

Subunit structurei

Interacts with COA1.1 Publication

Protein-protein interaction databases

BioGridi132839. 3 interactions.
IntActiQ5JTJ3. 2 interactions.
STRINGi9606.ENSP00000355572.

Structurei

3D structure databases

ProteinModelPortaliQ5JTJ3.
SMRiQ5JTJ3. Positions 43-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG80742.
GeneTreeiENSGT00390000004094.
HOGENOMiHOG000196422.
HOVERGENiHBG056284.
InParanoidiQ5JTJ3.
KOiK18179.
OMAiRDEYWRC.
OrthoDBiEOG74R1T7.
PhylomeDBiQ5JTJ3.
TreeFamiTF335992.

Family and domain databases

Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
SUPFAMiSSF47694. SSF47694. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JTJ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPGGPLLSP SRGFLLCKTG WHSNRLLGDC GPHTPVSTAL SFIAVGMAAP
60 70 80 90 100
SMKERQVCWG ARDEYWKCLD ENLEDASQCK KLRSSFESSC PQQWIKYFDK
110 120
RRDYLKFKEK FEAGQFEPSE TTAKS
Length:125
Mass (Da):14,116
Last modified:February 15, 2005 - v1
Checksum:i69192034A460F462
GO
Isoform 2 (identifier: Q5JTJ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: MGPGGPLLSP...GPHTPVSTAL → MVARKGQKSP...KEAGRGRAES

Note: Gene prediction based on EST data.
Show »
Length:156
Mass (Da):18,094
Checksum:i9D5D3FA9B17E51E7
GO
Isoform 3 (identifier: Q5JTJ3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Note: Gene prediction based on EST data. Initiator Met-1 is removed. Contains a N-acetylalanine at position 2.1 Publication
Show »
Length:79
Mass (Da):9,428
Checksum:iE743974EE94DA3FE
GO

Sequence cautioni

The sequence AAH25793.1 differs from that shown.Contaminating sequence.Curated
The sequence AAH25793.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4646Missing in isoform 3. CuratedVSP_023655Add
BLAST
Alternative sequencei1 – 4040MGPGG…VSTAL → MVARKGQKSPRFRRVSCFLR LGRSTLLELEPAGRPCSGRT RHRALHRRLVACVTVSSRRH RKEAGRGRAES in isoform 2. CuratedVSP_023656Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355472 Genomic DNA. Translation: CAI22928.1.
AL355472 Genomic DNA. Translation: CAI22929.1.
AL355472 Genomic DNA. Translation: CAI22930.1.
BC025793 mRNA. Translation: AAH25793.1. Sequence problems.
BC116455 mRNA. Translation: AAI16456.1.
CCDSiCCDS31059.1. [Q5JTJ3-1]
CCDS55690.1. [Q5JTJ3-3]
RefSeqiNP_001013003.1. NM_001012985.2. [Q5JTJ3-1]
NP_001288662.1. NM_001301733.1. [Q5JTJ3-3]
UniGeneiHs.23198.

Genome annotation databases

EnsembliENST00000366612; ENSP00000355571; ENSG00000168275. [Q5JTJ3-3]
ENST00000366613; ENSP00000355572; ENSG00000168275. [Q5JTJ3-1]
ENST00000619305; ENSP00000479686; ENSG00000168275. [Q5JTJ3-3]
GeneIDi388753.
KEGGihsa:388753.
UCSCiuc001hwb.3. human. [Q5JTJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355472 Genomic DNA. Translation: CAI22928.1.
AL355472 Genomic DNA. Translation: CAI22929.1.
AL355472 Genomic DNA. Translation: CAI22930.1.
BC025793 mRNA. Translation: AAH25793.1. Sequence problems.
BC116455 mRNA. Translation: AAI16456.1.
CCDSiCCDS31059.1. [Q5JTJ3-1]
CCDS55690.1. [Q5JTJ3-3]
RefSeqiNP_001013003.1. NM_001012985.2. [Q5JTJ3-1]
NP_001288662.1. NM_001301733.1. [Q5JTJ3-3]
UniGeneiHs.23198.

3D structure databases

ProteinModelPortaliQ5JTJ3.
SMRiQ5JTJ3. Positions 43-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132839. 3 interactions.
IntActiQ5JTJ3. 2 interactions.
STRINGi9606.ENSP00000355572.

PTM databases

PhosphoSiteiQ5JTJ3.

Polymorphism and mutation databases

BioMutaiCOA6.
DMDMi74742178.

Proteomic databases

MaxQBiQ5JTJ3.
PaxDbiQ5JTJ3.
PRIDEiQ5JTJ3.

Protocols and materials databases

DNASUi388753.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366612; ENSP00000355571; ENSG00000168275. [Q5JTJ3-3]
ENST00000366613; ENSP00000355572; ENSG00000168275. [Q5JTJ3-1]
ENST00000619305; ENSP00000479686; ENSG00000168275. [Q5JTJ3-3]
GeneIDi388753.
KEGGihsa:388753.
UCSCiuc001hwb.3. human. [Q5JTJ3-1]

Organism-specific databases

CTDi388753.
GeneCardsiGC01P234510.
HGNCiHGNC:18025. COA6.
HPAiHPA028588.
MIMi614772. gene.
neXtProtiNX_Q5JTJ3.
PharmGKBiPA25617.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG80742.
GeneTreeiENSGT00390000004094.
HOGENOMiHOG000196422.
HOVERGENiHBG056284.
InParanoidiQ5JTJ3.
KOiK18179.
OMAiRDEYWRC.
OrthoDBiEOG74R1T7.
PhylomeDBiQ5JTJ3.
TreeFamiTF335992.

Miscellaneous databases

GenomeRNAii388753.
NextBioi102341.
PROiQ5JTJ3.
SOURCEiSearch...

Gene expression databases

BgeeiQ5JTJ3.
CleanExiHS_C1orf31.
ExpressionAtlasiQ5JTJ3. baseline and differential.
GenevisibleiQ5JTJ3. HS.

Family and domain databases

Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
SUPFAMiSSF47694. SSF47694. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Ovary and Testis.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase."
    Szklarczyk R., Wanschers B.F., Cuypers T.D., Esseling J.J., Riemersma M., van den Brand M.A., Gloerich J., Lasonder E., van den Heuvel L.P., Nijtmans L.G., Huynen M.A.
    Genome Biol. 13:RESEARCH0012.1-RESEARCH0012.14(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH COA1.
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS] (ISOFORM 3).

Entry informationi

Entry nameiCOA6_HUMAN
AccessioniPrimary (citable) accession number: Q5JTJ3
Secondary accession number(s): Q5JTJ2, Q5JTJ4, Q8TA88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: February 15, 2005
Last modified: June 24, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.