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Protein

RRP12-like protein

Gene

RRP12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
RRP12-like protein
Gene namesi
Name:RRP12
Synonyms:KIAA0690
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:29100. RRP12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei903 – 923HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23223.
OpenTargetsiENSG00000052749.
PharmGKBiPA162402122.

Polymorphism and mutation databases

BioMutaiRRP12.
DMDMi71153787.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507681 – 1297RRP12-like proteinAdd BLAST1297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Cross-linki71Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei72PhosphoserineCombined sources1
Modified residuei77PhosphothreonineCombined sources1
Modified residuei88PhosphothreonineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Modified residuei1049PhosphoserineCombined sources1
Modified residuei1072PhosphoserineCombined sources1
Modified residuei1080PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5JTH9.
MaxQBiQ5JTH9.
PaxDbiQ5JTH9.
PeptideAtlasiQ5JTH9.
PRIDEiQ5JTH9.

2D gel databases

SWISS-2DPAGEQ5JTH9.

PTM databases

iPTMnetiQ5JTH9.
PhosphoSitePlusiQ5JTH9.
SwissPalmiQ5JTH9.

Expressioni

Tissue specificityi

Weakly expressed. Expressed at intermediate level in testis and ovary.1 Publication

Gene expression databases

BgeeiENSG00000052749.
CleanExiHS_RRP12.
ExpressionAtlasiQ5JTH9. baseline and differential.
GenevisibleiQ5JTH9. HS.

Organism-specific databases

HPAiHPA049945.

Interactioni

Protein-protein interaction databases

BioGridi116829. 82 interactors.
IntActiQ5JTH9. 20 interactors.
MINTiMINT-1160282.
STRINGi9606.ENSP00000360031.

Structurei

3D structure databases

ProteinModelPortaliQ5JTH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1054 – 1090Glu-richAdd BLAST37

Sequence similaritiesi

Belongs to the RRP12 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1248. Eukaryota.
ENOG410XQ3D. LUCA.
GeneTreeiENSGT00390000013106.
HOGENOMiHOG000006643.
HOVERGENiHBG080767.
InParanoidiQ5JTH9.
KOiK14794.
OMAiAQDYVTW.
OrthoDBiEOG091G00MA.
PhylomeDBiQ5JTH9.
TreeFamiTF300780.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR012978. Uncharacterised_NUC173.
[Graphical view]
PfamiPF08161. NUC173. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JTH9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRSGKLPSG VSAKLKRWKK GHSSDSNPAI CRHRQAARSR FFSRPSGRSD
60 70 80 90 100
LTVDAVKLHN ELQSGSLRLG KSEAPETPME EEAELVLTEK SSGTFLSGLS
110 120 130 140 150
DCTNVTFSKV QRFWESNSAA HKEICAVLAA VTEVIRSQGG KETETEYFAA
160 170 180 190 200
LMTTMEAVES PESLAAVAYL LNLVLKRVPS PVLIKKFSDT SKAFMDIMSA
210 220 230 240 250
QASSGSTSVL RWVLSCLATL LRKQDLEAWG YPVTLQVYHG LLSFTVHPKP
260 270 280 290 300
KIRKAAQHGV CSVLKGSEFM FEKAPAHHPA AISTAKFCIQ EIEKSGGSKE
310 320 330 340 350
ATTTLHMLTL LKDLLPCFPE GLVKSCSETL LRVMTLSHVL VTACAMQAFH
360 370 380 390 400
SLFHARPGLS TLSAELNAQI ITALYDYVPS ENDLQPLLAW LKVMEKAHIN
410 420 430 440 450
LVRLQWDLGL GHLPRFFGTA VTCLLSPHSQ VLTAATQSLK EILKECVAPH
460 470 480 490 500
MADIGSVTSS ASGPAQSVAK MFRAVEEGLT YKFHAAWSSV LQLLCVFFEA
510 520 530 540 550
CGRQAHPVMR KCLQSLCDLR LSPHFPHTAA LDQAVGAAVT SMGPEVVLQA
560 570 580 590 600
VPLEIDGSEE TLDFPRSWLL PVIRDHVQET RLGFFTTYFL PLANTLKSKA
610 620 630 640 650
MDLAQAGSTV ESKIYDTLQW QMWTLLPGFC TRPTDVAISF KGLARTLGMA
660 670 680 690 700
ISERPDLRVT VCQALRTLIT KGCQAEADRA EVSRFAKNFL PILFNLYGQP
710 720 730 740 750
VAAGDTPAPR RAVLETIRTY LTITDTQLVN SLLEKASEKV LDPASSDFTR
760 770 780 790 800
LSVLDLVVAL APCADEAAIS KLYSTIRPYL ESKAHGVQKK AYRVLEEVCA
810 820 830 840 850
SPQGPGALFV QSHLEDLKKT LLDSLRSTSS PAKRPRLKCL LHIVRKLSAE
860 870 880 890 900
HKEFITALIP EVILCTKEVS VGARKNAFAL LVEMGHAFLR FGSNQEEALQ
910 920 930 940 950
CYLVLIYPGL VGAVTMVSCS ILALTHLLFE FKGLMGTSTV EQLLENVCLL
960 970 980 990 1000
LASRTRDVVK SALGFIKVAV TVMDVAHLAK HVQLVMEAIG KLSDDMRRHF
1010 1020 1030 1040 1050
RMKLRNLFTK FIRKFGFELV KRLLPEEYHR VLVNIRKAEA RAKRHRALSQ
1060 1070 1080 1090 1100
AAVEEEEEEE EEEEPAQGKG DSIEEILADS EDEEDNEEEE RSRGKEQRKL
1110 1120 1130 1140 1150
ARQRSRAWLK EGGGDEPLNF LDPKVAQRVL ATQPGPGRGR KKDHGFKVSA
1160 1170 1180 1190 1200
DGRLIIREEA DGNKMEEEEG AKGEDEEMAD PMEDVIIRNK KHQKLKHQKE
1210 1220 1230 1240 1250
AEEEELEIPP QYQAGGSGIH RPVAKKAMPG AEYKAKKAKG DVKKKGRPDP
1260 1270 1280 1290
YAYIPLNRSK LNRRKKMKLQ GQFKGLVKAA RRGSQVGHKN RRKDRRP
Length:1,297
Mass (Da):143,702
Last modified:July 19, 2005 - v2
Checksum:i23A203CBFB7C46D3
GO
Isoform 2 (identifier: Q5JTH9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-251: Missing.

Note: No experimental confirmation available.
Show »
Length:1,197
Mass (Da):132,709
Checksum:i6FBE0C051493D000
GO
Isoform 3 (identifier: Q5JTH9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-212: Missing.

Note: No experimental confirmation available.
Show »
Length:1,236
Mass (Da):137,114
Checksum:i39277064AC555FB5
GO

Sequence cautioni

The sequence BAA31665 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti249K → R in BAG59012 (PubMed:14702039).Curated1
Sequence conflicti818K → R in BAG59012 (PubMed:14702039).Curated1
Sequence conflicti1196K → R in BAG59012 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0577561145G → S.3 PublicationsCorresponds to variant rs2275580dbSNPEnsembl.1
Natural variantiVAR_0577571281R → Q.2 PublicationsCorresponds to variant rs1048445dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014798152 – 251Missing in isoform 2. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_045674152 – 212Missing in isoform 3. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014590 mRNA. Translation: BAA31665.1. Different initiation.
AK296315 mRNA. Translation: BAG59012.1.
AL355490 Genomic DNA. Translation: CAI40776.1.
AL355490 Genomic DNA. Translation: CAI40777.1.
BC002621 mRNA. Translation: AAH02621.3.
BC012745 mRNA. Translation: AAH12745.1.
AL832924 mRNA. Translation: CAH10606.1.
CCDSiCCDS44467.1. [Q5JTH9-3]
CCDS60605.1. [Q5JTH9-2]
CCDS7457.1. [Q5JTH9-1]
PIRiT00356.
RefSeqiNP_001138586.1. NM_001145114.1. [Q5JTH9-3]
NP_001271266.1. NM_001284337.1. [Q5JTH9-2]
NP_055994.2. NM_015179.3. [Q5JTH9-1]
UniGeneiHs.434251.

Genome annotation databases

EnsembliENST00000315563; ENSP00000324315; ENSG00000052749. [Q5JTH9-2]
ENST00000370992; ENSP00000360031; ENSG00000052749. [Q5JTH9-1]
ENST00000414986; ENSP00000414863; ENSG00000052749. [Q5JTH9-3]
ENST00000536831; ENSP00000446184; ENSG00000052749. [Q5JTH9-1]
GeneIDi23223.
KEGGihsa:23223.
UCSCiuc001knf.4. human. [Q5JTH9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014590 mRNA. Translation: BAA31665.1. Different initiation.
AK296315 mRNA. Translation: BAG59012.1.
AL355490 Genomic DNA. Translation: CAI40776.1.
AL355490 Genomic DNA. Translation: CAI40777.1.
BC002621 mRNA. Translation: AAH02621.3.
BC012745 mRNA. Translation: AAH12745.1.
AL832924 mRNA. Translation: CAH10606.1.
CCDSiCCDS44467.1. [Q5JTH9-3]
CCDS60605.1. [Q5JTH9-2]
CCDS7457.1. [Q5JTH9-1]
PIRiT00356.
RefSeqiNP_001138586.1. NM_001145114.1. [Q5JTH9-3]
NP_001271266.1. NM_001284337.1. [Q5JTH9-2]
NP_055994.2. NM_015179.3. [Q5JTH9-1]
UniGeneiHs.434251.

3D structure databases

ProteinModelPortaliQ5JTH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116829. 82 interactors.
IntActiQ5JTH9. 20 interactors.
MINTiMINT-1160282.
STRINGi9606.ENSP00000360031.

PTM databases

iPTMnetiQ5JTH9.
PhosphoSitePlusiQ5JTH9.
SwissPalmiQ5JTH9.

Polymorphism and mutation databases

BioMutaiRRP12.
DMDMi71153787.

2D gel databases

SWISS-2DPAGEQ5JTH9.

Proteomic databases

EPDiQ5JTH9.
MaxQBiQ5JTH9.
PaxDbiQ5JTH9.
PeptideAtlasiQ5JTH9.
PRIDEiQ5JTH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315563; ENSP00000324315; ENSG00000052749. [Q5JTH9-2]
ENST00000370992; ENSP00000360031; ENSG00000052749. [Q5JTH9-1]
ENST00000414986; ENSP00000414863; ENSG00000052749. [Q5JTH9-3]
ENST00000536831; ENSP00000446184; ENSG00000052749. [Q5JTH9-1]
GeneIDi23223.
KEGGihsa:23223.
UCSCiuc001knf.4. human. [Q5JTH9-1]

Organism-specific databases

CTDi23223.
DisGeNETi23223.
GeneCardsiRRP12.
H-InvDBHIX0009088.
HGNCiHGNC:29100. RRP12.
HPAiHPA049945.
neXtProtiNX_Q5JTH9.
OpenTargetsiENSG00000052749.
PharmGKBiPA162402122.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1248. Eukaryota.
ENOG410XQ3D. LUCA.
GeneTreeiENSGT00390000013106.
HOGENOMiHOG000006643.
HOVERGENiHBG080767.
InParanoidiQ5JTH9.
KOiK14794.
OMAiAQDYVTW.
OrthoDBiEOG091G00MA.
PhylomeDBiQ5JTH9.
TreeFamiTF300780.

Miscellaneous databases

ChiTaRSiRRP12. human.
GeneWikiiRRP12.
GenomeRNAii23223.
PROiQ5JTH9.

Gene expression databases

BgeeiENSG00000052749.
CleanExiHS_RRP12.
ExpressionAtlasiQ5JTH9. baseline and differential.
GenevisibleiQ5JTH9. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR012978. Uncharacterised_NUC173.
[Graphical view]
PfamiPF08161. NUC173. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiRRP12_HUMAN
AccessioniPrimary (citable) accession number: Q5JTH9
Secondary accession number(s): B4DK00
, E9PCK7, Q5JTH8, Q69YK4, Q96E87, Q9BUH3, Q9Y4C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.